Itga2b (integrin subunit alpha 2b) - Rat Genome Database

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Gene: Itga2b (integrin subunit alpha 2b) Rattus norvegicus
Analyze
Symbol: Itga2b
Name: integrin subunit alpha 2b
RGD ID: 1596428
Description: Enables fibrinogen binding activity. Involved in platelet aggregation and positive regulation of leukocyte migration. Located in cell surface. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; blood platelet disease; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin alpha 2b (Cd41b); integrin alpha-IIb; integrin, alpha 2B; LOC685269; similar to Integrin alpha-IIb precursor (Platelet membrane glycoprotein IIb) (GPalpha IIb) (GPIIb) (CD41 antigen)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21087,408,532 - 87,426,055 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,408,536 - 87,426,168 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01090,397,960 - 90,416,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,398,132 - 90,415,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,186,491 - 90,205,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,557,086 - 91,574,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1086,112,796 - 86,134,968 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
anagrelide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
cangrelor  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
D-glucose  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
etoposide  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methyllycaconitine  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paracetamol  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
urethane  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. RGD-containing peptides inhibit fibrinogen binding to platelet alpha(IIb)beta3 by inducing an allosteric change in the amino-terminal portion of alpha(IIb). Basani RB, etal., J Biol Chem. 2001 Apr 27;276(17):13975-81. Epub 2001 Jan 18.
2. Analysis of combined treatment of embolic stroke in rat with r-tPA and a GPIIb/IIIa inhibitor. Ding G, etal., J Cereb Blood Flow Metab. 2005 Jan;25(1):87-97.
3. Different biochemical expression pattern of platelet surface glycoproteins suggests molecular diversity of Glanzmann's thrombasthenia in Iran. Farsinejad A, etal., Blood Coagul Fibrinolysis. 2013 Sep;24(6):613-8. doi: 10.1097/MBC.0b013e328360a558.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. An exon 28 mutation resulting in alternative splicing of the glycoprotein IIb transcript and Glanzmann's thrombasthenia. Iwamoto S, etal., Blood. 1994 Feb 15;83(4):1017-23.
6. Molecular defects in ITGA2B and ITGB3 genes in patients with Glanzmann thrombasthenia. Kannan M, etal., J Thromb Haemost. 2009 Nov;7(11):1878-85. doi: 10.1111/j.1538-7836.2009.03579.x. Epub 2009 Aug 19.
7. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
8. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees. Kunicki TJ, etal., Blood. 2004 Oct 15;104(8):2359-67. Epub 2004 Jun 29.
9. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
10. Heterozygous ITGA2B R995W mutation inducing constitutive activation of the alphaIIbbeta3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia. Kunishima S, etal., Blood. 2011 May 19;117(20):5479-84. doi: 10.1182/blood-2010-12-323691. Epub 2011 Mar 31.
11. An alphaIIb mutation in patients with Glanzmann thrombasthenia located in the N-terminus of blade 1 of the beta-propeller (Asn2Asp) disrupts a calcium binding site in blade 6. Mansour W, etal., J Thromb Haemost. 2011 Jan;9(1):192-200. doi: 10.1111/j.1538-7836.2010.04087.x.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Glanzmann's thrombasthenia associated with deletion-insertion and alternative splicing in the glycoprotein IIb gene. Peretz H, etal., Blood. 1995 Jan 15;85(2):414-20.
14. A novel amino acid substitution of integrin alphaIIb in Glanzmann thrombasthenia confirms that the N-terminal region of the receptor plays a role in maintaining beta-propeller structure. Pillois X, etal., Platelets. 2013;24(1):77-80. doi: 10.3109/09537104.2012.665278. Epub 2012 Mar 6.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Platelets modulate ischemia/reperfusion-induced leukocyte recruitment in the mesenteric circulation. Salter JW, etal., Am J Physiol Gastrointest Liver Physiol. 2001 Dec;281(6):G1432-9.
22. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
23. Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia. Teeling JL, etal., Blood. 2001 Aug 15;98(4):1095-9.
24. An in-vivo analysis of capillary stasis and endothelial apoptosis in a model of hypertension. Tran ED and Schmid-Schonbein GW, Microcirculation. 2007 Nov-Dec;14(8):793-804.
25. Glycoprotein IIB/IIIA-inhibition and microcirculatory alterations during experimental endotoxemia--an intravital microscopic study in the rat. Walther A, etal., Microcirculation. 2004 Jan-Feb;11(1):79-88.
Additional References at PubMed
PMID:11606749   PMID:12900455   PMID:14681217   PMID:14751927   PMID:15031111   PMID:15067009   PMID:15908444   PMID:18971422   PMID:19360001   PMID:20228271   PMID:22516433   PMID:23082158  
PMID:23382103   PMID:28097150   PMID:30359790  


Genomics

Comparative Map Data
Itga2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21087,408,532 - 87,426,055 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,408,536 - 87,426,168 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01090,397,960 - 90,416,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,398,132 - 90,415,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,186,491 - 90,205,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,557,086 - 91,574,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1086,112,796 - 86,134,968 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
ITGA2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,372,181 - 44,389,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1744,372,180 - 44,389,649 (-)EnsemblGRCh38hg38GRCh38
GRCh371742,449,549 - 42,467,017 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,805,076 - 39,822,399 (-)NCBINCBI36Build 36hg18NCBI36
Build 341739,805,075 - 39,822,399NCBI
Celera1739,159,154 - 39,176,462 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,213,453 - 38,230,761 (-)NCBIHuRef
CHM1_11742,685,183 - 42,702,506 (-)NCBICHM1_1
T2T-CHM13v2.01745,226,172 - 45,243,631 (-)NCBIT2T-CHM13v2.0
Itga2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,344,123 - 102,360,709 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,344,123 - 102,360,948 (-)EnsemblGRCm39 Ensembl
GRCm3811102,453,297 - 102,469,883 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,453,297 - 102,470,122 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711102,314,611 - 102,331,197 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,269,387 - 102,285,834 (-)NCBIMGSCv36mm8
Celera11114,163,479 - 114,180,083 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
Itga2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,382,779 - 17,391,859 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,381,323 - 17,392,122 (-)NCBIChiLan1.0ChiLan1.0
ITGA2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11713,176,843 - 13,193,269 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,176,843 - 13,193,269 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01713,009,514 - 13,027,289 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ITGA2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,049,643 - 19,064,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,050,001 - 19,063,992 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,439,814 - 18,453,677 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,744,435 - 19,758,300 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,714,740 - 19,758,300 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,598,247 - 18,612,116 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,781,219 - 18,795,078 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,925,492 - 18,939,347 (+)NCBIUU_Cfam_GSD_1.0
Itga2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,365,697 - 18,380,441 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541814,171 - 828,291 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936541813,815 - 828,826 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,001,082 - 62,019,470 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,001,352 - 62,019,289 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607732,766,163 - 32,785,616 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795683,968 - 703,710 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795683,899 - 695,262 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itga2b
68 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:133
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000036112, ENSRNOT00000055179
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat

Markers in Region
RH139967  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,408,529 - 87,408,717 (+)MAPPERmRatBN7.2
Rnor_6.01090,397,958 - 90,398,145NCBIRnor6.0
Rnor_5.01090,186,489 - 90,186,676UniSTSRnor5.0
RGSC_v3.41091,557,082 - 91,557,269UniSTSRGSC3.4
Celera1086,117,379 - 86,117,566UniSTS
RH 3.4 Map10925.29UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 23 23 11 23 10 1
Low 3 39 33 18 8 18 2 5 72 25 41 10 2
Below cutoff 1 6 6 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036112   ⟹   ENSRNOP00000032017
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,412,109 - 87,421,141 (-)Ensembl
Rnor_6.0 Ensembl1090,401,537 - 90,410,569 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000055179   ⟹   ENSRNOP00000052051
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,410,742 - 87,426,168 (-)Ensembl
Rnor_6.0 Ensembl1090,398,132 - 90,415,070 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115902   ⟹   ENSRNOP00000088856
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,408,536 - 87,426,168 (-)Ensembl
RefSeq Acc Id: XM_001063315   ⟹   XP_001063315
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21087,408,532 - 87,426,055 (-)NCBI
Rnor_6.01090,397,960 - 90,416,550 (-)NCBI
Rnor_5.01090,186,491 - 90,205,094 (-)NCBI
RGSC_v3.41091,557,086 - 91,574,194 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_001063315 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06216 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001063315   ⟸   XM_001063315
- UniProtKB: A0A8I6GGN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052051   ⟸   ENSRNOT00000055179
RefSeq Acc Id: ENSRNOP00000032017   ⟸   ENSRNOT00000036112
RefSeq Acc Id: ENSRNOP00000088856   ⟸   ENSRNOT00000115902
Protein Domains
Integrin_alpha2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAC0-F1-model_v2 AlphaFold D3ZAC0 1-1034 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697791
Promoter ID:EPDNEW_R8314
Type:single initiation site
Name:Itga2b_1
Description:integrin subunit alpha 2b
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01090,415,102 - 90,415,162EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596428 AgrOrtholog
BioCyc Gene G2FUF-23105 BioCyc
Ensembl Genes ENSRNOG00000022071 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000032017.4 UniProtKB/TrEMBL
  ENSRNOP00000052051.4 UniProtKB/TrEMBL
  ENSRNOP00000088856 ENTREZGENE
  ENSRNOP00000088856.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036112.5 UniProtKB/TrEMBL
  ENSRNOT00000055179.6 UniProtKB/TrEMBL
  ENSRNOT00000115902 ENTREZGENE
  ENSRNOT00000115902.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
NCBI Gene 685269 ENTREZGENE
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PharmGKB ITGA2B RGD
PhenoGen Itga2b PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A8I6GGN2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAC0_RAT UniProtKB/TrEMBL
  D3ZXC1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itga2b  integrin subunit alpha 2b  Itga2b  integrin, alpha 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-29 Itga2b  integrin, alpha 2B  Itga2b  integrin, alpha 2b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-08 Itga2b  integrin, alpha 2b  LOC685269  similar to Integrin alpha-IIb precursor (Platelet membrane glycoprotein IIb) (GPalpha IIb) (GPIIb) (CD41 antigen)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685269  similar to Integrin alpha-IIb precursor (Platelet membrane glycoprotein IIb) (GPalpha IIb) (GPIIb) (CD41 antigen)      Symbol and Name status set to provisional 70820 PROVISIONAL