Ramp2 (receptor activity modifying protein 2) - Rat Genome Database

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Gene: Ramp2 (receptor activity modifying protein 2) Rattus norvegicus
Analyze
Symbol: Ramp2 (Ensembl: Vps25)
Name: receptor activity modifying protein 2 (Ensembl:vacuolar protein sorting 25 homolog)
RGD ID: 61872
Description: Enables coreceptor activity. Involved in several processes, including female pregnancy; response to estradiol; and response to progesterone. Predicted to be located in cytoplasm. Predicted to be part of adrenomedullin receptor complex. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Biomarker of adult respiratory distress syndrome; congestive heart failure; hypertension; kidney disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RAMP2 (receptor activity modifying protein 2); INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: receptor (calcitonin) activity modifying protein 2; receptor (G protein-coupled) activity modifying protein 2; receptor activity modifying protein 2 isoform; receptor activity-modifying protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,689,148 - 86,690,956 (+)NCBIGRCr8
mRatBN7.21086,187,366 - 86,190,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,226,790 - 91,228,598 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,701,301 - 90,703,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,094,462 - 86,096,270 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,166,170 - 89,168,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,166,890 - 89,168,965 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,965,679 - 88,967,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,275,463 - 90,277,242NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,289,832 - 90,291,611NCBI
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
calciol  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
desferrioxamine B  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diethyl malate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
indole-3-methanol  (EXP)
isoprenaline  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (EXP)
nitric oxide  (EXP)
nitroprusside  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adherens junction assembly  (ISO,ISS)
adrenomedullin receptor signaling pathway  (ISO)
angiogenesis  (IBA,IEA,ISO,ISS)
basement membrane assembly  (ISO,ISS)
bicellular tight junction assembly  (ISO,ISS)
calcium ion transport  (IBA,IEA,ISO,ISS)
cellular response to hormone stimulus  (IBA,IEA,IEP)
cellular response to vascular endothelial growth factor stimulus  (ISO,ISS)
female pregnancy  (IEP)
G protein-coupled receptor signaling pathway  (IBA,IEA,ISO)
heart development  (ISO,ISS)
intracellular protein transport  (IEA)
intracellular signal transduction  (IEA)
monoatomic ion homeostasis  (IEA)
multivesicular body sorting pathway  (IEA)
negative regulation of endothelial cell apoptotic process  (ISO,ISS)
negative regulation of sodium ion transport  (IEA)
negative regulation of vascular permeability  (ISO,ISS)
positive regulation of angiogenesis  (ISO,ISS)
positive regulation of gene expression  (ISO,ISS)
positive regulation of potassium ion import across plasma membrane  (IEA)
positive regulation of protein binding  (IDA)
positive regulation of vasculogenesis  (ISO)
protein localization to plasma membrane  (IBA,IEA,ISO,ISS)
protein transport  (IBA,IEA,ISO,ISS)
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  (IEA)
receptor internalization  (IBA,IDA,IEA,ISO)
regulation of blood pressure  (ISO,ISS)
regulation of G protein-coupled receptor signaling pathway  (IEA)
response to estradiol  (IEP)
response to hypoxia  (IEP)
response to progesterone  (IEP)
sprouting angiogenesis  (ISO,ISS)
vascular associated smooth muscle cell development  (ISO,ISS)
vasculogenesis  (ISO,ISS)

Cellular Component
adrenomedullin receptor complex  (ISO)
cell surface  (IBA,IEA,ISO,ISS)
cytoplasm  (ISO,ISS)
cytosol  (IEA)
ESCRT II complex  (IEA)
membrane  (IEA)
plasma membrane  (ISO,ISS)
receptor complex  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. Bomberger JM, etal., J Biol Chem. 2005 Mar 11;280(10):9297-307. Epub 2004 Dec 21.
2. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
3. Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts. Dai K, etal., Oncogene. 2020 Feb;39(9):1914-1930. doi: 10.1038/s41388-019-1112-z. Epub 2019 Nov 21.
4. Hypoxic induction of receptor activity-modifying protein 2 alters regulation of pulmonary endothelin-1 by adrenomedullin: induction under normoxia versus inhibition under hypoxia. Dschietzig T, etal., J Pharmacol Exp Ther. 2007 Apr;321(1):409-19. Epub 2007 Jan 24.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. [Changes of intermedin/adrenomedullin 2 and its receptors in the right ventricle of rats with chronic hypoxic pulmonary hypertension.] Gong YS, etal., Sheng Li Xue Bao. 2007 Apr 25;59(2):210-4.
8. CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS. Hay DL, etal., Br J Pharmacol. 2003 Oct;140(3):477-86. Epub 2003 Aug 26.
9. Adrenomedullin production is increased in colorectal adenocarcinomas; its relation to matrix metalloproteinase-9. Hikosaka T, etal., Peptides. 2011 Sep;32(9):1825-31. doi: 10.1016/j.peptides.2011.07.012. Epub 2011 Aug 3.
10. The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats. Hiragushi K, etal., Kidney Int. 2004 Feb;65(2):540-50.
11. The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis. Hwang IS, etal., Regul Pept. 2006 Jul 15;135(1-2):69-77. Epub 2006 May 19.
12. Estrogen and phytoestrogen regulate the mRNA expression of adrenomedullin and adrenomedullin receptor components in the rat uterus. Ikeda K, etal., Mol Cell Endocrinol. 2004 Aug 31;223(1-2):27-34.
13. Intermedin1-53 protects the heart against isoproterenol-induced ischemic injury in rats. Jia YX, etal., Eur J Pharmacol. 2006 Nov 7;549(1-3):117-23. Epub 2006 Aug 17.
14. Alteration of the adrenomedullin receptor components gene expression associated with the blood pressure in pregnancy-induced hypertension. Makino Y, etal., J Clin Endocrinol Metab. 2001 Oct;86(10):5079-82.
15. Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation. Man SY, etal., Neuropeptides. 2007 Jun;41(3):177-87. Epub 2007 Mar 1.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Effects of endothelin on adrenomedullin secretion and expression of adrenomedullin receptors in rat cardiomyocytes. Mishima K, etal., Biochem Biophys Res Commun. 2001 Sep 14;287(1):264-9.
18. Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy. Nagae T, etal., Biochem Biophys Res Commun 2000 Apr 2;270(1):89-93.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Ventricular adrenomedullin system in the transition from LVH to heart failure in rats. Nishikimi T, etal., Hypertension 2003 Mar;41(3):512-8.
21. Novel regulation of adrenomedullin receptor by PDGF: role of receptor activity modifying protein-3. Nowak W, etal., Am J Physiol Cell Physiol 2002 Jun;282(6):C1322-31.
22. Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Oliver KR, etal., Eur J Neurosci 2001 Aug;14(4):618-28.
23. Potentiated response to adrenomedullin in myocardia and aortas in spontaneously hypertensive rat. Pan ChS, etal., Basic Res Cardiol. 2006 May;101(3):193-203. Epub 2006 Feb 6.
24. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Qing X, etal., Am J Physiol Lung Cell Mol Physiol 2001 Mar;280(3):L547-54.
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Association study of calcitonin-receptor-like receptor gene in essential hypertension. Sano M, etal., Am J Hypertens. 2005 Mar;18(3):403-8.
29. Changes in the expression of calcitonin receptor-like receptor, receptor activity-modifying protein (RAMP) 1, RAMP2, and RAMP3 in rat uterus during pregnancy, labor, and by steroid hormone treatments. Thota C, etal., Biol Reprod. 2003 Oct;69(4):1432-7. Epub 2003 Jun 11.
30. Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro. Tomoda Y, etal., Cardiovasc Res 2001 Mar;49(4):721-30.
31. Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats. Yoshihara F, etal., Hypertension 2001 Feb;37(2):216-22.
32. Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy. Yoshihara F, etal., Regul Pept. 2005 Apr 15;127(1-3):239-44.
33. [Alterations of intermedin and its receptor system in oleic acid-induced acute lung injury of rats] Yu XM, etal., Beijing Da Xue Xue Bao. 2006 Oct 18;38(5):496-500.
Additional References at PubMed
PMID:1299115   PMID:8889548   PMID:9620797   PMID:10854696   PMID:10882736   PMID:11099398   PMID:11804624   PMID:12538603   PMID:12732346   PMID:12899678   PMID:14715154   PMID:14722252  
PMID:15193773   PMID:15315911   PMID:15623431   PMID:16040721   PMID:16964401   PMID:18097473   PMID:18434369   PMID:20074556   PMID:20596610   PMID:21034462   PMID:22102369   PMID:22500019  
PMID:24505304   PMID:25061099   PMID:26927337  


Genomics

Comparative Map Data
Ramp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,689,148 - 86,690,956 (+)NCBIGRCr8
mRatBN7.21086,187,366 - 86,190,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,226,790 - 91,228,598 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,701,301 - 90,703,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,094,462 - 86,096,270 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,166,170 - 89,168,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,166,890 - 89,168,965 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,965,679 - 88,967,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,275,463 - 90,277,242NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,289,832 - 90,291,611NCBI
Cytogenetic Map10q31NCBI
RAMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,761,227 - 42,763,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,758,447 - 42,763,041 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,913,245 - 40,915,059 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,166,738 - 38,168,585 (+)NCBINCBI36Build 36hg18NCBI36
Build 341738,166,737 - 38,168,580NCBI
Celera1737,569,491 - 37,571,338 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,678,311 - 36,680,158 (+)NCBIHuRef
CHM1_11741,148,776 - 41,150,623 (+)NCBICHM1_1
T2T-CHM13v2.01743,618,368 - 43,620,182 (+)NCBIT2T-CHM13v2.0
Ramp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,137,160 - 101,139,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,136,854 - 101,150,372 (+)EnsemblGRCm39 Ensembl
GRCm3811101,246,334 - 101,248,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,246,028 - 101,259,546 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,107,648 - 101,109,564 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,062,424 - 101,064,340 (+)NCBIMGSCv36mm8
Celera11112,542,561 - 112,544,477 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.47NCBI
Ramp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545116,584,742 - 16,586,093 (+)NCBIChiLan1.0ChiLan1.0
RAMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,222,750 - 22,225,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,112,840 - 24,115,133 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,554,888 - 14,557,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,779,666 - 14,781,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,779,666 - 14,781,481 (-)Ensemblpanpan1.1panPan2
RAMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,250,711 - 20,252,485 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,712,023 - 19,713,795 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,969,093 - 20,970,865 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,969,095 - 20,971,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,753,999 - 19,755,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,020,208 - 20,021,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,122,921 - 20,124,693 (-)NCBIUU_Cfam_GSD_1.0
Ramp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,593,351 - 19,595,280 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,479,650 - 17,482,716 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,479,899 - 17,481,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,092,196 - 20,094,469 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,092,204 - 20,094,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,346,948 - 20,349,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,526,915 - 63,529,697 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,526,305 - 63,528,767 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,320,238 - 34,322,154 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ramp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,435,121 - 1,436,421 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ramp2
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:84
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000043953
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat

Markers in Region
RH128282  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,190,466 - 86,190,663 (+)MAPPERmRatBN7.2
Rnor_6.01089,168,745 - 89,168,941NCBIRnor6.0
Rnor_5.01088,967,241 - 88,967,437UniSTSRnor5.0
RGSC_v3.41090,277,025 - 90,277,221UniSTSRGSC3.4
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 26 26 6 26 3 66 28 32 11
Low 8 31 15 13 15 8 8 8 7 9 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000043953   ⟹   ENSRNOP00000043210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,167,146 - 89,168,965 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088331   ⟹   ENSRNOP00000073785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,166,890 - 89,168,864 (+)Ensembl
RefSeq Acc Id: NM_031646   ⟹   NP_113834
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,689,148 - 86,690,956 (+)NCBI
mRatBN7.21086,188,876 - 86,190,687 (+)NCBI
Rnor_6.01089,167,183 - 89,168,962 (+)NCBI
Rnor_5.01088,965,679 - 88,967,458 (+)NCBI
RGSC_v3.41090,275,463 - 90,277,242 (+)RGD
Sequence:
RefSeq Acc Id: NP_113834   ⟸   NM_031646
- Peptide Label: precursor
- UniProtKB: Q9JHJ1 (UniProtKB/Swiss-Prot),   A0A8L2QNA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043210   ⟸   ENSRNOT00000043953
RefSeq Acc Id: ENSRNOP00000073785   ⟸   ENSRNOT00000088331
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHJ1-F1-model_v2 AlphaFold Q9JHJ1 1-182 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697748
Promoter ID:EPDNEW_R8271
Type:multiple initiation site
Name:Ramp2_1
Description:receptor activity modifying protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,167,159 - 89,167,219EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61872 AgrOrtholog
BioCyc Gene G2FUF-23189 BioCyc
Ensembl Genes ENSRNOG00000020415 Ensembl
  ENSRNOG00000020441 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065003184 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000043754.5 UniProtKB/TrEMBL
  ENSRNOT00000043953 ENTREZGENE
  ENSRNOT00000043953.5 UniProtKB/TrEMBL
  ENSRNOT00000076658.3 UniProtKB/TrEMBL
  ENSRNOT00000076944.3 UniProtKB/TrEMBL
  ENSRNOT00000078931.2 UniProtKB/TrEMBL
  ENSRNOT00065004495 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.10.570 UniProtKB/TrEMBL
  1.10.150.510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Cyclin-like_sf UniProtKB/TrEMBL
  ESCRT-II_cplx_Vps25-sub UniProtKB/TrEMBL
  ESCRT-II_cplx_Vps25-sub_N UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  RAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAMP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:58966 UniProtKB/Swiss-Prot
NCBI Gene 58966 ENTREZGENE
PANTHER PTHR13149 UniProtKB/TrEMBL
  PTHR14076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE WNK4 UniProtKB/TrEMBL
  VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25 UniProtKB/TrEMBL
Pfam ESCRT-II UniProtKB/TrEMBL
  OSR1_C UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  RAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ramp2 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020415 RatGTEx
  ENSRNOG00000020441 RatGTEx
  ENSRNOG00065003184 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF47954 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0G2K231_RAT UniProtKB/TrEMBL
  A0A8I5ZT86_RAT UniProtKB/TrEMBL
  A0A8I6APN0_RAT UniProtKB/TrEMBL
  A0A8L2QNA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QP36_RAT UniProtKB/TrEMBL
  A5YW89_RAT UniProtKB/TrEMBL
  Q9JHJ1 ENTREZGENE
  Q9WVQ3_RAT UniProtKB/TrEMBL
  RAMP2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Ramp2  receptor activity modifying protein 2  Ramp2  receptor (G protein-coupled) activity modifying protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ramp2  receptor (G protein-coupled) activity modifying protein 2  Ramp2  receptor (calcitonin) activity modifying protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ramp2  receptor (calcitonin) activity modifying protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in renal cortex and medulla 68718
gene_expression expressed in atria and ventricles of the heart 625420
gene_expression expressed in quiescent mesangial cells 631307
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determines its glycosylation state 61729
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determines its glycosylation state 68718
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determines its glycosylation state 68902
gene_physical_interaction forms a complex with calcitonin receptor-like receptor (CRLR) to form a functional adrenomedullin receptor 625420
gene_process involved in potentiating adrenomedullin-mediated adenylate cyclase activity and inhibition of DNA synthesis 631307