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Gene: Rpl23a (ribosomal protein L23A) Rattus norvegicus

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Symbol:

Rpl23a

Name:

ribosomal protein L23A

RGD ID:

1304897

Description:

Enables large ribosomal subunit rRNA binding activity. Predicted to be involved in translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPL23A (ribosomal protein L23a); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrolein; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

60S ribosomal protein L23a; large ribosomal subunit protein uL23; LOC360572

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RPL23A (ribosomal protein L23a)	RGD	RGD
Mus musculus (house mouse):	Rpl23a (ribosomal protein L23A)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Rpl23a (ribosomal protein L23a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RPL23A (ribosomal protein L23a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC106558887 (60S ribosomal protein L23a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rpl23a (ribosomal protein L23a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RPL23A (ribosomal protein L23a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RPL23A (ribosomal protein L23a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rpl23a (ribosomal protein L23a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ITGB5 (integrin subunit beta 5)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RPL23A (ribosomal protein L23a)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Mus musculus (house mouse):	Rpl23a (ribosomal protein L23A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	rpl23a (ribosomal protein L23a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rpl-25.1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RPL25	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RpL23A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rpl-25.2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rpl23a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)

Related Pseudogenes:

Rpl23a-ps20 Rpl23a-ps6

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	63,574,732 - 63,577,511 (-)	NCBI		GRCr8
mRatBN7.2	10	63,076,660 - 63,079,346 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	63,076,066 - 63,079,346 (-)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	15	31,302,329 - 31,302,979 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	67,708,947 - 67,711,633 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	67,214,301 - 67,216,987 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	62,685,257 - 62,688,055 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	65,441,295 - 65,443,981 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	65,441,295 - 65,443,981 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	66,190,636 - 66,193,322 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	64,451,931 - 64,454,617 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	62,054,259 - 62,056,945 (-)	NCBI		Celera
Cytogenetic Map	10	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Parkinson's disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chloropicrin (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibric acid (EXP)

copper(II) sulfate (ISO)

cylindrospermopsin (ISO)

dihydroartemisinin (ISO)

enzyme inhibitor (ISO)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

furan (EXP)

furfural (ISO)

glafenine (EXP)

hydralazine (ISO)

indometacin (EXP)

inulin (ISO)

ivermectin (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

methotrexate (ISO)

paclitaxel (ISO)

paracetamol (ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sodium fluoride (ISO)

thioacetamide (EXP)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

translation (IEA)

Cellular Component

cytoplasm (ISO)

cytosolic large ribosomal subunit (IBA,IDA,ISO)

cytosolic ribosome (ISO)

nucleus (ISO,ISS)

ribosomal subunit (IEA)

synapse (ISO)

Molecular Function

large ribosomal subunit rRNA binding (IDA)

protein binding (ISO)

rRNA binding (IEA)

structural constituent of ribosome (IBA,IEA,ISO)

TORC2 complex binding (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (ISO)

translation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Structures of the human and Drosophila 80S ribosome.	Anger AM, etal., Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104.
2.	Carbodiimide-induced protein--RNA crosslinking in mammalian ribosomal subunits.	Buisson M and Reboud AM, FEBS Lett. 1982 Nov 8;148(2):247-50.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Identification of an amino acid-regulated mRNA from rat liver as the mammalian equivalent of bacterial ribosomal protein L22.	Laine RO, etal., J Biol Chem. 1991 Sep 15;266(26):16969-72.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:8428950	PMID:9053844	PMID:9687515	PMID:12477932	PMID:12962325	PMID:16791210	PMID:16854843	PMID:20458337	PMID:21045808	PMID:22658674	PMID:22681889	PMID:22871113
PMID:23376485	PMID:24625528	PMID:25468996	PMID:26316108	PMID:30053369	PMID:35352799

Genomics

Comparative Map Data

Rpl23a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	63,574,732 - 63,577,511 (-)	NCBI		GRCr8
mRatBN7.2	10	63,076,660 - 63,079,346 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	63,076,066 - 63,079,346 (-)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	15	31,302,329 - 31,302,979 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	67,708,947 - 67,711,633 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	67,214,301 - 67,216,987 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	62,685,257 - 62,688,055 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	65,441,295 - 65,443,981 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	65,441,295 - 65,443,981 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	66,190,636 - 66,193,322 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	64,451,931 - 64,454,617 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	62,054,259 - 62,056,945 (-)	NCBI		Celera
Cytogenetic Map	10	q25	NCBI

RPL23A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	28,719,985 - 28,724,359 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	28,719,985 - 28,724,359 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	27,047,003 - 27,051,377 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	24,071,127 - 24,075,501 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	24,071,017 - 24,075,500	NCBI
Celera	17	23,906,165 - 23,910,537 (+)	NCBI		Celera
Cytogenetic Map	17	q11.2	NCBI
HuRef	17	23,255,900 - 23,260,272 (+)	NCBI		HuRef
CHM1_1	17	27,109,472 - 27,113,844 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	29,662,794 - 29,667,166 (+)	NCBI		T2T-CHM13v2.0

Rpl23a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	78,071,761 - 78,074,410 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	78,071,758 - 78,074,410 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	78,180,935 - 78,183,584 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	78,180,932 - 78,183,584 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	77,994,437 - 77,997,086 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	77,997,130 - 77,999,738 (-)	NCBI		MGSCv36	mm8
Celera	11	85,680,808 - 85,683,457 (-)	NCBI		Celera
Cytogenetic Map	11	B5	NCBI
cM Map	11	46.74	NCBI

Rpl23a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955481	4,433,417 - 4,437,754 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955481	4,433,367 - 4,437,838 (-)	NCBI	ChiLan1.0	ChiLan1.0

RPL23A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	35,735,384 - 35,741,278 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	37,615,906 - 37,620,420 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	28,051,502 - 28,055,630 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	28,556,527 - 28,561,032 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

LOC106558887
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	11,192,720 - 11,193,214 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	12,818,516 - 12,818,999 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	11,192,761 - 11,193,244 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	43,733,264 - 43,736,897 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	11,061,449 - 11,061,932 (+)	NCBI		UMICH_Zoey_3.1

Rpl23a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	42,051,881 - 42,055,814 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936538	4,929,895 - 4,933,761 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936538	4,929,893 - 4,933,759 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RPL23A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	44,957,142 - 44,960,735 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	44,956,851 - 44,960,737 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	46,941,786 - 46,945,674 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RPL23A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	22,488,144 - 22,491,864 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666075	7,631,113 - 7,635,309 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rpl23a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624786	1,294,185 - 1,297,993 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	43
Count of miRNA genes:	41
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000035657
Prediction methods:	Microtar, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35893451	64140567	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	51071897	96071897	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31796281	76796281	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	27443787	72443787	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	35509383	91417879	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	56868440	76129113	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	58073360	103073360	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	19939207	64939207	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	54296336	99451733	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41831278	86831278	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50464802	95464802	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44939359	89939359	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45529164	96099749	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18668419	63668419	Rat
10450493	Bp382	Blood pressure QTL 382		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50860288	95860288	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28950353	73950353	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35893263	64653589	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29800910	64653589	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	27443787	72443787	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62556066	107556066	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42823274	87823274	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62556066	107556066	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44939359	89939359	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42823274	87823274	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61843496	98710773	Rat
2306787	Ean3	Experimental allergic neuritis QTL 3	3.1		nervous system integrity trait (VT:0010566)	body weight loss (CMO:0001399)	10	54296227	67476781	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2306792	Ean4	Experimental allergic neuritis QTL 4	4		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	49495492	94495492	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15533012	73695498	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24662123	73695339	Rat
2298480	Eau7	Experimental allergic uveoretinitis QTL 7		0.0049	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	35509383	80509383	Rat
70363	Bp71	Blood pressure QTL 71		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	61843496	106843496	Rat
61402	Niddm3	Non-insulin dependent diabetes mellitus QTL 3	4.58		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	61843633	83061236	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29800910	91417879	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	20110614	65110614	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
2289985	Bp305	Blood pressure QTL 305			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	29076978	74076978	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	55307972	93608131	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61843496	100198886	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	43608793	88608793	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	27443787	72443787	Rat
1331839	Eae18b	Experimental allergic encephalomyelitis QTL 18b	5.8	0.03	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	61746532	68282731	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
7207811	Bmd90	Bone mineral density QTL 90	5.2		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	10	49943710	94943710	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31129113	76129113	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44939359	89939359	Rat
631526	Bp76	Blood pressure QTL 76		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	61843633	67241334	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61843496	100198886	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47869129	92869129	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
12880050	Am10	Aortic mass QTL 10		0.016	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	39503487	84503487	Rat
2292436	Bp310	Blood pressure QTL 310			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50604677	95604677	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	35509383	88177745	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	61997479	106997479	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	20110614	65110614	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
6	38	94	64	60	48	6	48	6	144	56	82	34	49	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063269378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221170	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221186	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224628	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000035657 ⟹ ENSRNOP00000036391

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	63,076,066 - 63,079,346 (-)	Ensembl
Rnor_6.0 Ensembl	10	65,441,295 - 65,443,981 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114672 ⟹ ENSRNOP00000082672

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	63,076,660 - 63,079,341 (-)	Ensembl

RefSeq Acc Id:

NM_001108283 ⟹ NP_001101753

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	63,574,732 - 63,577,418 (-)	NCBI
mRatBN7.2	10	63,076,660 - 63,079,346 (-)	NCBI
Rnor_6.0	10	65,441,295 - 65,443,981 (-)	NCBI
Rnor_5.0	10	66,190,636 - 66,193,322 (+)	NCBI
RGSC_v3.4	10	64,451,931 - 64,454,617 (+)	RGD
Celera	10	62,054,259 - 62,056,945 (-)	RGD

Sequence:

show sequence

CTCATGGGAATGAGGCTGGGTAACCCTTTTCGCCAAGATGGCGCCGAAAGCGAAGAAGGAAGCT
CCTGCCCCTCCCAAAGCCGAAGCCAAAGCGAAGGCCTTGAAAGCTAAGAAGGCAGTGCTGAAAG
GTGTCCACAGTCACAAAAAGAAGAAGATCCGAACGTCACCCACTTTCCGGCGGCCCAAGACCCT
GCGGCTCCGGAGGCAGCCAAAATATCCTCGAAAGAGTGCACCCAGGAGAAACAAGCTTGACCAC
TATGCTATCATCAAATTCCCACTGACCACCGAGTCAGCTATGAAGAAAATAGAGGACAACAACA
CGCTTGTGTTCATTGTGGATGTTAAGGCCAACAAGCACCAGATCAAACAGGCCGTGAAAAAACT
CTATGATATAGATGTGGCCAAAGTCAATACTCTGATACGGCCTGACGGAGAGAAGAAGGCATAT
GTTCGCTTGGCTCCTGATTATGATGCTCTAGATGTTGCCAACAAGATTGGGATCATCTAAAGTG
AGTCCAGATGGTTAATTCTAAATATATACTTTTTTTCCACCATAAATAATGC

hide sequence

RefSeq Acc Id:

XM_063269378 ⟹ XP_063125448

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	63,574,738 - 63,577,511 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101753	(Get FASTA)	NCBI Sequence Viewer
	XP_063125448	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68782	(Get FASTA)	NCBI Sequence Viewer
	EDM05322	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000036391.4
	ENSRNOP00000044111.4
	ENSRNOP00055037906
	ENSRNOP00060040317
	ENSRNOP00065031521
GenBank Protein	P62752	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001101753 ⟸ NM_001108283
- UniProtKB:	P62752 (UniProtKB/Swiss-Prot), B5DES1 (UniProtKB/TrEMBL), D3ZTX9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRQPKYPRKS APRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLI RPDGEKKAYVRLAPDYDALDVANKIGII hide sequence

Ensembl Acc Id:

ENSRNOP00000036391 ⟸ ENSRNOT00000035657

Ensembl Acc Id:

ENSRNOP00000082672 ⟸ ENSRNOT00000114672

RefSeq Acc Id:	XP_063125448 ⟸ XM_063269378
- Peptide Label:	isoform X1
- UniProtKB:	D3ZTX9 (UniProtKB/TrEMBL), A0A8L2QIC1 (UniProtKB/TrEMBL)

Protein Domains

Large ribosomal subunit protein uL23 N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P62752-F1-model_v2	AlphaFold	P62752	1-156	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697469

Promoter ID:

EPDNEW_R7994

Type:

multiple initiation site

Name:

Rpl23a_1

Description:

ribosomal protein L23a

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	65,443,956 - 65,444,016	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304897	AgrOrtholog
BioCyc Gene	G2FUF-24090	BioCyc
Ensembl Genes	ENSRNOG00000023344	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00000032148	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00055026742	UniProtKB/Swiss-Prot
	ENSRNOG00060027884	UniProtKB/Swiss-Prot
	ENSRNOG00065022762	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000035657.4	UniProtKB/TrEMBL
	ENSRNOT00000043836.4	UniProtKB/TrEMBL
	ENSRNOT00055046180	UniProtKB/Swiss-Prot
	ENSRNOT00060048402	UniProtKB/Swiss-Prot
	ENSRNOT00065038862	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.70.330	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Nucleotide-bd_a/b_plait_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_L23	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_L23/L15e_core_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_L23/L25_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_L23/L25_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_L25/23	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:360572	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	360572	ENTREZGENE
PANTHER	60S RIBOSOMAL PROTEIN L23A	UniProtKB/TrEMBL
	PTHR11620	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RIBOSOMAL_L23EN DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RIBOSOMAL_L23EN DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	Ribosomal_L23	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_L23eN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Rpl23a	PhenoGen
PROSITE	RIBOSOMAL_L23	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000023344	RatGTEx
	ENSRNOG00000032148	RatGTEx
	ENSRNOG00055026742	RatGTEx
	ENSRNOG00060027884	RatGTEx
	ENSRNOG00065022762	RatGTEx
Superfamily-SCOP	SSF54189	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2QIC1	ENTREZGENE, UniProtKB/TrEMBL
	B5DES1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZTX9	ENTREZGENE, UniProtKB/TrEMBL
	P62752	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	P29316	UniProtKB/Swiss-Prot
	P39024	UniProtKB/Swiss-Prot
	Q92774	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-04-07	Rpl23a	ribosomal protein L23A	Rpl23a	ribosomal protein L23a	Name changed	629549	APPROVED
2005-12-06	Rpl23a	ribosomal protein L23a	Rpl23a_predicted	ribosomal protein L23a (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Rpl23a_predicted	ribosomal protein L23a (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

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Imported Disease Annotations - CTD

RGD Manual Annotations