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Gene: Tpm1 (tropomyosin 1) Rattus norvegicus
Symbol: Tpm1
Name: tropomyosin 1
RGD ID: 3898
Description: Exhibits several functions, including actin filament binding activity; disordered domain specific binding activity; and protein dimerization activity. Involved in several processes, including muscle filament sliding; regulation of actin filament organization; and ruffle organization. Localizes to actin cytoskeleton and protein-containing complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Orthologous to human TPM1 (tropomyosin 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha; Alpha-tm; hepatoma alpha tropomyosin; smooth muscle alpha-tropomyosin; striated muscle alpha-tropomyosin; Tma2; Tmsa; Tropomyosin 1 (alpha); tropomyosin 1 alpha chain; tropomyosin 1, alpha; tropomyosin 3; tropomyosin 3 alpha; tropomyosin 3, alpha; tropomyosin alpha-1 chain; tropomyosin-alpha
Homo sapiens (human) : TPM1 (tropomyosin 1)  HGNC  Alliance
Mus musculus (house mouse) : Tpm1 (tropomyosin 1, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpm1 (tropomyosin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TPM1 (tropomyosin 1)
Canis lupus familiaris (dog) : TPM1 (tropomyosin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpm1 (tropomyosin 1)
Sus scrofa (pig) : TPM1 (tropomyosin 1)
Chlorocebus sabaeus (African green monkey) : TPM1 (tropomyosin 1)
Heterocephalus glaber (naked mole-rat) : Tpm1 (tropomyosin 1)
more info ...
Allele / Splice: Tpm1_v8   Tpm1_v4   Tpm1_v7   Tpm1_v5   Tpm1_v3   Tpm1_v2   Tpm1_v6   Tpm1_v9   Tpm1_v1  
Is Marker For: QTLs:   Inf1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0872,814,737 - 72,841,496 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl872,814,740 - 72,842,228 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0877,147,580 - 77,174,392 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4871,331,304 - 71,358,063 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1871,355,970 - 71,371,766 (-)NCBI
Celera874,042,032 - 74,068,764 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tpm1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3898
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.