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Gene: Wnk4 (WNK lysine deficient protein kinase 4) Rattus norvegicus
Symbol: Wnk4
Name: WNK lysine deficient protein kinase 4
Description: Exhibits protein serine/threonine kinase activity. Involved in negative regulation of sodium ion transport and protein phosphorylation. Localizes to cytosol and membrane. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4); INTERACTS WITH 1,3-dinitrobenzene; 3,3',4,4',5-pentachlorobiphenyl; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ac2-059; Prkwnk4; protein kinase lysine-deficient 4; protein kinase with no lysine 4; protein kinase, lysine deficient 4; protein kinase, lysine-deficient 4; serine/threonine-protein kinase WNK4; WNK4 Ser/Thr kinase
Homo sapiens (human) : WNK4 (WNK lysine deficient protein kinase 4)  HGNC  Alliance
Mus musculus (house mouse) : Wnk4 (WNK lysine deficient protein kinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wnk4 (WNK lysine deficient protein kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : WNK4 (WNK lysine deficient protein kinase 4)
Canis lupus familiaris (dog) : VPS25 (vacuolar protein sorting 25 homolog)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wnk4 (WNK lysine deficient protein kinase 4)
Sus scrofa (pig) : WNK4 (WNK lysine deficient protein kinase 4)
Chlorocebus sabaeus (African green monkey) : WNK4 (WNK lysine deficient protein kinase 4)
Heterocephalus glaber (naked mole-rat) : Wnk4 (WNK lysine deficient protein kinase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01089,181,139 - 89,198,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,181,165 - 89,198,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,979,661 - 88,997,344 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,289,273 - 90,306,225 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11090,303,667 - 90,320,558 (+)NCBI
Celera1084,920,709 - 84,937,662 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Wnk4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631401
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.