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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of FASLG mRNA, Carbon Tetrachloride results in increased expression of FASLG protein

PMID:16609999, PMID:16644059, PMID:17105443
multiple interactionsEXP 6480464CTDIL10 protein promotes the reaction [Carbon Tetrachloride results in increased expression of FASLG mRNA], IL10 protein promotes the reaction [Carbon Tetrachloride results in increased expression of FASLG protein]

PMID:16609999, PMID:17105443
increases expressionISORGD:15530646480464CTDCarbon Tetrachloride results in increased expression of FASL mRNA, Carbon Tetrachloride results in increased expression of FASL protein

PMID:18291569, PMID:18436364, PMID:23279844, PMID:23994094, PMID:25432964
multiple interactionsISORGD:15530646480464CTDcaffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased expression of FASL protein], Changkil inhibits the reaction [Carbon Tetrachloride results in increased expression of FASL protein], Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein]], Flavonoids inhibits the reaction [Carbon Tetrachloride results in increased expression of FASL mRNA], Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of FASL mRNA], PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein], Saponins inhibits the reaction [Carbon Tetrachloride results in increased expression of FASL mRNA], SC 560 promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein]

PMID:18291569, PMID:18436364, PMID:23279844, PMID:23994094, PMID:25432964
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.