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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of FASLG protein

PMID:15799720
multiple interactionsEXP 6480464CTD1, 2-bis(2-aminophenoxy)ethane N, N, N', N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Hydrogen Peroxide results in increased expression of FASLG protein], [mitoquinol co-treated with mitoquinone] inhibits the reaction [Hydrogen Peroxide results in increased expression of FASL protein]

PMID:15799720
increases chemical synthesisISORGD:16063426480464CTDFASL protein results in increased chemical synthesis of Hydrogen Peroxide

PMID:17724027
increases expressionISORGD:16063426480464CTDHydrogen Peroxide results in increased expression of FASLG mRNA

PMID:21347231
multiple interactionsISORGD:16063426480464CTD[Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA, [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA, Pyruvic Acid inhibits the reaction [FASL protein results in increased chemical synthesis of Hydrogen Peroxide]

PMID:16510162, PMID:17724027
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.