Pitpna (phosphatidylinositol transfer protein, alpha) - Rat Genome Database

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Gene: Pitpna (phosphatidylinositol transfer protein, alpha) Rattus norvegicus
Analyze
Symbol: Pitpna
Name: phosphatidylinositol transfer protein, alpha
RGD ID: 61885
Description: Enables anion binding activity; phospholipid binding activity; and phospholipid transfer activity. Involved in phospholipid transport. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human PITPNA (phosphatidylinositol transfer protein alpha); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: phosphatidylinositol transfer protein ; phosphatidylinositol transfer protein alpha isoform; PI-TP-alpha; Pitpn; ptdIns transfer protein alpha; ptdInsTP alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,929,050 - 60,969,614 (+)NCBIGRCr8
mRatBN7.21060,430,712 - 60,473,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,430,748 - 60,471,342 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,077,879 - 65,118,066 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,583,298 - 64,623,485 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,045,869 - 60,086,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,731,767 - 63,772,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,731,767 - 63,772,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,232,947 - 64,273,229 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,908,533 - 62,948,856 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,922,155 - 62,962,479 (+)NCBI
Celera1059,458,996 - 59,498,755 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
deguelin  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
heparin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
Mesaconitine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylparaben  (ISO)
Nonylphenol  (EXP)
paracetamol  (EXP,ISO)
perfluorododecanoic acid  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
propiconazole  (EXP)
propylparaben  (ISO)
pyrimidifen  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mutant rat phosphatidylinositol/phosphatidylcholine transfer proteins specifically defective in phosphatidylinositol transfer: implications for the regulation of phospholipid transfer activity. Alb JG, etal., Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8826-30. doi: 10.1073/pnas.92.19.8826.
2. Isolation and sequence of cDNA clones encoding rat phosphatidylinositol transfer protein. Dickeson SK, etal., J Biol Chem 1989 Oct 5;264(28):16557-64.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Sterol carrier protein-2 functions in phosphatidylinositol transfer and signaling. Schroeder F, etal., Biochemistry. 2003 Mar 25;42(11):3189-202.
9. Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells. Shadan S, etal., Traffic. 2008 Sep;9(10):1743-56. doi: 10.1111/j.1600-0854.2008.00794.x. Epub 2008 Jul 9.
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. Modifications of cysteine residues in the solution and membrane-associated conformations of phosphatidylinositol transfer protein have differential effects on lipid transfer activity. Tremblay JM, etal., Biochemistry 2001 Aug 7;40(31):9151-8.
13. Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms. Vordtriede PB, etal., Biochemistry. 2005 Nov 15;44(45):14760-71.
14. Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine. Yoder MD, etal., J Biol Chem. 2001 Mar 23;276(12):9246-52. Epub 2000 Dec 4.
Additional References at PubMed
PMID:3606604   PMID:15489334   PMID:16244667   PMID:16779671   PMID:17634366   PMID:18570454   PMID:22822086   PMID:22871113   PMID:23376485   PMID:28718450  


Genomics

Comparative Map Data
Pitpna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,929,050 - 60,969,614 (+)NCBIGRCr8
mRatBN7.21060,430,712 - 60,473,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,430,748 - 60,471,342 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,077,879 - 65,118,066 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,583,298 - 64,623,485 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,045,869 - 60,086,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,731,767 - 63,772,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,731,767 - 63,772,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,232,947 - 64,273,229 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,908,533 - 62,948,856 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,922,155 - 62,962,479 (+)NCBI
Celera1059,458,996 - 59,498,755 (+)NCBICelera
Cytogenetic Map10q24NCBI
PITPNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,517,718 - 1,562,792 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,517,718 - 1,562,792 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,421,012 - 1,466,086 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,368,033 - 1,412,835 (-)NCBINCBI36Build 36hg18NCBI36
Build 34171,368,034 - 1,412,835NCBI
Celera171,436,720 - 1,481,546 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,321,442 - 1,362,012 (-)NCBIHuRef
CHM1_1171,429,972 - 1,474,726 (-)NCBICHM1_1
T2T-CHM13v2.0171,406,472 - 1,451,511 (-)NCBIT2T-CHM13v2.0
Pitpna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,478,889 - 75,519,630 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,478,923 - 75,519,630 (+)EnsemblGRCm39 Ensembl
GRCm381175,588,079 - 75,628,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,588,097 - 75,628,804 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,401,610 - 75,442,280 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,404,303 - 75,444,973 (+)NCBIMGSCv36mm8
Celera1183,097,260 - 83,137,915 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Pitpna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,611,830 - 1,645,753 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,611,579 - 1,649,481 (+)NCBIChiLan1.0ChiLan1.0
PITPNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,088,544 - 9,133,385 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,054,808 - 11,099,477 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,500,900 - 1,545,643 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,400,504 - 1,442,141 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,404,137 - 1,440,224 (-)Ensemblpanpan1.1panPan2
PITPNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,681,533 - 45,724,915 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,683,853 - 45,724,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha944,833,638 - 44,876,376 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,509,554 - 46,552,503 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,509,553 - 46,552,617 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,279,916 - 45,322,629 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,574,196 - 45,617,095 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,627,661 - 45,671,038 (-)NCBIUU_Cfam_GSD_1.0
Pitpna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560244,785,512 - 44,826,539 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,667,162 - 7,704,315 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365387,663,457 - 7,704,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PITPNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,739,633 - 47,785,375 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,739,631 - 47,785,387 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,624,341 - 49,670,292 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PITPNA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,193,326 - 1,235,677 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605920,750,511 - 20,794,613 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pitpna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,242,046 - 4,274,625 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,238,500 - 4,274,890 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pitpna
123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:183
Interacting mature miRNAs:209
Transcripts:ENSRNOT00000005368
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
PITPN  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2185,149,741 - 85,149,911 (+)MAPPERmRatBN7.2
Rnor_6.0188,222,609 - 88,222,778NCBIRnor6.0
Rnor_6.0187,807,885 - 87,808,054NCBIRnor6.0
Rnor_5.0188,984,754 - 88,984,923UniSTSRnor5.0
Rnor_5.0189,384,333 - 89,384,502UniSTSRnor5.0
RGSC_v3.4184,944,221 - 84,944,390UniSTSRGSC3.4
Celera179,525,231 - 79,525,400UniSTS
Cytogenetic Map10q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005368   ⟹   ENSRNOP00000005368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,430,748 - 60,471,342 (+)Ensembl
Rnor_6.0 Ensembl1063,731,767 - 63,772,049 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090554   ⟹   ENSRNOP00000072145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,440,252 - 60,463,327 (+)Ensembl
Rnor_6.0 Ensembl1063,731,959 - 63,769,424 (+)Ensembl
RefSeq Acc Id: NM_017231   ⟹   NP_058927
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,929,050 - 60,969,614 (+)NCBI
mRatBN7.21060,430,776 - 60,471,342 (+)NCBI
Rnor_6.01063,731,767 - 63,772,049 (+)NCBI
Rnor_5.01064,232,947 - 64,273,229 (-)NCBI
RGSC_v3.41062,908,533 - 62,948,856 (+)RGD
Celera1059,458,996 - 59,498,755 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058927 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41984 (Get FASTA)   NCBI Sequence Viewer  
  AAH70945 (Get FASTA)   NCBI Sequence Viewer  
  EDM05230 (Get FASTA)   NCBI Sequence Viewer  
  EDM05231 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005368
  ENSRNOP00000005368.7
  ENSRNOP00000072145.2
GenBank Protein P16446 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058927   ⟸   NM_017231
- UniProtKB: P16446 (UniProtKB/Swiss-Prot),   R9PXS4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072145   ⟸   ENSRNOT00000090554
Ensembl Acc Id: ENSRNOP00000005368   ⟸   ENSRNOT00000005368

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16446-F1-model_v2 AlphaFold P16446 1-271 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697448
Promoter ID:EPDNEW_R7965
Type:initiation region
Name:Pitpna_1
Description:phosphatidylinositol transfer protein, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01063,731,722 - 63,731,782EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61885 AgrOrtholog
BioCyc Gene G2FUF-24194 BioCyc
Ensembl Genes ENSRNOG00000003846 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005368 UniProtKB/TrEMBL
  ENSRNOT00000005368.8 UniProtKB/Swiss-Prot
  ENSRNOT00000090554.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.530.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103390 IMAGE-MGC_LOAD
InterPro PI_transfer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29525 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91736 IMAGE-MGC_LOAD
NCBI Gene 29525 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10658 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IP_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pitpna PhenoGen
PRINTS PITRANSFER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003846 RatGTEx
Superfamily-SCOP Bet v1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229406
UniProt A0A8L2R5F2_RAT UniProtKB/TrEMBL
  A6HGS7_RAT UniProtKB/TrEMBL
  P16446 ENTREZGENE, UniProtKB/Swiss-Prot
  R9PXS4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Pitpna  phosphatidylinositol transfer protein, alpha  Pitpn  phosphatidylinositol transfer protein   Symbol and Name updated 1299863 APPROVED
2002-06-10 Pitpn  phosphatidylinositol transfer protein       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 271 amino acids; 31.9 kDa 727320