RGD Reference Report - MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis. - Rat Genome Database

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MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis.

Authors: He, Jin  Yue, Yan  Dong, Chunsheng  Xiong, Sidong 
Citation: He J, etal., Clin Invest Med. 2013 Apr 1;36(2):E103-11. doi: 10.25011/cim.v36i2.19573.
RGD ID: 41404700
Pubmed: PMID:23544605   (View Abstract at PubMed)
DOI: DOI:10.25011/cim.v36i2.19573   (Journal Full-text)


PURPOSE: The participation of microRNAs (miRNAs) in cardiovascular diseases suggests them as potential targets for novel preventive and therapeutic strategies. In this study, the key myocardial miRNA, miR-21, was identified in the murine coxsackievirus B3 (CVB3)-induced myocarditis model and its contribution to disease progression was explored.
METHODS: Myocardial microRNA expression changes in CVB3-infected mice were analyzed by real-time PCR and miR-21 was found to be the miRNA whose expression was significantly reduced. Mice were injected with plasmid encoding miR-21 (pMDH-miR-21) at day 1 post CVB3 infection and myocarditis severity was evaluated 7 days post-infection. The underlying mechanism of miR-21 in viral myocarditis was also investigated.
RESULTS: Myocardial miR-21 expression was negatively related to viral myocarditis severity. Recovery of miR-21 expression, by injecting with pMDH-miR-21, significantly relieved CVB3-induced myocarditis as shown by increased body weight, reduced myocardial injury, lowered myocarditis score and increased survival rate. Further study showed that miR-21 could protect myocardial apoptosis by specifically inhibiting its target programmed cell death 4 (PDCD4) expression.
CONCLUSION: miR-21 administration efficiently alleviated CVB3-induced myocarditis by repressing PDCD4-mediated apoptosis. Our study not only helps to better understand the pathogenesis of viral myocarditis, but also proves the potential of miR-21 as a novel therapeutic target for treatment of CVB3-induced myocarditis and other apoptosis-mediated cardiovascular diseases.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR21HumanViral Myocarditis amelioratesISOMir21a (Mus musculus)associated with Coxsackievirus InfectionsRGD 
Mir21RatViral Myocarditis amelioratesISOMir21a (Mus musculus)associated with Coxsackievirus InfectionsRGD 
Mir21aMouseViral Myocarditis amelioratesIDA associated with Coxsackievirus InfectionsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir21  (microRNA 21)

Genes (Mus musculus)
Mir21a  (microRNA 21a)

Genes (Homo sapiens)
MIR21  (microRNA 21)


Additional Information