Col1a1 (collagen type I alpha 1 chain) - Rat Genome Database

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Gene: Col1a1 (collagen type I alpha 1 chain) Rattus norvegicus
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Symbol: Col1a1
Name: collagen type I alpha 1 chain
RGD ID: 61817
Description: Predicted to enable identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to mechanical stimulus; and cellular response to vitamin E. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in extracellular space and secretory granule. Used to study cholestasis and metabolic dysfunction-associated steatotic liver disease. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; liver disease (multiple); rheumatic heart disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (R)-carnitine; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-1 type I collagen; COLIA1; collagen alpha-1(I) chain; collagen, type 1, alpha 1; collagen, type I, alpha 1; procollagen type I alpha 1; procollagen type I, alpha 1; procollagen, type 1, alpha 1; procollagen, type I, alpha 1; type I-alpha 1 collagen
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,380,458 - 80,397,461 (+)NCBIGRCr8
mRatBN7.21079,883,622 - 79,900,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,832,832 - 84,849,838 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,330,903 - 84,347,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,723,993 - 79,740,998 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,745,801 - 82,762,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,745,801 - 82,762,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,563,434 - 82,580,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,622,438 - 83,639,368 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,636,918 - 83,653,733 (+)NCBI
Celera1078,658,450 - 78,675,438 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Col1a1Rataggressive periodontitis  ISOCOL1A1 (Homo sapiens)5688299DNA:SNPRGD 
Col1a1Ratalcoholic hepatitis  ISOCOL1A1 (Homo sapiens)5688335 RGD 
Col1a1RatArteriovenous Fistula  IEP 8552771in Long Evans rats and mRNA:increased expression:aortaRGD 
Col1a1Ratbeta thalassemia  ISOCOL1A1 (Homo sapiens)11041179DNA:SNPRGD 
Col1a1RatBisphosphonate-Associated Osteonecrosis of the Jaw treatmentISOCOL1A1 (Homo sapiens)11041182associated with Multiple MyelomaRGD 
Col1a1Ratbladder neck obstruction treatmentIEP 7257549 RGD 
Col1a1RatBone Fractures  ISOCOL1A1 (Homo sapiens)734801 RGD 
Col1a1RatCaffey disease  ISOCOL1A1 (Homo sapiens)5688296DNA:mutation:exon:3040C>T (human)RGD 
Col1a1RatCaffey disease  ISOCOL1A1 (Homo sapiens)11667069DNA:missense mutation:exon:c.3040C>T(p.R836C)(human)RGD 
Col1a1RatCardiac Fibrosis  IEP 5688337associated with Hypertension and mRNA:increased expression:heartRGD 
Col1a1RatCardiac Fibrosis  IEP 156430318protein:increased expression:blood serum (rat)RGD 
Col1a1RatCardiac Fibrosis treatmentIDA 8552780 RGD 
Col1a1Ratcholestasis  IEP 8552776mRNA:increased expression:liver (rat)RGD 
Col1a1Ratcholestasis  ISOCol1a1 (Mus musculus)8552675mRNA:increased expression:liver (mouse)RGD 
Col1a1Ratcholestasis treatmentIDA 8552699 RGD 
Col1a1Ratchronic obstructive pulmonary disease  ISOCOL1A1 (Homo sapiens)5131854 RGD 
Col1a1RatChronic Pancreatitis treatmentIDA 8552779 RGD 
Col1a1RatContracture treatmentIEP 11041578 RGD 
Col1a1Ratcutaneous leishmaniasis  ISOCOL1A1 (Homo sapiens)11041176DNA:SNPs: :rs1061237 and rs2586488 (human)RGD 
Col1a1Ratdegenerative disc disease  ISOCOL1A1 (Homo sapiens)5688293DNA:SNP: :rs2075555 (human)RGD 
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Col1a1Ratasphyxia neonatorum  ISOCOL1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Asphyxia neonatorumClinVarPMID:25741868 and PMID:8364588
Col1a1Ratautosomal recessive limb-girdle muscular dystrophy type 2D  ISOCOL1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive limb-girdle muscular dystrophy type 2DClinVarPMID:25106685 and PMID:28492532
Col1a1RatBone Fractures  ISOCOL1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Recurrent fracturesClinVarPMID:17078022 more ...
Col1a1RatCaffey disease  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10739762 more ...
Col1a1RatCombined Osteogenesis Imperfecta and Ehlers-Danlos Syndrome 1  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10739762 more ...
Col1a1Ratcongenital heart disease  ISOCOL1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital heart diseaseClinVarPMID:28492532
Col1a1Ratconnective tissue disease  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15741671 more ...
Col1a1Ratdentinogenesis imperfecta  ISOCOL1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dentinogenesis imperfectaClinVarPMID:17078022 more ...
Col1a1Ratdilated cardiomyopathy  ISOCOL1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary dilated cardiomyopathyClinVarPMID:25741868
Col1a1RatEhlers-Danlos syndrome  ISOCOL1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndromeClinVarPMID:10739762 more ...
Col1a1RatEhlers-Danlos syndrome arthrochalasia type 1  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10739762 more ...
Col1a1RatEhlers-Danlos syndrome arthrochalasia type 2  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18311573 more ...
Col1a1RatEhlers-Danlos syndrome cardiac valvular type  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10739762 more ...
Col1a1RatEhlers-Danlos syndrome cardiac valvular type  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10739762 more ...
Col1a1RatEhlers-Danlos syndrome cardiac valvular type  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10931857 more ...
Col1a1RatEhlers-Danlos syndrome cardiac valvular type  ISOCOL1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome and arthrochalasis typeClinVarPMID:10739762 more ...
Col1a1RatEhlers-Danlos syndrome cardiac valvular type  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10931857 more ...
Col1a1RatEhlers-Danlos syndrome classic type 1  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10739762 more ...
Col1a1RatEhlers-Danlos syndrome classic type 1  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10739762 more ...
Col1a1RatEhlers-Danlos syndrome classic type 1  ISOCOL1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10739762 more ...
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Col1a1Rataortic valve insufficiency  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21216836
Col1a1Ratautoimmune disease  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25055964
Col1a1RatCaffey disease  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Col1a1Ratcalcinosis  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21335463
Col1a1Ratcholangitis  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25055964
Col1a1RatDissecting Aneurysm  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8757037
Col1a1RatEhlers-Danlos syndrome arthrochalasia type 1  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Col1a1RatExperimental Liver Cirrhosis  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136 more ...
Col1a1Ratextrahepatic cholestasis  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28789951 and PMID:31932644
Col1a1RatFibrosis  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20388698
Col1a1Ratheart valve disease  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21335463
Col1a1Rathypertension  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11682445
Col1a1RatKeloid  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20128793
Col1a1RatLeft Ventricular Hypertrophy  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11181017
Col1a1Ratliver cirrhosis  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21863215 more ...
Col1a1RatNephrogenic Fibrosing Dermopathy  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20570839
Col1a1Ratnephrosclerosis  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30818366
Col1a1Ratnephrotic syndrome  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:1281619
Col1a1Ratoral submucous fibrosis  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16311067
Col1a1Ratosteogenesis imperfecta  ISOCOL1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8757037
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Col1a1Rat(+)-beta-thujone multiple interactionsISOCOL1A1 (Homo sapiens)6480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of COL1A1 mRNACTDPMID:38000518
Col1a1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]CTDPMID:31697999
Col1a1Rat(+)-schisandrin B decreases expressionISOCOL1A1 (Homo sapiens)6480464schizandrin B results in decreased expression of COL1A1 mRNACTDPMID:31697999
Col1a1Rat(+)-schisandrin B multiple interactionsISOCOL1A1 (Homo sapiens)6480464MIR30E mRNA affects the reaction [schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]] more ...CTDPMID:31697999
Col1a1Rat(+)-Tetrandrine decreases expressionISOCOL1A1 (Homo sapiens)6480464tetrandrine results in decreased expression of COL1A1 mRNACTDPMID:27235791
Col1a1Rat(-)-anisomycin multiple interactionsISOCOL1A1 (Homo sapiens)6480464Anisomycin inhibits the reaction [1-hydroxyalantolactone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]]CTDPMID:34758440
Col1a1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOCol1a1 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]CTDPMID:20438794
Col1a1Rat(-)-epigallocatechin 3-gallate increases expressionISOCOL1A1 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of COL1A1 mRNACTDPMID:20706672
Col1a1Rat(-)-selegiline multiple interactionsISOCol1a1 (Mus musculus)6480464[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]CTDPMID:34609854
Col1a1Rat(1->4)-beta-D-glucan multiple interactionsISOCol1a1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of COL1A1 mRNACTDPMID:36331819
Col1a1Rat(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid multiple interactionsISOCol1a1 (Mus musculus)6480464argatroban inhibits the reaction [Dietary Fats results in increased expression of COL1A1 mRNA]CTDPMID:22841818
Col1a1Rat(R)-camphor multiple interactionsISOCOL1A1 (Homo sapiens)6480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of COL1A1 mRNACTDPMID:38000518
Col1a1Rat(R)-carnitine multiple interactionsEXP 6480464Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of COL1A1 mRNA] and Carnitine inhibits the reaction [Sunitinib results in increased expression of COL1A1 mRNA]CTDPMID:26581635 and PMID:28973641
Col1a1Rat(R)-linalyl acetate multiple interactionsISOCOL1A1 (Homo sapiens)6480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of COL1A1 mRNACTDPMID:38000518
Col1a1Rat(R)-lipoic acid multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA and Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]CTDPMID:21251946 and PMID:23830814
Col1a1Rat(R)-lipoic acid multiple interactionsISOCol1a1 (Mus musculus)6480464Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA] and Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL1A1 mRNA]CTDPMID:34252510 and PMID:35187969
Col1a1Rat(R)-noradrenaline multiple interactionsEXP 6480464carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA] and Doxazosin inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]CTDPMID:10722803 and PMID:19575289
Col1a1Rat(R)-noradrenaline multiple interactionsISOCol1a1 (Mus musculus)6480464[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA] and FPS-ZM1 inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]CTDPMID:34609854
Col1a1Rat(R)-noradrenaline increases expressionISOCol1a1 (Mus musculus)6480464Norepinephrine results in increased expression of COL1A1 mRNACTDPMID:34609854
Col1a1Rat(R)-noradrenaline increases expressionEXP 6480464Norepinephrine results in increased expression of COL1A1 mRNACTDPMID:10722803 more ...

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Biological Process
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Col1a1Ratblood vessel development involved_inISOCOL1A1 (Homo sapiens)1624291 PMID:17211858RGDPMID:17211858
Col1a1Ratblood vessel development acts_upstream_of_or_withinIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratblood vessel development involved_inIEAUniProtKB:P02452 and ensembl:ENSP000002259641600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratblood vessel development involved_inIBAMGI:88467 and PANTHER:PTN0006144971600115GO_REF:0000033GO_CentralGO_REF:0000033
Col1a1Ratblood vessel development acts_upstream_of_or_withinISOCol1a1 (Mus musculus)1624291MGI:2179405 PMID:14630726RGDPMID:14630726
Col1a1Ratbone trabecula formation acts_upstream_of_or_withinIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratbone trabecula formation acts_upstream_of_or_withinISOCol1a1 (Mus musculus)1624291MGI:97009 PMID:17440987RGDPMID:17440987
Col1a1Ratcartilage development involved in endochondral bone morphogenesis acts_upstream_of_or_withinISOCol1a1 (Mus musculus)1624291MGI:3769585 PMID:18248096RGDPMID:18248096
Col1a1Ratcartilage development involved in endochondral bone morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratcellular response to amino acid stimulus acts_upstream_of_or_withinISOCol1a1 (Mus musculus)1624291 PMID:20548288RGDPMID:20548288
Col1a1Ratcellular response to amino acid stimulus acts_upstream_of_or_withinIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratcellular response to epidermal growth factor stimulus  IEP 2316227 RGD 
Col1a1Ratcellular response to fibroblast growth factor stimulus  IEP 8552747 RGD 
Col1a1Ratcellular response to fluoride  IEP 8552690 RGD 
Col1a1Ratcellular response to glucose stimulus  IEP 401824679 RGD 
Col1a1Ratcellular response to mechanical stimulus  IEP 8552682uniaxial mechanical tensionRGD 
Col1a1Ratcellular response to mechanical stimulus involved_inIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratcellular response to mechanical stimulus involved_inISOCol1a1 (Mus musculus)1624291 PMID:21625049RGDPMID:21625049
Col1a1Ratcellular response to retinoic acid  IEP 8552777 RGD 
Col1a1Ratcellular response to retinoic acid  IEP 2316228 RGD 
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Cellular Component
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Col1a1Ratcollagen trimer part_ofIEAUniProtKB-KW:KW-01761600115GO_REF:0000043UniProtGO_REF:0000043
Col1a1Ratcollagen trimer part_ofIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratcollagen trimer part_ofISOCol1a1 (Mus musculus)1624291MGI:2179405 PMID:10608859 more ...RGDPMID:10608859 more ...
Col1a1Ratcollagen type I trimer part_ofISOCOL1A1 (Homo sapiens)1624291 PMID:14976317 more ...RGDPMID:14976317 more ...
Col1a1Ratcollagen type I trimer part_ofIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratcollagen type I trimer part_ofISOCol1a1 (Mus musculus)1624291MGI:1857154 PMID:7790374 and PMID:8018053RGDPMID:7790374 and PMID:8018053
Col1a1Ratcollagen type I trimer part_ofIBAMGI:88467 and PANTHER:PTN0006144971600115GO_REF:0000033GO_CentralGO_REF:0000033
Col1a1Ratcollagen type I trimer part_ofIEAUniProtKB:P02452 and ensembl:ENSP000002259641600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratcollagen-containing extracellular matrix is_active_inIBAFB:FBgn0000299 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Col1a1Ratcollagen-containing extracellular matrix located_inISOCol1a1 (Mus musculus)1624291 PMID:34368841RGDPMID:34368841
Col1a1Ratcytoplasm located_inISOCol1a1 (Mus musculus)1624291 PMID:29636669 and PMID:8018053RGDPMID:29636669 and PMID:8018053
Col1a1Ratcytoplasm located_inIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratcytoplasm is_active_inIBAMGI:88467 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Col1a1Ratextracellular matrix located_inIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratextracellular matrix located_inISOCol1a1 (Mus musculus)1624291 PMID:10878613 more ...RGDPMID:10878613 more ...
Col1a1Ratextracellular region located_inTAS 1600115Reactome:R-NUL-2731094ReactomeReactome:R-NUL-2731094
Col1a1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Col1a1Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Col1a1Ratextracellular region located_inTAS 1600115Reactome:R-NUL-2465871ReactomeReactome:R-NUL-2465871
Col1a1Ratextracellular region located_inTAS 1600115Reactome:R-NUL-4084908ReactomeReactome:R-NUL-4084908
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Molecular Function
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Col1a1Ratextracellular matrix structural constituent enablesIEAInterPro:IPR0008851600115GO_REF:0000002InterProGO_REF:0000002
Col1a1Ratextracellular matrix structural constituent enablesIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratextracellular matrix structural constituent enablesISOCol1a1 (Mus musculus)1624291 PMID:15383546RGDPMID:15383546
Col1a1Ratextracellular matrix structural constituent conferring tensile strength enablesIBAPANTHER:PTN001166351 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Col1a1Ratidentical protein binding enablesISOCOL1A1 (Homo sapiens)1624291 PMID:17211858RGDPMID:17211858
Col1a1Ratidentical protein binding enablesIEAUniProtKB:P02452 and ensembl:ENSP000002259641600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratidentical protein binding enablesISOCol1a1 (Mus musculus)1624291PR:P11087 PMID:9213002RGDPMID:9213002
Col1a1Ratidentical protein binding enablesIEAUniProtKB:P11087 and ensembl:ENSMUSP000000015471600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Col1a1Ratplatelet-derived growth factor binding enablesISOCOL1A1 (Homo sapiens)1624291 PMID:8900172RGDPMID:8900172
Col1a1Ratplatelet-derived growth factor binding enablesIEAUniProtKB:P02452 and ensembl:ENSP000002259641600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratprotease binding enablesISOCOL1A1 (Homo sapiens)1624291UniProtKB:P39900 and PMID:19932771RGDPMID:19932771
Col1a1Ratprotease binding enablesIEAUniProtKB:P02452 and ensembl:ENSP000002259641600115GO_REF:0000107EnsemblGO_REF:0000107
Col1a1Ratprotein binding  IPIMrc2 (Rattus norvegicus)1579812 RGD 
Col1a1Ratprotein binding enablesISOCol1a1 (Mus musculus)1624291MGI:88468 more ...RGDPMID:17018525 more ...
Col1a1Ratprotein binding enablesIPIUniProtKB:Q9UBG013432280PMID:26481812IntAct 
Col1a1Ratprotein binding enablesISOCOL1A1 (Homo sapiens)1624291UniProtKB:O01949 more ...RGDPMID:14749390 more ...
1 to 17 of 17 rows

Imported Annotations - SMPDB

1 to 16 of 16 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Col1a1Ratacenocoumarol pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00269
Col1a1Ratalteplase pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00280
Col1a1Rataminocaproic acid pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00286
Col1a1Ratanistreplase pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00281
Col1a1Rataprotinin pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00288
Col1a1Ratargatroban pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00276
Col1a1Ratbivalirudin pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00277
Col1a1Ratdicoumarol pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00656
Col1a1Ratdicoumarol pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00270
Col1a1Ratenoxaparin pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00272
Col1a1Ratfondaparinux pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00273
Col1a1Ratheparin pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00274
Col1a1Ratphenindione pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00655
Col1a1Ratreteplase pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00285
Col1a1Rattranexamic acid pharmacodynamics pathway  ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00287
Col1a1Ratwarfarin pharmacodynamics pathway   ISOCOL1A1 (Homo sapiens)10402751 SMPDBSMP:00268
1 to 16 of 16 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Col1a1Ratcell-extracellular matrix signaling pathway  IEA 6907045 KEGGrno:04512
Col1a1RatEntamoebiasis pathway  IEA 6907045 KEGGrno:05146

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Col1a1Ratinterleukin-4 signaling pathway  ISOCOL1A1 (Homo sapiens)6484113 PIDPID:200022
Col1a1Ratsyndecan signaling pathway  ISOCOL1A1 (Homo sapiens)6484113 PIDPID:200156

1 to 20 of 139 rows
#
Reference Title
Reference Citation
1. The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension. Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21.
2. Lack of association between osteoarthritis of the hip and gene polymorphisms of VDR, COL1A1, and COL2A1 in postmenopausal women. Aerssens J, etal., Arthritis Rheum. 1998 Nov;41(11):1946-50.
3. Combination of ADMSCs and chondrocytes reduces hypertrophy and improves the functional properties of osteoarthritic cartilage. Ahmed MR, etal., Osteoarthritis Cartilage. 2014 Nov;22(11):1894-901. doi: 10.1016/j.joca.2014.07.028. Epub 2014 Aug 13.
4. Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil: role of COL1A1. Almeida L, etal., Infect Genet Evol. 2015 Mar;30:225-9. doi: 10.1016/j.meegid.2014.12.034. Epub 2015 Jan 3.
5. Albumin and procollagen type I gene regulation in alcohol and viral-induced human liver disease. Annoni G, etal., Boll Ist Sieroter Milan. 1991-1992;70(1-2):391-7.
6. Polymorphism analysis in the COLIA1 gene of patients with thalassemia major and intermedia. Arisal O, etal., Haematologia (Budap). 2002;32(4):475-82.
7. Alteration of type I collagen in the radial artery of patients with end-stage renal disease. Bai Y, etal., Am J Med Sci. 2015 Apr;349(4):292-7. doi: 10.1097/MAJ.0000000000000408.
8. A novel, non-functional, COL1A1 polymorphism is not associated with lumbar disk disease in young male Greek subjects unlike that of the Sp1 site. Bei T, etal., Hormones (Athens). 2008 Jul-Sep;7(3):251-4.
9. Prevention of glomerulosclerosis by early cyclosporine treatment of experimental lupus nephritis. Bergijk EC, etal., Kidney Int. 1994 Dec;46(6):1663-73.
10. Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Bhatt RS, etal., Genes Dev. 2000 Sep 1;14(17):2216-28.
11. Vitamin E protects chondrocytes against hydrogen peroxide-induced oxidative stress in vitro. Bhatti FU, etal., Inflamm Res. 2013 Aug;62(8):781-9. doi: 10.1007/s00011-013-0635-y. Epub 2013 May 31.
12. Parathyroid hormone inhibits collagen synthesis and the activity of rat col1a1 transgenes mainly by a cAMP-mediated pathway in mouse calvariae. Bogdanovic Z, etal., J Cell Biochem. 2000 Feb;77(1):149-58.
13. Analysis of the odontogenic and osteogenic potentials of dental pulp in vivo using a Col1a1-2.3-GFP transgene. Braut A, etal., Int J Dev Biol 2003 May;47(4):281-92.
14. Ehlers-Danlos syndrome type VIIA and VIIB result from splice-junction mutations or genomic deletions that involve exon 6 in the COL1A1 and COL1A2 genes of type I collagen. Byers PH, etal., Am J Med Genet 1997 Oct 3;72(1):94-105.
15. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
16. MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension. Castoldi G, etal., J Cell Physiol. 2012 Feb;227(2):850-6. doi: 10.1002/jcp.22939.
17. First mouse model for combined osteogenesis imperfecta and Ehlers-Danlos syndrome. Chen F, etal., J Bone Miner Res. 2014 Jun;29(6):1412-23. doi: 10.1002/jbmr.2177.
18. A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation. Chen JY, etal., J Ethnopharmacol. 2012 Aug 1;142(3):811-8. doi: 10.1016/j.jep.2012.06.005. Epub 2012 Jun 15.
19. Single-nucleotide polymorphisms in the COL1A1 regulatory regions are associated with otosclerosis. Chen W, etal., Clin Genet. 2007 May;71(5):406-14.
20. High-flow-induced arterial remodeling in rats with different susceptibilities to cerebral aneurysms. Coutard M, etal., J Vasc Res. 2006;43(3):217-28. Epub 2006 Jan 20.
1 to 20 of 139 rows
1 to 10 of 11 rows
PMID:1874719   PMID:2209468   PMID:2779548   PMID:4126850   PMID:4290711   PMID:4327399   PMID:4335087   PMID:4342027   PMID:4366532   PMID:4636751   PMID:5337886   PMID:5411206  
PMID:5777344   PMID:6395893   PMID:7573384   PMID:7589890   PMID:7629088   PMID:7704020   PMID:7790374   PMID:8018053   PMID:8097422   PMID:8130375   PMID:8163675   PMID:8686743  
PMID:8889548   PMID:8900172   PMID:8906420   PMID:8984825   PMID:9213002   PMID:10065941   PMID:10608859   PMID:10878613   PMID:12199527   PMID:12477932   PMID:12647294   PMID:14630726  
PMID:14749390   PMID:14976317   PMID:15095409   PMID:15383546   PMID:15647278   PMID:15677443   PMID:15703183   PMID:16306131   PMID:16311053   PMID:16751282   PMID:16938497   PMID:16971509  
PMID:17018525   PMID:17029294   PMID:17118335   PMID:17156988   PMID:17206378   PMID:17211858   PMID:17440987   PMID:17485851   PMID:17576241   PMID:17616939   PMID:17662583   PMID:17924680  
PMID:18041732   PMID:18095594   PMID:18348167   PMID:18375391   PMID:18471258   PMID:18553566   PMID:18726071   PMID:18727865   PMID:18782537   PMID:19393425   PMID:19418583   PMID:19426591  
PMID:19667256   PMID:19679517   PMID:19932771   PMID:20006603   PMID:20018240   PMID:20149607   PMID:20388018   PMID:20548288   PMID:20551380   PMID:20603131   PMID:20875682   PMID:21055467  
PMID:21166192   PMID:21625049   PMID:21645221   PMID:21729992   PMID:22206666   PMID:22847422   PMID:23093703   PMID:23200051   PMID:23508044   PMID:23633075   PMID:23658023   PMID:23959432  
PMID:24006456   PMID:24036265   PMID:24116223   PMID:24735795   PMID:25655816   PMID:25784725   PMID:25931508   PMID:26049074   PMID:26567337   PMID:26674152   PMID:26702050   PMID:26807691  
PMID:27031437   PMID:27068509   PMID:27108411   PMID:27155082   PMID:27351590   PMID:27559042   PMID:27756197   PMID:28031326   PMID:28320405   PMID:28713909   PMID:28731181   PMID:28849131  
1 to 10 of 11 rows



Col1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,380,458 - 80,397,461 (+)NCBIGRCr8
mRatBN7.21079,883,622 - 79,900,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,832,832 - 84,849,838 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,330,903 - 84,347,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,723,993 - 79,740,998 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,745,801 - 82,762,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,745,801 - 82,762,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,563,434 - 82,580,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,622,438 - 83,639,368 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,636,918 - 83,653,733 (+)NCBI
Celera1078,658,450 - 78,675,438 (+)NCBICelera
Cytogenetic Map10q26NCBI
COL1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,184,101 - 50,201,631 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,184,101 - 50,201,632 (-)EnsemblGRCh38hg38GRCh38
GRCh371748,261,462 - 48,278,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,616,456 - 45,633,999 (-)NCBINCBI36Build 36hg18NCBI36
Build 341745,616,455 - 45,633,992NCBI
Celera1744,722,303 - 44,739,829 (-)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,630,129 - 43,647,463 (-)NCBIHuRef
CHM1_11748,325,754 - 48,343,284 (-)NCBICHM1_1
T2T-CHM13v2.01751,051,162 - 51,068,680 (-)NCBIT2T-CHM13v2.0
Col1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,827,050 - 94,843,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,827,050 - 94,843,868 (+)EnsemblGRCm39 Ensembl
GRCm381194,936,224 - 94,953,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,936,224 - 94,953,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv371194,797,584 - 94,813,181 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,752,360 - 94,767,957 (+)NCBIMGSCv36mm8
Celera11104,549,617 - 104,565,301 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Col1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,468,290 - 11,483,073 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,468,156 - 11,484,410 (+)NCBIChiLan1.0ChiLan1.0
COL1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,373,893 - 66,390,381 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,180,391 - 71,196,792 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01744,274,349 - 44,291,764 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11749,149,277 - 49,166,833 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,150,677 - 49,166,677 (-)Ensemblpanpan1.1panPan2
COL1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,183,852 - 26,199,927 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,183,852 - 26,199,927 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,576,913 - 25,592,983 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,978,359 - 26,994,434 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,978,317 - 26,994,453 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,746,094 - 25,762,176 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,004,757 - 26,020,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,134,702 - 26,150,789 (-)NCBIUU_Cfam_GSD_1.0
Col1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,609,297 - 25,626,616 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,448,654 - 11,464,444 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,448,552 - 11,465,836 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COL1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,379,090 - 26,397,004 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,379,087 - 26,397,180 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
COL1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,134,648 - 43,152,313 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,134,779 - 43,150,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,850,099 - 13,867,746 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Col1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,168,797 - 6,183,071 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,167,504 - 6,183,208 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Col1a1
124 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 83632785 83632786 A C snv SS/JrHsdMcwi (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:504
Count of miRNA genes:227
Interacting mature miRNAs:291
Transcripts:ENSRNOT00000005311
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 86 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat

1 to 10 of 86 rows
PMC151926P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,899,135 - 79,899,468 (+)MAPPERmRatBN7.2
Rnor_6.01082,761,301 - 82,761,633NCBIRnor6.0
Rnor_5.01082,578,875 - 82,579,207UniSTSRnor5.0
RGSC_v3.41083,637,879 - 83,638,211UniSTSRGSC3.4
Celera1078,673,949 - 78,674,281UniSTS
Cytogenetic Map10q31UniSTS
PMC34669P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,898,190 - 79,898,850 (+)MAPPERmRatBN7.2
Rnor_6.01082,760,356 - 82,761,015NCBIRnor6.0
Rnor_5.01082,577,930 - 82,578,589UniSTSRnor5.0
RGSC_v3.41083,636,934 - 83,637,593UniSTSRGSC3.4
Celera1078,673,004 - 78,673,663UniSTS
Cytogenetic Map10q31UniSTS
RH128280  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81080,397,206 - 80,397,449 (+)Marker Load Pipeline
mRatBN7.21079,900,370 - 79,900,613 (+)MAPPERmRatBN7.2
Rnor_6.01082,762,536 - 82,762,778NCBIRnor6.0
Rnor_5.01082,580,110 - 82,580,352UniSTSRnor5.0
RGSC_v3.41083,639,114 - 83,639,356UniSTSRGSC3.4
Celera1078,675,184 - 78,675,426UniSTS
RH 3.4 Map10723.7UniSTS
Cytogenetic Map10q31UniSTS
PMC275467P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,883,057 - 79,883,318 (+)MAPPERmRatBN7.2
Rnor_6.01082,745,237 - 82,745,497NCBIRnor6.0
Rnor_5.01082,562,870 - 82,563,130UniSTSRnor5.0
RGSC_v3.41083,621,874 - 83,622,134UniSTSRGSC3.4
Celera1078,657,886 - 78,658,146UniSTS
Cytogenetic Map10q31UniSTS
COL1A1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81080,392,172 - 80,392,437 (+)Marker Load Pipeline
mRatBN7.21079,895,336 - 79,895,601 (+)MAPPERmRatBN7.2
Rnor_6.01082,757,500 - 82,757,764NCBIRnor6.0
Rnor_5.01082,575,074 - 82,575,338UniSTSRnor5.0
RGSC_v3.41083,634,078 - 83,634,342UniSTSRGSC3.4
Celera1078,670,150 - 78,670,414UniSTS
Cytogenetic Map10q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000005311   ⟹   ENSRNOP00000005311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)Ensembl
Rnor_6.0 Ensembl1082,745,801 - 82,762,789 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114204   ⟹   ENSRNOP00000088255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,883,623 - 79,900,624 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115096   ⟹   ENSRNOP00000081061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115180   ⟹   ENSRNOP00000081946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)Ensembl
RefSeq Acc Id: NM_053304   ⟹   NP_445756
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,380,458 - 80,397,461 (+)NCBI
mRatBN7.21079,883,622 - 79,900,625 (+)NCBI
Rnor_6.01082,745,801 - 82,762,790 (+)NCBI
Rnor_5.01082,563,434 - 82,580,364 (+)NCBI
RGSC_v3.41083,622,438 - 83,639,368 (+)RGD
Celera1078,658,450 - 78,675,438 (+)RGD
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_445756 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40834 (Get FASTA)   NCBI Sequence Viewer  
  AAA64617 (Get FASTA)   NCBI Sequence Viewer  
  AAI33729 (Get FASTA)   NCBI Sequence Viewer  
  AID57764 (Get FASTA)   NCBI Sequence Viewer  
  CAB01633 (Get FASTA)   NCBI Sequence Viewer  
  EDM05726 (Get FASTA)   NCBI Sequence Viewer  
  EDM05727 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005311.5
  ENSRNOP00000081946
GenBank Protein P02454 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_445756   ⟸   NM_053304
- Peptide Label: precursor
- UniProtKB: P02455 (UniProtKB/Swiss-Prot),   A3KNA1 (UniProtKB/Swiss-Prot),   Q63079 (UniProtKB/Swiss-Prot),   P02454 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005311   ⟸   ENSRNOT00000005311
Ensembl Acc Id: ENSRNOP00000081061   ⟸   ENSRNOT00000115096
Ensembl Acc Id: ENSRNOP00000081946   ⟸   ENSRNOT00000115180
Ensembl Acc Id: ENSRNOP00000088255   ⟸   ENSRNOT00000114204
Fibrillar collagen NC1   VWFC

Name Modeler Protein Id AA Range Protein Structure
AF-P02454-F1-model_v2 AlphaFold P02454 1-1453 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697611
Promoter ID:EPDNEW_R8136
Type:multiple initiation site
Name:Col1a1_1
Description:collagen type I alpha 1 chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01082,745,796 - 82,745,856EPDNEW


1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23579 BioCyc
Ensembl Genes ENSRNOG00000003897 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005311.7 UniProtKB/Swiss-Prot
  ENSRNOT00000115180 ENTREZGENE
Gene3D-CATH 2.60.120.1000 UniProtKB/Swiss-Prot
  Complement Module, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7125649 IMAGE-MGC_LOAD
InterPro Collagen UniProtKB/Swiss-Prot
  Collagen_superfamily UniProtKB/Swiss-Prot
  Fib_collagen_C UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
KEGG Report rno:29393 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156780 IMAGE-MGC_LOAD
NCBI Gene 29393 ENTREZGENE
PANTHER COLLAGEN ALPHA UniProtKB/Swiss-Prot
  COLLAGEN TRIPLE HELIX REPEAT UniProtKB/Swiss-Prot
Pfam COLFI UniProtKB/Swiss-Prot
  Collagen UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
PharmGKB COL1A1 RGD
PhenoGen Col1a1 PhenoGen
PROSITE NC1_FIB UniProtKB/Swiss-Prot
  VWFC_1 UniProtKB/Swiss-Prot
  VWFC_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003897 RatGTEx
SMART COLFI UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot
UniProt A0A068F650_RAT UniProtKB/TrEMBL
  A0A8I5ZRN2_RAT UniProtKB/TrEMBL
  A0A8I6G8P4_RAT UniProtKB/TrEMBL
  A0A8I6GG08_RAT UniProtKB/TrEMBL
  A3KNA1 ENTREZGENE
  A6HI72_RAT UniProtKB/TrEMBL
  CO1A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P02455 ENTREZGENE
  Q63079 ENTREZGENE
UniProt Secondary A3KNA1 UniProtKB/Swiss-Prot
  P02455 UniProtKB/Swiss-Prot
  Q63079 UniProtKB/Swiss-Prot
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Col1a1  collagen type I alpha 1 chain  Col1a1  collagen, type I, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Col1a1  collagen, type I, alpha 1  Col1a1  procollagen, type 1, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Col1a1  procollagen, type 1, alpha 1    collagen, type 1, alpha 1   Name updated 1299863 APPROVED
2002-06-10 Col1a1  collagen, type 1, alpha 1       Name updated 70584 APPROVED

Note Type Note Reference
gene_expression expression is higher in unstimulated, cultured cardiac fibroblasts from adult SHR rats than in those from WKY rats. 1358958
gene_regulation expression levels in knee are modulated by mechanical load 1299105
gene_regulation steady state transcript levels in cultured fetal lung fibroblasts are not changed by prolonged hypoxia 1299106
gene_regulation expression in hepatic stellate cells is downregulated upon treatment with TNF-alpha and this effect may be mediated by p38 MAP kinase 1299107
gene_regulation Bradykinin attenuates mRNA expression in cultured cardiac fibroblasts from SHR but not WKY rats 1358958