IRX1 (iroquois homeobox 1) - Rat Genome Database

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Gene: IRX1 (iroquois homeobox 1) Homo sapiens
Analyze
Symbol: IRX1
Name: iroquois homeobox 1
RGD ID: 1349465
HGNC Page HGNC:14358
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Implicated in congenital heart disease.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homeodomain protein IRXA1; iroquois homeobox protein 1; iroquois-class homeodomain protein IRX-1; IRX-5; IRXA1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: IRX1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3853,595,832 - 3,601,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl53,595,832 - 3,601,403 (+)EnsemblGRCh38hg38GRCh38
GRCh3753,595,946 - 3,601,517 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3653,649,168 - 3,654,517 (+)NCBINCBI36Build 36hg18NCBI36
Build 3453,649,167 - 3,654,517NCBI
Celera53,626,588 - 3,631,937 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef53,569,035 - 3,575,436 (+)NCBIHuRef
CHM1_153,596,269 - 3,601,617 (+)NCBICHM1_1
T2T-CHM13v2.053,514,530 - 3,520,100 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRX1Humancongenital heart disease  IAGP 329950497DNA:missense mutations:CDS:p.Q240E more ...RGD 
IRX1Humancongestive heart failure treatmentISOIrx1 (Rattus norvegicus)329950496 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRX1Humanbasal cell carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:36428691
IRX1Humanlung disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21238641

1 to 20 of 83 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRX1Human(+)-schisandrin B multiple interactionsISOIrx1 (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of IRX1 mRNA]CTDPMID:31150632
IRX1Human(1->4)-beta-D-glucan multiple interactionsISOIrx1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IRX1 mRNACTDPMID:36331819
IRX1Human1,1-dichloroethene decreases expressionISOIrx1 (Mus musculus)6480464vinylidene chloride results in decreased expression of IRX1 mRNACTDPMID:26682919
IRX1Human1,2-dimethylhydrazine decreases expressionISOIrx1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of IRX1 mRNACTDPMID:22206623
IRX1Human17beta-estradiol decreases expressionISOIrx1 (Mus musculus)6480464Estradiol results in decreased expression of IRX1 mRNACTDPMID:39298647
IRX1Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISOIrx1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of IRX1 mRNACTDPMID:24058054
IRX1Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOIrx1 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of IRX1 mRNACTDPMID:21215274 and PMID:32109520
IRX1Human2,3,7,8-Tetrachlorodibenzofuran decreases expressionISOIrx1 (Rattus norvegicus)64804642 more ...CTDPMID:32109520
IRX1Human4,4'-sulfonyldiphenol decreases expressionISOIrx1 (Mus musculus)6480464bisphenol S results in decreased expression of IRX1 mRNACTDPMID:39298647
IRX1Human4-hydroxyphenyl retinamide increases expressionISOIrx1 (Mus musculus)6480464Fenretinide results in increased expression of IRX1 mRNACTDPMID:28973697
IRX1Human5-aza-2'-deoxycytidine decreases methylationISOIrx1 (Rattus norvegicus)3299504965-aza-2'-deoxycytidine decreases methylation of Irx1 DNA in failing heart left ventricleRGD 
IRX1Human5-aza-2'-deoxycytidine decreases methylationISOIrx1 (Mus musculus)6480464Decitabine results in decreased methylation of IRX1 enhancerCTDPMID:27923600
IRX1Human5-aza-2'-deoxycytidine multiple interactionsEXP 6480464[Decitabine affects the methylation of IRX1 gene] which affects the expression of IRX1 mRNACTDPMID:18559491
IRX1Human6-propyl-2-thiouracil increases expressionISOIrx1 (Rattus norvegicus)6480464Propylthiouracil results in increased expression of IRX1 mRNACTDPMID:24780913
IRX1Human6-propyl-2-thiouracil decreases expressionISOIrx1 (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of IRX1 mRNACTDPMID:30047161
IRX1Humanacetamide decreases expressionISOIrx1 (Rattus norvegicus)6480464acetamide results in decreased expression of IRX1 mRNACTDPMID:31881176
IRX1Humanacrylamide decreases expressionISOIrx1 (Rattus norvegicus)6480464Acrylamide results in decreased expression of IRX1 mRNACTDPMID:28959563
IRX1Humanaflatoxin B1 increases methylationEXP 6480464Aflatoxin B1 results in increased methylation of IRX1 intronCTDPMID:30157460
IRX1Humanall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of IRX1 mRNACTDPMID:21934132
IRX1Humanalpha-Zearalanol multiple interactionsISOIrx1 (Rattus norvegicus)6480464[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of IRX1 mRNACTDPMID:35163327

1 to 20 of 83 rows

Biological Process
1 to 10 of 10 rows

  
1 to 10 of 10 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRX1Humanchromatin located_inISAtfclass:3.1.4150520179 NTNU_SBGO_REF:0000113
IRX1Humannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
IRX1Humannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
IRX1Humannucleus located_inIEAInterPro:IPR003893150520179 InterProGO_REF:0000002
IRX1Humannucleus is_active_inIBAMGI:1197522 more ...150520179 GO_CentralGO_REF:0000033

Molecular Function
1 to 9 of 9 rows

  
1 to 9 of 9 rows

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRX1HumanAbnormal systemic blood pressure  IAGP 329950498abnormal systolic blood pressure and DNA:altered methylationRGD 

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Exome sequencing reveals novel IRXI mutation in congenital heart disease. Guo C, etal., Mol Med Rep. 2017 May;15(5):3193-3197. doi: 10.3892/mmr.2017.6410. Epub 2017 Mar 30.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure. Wang W, etal., Clin Epigenetics. 2023 Mar 3;15(1):38. doi: 10.1186/s13148-023-01457-1.
5. IRX1 hypermethylation promotes heart failure by inhibiting CXCL14 expression. Zeng L, etal., Cell Cycle. 2019 Dec;18(23):3251-3262. doi: 10.1080/15384101.2019.1673099. Epub 2019 Oct 22.
PMID:8889548   PMID:10370142   PMID:11435706   PMID:12477932   PMID:15489334   PMID:18421076   PMID:18559491   PMID:19240061   PMID:19274049   PMID:19322201   PMID:20029986   PMID:20306291  
PMID:20440264   PMID:21602894   PMID:21649733   PMID:21873635   PMID:22542470   PMID:23284306   PMID:23456299   PMID:25822025   PMID:26815016   PMID:28473536   PMID:28790370   PMID:29802960  
PMID:30862593   PMID:31846199   PMID:32200543   PMID:33069783   PMID:33961781   PMID:35328612   PMID:37116364   PMID:37828025  



IRX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3853,595,832 - 3,601,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl53,595,832 - 3,601,403 (+)EnsemblGRCh38hg38GRCh38
GRCh3753,595,946 - 3,601,517 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3653,649,168 - 3,654,517 (+)NCBINCBI36Build 36hg18NCBI36
Build 3453,649,167 - 3,654,517NCBI
Celera53,626,588 - 3,631,937 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef53,569,035 - 3,575,436 (+)NCBIHuRef
CHM1_153,596,269 - 3,601,617 (+)NCBICHM1_1
T2T-CHM13v2.053,514,530 - 3,520,100 (+)NCBIT2T-CHM13v2.0
Irx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391372,106,351 - 72,111,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1372,106,040 - 72,111,842 (-)EnsemblGRCm39 Ensembl
GRCm381371,958,232 - 71,963,723 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1371,957,921 - 71,963,723 (-)EnsemblGRCm38mm10GRCm38
MGSCv371372,095,680 - 72,101,171 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361372,424,607 - 72,429,479 (-)NCBIMGSCv36mm8
Celera1374,285,058 - 74,290,917 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1338.43NCBI
Irx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8133,123,122 - 33,128,951 (+)NCBIGRCr8
mRatBN7.2131,294,615 - 31,300,444 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl131,294,615 - 31,300,444 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx131,103,832 - 31,109,675 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0137,102,756 - 37,108,597 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0131,302,605 - 31,308,446 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0133,910,912 - 33,916,741 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl133,910,912 - 33,916,741 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0135,319,895 - 35,325,724 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4171,390,894 - 1,396,724 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1171,391,104 - 1,396,424 (+)NCBI
Celera129,929,767 - 29,935,596 (+)NCBICelera
Cytogenetic Map1p11NCBI
Irx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555042,072,540 - 2,099,781 (+)NCBIChiLan1.0ChiLan1.0
IRX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v243,848,593 - 3,854,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan152,002,201 - 2,007,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v053,922,252 - 3,927,836 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.153,610,229 - 3,615,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl53,610,225 - 3,615,279 (+)Ensemblpanpan1.1panPan2
IRX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1349,537,231 - 9,544,029 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl349,538,479 - 9,544,029 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3414,053,493 - 14,058,919 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0349,440,824 - 9,446,274 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl349,440,808 - 9,446,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1349,488,276 - 9,493,698 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0349,467,500 - 9,472,927 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0349,682,784 - 9,688,233 (-)NCBIUU_Cfam_GSD_1.0
Irx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213242,538,955 - 242,544,555 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366343,130,167 - 3,135,537 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366343,130,197 - 3,135,273 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1677,695,071 - 77,701,236 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11677,695,704 - 77,701,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IRX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.143,365,880 - 3,371,520 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl43,366,384 - 3,371,670 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606425,439,633 - 25,445,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247512,010,004 - 2,014,721 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247512,005,849 - 2,014,775 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in IRX1
63 total Variants

1 to 10 of 217 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 5p15.33-15.1(chr5:49978-15678451)x1 copy number loss See cases [RCV000050295] Chr5:49978..15678451 [GRCh38]
Chr5:50093..15678560 [GRCh37]
Chr5:103093..15731560 [NCBI36]
Chr5:5p15.33-15.1		 pathogenic
GRCh38/hg38 5p15.33-15.32(chr5:3502990-4580491)x3 copy number gain See cases [RCV000050886] Chr5:3502990..4580491 [GRCh38]
Chr5:3503104..4580604 [GRCh37]
Chr5:3556104..4633604 [NCBI36]
Chr5:5p15.33-15.32		 pathogenic
GRCh38/hg38 5p15.33(chr5:49978-4014647)x1 copy number loss See cases [RCV000051100] Chr5:49978..4014647 [GRCh38]
Chr5:50093..4014761 [GRCh37]
Chr5:103093..4067761 [NCBI36]
Chr5:5p15.33		 pathogenic
GRCh38/hg38 5p15.33-12(chr5:54839-45649861)x3 copy number gain See cases [RCV000051810] Chr5:54839..45649861 [GRCh38]
Chr5:54954..45649963 [GRCh37]
Chr5:107954..45685720 [NCBI36]
Chr5:5p15.33-12		 pathogenic
GRCh38/hg38 5p15.33-13.2(chr5:54839-35680845)x3 copy number gain See cases [RCV000051811] Chr5:54839..35680845 [GRCh38]
Chr5:54954..35680947 [GRCh37]
Chr5:107954..35716704 [NCBI36]
Chr5:5p15.33-13.2		 pathogenic
GRCh38/hg38 5p15.33-15.31(chr5:3075612-7650835)x3 copy number gain See cases [RCV000051812] Chr5:3075612..7650835 [GRCh38]
Chr5:3075726..7650948 [GRCh37]
Chr5:3128726..7703948 [NCBI36]
Chr5:5p15.33-15.31		 pathogenic
GRCh38/hg38 5p15.33-15.31(chr5:21949-8872509)x3 copy number gain See cases [RCV000051808] Chr5:21949..8872509 [GRCh38]
Chr5:21949..8872621 [GRCh37]
Chr5:74949..8925621 [NCBI36]
Chr5:5p15.33-15.31		 pathogenic
GRCh38/hg38 5p15.33-15.31(chr5:49778-8872509)x3 copy number gain See cases [RCV000051809] Chr5:49778..8872509 [GRCh38]
Chr5:49893..8872621 [GRCh37]
Chr5:102893..8925621 [NCBI36]
Chr5:5p15.33-15.31		 pathogenic
GRCh38/hg38 5p15.33-15.31(chr5:22149-7213275)x1 copy number loss See cases [RCV000053397] Chr5:22149..7213275 [GRCh38]
Chr5:22149..7213388 [GRCh37]
Chr5:75149..7266388 [NCBI36]
Chr5:5p15.33-15.31		 pathogenic
GRCh38/hg38 5p15.33-14.3(chr5:22149-23132046)x1 copy number loss See cases [RCV000053398] Chr5:22149..23132046 [GRCh38]
Chr5:22149..23132155 [GRCh37]
Chr5:75149..23167912 [NCBI36]
Chr5:5p15.33-14.3		 pathogenic
1 to 10 of 217 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR544Ahsa-miR-544aOncomiRDBexternal_infoNANA22934698

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:197
Interacting mature miRNAs:203
Transcripts:ENST00000302006
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597029174GWAS1125248_HBMI-adjusted waist-hip ratio QTL GWAS1125248 (human)0.0000003body size trait (VT:0100005)535977163597717Human
597245133GWAS1341207_HBMI-adjusted waist-hip ratio QTL GWAS1341207 (human)4e-12body size trait (VT:0100005)535977163597717Human
407324575GWAS973551_Hwaist-hip ratio QTL GWAS973551 (human)4e-08BMI-adjusted hip circumferencehip circumference (CMO:0000014)535977163597717Human
597050317GWAS1146391_HBMI-adjusted waist-hip ratio QTL GWAS1146391 (human)2e-08body size trait (VT:0100005)535977163597717Human
597158490GWAS1254564_HBMI-adjusted hip circumference QTL GWAS1254564 (human)5e-10BMI-adjusted hip circumferencehip circumference (CMO:0000014)535977163597717Human

RH98982  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3753,601,268 - 3,601,392UniSTSGRCh37
Build 3653,654,268 - 3,654,392RGDNCBI36
Celera53,631,688 - 3,631,812RGD
Cytogenetic Map5p15.3UniSTS
HuRef53,575,187 - 3,575,311UniSTS
GeneMap99-GB4 RH Map522.69UniSTS
SHGC-56703  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3753,601,302 - 3,601,395UniSTSGRCh37
Build 3653,654,302 - 3,654,395RGDNCBI36
Celera53,631,722 - 3,631,815RGD
Cytogenetic Map5p15.3UniSTS
HuRef53,575,221 - 3,575,314UniSTS
TNG Radiation Hybrid Map5653.0UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1200 1269 2480 1981 4506 1128 1702 1 225 541 61 2219 4123 4489 17 3484 1 645 1267 1446 170 1



Ensembl Acc Id: ENST00000302006   ⟹   ENSP00000305244
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl53,595,832 - 3,601,403 (+)Ensembl
RefSeq Acc Id: NM_024337   ⟹   NP_077313
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3853,595,832 - 3,601,403 (+)NCBI
GRCh3753,596,168 - 3,601,517 (+)RGD
Build 3653,649,168 - 3,654,517 (+)NCBI Archive
Celera53,626,588 - 3,631,937 (+)RGD
HuRef53,569,035 - 3,575,436 (+)RGD
CHM1_153,596,269 - 3,601,617 (+)NCBI
T2T-CHM13v2.053,514,530 - 3,520,100 (+)NCBI
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_077313 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB50005 (Get FASTA)   NCBI Sequence Viewer  
  AAH29160 (Get FASTA)   NCBI Sequence Viewer  
  AAQ16544 (Get FASTA)   NCBI Sequence Viewer  
  AAQ16553 (Get FASTA)   NCBI Sequence Viewer  
  EAX08131 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000305244
  ENSP00000305244.3
GenBank Protein P78414 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_077313   ⟸   NM_024337
- UniProtKB: Q7Z2F8 (UniProtKB/Swiss-Prot),   Q8N312 (UniProtKB/Swiss-Prot),   P78414 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000305244   ⟸   ENST00000302006

Name Modeler Protein Id AA Range Protein Structure
AF-P78414-F1-model_v2 AlphaFold P78414 1-480 view protein structure

RGD ID:6869200
Promoter ID:EPDNEW_H7765
Type:initiation region
Name:IRX1_1
Description:iroquois homeobox 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3853,596,094 - 3,596,154EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
COSMIC IRX1 COSMIC
Ensembl Genes ENSG00000170549 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000302006 ENTREZGENE
  ENST00000302006.4 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
GTEx ENSG00000170549 GTEx
HGNC ID HGNC:14358 ENTREZGENE
Human Proteome Map IRX1 Human Proteome Map
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_KN_domain UniProtKB/Swiss-Prot
  Iroquois_homeo UniProtKB/Swiss-Prot
KEGG Report hsa:79192 UniProtKB/Swiss-Prot
NCBI Gene 79192 ENTREZGENE
OMIM 606197 OMIM
PANTHER IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX UniProtKB/Swiss-Prot
  IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-1 UniProtKB/Swiss-Prot
Pfam Homeobox_KN UniProtKB/Swiss-Prot
PharmGKB PA29924 PharmGKB
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
  IRO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt IRX1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q7Z2F8 ENTREZGENE
  Q8N312 ENTREZGENE
UniProt Secondary Q7Z2F8 UniProtKB/Swiss-Prot
  Q8N312 UniProtKB/Swiss-Prot
1 to 30 of 30 rows