Tpm1 (tropomyosin 1) - Rat Genome Database

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Gene: Tpm1 (tropomyosin 1) Chinchilla lanigera
Analyze
Symbol: Tpm1
Name: tropomyosin 1
RGD ID: 8710882
Description: ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); cytoskeletal protein binding (ortholog); INVOLVED IN actin filament capping (ortholog); cardiac muscle contraction (ortholog); cellular response to reactive oxygen species (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH atrial heart septal defect 1 (ortholog); Bloom syndrome (ortholog); cardiomyopathy (ortholog); FOUND IN actin cytoskeleton (ortholog); bleb (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: tropomyosin 1 (alpha); tropomyosin alpha-1 chain
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545012,194,755 - 12,224,011 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545012,197,241 - 12,223,372 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References


Genomics

Comparative Map Data
Tpm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545012,194,755 - 12,224,011 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545012,197,241 - 12,223,372 (-)NCBIChiLan1.0ChiLan1.0
TPM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1563,042,632 - 63,071,915 (+)EnsemblGRCh38hg38GRCh38
GRCh381563,042,698 - 63,071,915 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371563,334,946 - 63,364,114 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,121,891 - 61,151,167 (+)NCBINCBI36hg18NCBI36
Build 341561,121,940 - 61,145,344NCBI
Celera1540,214,544 - 40,243,825 (+)NCBI
Cytogenetic Map15q22.2NCBI
HuRef1540,157,801 - 40,187,095 (+)NCBIHuRef
CHM1_11563,453,982 - 63,483,261 (+)NCBICHM1_1
Tpm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39966,929,872 - 66,956,954 (-)NCBIGRCm39mm39
GRCm39 Ensembl966,929,872 - 66,956,688 (-)Ensembl
GRCm38967,022,590 - 67,049,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl967,022,590 - 67,049,406 (-)EnsemblGRCm38mm10GRCm38
MGSCv37966,870,400 - 66,897,020 (-)NCBIGRCm37mm9NCBIm37
MGSCv36966,821,737 - 66,848,357 (-)NCBImm8
Celera964,256,822 - 64,283,903 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map936.27NCBI
Tpm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2867,635,479 - 67,662,330 (-)NCBI
Rnor_6.0 Ensembl872,814,740 - 72,842,228 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0872,814,737 - 72,841,496 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0877,147,580 - 77,174,392 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4871,331,304 - 71,358,063 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1871,355,970 - 71,371,766 (-)NCBI
Celera874,042,032 - 74,068,764 (+)NCBICelera
Cytogenetic Map8q24NCBI
TPM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11560,286,587 - 60,315,530 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1560,286,587 - 60,315,530 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01541,989,239 - 42,018,520 (+)NCBIMhudiblu_PPA_v0panPan3
TPM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13027,636,407 - 27,664,907 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3027,636,283 - 27,664,442 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3027,555,422 - 27,583,889 (+)NCBI
ROS_Cfam_1.03027,808,901 - 27,837,409 (+)NCBI
UMICH_Zoey_3.13027,745,620 - 27,774,085 (+)NCBI
UNSW_CanFamBas_1.03027,807,813 - 27,836,317 (+)NCBI
UU_Cfam_GSD_1.03028,051,643 - 28,080,112 (+)NCBI
Tpm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640105,795,687 - 105,822,712 (+)NCBI
SpeTri2.0NW_00493647123,643,645 - 23,670,775 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1108,986,981 - 109,019,440 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11108,986,981 - 109,016,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21120,211,175 - 120,240,270 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPM1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12620,458,287 - 20,487,387 (-)NCBI
ChlSab1.1 Ensembl2620,466,037 - 20,487,135 (-)Ensembl
Vero_WHO_p1.0NW_023666048120,912,655 - 120,941,683 (+)NCBI
Tpm1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247819,414,500 - 9,442,357 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000013071   ⟹   ENSCLAP00000012921
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545012,194,755 - 12,224,011 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000013072   ⟹   ENSCLAP00000012922
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545012,194,755 - 12,224,011 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000013073   ⟹   ENSCLAP00000012923
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545012,194,755 - 12,218,121 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000013074   ⟹   ENSCLAP00000012924
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545012,198,004 - 12,223,268 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000013075   ⟹   ENSCLAP00000012925
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545012,201,878 - 12,224,011 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000013076   ⟹   ENSCLAP00000012926
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545012,201,878 - 12,224,011 (-)Ensembl
RefSeq Acc Id: XM_005393795   ⟹   XP_005393852
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545012,197,241 - 12,223,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005393797   ⟹   XP_005393854
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545012,197,241 - 12,223,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005393799   ⟹   XP_005393856
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545012,197,241 - 12,223,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005393800   ⟹   XP_005393857
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545012,197,241 - 12,223,372 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005393801   ⟹   XP_005393858
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545012,198,559 - 12,223,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013518944   ⟹   XP_013374398
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545012,202,398 - 12,223,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013518945   ⟹   XP_013374399
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545012,202,398 - 12,223,368 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005393852   ⟸   XM_005393795
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005393854   ⟸   XM_005393797
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005393856   ⟸   XM_005393799
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005393857   ⟸   XM_005393800
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_005393858   ⟸   XM_005393801
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_013374398   ⟸   XM_013518944
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013374399   ⟸   XM_013518945
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000012923   ⟸   ENSCLAT00000013073
RefSeq Acc Id: ENSCLAP00000012924   ⟸   ENSCLAT00000013074
RefSeq Acc Id: ENSCLAP00000012925   ⟸   ENSCLAT00000013075
RefSeq Acc Id: ENSCLAP00000012926   ⟸   ENSCLAT00000013076
RefSeq Acc Id: ENSCLAP00000012921   ⟸   ENSCLAT00000013071
RefSeq Acc Id: ENSCLAP00000012922   ⟸   ENSCLAT00000013072


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008921 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000012921 ENTREZGENE
  ENSCLAP00000012922 ENTREZGENE
  ENSCLAP00000012924 ENTREZGENE
  ENSCLAP00000012925 ENTREZGENE
  ENSCLAP00000012926 ENTREZGENE
Ensembl Transcript ENSCLAT00000013071 ENTREZGENE
  ENSCLAT00000013072 ENTREZGENE
  ENSCLAT00000013074 ENTREZGENE
  ENSCLAT00000013075 ENTREZGENE
  ENSCLAT00000013076 ENTREZGENE
NCBI Gene Tpm1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-30 Tpm1  tropomyosin 1    tropomyosin 1 (alpha)  Symbol and/or name change 5135510 APPROVED