MIR21 (microRNA mir-21) - Rat Genome Database

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Gene: MIR21 (microRNA mir-21) Sus scrofa
Analyze
Symbol: MIR21 (Ensembl: ssc-mir-21)
Name: microRNA mir-21 (Ensembl:ssc-mir-21)
RGD ID: 13974410
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA 21; ssc-mir-21
RGD Orthologs
Human
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,065,267 - 36,065,358 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,065,267 - 36,065,358 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,340,385 - 37,340,476 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
allergic contact dermatitis  (ISO)
Angina Pectoris  (ISO)
atherosclerosis  (ISO)
Atrial Remodeling  (ISO)
autoimmune uveitis  (ISO)
brain glioma  (ISO)
breast cancer  (ISO)
Burkitt lymphoma  (ISO)
Cardio-Renal Syndrome  (ISO)
Cardiomegaly  (ISO)
cerebral infarction  (ISO)
cervical cancer  (ISO)
cervical squamous cell carcinoma  (ISO)
cervicitis  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
cholangiocarcinoma  (ISO)
Cholangiofibrosis  (ISO)
Chronic Hepatitis  (ISO)
chronic lymphocytic leukemia  (ISO)
colon cancer  (ISO)
colorectal cancer  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cryptosporidiosis  (ISO)
dengue disease  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
esophageal cancer  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Colitis  (ISO)
Fibrosis  (ISO)
Fusobacterium Infections  (ISO)
glioblastoma  (ISO)
Haemophilus Infections  (ISO)
heart disease  (ISO)
hepatitis C  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertensive heart disease  (ISO)
Inflammation  (ISO)
influenza  (ISO)
intestinal obstruction  (ISO)
Intestinal Reperfusion Injury  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
irritable bowel syndrome  (ISO)
Joubert syndrome  (ISO)
kidney disease  (ISO)
laryngeal squamous cell carcinoma  (ISO)
listeriosis  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung adenoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Microsatellite Instability  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
papillomavirus infectious disease  (ISO)
Parkinson's disease  (ISO)
Peritoneal Fibrosis  (ISO)
peritonitis  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (ISO)
sciatic neuropathy  (ISO)
skin melanoma  (ISO)
skin papilloma  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
thyroid gland anaplastic carcinoma  (ISO)
thyroid gland cancer  (ISO)
toxic shock syndrome  (ISO)
Varicose Ulcer  (ISO)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
BMP signaling pathway  (ISO)
cellular response to angiotensin  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
endothelial tube morphogenesis  (ISO)
epithelial to mesenchymal transition involved in cardiac fibroblast development  (ISO)
female pregnancy  (ISO)
inflammatory response to antigenic stimulus  (ISO)
miRNA-mediated gene silencing  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of aortic smooth muscle cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cartilage development  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of chondrocyte proliferation  (ISO)
negative regulation of cytokine-mediated signaling pathway  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of hydrogen peroxide-mediated programmed cell death  (ISO)
negative regulation of hydrogen sulfide biosynthetic process  (ISO)
negative regulation of innate immune response  (ISO)
negative regulation of interleukin-1-mediated signaling pathway  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-21 production  (ISO)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of myofibroblast cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of NIK/NF-kappaB signaling  (ISO)
negative regulation of regulatory T cell differentiation  (ISO)
negative regulation of stress fiber assembly  (ISO)
negative regulation of superoxide dismutase activity  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (ISO)
negative regulation of type I interferon production  (ISO)
negative regulation of type I interferon-mediated signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
phenotypic switching  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial tube morphogenesis  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of keratinocyte proliferation  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of metalloendopeptidase activity  (ISO)
positive regulation of myofibroblast differentiation  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of potassium ion export across plasma membrane  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of replicative senescence  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular associated smooth muscle contraction  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
positive regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of wound healing  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
regulation of cell migration  (ISO)
regulation of cell shape  (ISO)
regulation of epidermal growth factor receptor signaling pathway  (ISO)
regulation of gene expression  (ISO)
regulation of mesenchymal stem cell differentiation  (ISO)
response to bacterium  (ISO)
response to hypoxia  (ISO)
response to muscle activity  (ISO)
response to oxygen levels  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:15885146   PMID:16381832   PMID:18548309   PMID:19196471   PMID:19917043   PMID:20180025   PMID:21312241   PMID:24499489   PMID:24889251   PMID:25230983   PMID:27093346   PMID:29775626  
PMID:30051550   PMID:32299591  


Genomics

Comparative Map Data
MIR21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,065,267 - 36,065,358 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,065,267 - 36,065,358 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,340,385 - 37,340,476 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIR21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,841,266 - 59,841,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1759,841,266 - 59,841,337 (+)EnsemblGRCh38hg38GRCh38
GRCh371757,918,627 - 57,918,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,273,408 - 55,273,479 (+)NCBINCBI36Build 36hg18NCBI36
Celera1754,382,140 - 54,382,211 (+)NCBICelera
Cytogenetic Map17q23.1NCBI
HuRef1753,291,116 - 53,291,187 (+)NCBIHuRef
CHM1_11757,982,648 - 57,982,719 (+)NCBICHM1_1
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBIT2T-CHM13v2.0
Mir21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,474,893 - 86,474,984 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,474,893 - 86,474,984 (-)EnsemblGRCm39 Ensembl
GRCm381186,584,067 - 86,584,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,584,067 - 86,584,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,397,569 - 86,397,660 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1196,199,974 - 96,200,065 (-)NCBICelera
Cytogenetic Map11CNCBI
Mir21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21071,405,257 - 71,405,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1071,405,257 - 71,405,348 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1076,026,707 - 76,026,798 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01075,531,582 - 75,531,673 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01070,996,132 - 70,996,223 (-)NCBIRnor_WKY
Rnor_6.01073,902,210 - 73,902,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,902,210 - 73,902,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,197,081 - 76,197,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1070,326,375 - 70,326,466 (-)NCBICelera
Cytogenetic Map10q26NCBI
MIR21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,340,550 - 34,340,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,340,533 - 34,340,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha933,572,293 - 33,572,352 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0935,150,885 - 35,150,944 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl935,150,868 - 35,150,959 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1933,934,637 - 33,934,696 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0934,220,122 - 34,220,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0934,306,261 - 34,306,320 (+)NCBIUU_Cfam_GSD_1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000020150
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1236,065,267 - 36,065,358 (+)Ensembl
RefSeq Acc Id: NR_038508
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11236,065,267 - 36,065,358 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000018555 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000020150 ENTREZGENE
miRBase MI0002459 ENTREZGENE
NCBI Gene MIR21 ENTREZGENE
RNAcentral URS0000013967 RNACentral
  URS000020E260 RNACentral
  URS000039ED8D RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR21  microRNA mir-21    microRNA 21  Symbol and/or name change 5135510 APPROVED