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Gene: Tpm1 (tropomyosin 1, alpha) Mus musculus
Symbol: Tpm1
Name: tropomyosin 1, alpha
Description: Exhibits actin filament binding activity. Involved in several processes, including cardiac muscle contraction; positive regulation of heart rate by epinephrine; and ventricular cardiac muscle tissue morphogenesis. Localizes to the myofibril. Used to study dilated cardiomyopathy 1Y and hypertrophic cardiomyopathy 3. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Is expressed in several structures, including central nervous system; gut; heart; limb segment; and musculature. Orthologous to human TPM1 (tropomyosin 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA986836; AI854628; alpha tropomyosin; alpha-TM; alpha-tropomyosin; expressed sequence AI854628; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa; tropomyosin 1 kappa; tropomyosin alpha-1 chain; tropomyosin-1
Homo sapiens (human) : TPM1 (tropomyosin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tpm1 (tropomyosin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpm1 (tropomyosin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TPM1 (tropomyosin 1)
Canis lupus familiaris (dog) : TPM1 (tropomyosin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpm1 (tropomyosin 1)
Sus scrofa (pig) : TPM1 (tropomyosin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38967,022,590 - 67,049,672 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37966,870,400 - 66,897,020 (-)NCBIGRCm37mm9NCBIm37
MGSCv36966,821,737 - 66,848,357 (-)NCBImm8
Celera964,256,822 - 64,283,903 (-)NCBICelera
Cytogenetic Map9 CNCBI
cM Map936.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Tpm1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11445
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.