Itga3 (integrin subunit alpha 3) - Rat Genome Database

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Gene: Itga3 (integrin subunit alpha 3) Rattus norvegicus
Analyze
Symbol: Itga3
Name: integrin subunit alpha 3
RGD ID: 1310333
Description: Enables several functions, including fibronectin binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including maternal process involved in female pregnancy; positive regulation of epithelial cell migration; and regulation of cell projection organization. Located in cell surface; growth cone filopodium; and perinuclear region of cytoplasm. Part of integrin alpha3-beta1 complex. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of glomerulonephritis and myocardial infarction. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa. Orthologous to human ITGA3 (integrin subunit alpha 3); PARTICIPATES IN altered Reelin signaling pathway; integrin mediated signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: integrin alpha 3 ; integrin alpha-3; integrin, alpha 3; LOC360606
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,486,998 - 80,522,548 (-)NCBIGRCr8
mRatBN7.21079,990,160 - 80,022,206 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,990,161 - 80,022,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,939,254 - 84,971,203 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,437,323 - 84,469,271 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,830,424 - 79,862,336 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,855,841 - 82,887,755 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,855,613 - 82,887,497 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,666,856 - 82,698,319 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,728,710 - 83,759,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,744,399 - 83,774,825 (-)NCBI
Celera1078,763,866 - 78,796,174 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-pinene  (ISO)
aluminium oxide  (ISO)
amphetamine  (EXP)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diethyl malate  (ISO)
dimethylselenide  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethyl trans-caffeate  (ISO)
ethylparaben  (ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylseleninic acid  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nitrofen  (EXP)
notoginsenoside R1  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
superoxide  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling. Bryant JE, etal., J Mol Cell Cardiol. 2009 Feb;46(2):186-92. Epub 2008 Nov 7.
2. TGF-beta1 and integrin synergistically facilitate the differentiation of rat podocytes by increasing alpha-smooth muscle actin expression. Chen CA, etal., Transl Res. 2006 Sep;148(3):134-41.
3. Identification of integrin alpha 3 beta 1 as a neuronal thrombospondin receptor mediating neurite outgrowth. DeFreitas MF, etal., Neuron. 1995 Aug;15(2):333-43.
4. Integrin signaling in inflammatory and neuropathic pain in the rat. Dina OA, etal., Eur J Neurosci. 2004 Feb;19(3):634-42.
5. Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. Dina OA, etal., Pain. 2005 May;115(1-2):191-203.
6. Reelin glycoprotein: structure, biology and roles in health and disease. Fatemi SH Mol Psychiatry. 2005 Mar;10(3):251-7.
7. Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding. Gatlin JC, etal., Mol Biol Cell. 2006 Dec;17(12):5115-30. Epub 2006 Sep 20.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins. Heintz TG, etal., PLoS One. 2016 Aug 12;11(8):e0158558. doi: 10.1371/journal.pone.0158558. eCollection 2016.
11. Integrins: bidirectional, allosteric signaling machines. Hynes RO Cell 2002 Sep 20;110(6):673-87.
12. Spironolactone ameliorates podocytic adhesive capacity via restoring integrin {alpha}3 expression in streptozotocin-induced diabetic rats. Lin S, etal., J Renin Angiotensin Aldosterone Syst. 2010 Jun 4.
13. Laminin-332-beta1 integrin interactions negatively regulate invadopodia. Liu S, etal., J Cell Physiol. 2010 Apr;223(1):134-42.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Integrin alpha3beta1 interacts with I1PP2A/lanp and phosphatase PP1. Mutz D, etal., J Neurosci Res. 2006 Dec;84(8):1759-70.
16. Podocyte foot process effacement in very early phase of passive Heymann nephritis is not a prerequisite for proteinuria. Nosaka H, etal., J Nephrol. 2009 Jul-Aug;22(4):484-90.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Effect of ovarian stimulation with human menopausal gonadotropin and recombinant follicle stimulating hormone on the expression of integrins alpha3, beta1 in the rat endometrium during the implantation period. Sendag F, etal., Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):57-60. Epub 2010 Mar 1.
22. Expression and function of laminin and integrins on adhesion/migration of primary culture cells derived from rat oral epithelium. Sugisawa M, etal., J Periodontal Res. 2010 Apr;45(2):284-91.
23. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
24. Expression of collagen binding integrins during cardiac development and hypertrophy. Terracio L, etal., Circ Res. 1991 Mar;68(3):734-44.
25. A neuronal cell line (PC12) expresses two beta 1-class integrins-alpha 1 beta 1 and alpha 3 beta 1-that recognize different neurite outgrowth-promoting domains in laminin. Tomaselli KJ, etal., Neuron. 1990 Nov;5(5):651-62.
26. Spatiotemporal expression of alpha(1), alpha(3) and beta(1) integrin subunits is altered in rat myometrium during pregnancy and labour. Williams SJ, etal., Reprod Fertil Dev. 2010;22(4):718-32.
Additional References at PubMed
PMID:7534781   PMID:9553049   PMID:10455171   PMID:11891657   PMID:12591243   PMID:12904471   PMID:14566019   PMID:15091337   PMID:16459165   PMID:16557522   PMID:16750664   PMID:19056867  
PMID:19581412   PMID:19933311   PMID:20563599   PMID:21237282   PMID:21310825   PMID:21423176   PMID:23154389   PMID:23376485   PMID:23382219   PMID:23595732   PMID:24220332   PMID:24621570  
PMID:25063885   PMID:28701000  


Genomics

Comparative Map Data
Itga3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,486,998 - 80,522,548 (-)NCBIGRCr8
mRatBN7.21079,990,160 - 80,022,206 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,990,161 - 80,022,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,939,254 - 84,971,203 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,437,323 - 84,469,271 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,830,424 - 79,862,336 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,855,841 - 82,887,755 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,855,613 - 82,887,497 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,666,856 - 82,698,319 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,728,710 - 83,759,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,744,399 - 83,774,825 (-)NCBI
Celera1078,763,866 - 78,796,174 (-)NCBICelera
Cytogenetic Map10q26NCBI
ITGA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,056,110 - 50,090,481 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,055,968 - 50,090,481 (+)EnsemblGRCh38hg38GRCh38
GRCh371748,133,474 - 48,167,845 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,488,730 - 45,522,843 (+)NCBINCBI36Build 36hg18NCBI36
Build 341745,488,729 - 45,522,843NCBI
Celera1744,591,582 - 44,627,962 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,500,496 - 43,535,731 (+)NCBIHuRef
CHM1_11748,197,214 - 48,232,155 (+)NCBICHM1_1
T2T-CHM13v2.01750,921,575 - 50,957,585 (+)NCBIT2T-CHM13v2.0
Itga3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,935,301 - 94,967,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,935,300 - 94,967,627 (-)EnsemblGRCm39 Ensembl
GRCm381195,044,475 - 95,076,844 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,044,474 - 95,076,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,905,796 - 94,938,028 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,860,572 - 94,892,804 (-)NCBIMGSCv36mm8
Celera11104,654,874 - 104,687,668 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Itga3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,561,704 - 11,589,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,563,120 - 11,590,119 (-)NCBIChiLan1.0ChiLan1.0
ITGA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,243,873 - 66,279,253 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,050,327 - 71,085,737 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01744,145,974 - 44,181,343 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11749,019,889 - 49,055,245 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,019,892 - 49,055,245 (+)Ensemblpanpan1.1panPan2
ITGA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,065,792 - 26,095,649 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,062,393 - 26,094,422 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,458,998 - 25,488,798 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,860,362 - 26,890,161 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,856,943 - 26,890,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,628,148 - 25,657,945 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,886,765 - 25,916,569 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,016,729 - 26,046,536 (+)NCBIUU_Cfam_GSD_1.0
Itga3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,491,793 - 25,521,235 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,553,861 - 11,583,380 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,553,904 - 11,583,387 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,235,258 - 26,269,324 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,234,769 - 26,269,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,288,983 - 26,308,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,248,341 - 43,282,045 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,250,435 - 43,281,670 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,964,390 - 13,998,162 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,062,290 - 6,092,557 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,062,438 - 6,092,556 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itga3
164 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:258
Count of miRNA genes:132
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000005644, ENSRNOT00000035894, ENSRNOT00000055534
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 24 2 2 1 2 53 35 30 11
Low 19 53 37 18 37 8 11 21 10 8
Below cutoff 2 2 2 1

Sequence


RefSeq Acc Id: ENSRNOT00000005644   ⟹   ENSRNOP00000005644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,990,162 - 80,022,118 (-)Ensembl
Rnor_6.0 Ensembl1082,855,613 - 82,887,497 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000035894   ⟹   ENSRNOP00000034608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,991,298 - 80,021,951 (-)Ensembl
Rnor_6.0 Ensembl1082,856,903 - 82,887,301 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098623   ⟹   ENSRNOP00000096273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,990,162 - 80,022,118 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105286   ⟹   ENSRNOP00000096579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,990,161 - 80,022,061 (-)Ensembl
RefSeq Acc Id: NM_001108292   ⟹   NP_001101762
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,486,998 - 80,518,901 (-)NCBI
mRatBN7.21079,990,160 - 80,022,061 (-)NCBI
RefSeq Acc Id: NM_001372214   ⟹   NP_001359143
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,486,998 - 80,518,901 (-)NCBI
mRatBN7.21079,990,160 - 80,022,061 (-)NCBI
RefSeq Acc Id: XM_008768184   ⟹   XP_008766406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,486,998 - 80,522,548 (-)NCBI
mRatBN7.21079,990,160 - 80,022,206 (-)NCBI
Rnor_6.01082,855,841 - 82,887,755 (-)NCBI
Sequence:
RefSeq Acc Id: XP_008766406   ⟸   XM_008768184
- Peptide Label: isoform X1
- UniProtKB: D3ZQM3 (UniProtKB/TrEMBL),   I4DUB5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034608   ⟸   ENSRNOT00000035894
RefSeq Acc Id: ENSRNOP00000005644   ⟸   ENSRNOT00000005644
RefSeq Acc Id: NP_001359143   ⟸   NM_001372214
- Peptide Label: isoform 2
- UniProtKB: I4DUB5 (UniProtKB/TrEMBL),   D3ZQM3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001101762   ⟸   NM_001108292
- Peptide Label: isoform 1
- UniProtKB: D3ZCG9 (UniProtKB/TrEMBL),   A0A8I6GLI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096579   ⟸   ENSRNOT00000105286
RefSeq Acc Id: ENSRNOP00000096273   ⟸   ENSRNOT00000098623
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQM3-F1-model_v2 AlphaFold D3ZQM3 1-1067 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310333 AgrOrtholog
BioCyc Gene G2FUF-23567 BioCyc
Ensembl Genes ENSRNOG00000004276 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005644 ENTREZGENE
  ENSRNOT00000005644.7 UniProtKB/TrEMBL
  ENSRNOT00000035894.8 UniProtKB/TrEMBL
  ENSRNOT00000098623.1 UniProtKB/TrEMBL
  ENSRNOT00000105286 ENTREZGENE
  ENSRNOT00000105286.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
NCBI Gene 360606 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-3 UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PhenoGen Itga3 PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004276 RatGTEx
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A8I6GLI8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCG9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQM3 ENTREZGENE, UniProtKB/TrEMBL
  I4DUB5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itga3  integrin subunit alpha 3  Itga3  integrin, alpha 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Itga3  integrin, alpha 3  Itga3  integrin alpha 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Itga3  integrin alpha 3   Itga3_predicted  integrin alpha 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Itga3_predicted  integrin alpha 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED