Gene: Tpm1 (tropomyosin 1) Rattus norvegicus
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Symbol: Tpm1
Name: tropomyosin 1
Description: ENCODES a protein that exhibits actin binding; actin filament binding; disordered domain specific binding; INVOLVED IN actin filament capping; cardiac muscle contraction; muscle filament sliding; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH atrial heart septal defect 1 (ortholog); cardiomyopathy (ortholog); catecholaminergic polymorphic ventricular tachycardia (ortholog); FOUND IN actin cytoskeleton; protein-containing complex; bleb (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate
AGR Description: Exhibits several functions, including actin filament binding activity, disordered domain specific binding activity, and protein dimerization activity; involved in several processes, including cardiac muscle contraction, muscle filament sliding, and regulation of organelle organization; localizes to the actin cytoskeleton and protein-containing complex; orthologous to human TPM1 (tropomyosin 1).
Merged Description: Exhibits several functions, including actin filament binding activity, disordered domain specific binding activity, and protein dimerization activity; involved in several processes, including cardiac muscle contraction, muscle filament sliding, and regulation of organelle organization; localizes to the actin cytoskeleton and protein-containing complex; orthologous to human TPM1 (tropomyosin 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha; Alpha-tm; hepatoma alpha tropomyosin; smooth muscle alpha-tropomyosin; striated muscle alpha-tropomyosin; Tma2; Tmsa; Tropomyosin 1 (alpha); tropomyosin 1 alpha chain; tropomyosin 1, alpha; tropomyosin 3; tropomyosin 3 alpha; tropomyosin 3, alpha; tropomyosin alpha-1 chain; tropomyosin-alpha
Orthologs:
Homo sapiens (human) : TPM1 (tropomyosin 1)  HGNC  Alliance
Mus musculus (house mouse) : Tpm1 (tropomyosin 1, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpm1 (tropomyosin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TPM1 (tropomyosin 1)
Canis lupus familiaris (dog) : TPM1 (tropomyosin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpm1 (tropomyosin 1)
Sus scrofa (pig) : TPM1 (tropomyosin 1)
more info ...
Allele / Splice: Tpm1_v8   Tpm1_v4   Tpm1_v7   Tpm1_v5   Tpm1_v3   Tpm1_v2   Tpm1_v6   Tpm1_v9   Tpm1_v1  
Is Marker For: QTLs:   Inf1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0872,814,737 - 72,841,496 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0877,147,580 - 77,174,392 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4871,331,304 - 71,358,063 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1871,355,970 - 71,371,766 (-)NCBI
Celera874,042,032 - 74,068,764 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tpm1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3898
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.