Enables protein phosphatase binding activity. Involved in several processes, including cellular response to interferon-gamma; negative regulation of GTPase activity; and negative regulation of actin filament polymerization. Located in cell surface and ruffle. Used to study pulmonary hypertension. Biomarker of bacterial pneumonia; orchitis; and osteoarthritis. Human ortholog(s) of this gene implicated in coronary artery disease; coronary stenosis; myocardial infarction; neuroblastoma; and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1); PARTICIPATES IN malaria pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 2-acetamidofluorene; 5-azacytidine.
[Tetrachlorodibenzodioxin affects the methylation of PECAM1 intron] which results in decreased expression of PECAM1 mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of PECAM1 mRNA
[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PECAM1 mRNA
Probucol inhibits the reaction [Fluorouracil results in decreased expression of PECAM1 mRNA], Probucol inhibits the reaction [Fluorouracil results in decreased expression of PECAM1 protein]
[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PECAM1 mRNA
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PECAM1 mRNA
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PECAM1 mRNA
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PECAM1 mRNA
Curcumin inhibits the reaction [Particulate Matter results in increased expression of PECAM1 protein], Curcumin inhibits the reaction [titanium dioxide results in increased expression of PECAM1 protein]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 mRNA], Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 protein]
[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PECAM1 mRNA
HIF1A protein affects the reaction [Oxygen deficiency results in increased expression of PECAM1 protein], SENP1 protein affects the reaction [Oxygen deficiency results in increased expression of PECAM1 protein]
[Imatinib Mesylate co-treated with Paclitaxel] results in decreased expression of PECAM1 protein, zoledronic acid promotes the reaction [[Imatinib Mesylate co-treated with Paclitaxel] results in decreased expression of PECAM1 protein]
FLT1 protein affects the reaction [Acetaminophen results in increased expression of PECAM1 mRNA], Semaxinib inhibits the reaction [Acetaminophen results in increased expression of PECAM1 protein]
Probucol inhibits the reaction [Fluorouracil results in decreased expression of PECAM1 mRNA], Probucol inhibits the reaction [Fluorouracil results in decreased expression of PECAM1 protein]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 mRNA], Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 protein]
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PECAM1 mRNA