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Gene: Itga2b (integrin subunit alpha 2b) Rattus norvegicus
Symbol: Itga2b
Name: integrin subunit alpha 2b
Description: Exhibits fibrinogen binding activity. Involved in platelet aggregation and positive regulation of leukocyte migration. Localizes to cell surface. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: MODEL
Also known as: integrin alpha 2b (Cd41b); integrin alpha-IIb; integrin, alpha 2B; LOC685269; similar to Integrin alpha-IIb precursor (Platelet membrane glycoprotein IIb) (GPalpha IIb) (GPIIb) (CD41 antigen)
Homo sapiens (human) : ITGA2B (integrin subunit alpha 2b)  HGNC  Alliance
Mus musculus (house mouse) : Itga2b (integrin alpha 2b)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itga2b (integrin subunit alpha 2b)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGA2B (integrin subunit alpha 2b)
Canis lupus familiaris (dog) : ITGA2B (integrin subunit alpha 2b)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itga2b (integrin subunit alpha 2b)
Sus scrofa (pig) : ITGA2B (integrin subunit alpha 2b)
Chlorocebus sabaeus (African green monkey) : ITGA2B (integrin subunit alpha 2b)
Heterocephalus glaber (naked mole-rat) : Itga2b (integrin subunit alpha 2b)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01090,397,960 - 90,416,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,398,132 - 90,415,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,186,491 - 90,205,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,557,086 - 91,574,194 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1086,112,796 - 86,134,968 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Itga2b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1596428
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.