Krt19 (keratin 19) - Rat Genome Database

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Gene: Krt19 (keratin 19) Rattus norvegicus
Analyze
Symbol: Krt19 (Ensembl: Krt15)
Name: keratin 19 (Ensembl:keratin 14)
RGD ID: 619936
Description: Predicted to be a structural constituent of muscle. Predicted to be involved in cytoskeleton organization; epithelial cell differentiation; and response to estrogen. Predicted to act upstream of or within Notch signaling pathway and cell differentiation involved in embryonic placenta development. Part of dystrophin-associated glycoprotein complex. Orthologous to human KRT19 (keratin 19); INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CK-19; cytokeratin 19; cytokeratin-19; K19; Ka19; keratin 19, type I; keratin complex 1, acidic, gene 19; keratin, type I cytoskeletal 19; keratin-19; Krt1-19; MGC124534; MGC156553; type I keratin KA19
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,075,835 - 85,080,552 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,066,802 - 85,171,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,093,836 - 90,098,710 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01089,592,194 - 89,596,911 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01084,984,138 - 84,988,855 (-)NCBIRnor_WKY
Rnor_6.01088,055,843 - 88,060,560 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,055,841 - 88,060,561 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01087,848,518 - 87,853,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,080,953 - 89,085,670 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,095,322 - 89,100,040 (-)NCBI
Celera1083,795,223 - 83,800,127 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-acetamidofluorene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3'-diindolylmethane  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
boron nitride  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
daunorubicin  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enzalutamide  (ISO)
ethanol  (ISO)
etoposide  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glycidol  (ISO)
GW 3965  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoflavones  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lithium chloride  (ISO)
metformin  (EXP)
methylmercury chloride  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
naphthalene  (ISO)
natamycin  (ISO)
nickel atom  (ISO)
nystatin  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phosgene  (ISO)
picene  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
tranexamic acid  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Switch in the expression of the K19/K18 keratin genes as a very early evidence of testicular differentiation in the rat. Fridmacher V, etal., Mech Dev 1995 Aug;52(2-3):199-207.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex. Ursitti JA, etal., J Biol Chem. 2004 Oct 1;279(40):41830-8. Epub 2004 Jul 6.
Additional References at PubMed
PMID:10037815   PMID:11062258   PMID:12477932   PMID:15057822   PMID:15085952   PMID:15489334   PMID:16000376   PMID:16641100   PMID:19185580   PMID:19199708   PMID:19321664   PMID:23377137  
PMID:25232867   PMID:25446530   PMID:30361391  


Genomics

Comparative Map Data
Krt19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,075,835 - 85,080,552 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,066,802 - 85,171,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,093,836 - 90,098,710 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01089,592,194 - 89,596,911 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01084,984,138 - 84,988,855 (-)NCBIRnor_WKY
Rnor_6.01088,055,843 - 88,060,560 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,055,841 - 88,060,561 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01087,848,518 - 87,853,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,080,953 - 89,085,670 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,095,322 - 89,100,040 (-)NCBI
Celera1083,795,223 - 83,800,127 (-)NCBICelera
Cytogenetic Map10q31NCBI
KRT19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,523,617 - 41,528,308 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1741,523,617 - 41,528,308 (-)EnsemblGRCh38hg38GRCh38
GRCh371739,679,869 - 39,684,560 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,933,395 - 36,938,167 (-)NCBINCBI36Build 36hg18NCBI36
Build 341736,933,395 - 36,938,160NCBI
Celera1736,333,093 - 36,337,867 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,443,484 - 35,448,259 (-)NCBIHuRef
CHM1_11739,915,178 - 39,919,959 (-)NCBICHM1_1
T2T-CHM13v2.01742,379,161 - 42,383,869 (-)NCBIT2T-CHM13v2.0
Krt19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,031,636 - 100,036,752 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,031,636 - 100,039,491 (-)EnsemblGRCm39 Ensembl
GRCm3811100,140,810 - 100,145,926 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,140,810 - 100,148,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,002,124 - 100,007,233 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,956,900 - 99,962,009 (-)NCBIMGSCv36mm8
Celera11110,757,190 - 110,762,299 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.42NCBI
KRT19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11725,346,539 - 25,351,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,788,355 - 15,793,127 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11716,006,608 - 16,010,782 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1716,006,608 - 16,010,782 (+)Ensemblpanpan1.1panPan2
KRT19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,240,778 - 21,245,039 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,702,551 - 20,706,814 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,961,705 - 21,965,969 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1920,747,715 - 20,751,978 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0921,013,735 - 21,018,001 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0921,117,527 - 21,121,798 (+)NCBIUU_Cfam_GSD_1.0
Krt19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,630,470 - 20,634,420 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,440,693 - 16,444,791 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493649016,440,723 - 16,444,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,115,448 - 21,119,107 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11221,115,453 - 21,119,115 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,536,784 - 21,540,278 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRT19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,714,497 - 64,719,805 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,714,970 - 64,719,678 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607735,559,784 - 35,564,785 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Krt19
179 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:72
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000019133
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat

Markers in Region
D10Wox56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,080,953 - 85,081,059 (+)MAPPERmRatBN7.2
Rnor_6.01088,060,962 - 88,061,067NCBIRnor6.0
Rnor_5.01087,853,637 - 87,853,742UniSTSRnor5.0
RGSC_v3.41089,086,072 - 89,086,177UniSTSRGSC3.4
Celera1083,800,529 - 83,800,644UniSTS
Cytogenetic Map10q32.1UniSTS
RH137070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,075,876 - 85,076,056 (+)MAPPERmRatBN7.2
Rnor_6.01088,055,885 - 88,056,064NCBIRnor6.0
Rnor_5.01087,848,560 - 87,848,739UniSTSRnor5.0
RGSC_v3.41089,080,995 - 89,081,174UniSTSRGSC3.4
Celera1083,795,265 - 83,795,444UniSTS
RH 3.4 Map10841.0UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 1 8 3 2 1 2 28 29 11
Low 35 54 39 17 39 4 4 41 7 12 4
Below cutoff 1 4 6 31 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019133   ⟹   ENSRNOP00000019133
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1088,055,841 - 88,060,561 (-)Ensembl
RefSeq Acc Id: NM_199498   ⟹   NP_955792
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,075,835 - 85,080,552 (-)NCBI
Rnor_6.01088,055,843 - 88,060,560 (-)NCBI
Rnor_5.01087,848,518 - 87,853,235 (-)NCBI
RGSC_v3.41089,080,953 - 89,085,670 (-)RGD
Celera1083,795,223 - 83,800,127 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_955792   ⟸   NM_199498
- UniProtKB: Q9Z253 (UniProtKB/Swiss-Prot),   Q63279 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019133   ⟸   ENSRNOT00000019133
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63279-F1-model_v2 AlphaFold Q63279 1-403 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697709
Promoter ID:EPDNEW_R8234
Type:multiple initiation site
Name:Krt19_1
Description:keratin 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,060,573 - 88,060,633EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619936 AgrOrtholog
BioCyc Gene G2FUF-23252 BioCyc
Ensembl Genes ENSRNOG00000003899 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000014233 Ensembl
Ensembl Protein ENSRNOP00000019037.6 UniProtKB/TrEMBL
  ENSRNOP00000019133 ENTREZGENE
  ENSRNOP00000019133.3 UniProtKB/Swiss-Prot
  ENSRNOP00000068575.2 UniProtKB/TrEMBL
  ENSRNOP00000069752.2 UniProtKB/TrEMBL
  ENSRNOP00000070301.2 UniProtKB/TrEMBL
  ENSRNOP00000087249.1 UniProtKB/TrEMBL
  ENSRNOP00000089695.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019037.7 UniProtKB/TrEMBL
  ENSRNOT00000019133 ENTREZGENE
  ENSRNOT00000019133.5 UniProtKB/Swiss-Prot
  ENSRNOT00000080167.2 UniProtKB/TrEMBL
  ENSRNOT00000083895.2 UniProtKB/TrEMBL
  ENSRNOT00000086209.2 UniProtKB/TrEMBL
  ENSRNOT00000100338.1 UniProtKB/TrEMBL
  ENSRNOT00000102784.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7123832 IMAGE-MGC_LOAD
  IMAGE:7442082 IMAGE-MGC_LOAD
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360626 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156553 IMAGE-MGC_LOAD
  MGC:95050 IMAGE-MGC_LOAD
NCBI Gene 360626 ENTREZGENE
PANTHER KERATIN, TYPE I CYTOSKELETAL 14 UniProtKB/TrEMBL
  KERATIN, TYPE I CYTOSKELETAL 15 UniProtKB/TrEMBL
  KERATIN, TYPE I CYTOSKELETAL 19 UniProtKB/Swiss-Prot
  PTHR23239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Krt19 PhenoGen
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prefoldin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JT54_RAT UniProtKB/TrEMBL
  A0A0G2JW58_RAT UniProtKB/TrEMBL
  A0A0G2JXJ9_RAT UniProtKB/TrEMBL
  A0A8I6A5I5_RAT UniProtKB/TrEMBL
  A0A8I6GIB2_RAT UniProtKB/TrEMBL
  A0A8L2Q9T0_RAT UniProtKB/TrEMBL
  K1C19_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z253 ENTREZGENE
UniProt Secondary A0JN08 UniProtKB/Swiss-Prot
  Q5M7V2 UniProtKB/Swiss-Prot
  Q6S6J4 UniProtKB/Swiss-Prot
  Q9Z253 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Krt19  keratin 19  Krt19  keratin 19, type I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt19  keratin 19, type I  Krt19  keratin 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Krt19  keratin 19  Krt1-19  keratin complex 1, acidic, gene 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-04-26 Krt1-19  keratin complex 1, acidic, gene 19  Krt19  keratin 19  Data Merged 737654 APPROVED
2004-02-11 Krt1-19  keratin complex 1, acidic, gene 19      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Krt1-19  keratin complex 1, acidic, gene 19      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
null disappears during the progression of the testicular differentiation  
gene_expression mRNA was expressed during fetal ovary development in the undifferentiated gonads and in somatic cells of ovarian cords 633091
gene_regulation expression regulated at the transcriptional level 633091