RGD Reference Report - MicroRNA-21 and -146b are involved in the pathogenesis of murine viral myocarditis by regulating TH-17 differentiation. - Rat Genome Database

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MicroRNA-21 and -146b are involved in the pathogenesis of murine viral myocarditis by regulating TH-17 differentiation.

Authors: Liu, Yan Li  Wu, Weifeng  Xue, Yimin  Gao, Mengsha  Yan, Yuluan  Kong, Qing  Pang, Yu  Yang, Fan 
Citation: Liu YL, etal., Arch Virol. 2013 Sep;158(9):1953-63. doi: 10.1007/s00705-013-1695-6. Epub 2013 Apr 16.
RGD ID: 41404640
Pubmed: (View Article at PubMed) PMID:23588407
DOI: Full-text: DOI:10.1007/s00705-013-1695-6

Viral myocarditis (VMC) is a common cardiovascular disease, and microRNAs (miRNAs) have been postulated to be involved in its pathology. Using microarrays, we observed that miRNA-21 and -146b were upregulated in a murine model of VMC. We also found that miRNA-451 was downregulated. In vivo silencing of miRNA-21 and -146b resulted in less-severe VMC. Overexpression of miRNA-451 did not ameliorate the severity of VMC. Further work revealed that inhibition of miRNA-21 and -146b decreased the expression levels of Th17 and RORγt . Overexpression of miRNA-451 had no effect on IL-17 and RORγt expression. Inhibition of miRNA-21 and -146b might ameliorate myocardium inflammation by mediating downregulation of RORγt expression, indicating that these miRNAs are involved in the pathogenesis of murine VMC.

Annotation

Disease Annotations    
Viral Myocarditis  (IMP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Mir146b  (microRNA 146b)
Mir21  (microRNA 21)

Genes (Mus musculus)
Mir146b  (microRNA 146b)
Mir21a  (microRNA 21a)

Genes (Homo sapiens)
MIR146B  (microRNA 146b)
MIR21  (microRNA 21)


Additional Information