Col1a1 (collagen type I alpha 1 chain) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Col1a1 (collagen type I alpha 1 chain) Rattus norvegicus
Analyze
Symbol: Col1a1
Name: collagen type I alpha 1 chain
RGD ID: 61817
Description: Predicted to enable identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to mechanical stimulus; and cellular response to vitamin E. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in extracellular space and secretory granule. Used to study cholestasis and metabolic dysfunction-associated steatotic liver disease. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; liver disease (multiple); rheumatic heart disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (R)-carnitine; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-1 type I collagen; COLIA1; collagen alpha-1(I) chain; collagen, type 1, alpha 1; collagen, type I, alpha 1; procollagen type I alpha 1; procollagen type I, alpha 1; procollagen, type 1, alpha 1; procollagen, type I, alpha 1 ; type I-alpha 1 collagen
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,380,458 - 80,397,461 (+)NCBIGRCr8
mRatBN7.21079,883,622 - 79,900,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,832,832 - 84,849,838 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,330,903 - 84,347,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,723,993 - 79,740,998 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,745,801 - 82,762,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,745,801 - 82,762,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,563,434 - 82,580,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,622,438 - 83,639,368 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,636,918 - 83,653,733 (+)NCBI
Celera1078,658,450 - 78,675,438 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
aggressive periodontitis  (ISO)
alcoholic hepatitis  (ISO)
aortic valve insufficiency  (ISO)
Arteriovenous Fistula  (IEP)
asphyxia neonatorum  (ISO)
autoimmune disease  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2D  (ISO)
beta thalassemia  (ISO)
Bisphosphonate-Associated Osteonecrosis of the Jaw  (ISO)
bladder neck obstruction  (IEP)
Bone Fractures  (ISO)
Caffey disease  (ISO)
calcinosis  (ISO)
Cardiac Fibrosis  (IDA,IEP)
cholangitis  (ISO)
cholestasis  (IDA,IEP,ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pancreatitis  (IDA)
Combined Osteogenesis Imperfecta and Ehlers-Danlos Syndrome 1  (ISO)
congenital heart disease  (ISO)
connective tissue disease  (ISO)
Contracture  (IEP)
cutaneous leishmaniasis  (ISO)
degenerative disc disease  (ISO)
dentinogenesis imperfecta  (ISO)
dermatofibrosarcoma protuberans  (ISO)
Diabetic Nephropathies  (IEP)
dilated cardiomyopathy  (ISO)
Dissecting Aneurysm  (ISO)
Ehlers-Danlos syndrome  (ISO,ISS)
Ehlers-Danlos syndrome arthrochalasia type 1  (ISO)
Ehlers-Danlos syndrome arthrochalasia type 2  (ISO)
Ehlers-Danlos syndrome cardiac valvular type  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
end stage renal disease  (ISO)
Experimental Liver Cirrhosis  (IDA,IEP,IMP,ISO)
extrahepatic cholestasis  (ISO)
Femoral Fractures  (IDA)
Fetal Nutrition Disorders  (IEP)
Fibrosis  (ISO)
genetic disease  (ISO)
heart valve disease  (ISO)
hemorrhagic disease  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
High Myopia  (ISO)
Human Viral Hepatitis  (ISO)
Hypertelorism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (IEP)
hypertrophic cardiomyopathy  (ISO)
Intervertebral Disc Disease  (ISO)
Joint Instability  (ISO)
Keloid  (ISO)
keratoconus  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lipodermatosclerosis  (ISO)
liver benign neoplasm  (IEP)
liver cirrhosis  (ISO)
Lung Reperfusion Injury  (ISO)
lupus nephritis  (ISO)
Metabolic Bone Diseases  (ISO)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IDA,ISO)
multiple epiphyseal dysplasia 1  (ISO)
multiple sclerosis  (ISO)
Muscle Hypotonia  (ISO)
myocardial infarction  (IEP)
myocarditis  (ISO)
myopia  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
obesity  (IEP)
ocular hypertension  (ISO)
open-angle glaucoma  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (IEP)
Osteoarthritis, Hip  (ISO)
osteochondrodysplasia  (ISO)
osteogenesis imperfecta  (ISO,ISS)
osteogenesis imperfecta type 1  (ISO,ISS)
osteogenesis imperfecta type 2  (ISO,ISS)
osteogenesis imperfecta type 2C  (ISO)
osteogenesis imperfecta type 3  (ISO,ISS)
osteogenesis imperfecta type 4  (ISO,ISS)
osteoporosis  (ISO)
otosclerosis  (ISO)
phenylketonuria  (ISO)
Postmenopausal Osteoporosis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (IEP)
prostate cancer  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP)
rheumatic heart disease  (IEP)
Spontaneous Abortions  (ISO)
Spontaneous Fractures  (ISO)
Stickler syndrome 2  (ISO)
systemic scleroderma  (ISO)
Tendon Injuries  (IDA)
thoracic aortic aneurysm  (ISO)
Trachomatous Trichiasis  (ISO)
trichodontoosseous syndrome  (ISO)
Tubulointerstitial Fibrosis  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (IEP)
Ventral Hernia  (IDA)
Wiedemann-Rautenstrauch syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-schisandrin B  (EXP,ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-stearoyl-2-arachidonoyl-sn-glycerol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-HETE  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methyladenine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9,10-epoxy-12-octadecenoic acid  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (EXP,ISO)
acetic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
Activin A  (EXP)
adenine  (EXP,ISO)
aflatoxin B1  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
Alisol B  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allyl isothiocyanate  (ISO)
Allylamine  (EXP)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
ambroxol  (EXP)
aminoguanidine  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
amlodipine  (EXP)
Ammothamnine  (ISO)
amosite asbestos  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
andrographolide  (EXP,ISO)
angiotensin II  (ISO)
anthocyanin  (EXP)
antimycin A  (ISO)
Archazolid B  (ISO)
argatroban  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
aucubin  (EXP,ISO)
azathioprine  (ISO)
azelastine  (ISO)
baicalein  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boron atom  (ISO)
boron nitride  (ISO)
BQ 123  (ISO)
bromochloroacetic acid  (ISO)
bucladesine  (ISO)
busulfan  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium dichloride  (ISO)
calcium dihydroxide  (ISO)
calcium silicate  (ISO)
camostat  (EXP)
camphor  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
Carbaprostacyclin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carvedilol  (EXP)
casticin  (ISO)
celastrol  (EXP)
celecoxib  (EXP)
ceruletide  (EXP,ISO)
chenodeoxycholic acid  (EXP,ISO)
chloramphenicol  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cholate  (EXP)
choline  (EXP,ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
Clofop  (EXP)
clorgyline  (ISO)
clothianidin  (ISO)
clotrimazole  (EXP)
cocaine  (EXP)
coenzyme Q10  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
cortisol  (EXP)
crocidolite asbestos  (ISO)
cucurbitacin B  (ISO)
cucurbitacin E  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cystamine  (EXP)
cytarabine  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
DDT  (EXP,ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diazoxide  (ISO)
Didecyldimethylammonium  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
diiodine  (ISO)
diltiazem  (ISO)
Dimerumic acid  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
diminazene diaceturate  (ISO)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
edaravone  (ISO)
elemental boron  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
emodin  (EXP)
enalapril  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
epalrestat  (ISO)
eplerenone  (EXP)
eprosartan  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylisopropylamiloride  (EXP)
excitatory amino acid agonist  (ISO)
fasudil  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (ISO)
fingolimod hydrochloride  (ISO)
fisetin  (EXP)
folic acid  (ISO)
folpet  (ISO)
fomepizole  (EXP)
fonofos  (ISO)
fructose  (ISO)
fulvestrant  (EXP)
Fulvic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
geraniol  (EXP)
glucagon  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
glycerol 2-phosphate  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyoxal  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
guaiazulene  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP)
heptachlor  (ISO)
hesperetin  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydralazine  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
Icaritin  (ISO)
Ile(5)-angiotensin II  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
iron atom  (EXP)
iron dextran  (ISO)
iron(0)  (EXP)
iron(III) nitrilotriacetate  (EXP)
isoflavones  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
JTE-013  (EXP)
kainic acid  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
leukotriene B4  (ISO)
levonorgestrel  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lithocholic acid  (ISO)
losartan  (EXP,ISO)
LY-2157299  (ISO)
magnesium atom  (ISO)
malonaldehyde  (ISO)
maneb  (ISO)
mangiferin  (EXP)
manidipine  (EXP)
maraviroc  (ISO)
marinobufagenin  (EXP)
melatonin  (ISO)
menadione  (ISO)
menaquinone  (ISO)
mercaptopurine  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
metoprolol  (EXP,ISO)
mevalonic acid  (ISO)
miconazole  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP)
mirtazapine  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (EXP)
Morroniside  (EXP)
myo-inositol hexakisphosphate  (ISO)
myricitrin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-oleoyldopamine  (ISO)
N-palmitoyl dopamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
naphthalene  (ISO)
naringin  (ISO)
neoeriocitrin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nimodipine  (ISO)
nitrofen  (EXP)
NMN zwitterion  (ISO)
obeticholic acid  (EXP,ISO)
okadaic acid  (EXP)
olanzapine  (ISO)
olaparib  (ISO)
oleamide  (ISO)
oleanolic acid  (EXP)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
Osajin  (ISO)
ouabain  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
pamidronate  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paricalcitol  (ISO)
pentanal  (ISO)
Pentoxifylline  (EXP,ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP)
phenol  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phosphatidylcholine  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
picoxystrobin  (ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
Plantamajoside  (ISO)
poly(ethylene)  (ISO)
poly(guanylic acid)  (EXP)
Pomiferin  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
prostaglandin E2  (ISO)
Ptaquiloside  (ISO)
puerarin  (ISO)
purine-6-thiol  (EXP)
pyrazinecarboxamide  (EXP)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
ramipril  (EXP)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
rifaximin  (ISO)
rimonabant  (EXP)
rosmarinic acid  (EXP,ISO)
rotenone  (EXP)
rottlerin  (ISO)
rutin  (ISO)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sabinene  (ISO)
Sanggenon C  (ISO)
saralasin  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
sildenafil citrate  (ISO)
silibinin  (EXP)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
Sinomenine  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
sorafenib  (EXP,ISO)
spathulenol  (ISO)
sphingosine 1-phosphate  (EXP)
stattic  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sunitinib  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
teprenone  (ISO)
terbufos  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
Tetramethylthiourea  (EXP)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP)
theophylline  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (EXP,ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
tranexamic acid  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
uranium atom  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
verapamil  (ISO)
vildagliptin  (ISO)
vitamin D  (ISO)
vitamin E  (EXP)
vitamin K  (EXP)
warfarin  (EXP,ISO)
Y-27632  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (IBA,ISO)
bone trabecula formation  (ISO)
cartilage development involved in endochondral bone morphogenesis  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to fluoride  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to mechanical stimulus  (IEP,ISO)
cellular response to retinoic acid  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to vitamin E  (IEP)
collagen biosynthetic process  (ISO)
collagen fibril organization  (ISO)
collagen-activated tyrosine kinase receptor signaling pathway  (IDA)
embryonic skeletal system development  (ISO)
endochondral ossification  (ISO)
extracellular matrix organization  (IBA)
face morphogenesis  (ISO)
intramembranous ossification  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
ossification  (IBA,IEP)
osteoblast differentiation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
protein localization to nucleus  (ISO)
protein transport  (ISO)
response to cAMP  (IEP)
response to estradiol  (IEP)
response to fluoride  (IEP)
response to hydrogen peroxide  (IEP)
response to hyperoxia  (IEP)
response to insulin  (IEP)
response to mechanical stimulus  (IBA,IEP)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to peptide hormone  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (IEP)
sensory perception of sound  (ISO)
skeletal system development  (IBA,ISO)
skeletal system morphogenesis  (ISO)
skin development  (IBA,ISO)
skin morphogenesis  (ISO)
tooth mineralization  (ISO)
visual perception  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension. Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21.
2. Lack of association between osteoarthritis of the hip and gene polymorphisms of VDR, COL1A1, and COL2A1 in postmenopausal women. Aerssens J, etal., Arthritis Rheum. 1998 Nov;41(11):1946-50.
3. Combination of ADMSCs and chondrocytes reduces hypertrophy and improves the functional properties of osteoarthritic cartilage. Ahmed MR, etal., Osteoarthritis Cartilage. 2014 Nov;22(11):1894-901. doi: 10.1016/j.joca.2014.07.028. Epub 2014 Aug 13.
4. Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil: role of COL1A1. Almeida L, etal., Infect Genet Evol. 2015 Mar;30:225-9. doi: 10.1016/j.meegid.2014.12.034. Epub 2015 Jan 3.
5. Albumin and procollagen type I gene regulation in alcohol and viral-induced human liver disease. Annoni G, etal., Boll Ist Sieroter Milan. 1991-1992;70(1-2):391-7.
6. Polymorphism analysis in the COLIA1 gene of patients with thalassemia major and intermedia. Arisal O, etal., Haematologia (Budap). 2002;32(4):475-82.
7. Alteration of type I collagen in the radial artery of patients with end-stage renal disease. Bai Y, etal., Am J Med Sci. 2015 Apr;349(4):292-7. doi: 10.1097/MAJ.0000000000000408.
8. A novel, non-functional, COL1A1 polymorphism is not associated with lumbar disk disease in young male Greek subjects unlike that of the Sp1 site. Bei T, etal., Hormones (Athens). 2008 Jul-Sep;7(3):251-4.
9. Prevention of glomerulosclerosis by early cyclosporine treatment of experimental lupus nephritis. Bergijk EC, etal., Kidney Int. 1994 Dec;46(6):1663-73.
10. Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Bhatt RS, etal., Genes Dev. 2000 Sep 1;14(17):2216-28.
11. Vitamin E protects chondrocytes against hydrogen peroxide-induced oxidative stress in vitro. Bhatti FU, etal., Inflamm Res. 2013 Aug;62(8):781-9. doi: 10.1007/s00011-013-0635-y. Epub 2013 May 31.
12. Parathyroid hormone inhibits collagen synthesis and the activity of rat col1a1 transgenes mainly by a cAMP-mediated pathway in mouse calvariae. Bogdanovic Z, etal., J Cell Biochem. 2000 Feb;77(1):149-58.
13. Analysis of the odontogenic and osteogenic potentials of dental pulp in vivo using a Col1a1-2.3-GFP transgene. Braut A, etal., Int J Dev Biol 2003 May;47(4):281-92.
14. Ehlers-Danlos syndrome type VIIA and VIIB result from splice-junction mutations or genomic deletions that involve exon 6 in the COL1A1 and COL1A2 genes of type I collagen. Byers PH, etal., Am J Med Genet 1997 Oct 3;72(1):94-105.
15. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
16. MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension. Castoldi G, etal., J Cell Physiol. 2012 Feb;227(2):850-6. doi: 10.1002/jcp.22939.
17. First mouse model for combined osteogenesis imperfecta and Ehlers-Danlos syndrome. Chen F, etal., J Bone Miner Res. 2014 Jun;29(6):1412-23. doi: 10.1002/jbmr.2177.
18. A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation. Chen JY, etal., J Ethnopharmacol. 2012 Aug 1;142(3):811-8. doi: 10.1016/j.jep.2012.06.005. Epub 2012 Jun 15.
19. Single-nucleotide polymorphisms in the COL1A1 regulatory regions are associated with otosclerosis. Chen W, etal., Clin Genet. 2007 May;71(5):406-14.
20. High-flow-induced arterial remodeling in rats with different susceptibilities to cerebral aneurysms. Coutard M, etal., J Vasc Res. 2006;43(3):217-28. Epub 2006 Jan 20.
21. Outflow facility in mice with a targeted type I collagen mutation. Dai Y, etal., Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5749-53. doi: 10.1167/iovs.08-3367. Epub 2009 Sep 24.
22. Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis. Degiorgio-Miller AM, etal., Br J Dermatol. 2005 Feb;152(2):242-9.
23. Fibrosis-related gene expression in the prostate is modulated by doxazosin treatment. Delella FK, etal., Life Sci. 2012 Dec 17;91(25-26):1281-7. doi: 10.1016/j.lfs.2012.09.017. Epub 2012 Oct 12.
24. High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy. Dower K, etal., PLoS One. 2017 Jul 26;12(7):e0181861. doi: 10.1371/journal.pone.0181861. eCollection 2017.
25. The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis. Espira L, etal., J Mol Cell Cardiol. 2009 Aug;47(2):188-95. doi: 10.1016/j.yjmcc.2009.03.024. Epub 2009 Apr 10.
26. TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways. Fang L, etal., Toxicol Appl Pharmacol. 2013 Nov 1;272(3):713-25. doi: 10.1016/j.taap.2013.08.009. Epub 2013 Aug 16.
27. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
28. Extracellular matrix biosynthesis by cultured fetal rat lung epithelial cells. III. Effects of chronic exposure to epidermal growth factor on growth, differentiation, and collagen biosynthesis. Federspiel SJ, etal., Lab Invest. 1991 Apr;64(4):463-73.
29. Extracellular matrix biosynthesis by cultured fetal rat lung epithelial cells. IV. Effects of chronic exposure to retinoic acid on growth, differentiation, and collagen biosynthesis. Federspiel SJ, etal., Lab Invest. 1991 Oct;65(4):441-50.
30. Microarray analysis of retinoid-dependent gene activity during rat embryogenesis: increased collagen fibril production in a model of retinoid insufficiency. Flentke GR, etal., Dev Dyn. 2004 Apr;229(4):886-98.
31. Regulation of alpha 2(I), alpha 1(III), and alpha 2(V) collagen mRNAs by estradiol in the immature rat uterus. Frankel FR, etal., DNA 1988 Jun;7(5):347-54.
32. In vivo low-intensity pulsed ultrasound (LIPUS) following tendon injury promotes repair during granulation but suppresses decorin and biglycan expression during remodeling. Fu SC, etal., J Orthop Sports Phys Ther. 2010 Jul;40(7):422-9. doi: 10.2519/jospt.2010.3254.
33. Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells. Garcia-Trevijano ER, etal., Hepatology. 1999 Mar;29(3):960-70.
34. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
35. A novel COL1A1 mutation in infantile cortical hyperostosis (Caffey disease) expands the spectrum of collagen-related disorders. Gensure RC, etal., J Clin Invest. 2005 May;115(5):1250-7.
36. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
37. Dermatofibrosarcoma protuberans of the vulva and groin: detection of COL1A1-PDGFB fusion transcripts by RT-PCR. Gokden N, etal., J Cutan Pathol. 2003 Mar;30(3):190-5.
38. Relationship between SP1 polymorphism and osteoporosis in beta-thalassemia major patients. Guzeloglu-Kayisli O, etal., Pediatr Int. 2008 Aug;50(4):474-6. doi: 10.1111/j.1442-200X.2008.02609.x.
39. Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation. Han JM, etal., Food Chem Toxicol. 2012 Oct;50(10):3505-13. doi: 10.1016/j.fct.2012.07.018. Epub 2012 Jul 20.
40. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. He H, etal., Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10.
41. Effect of unloading followed by reloading on expression of collagen and related growth factors in rat tendon and muscle. Heinemeier KM, etal., J Appl Physiol. 2009 Jan;106(1):178-86. Epub 2008 Nov 6.
42. A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats. Hermida N, etal., Cardiovasc Res. 2009 Feb 15;81(3):601-9. doi: 10.1093/cvr/cvn315. Epub 2008 Nov 19.
43. Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Hie M and Tsukamoto I, Int J Mol Med. 2010 Oct;26(4):611-8. doi: 10.3892/ijmm_00000506.
44. Pathway-focused arrays reveal increased matrix metalloproteinase-7 (matrilysin) transcription in trachomatous trichiasis. Holland MJ, etal., Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3893-902. doi: 10.1167/iovs.09-5054. Epub 2010 Apr 7.
45. Prolonged hypoxia accelerates the posttranscriptional process of collagen synthesis in cultured fibroblasts. Horino Y, etal., Life Sci 2002 Nov 15;71(26):3031-45.
46. Biomechanical regulation of type I collagen gene expression in ACLs in organ culture. Hsieh AH, etal., J Orthop Res 2002 Mar;20(2):325-31.
47. Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
48. Interleukin-1beta enhanced action of kinins on extracellular matrix of spontaneous hypertensive rat cardiac fibroblasts. Imai C, etal., Clin Exp Hypertens 2005 Jan;27(1):59-69.
49. The COL1A1 gene and high myopia susceptibility in Japanese. Inamori Y, etal., Hum Genet. 2007 Sep;122(2):151-7. Epub 2007 Jun 8.
50. Effects of different exposures of hyperbaric oxygen on ligament healing in rats. Ishii Y, etal., J Orthop Res. 2002 Mar;20(2):353-6.
51. Comparison of antioxidative and antifibrotic effects of alpha-tocopherol with those of tocotrienol-rich fraction in a rat model of chronic pancreatitis. Jiang F, etal., Pancreas. 2011 Oct;40(7):1091-6. doi: 10.1097/MPA.0b013e31821b59c6.
52. Preventing effects of joint contracture by high molecular weight hyaluronan injections in a rat immobilized knee model. Kanazawa K, etal., Int J Clin Exp Pathol. 2015 Apr 1;8(4):3426-40. eCollection 2015.
53. Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw. Katz J, etal., Int J Oral Maxillofac Surg. 2011 Jun;40(6):605-11. doi: 10.1016/j.ijom.2011.02.002. Epub 2011 Mar 10.
54. Multicentric dermatofibrosarcoma protuberans in patients with adenosine deaminase-deficient severe combined immune deficiency. Kesserwan C, etal., J Allergy Clin Immunol. 2011 Dec 6.
55. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
56. Prevention of liver fibrosis by triple helix-forming oligodeoxyribonucleotides targeted to the promoter region of type I collagen gene. Koilan S, etal., Oligonucleotides. 2010 Oct;20(5):231-7. Epub 2010 Sep 6.
57. Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis. Kulozik M, etal., J Clin Invest. 1990 Sep;86(3):917-22.
58. Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNFalpha-signaling due to oxidative cellular stress in rats. Kuwata K, etal., Toxicology. 2011 Apr 28;283(1):8-17. Epub 2011 Feb 2.
59. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Lai CF, etal., Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92. doi: 10.1152/ajprenal.00670.2013. Epub 2014 Jun 11.
60. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
61. Extracellular matrix biosynthesis by cultured fetal rat lung epithelial cells. I. Characterization of the clone and the major genetic types of collagen produced. Leheup BP, etal., Lab Invest. 1989 Jun;60(6):791-807.
62. Type I collagen alpha1 Sp1 transcription factor binding site polymorphism is associated with reduced risk of hip osteoarthritis defined by severe joint space narrowing in elderly women. Lian K, etal., Arthritis Rheum. 2005 May;52(5):1431-6.
63. Activation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter. Lindahl GE, etal., J Biol Chem. 2002 Feb 22;277(8):6153-61. Epub 2001 Dec 17.
64. Sulfated glycosaminoglycans mediate the effects of FGF2 on the osteogenic potential of rat calvarial osteoprogenitor cells. Ling L, etal., J Cell Physiol. 2006 Dec;209(3):811-25.
65. ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. Lisse TS, etal., PLoS Genet. 2008 Feb;4(2):e7. doi: 10.1371/journal.pgen.0040007.
66. Association analysis of the vitamin D receptor gene, the type I collagen gene COL1A1, and the estrogen receptor gene in idiopathic osteoarthritis. Loughlin J, etal., J Rheumatol. 2000 Mar;27(3):779-84.
67. Optic nerve damage in mice with a targeted type I collagen mutation. Mabuchi F, etal., Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1841-5.
68. Gene expression in distinct regions of rat tendons in response to jump training combined with anabolic androgenic steroid administration. Marqueti RC, etal., Eur J Appl Physiol. 2012 Apr;112(4):1505-15. doi: 10.1007/s00421-011-2114-x. Epub 2011 Aug 14.
69. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
70. Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Mohan H, etal., Brain Pathol. 2010 Sep;20(5):966-75. Epub 2010 Mar 25.
71. Variable expressivity of osteogenesis imperfecta in a Brazilian family due to p.G1079S mutation in the COL1A1 gene. Moraes MV, etal., Genet Mol Res. 2012 Sep 13;11(3):3246-55. doi: 10.4238/2012.September.12.7.
72. Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). Nakajima A, etal., J Bone Miner Res. 2002 Nov;17(11):2038-47.
73. Effect of a specific endothelin A receptor antagonist on murine lupus nephritis. Nakamura T, etal., Kidney Int. 1995 Feb;47(2):481-9.
74. Absence of association between COL1A1 polymorphisms and high myopia in the Japanese population. Nakanishi H, etal., Invest Ophthalmol Vis Sci. 2009 Feb;50(2):544-50. doi: 10.1167/iovs.08-2425. Epub 2008 Oct 3.
75. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
76. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Ning W, etal., Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14895-900. Epub 2004 Oct 5.
77. [Evaluation of toxic doses of fluorine on expression of collagen genes and synthesis of some collagen proteins in rat skin]. Olszowski T Ann Acad Med Stetin. 2003;49:45-62.
78. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
79. Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Ota T, etal., Gastroenterology. 2007 Jan;132(1):282-93. Epub 2006 Oct 12.
80. Novel COL1A1 mutation (G559C) [correction of G599C] associated with mild osteogenesis imperfecta and dentinogenesis imperfecta. Pallos D, etal., Arch Oral Biol. 2001 May;46(5):459-70.
81. Transforming growth factor beta1 induces the expression of collagen type I by DNA methylation in cardiac fibroblasts. Pan X, etal., PLoS One. 2013;8(4):e60335. doi: 10.1371/journal.pone.0060335. Epub 2013 Apr 1.
82. Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Paracuellos P, etal., Structure. 2015 Nov 3;23(11):2133-42. doi: 10.1016/j.str.2015.09.004. Epub 2015 Oct 15.
83. A novel splicing mutation in COL1A1 gene caused type I osteogenesis imperfecta in a Chinese family. Peng H, etal., Gene. 2012 Jul 10;502(2):168-71. doi: 10.1016/j.gene.2012.04.023. Epub 2012 Apr 29.
84. Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral. Pereira R, etal., J Clin Invest 1993 Feb;91(2):709-16.
85. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Pereira RF, etal., Proc Natl Acad Sci U S A 1998 Feb 3;95(3):1142-7.
86. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
87. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
88. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
89. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Popov Y, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi: 10.1152/ajpgi.00394.2009. Epub 2010 Jan 7.
90. An immunocytochemical study of the routes of secretion of collagen and phosphophoryn from odontoblasts into dentin. Rabie AM and Veis A, Connect Tissue Res. 1995;31(3):197-209.
91. Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis. Reich HN, etal., J Mol Diagn. 2011 Mar;13(2):143-51.
92. GOA pipeline RGD automated data pipeline
93. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
94. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
95. Comprehensive gene review and curation RGD comprehensive gene curation
96. COL1A1 oligodeoxynucleotides decoy: biochemical and morphologic effects in an acute wound repair model. Rosensteel SM, etal., Exp Mol Pathol. 2010 Dec;89(3):307-13. Epub 2010 Jul 18.
97. Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. Schroder A, etal., J Urol. 2013 Jun;189(6):2377-84. doi: 10.1016/j.juro.2012.12.110. Epub 2013 Jan 9.
98. Involvement of renal corpuscle microRNA expression on epithelial-to-mesenchymal transition in maternal low protein diet in adult programmed rats. Sene Lde B, etal., PLoS One. 2013 Aug 19;8(8):e71310. doi: 10.1371/journal.pone.0071310. eCollection 2013.
99. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
100. Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway. Shi Y, etal., J Cell Biochem. 2012 Oct;113(10):3133-42. doi: 10.1002/jcb.24190.
101. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Staels B, etal., Hepatology. 2013 Dec;58(6):1941-52. doi: 10.1002/hep.26461. Epub 2013 Oct 29.
102. Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice. Sullivan BP, etal., Toxicol Sci. 2012 Mar;126(1):267-74. doi: 10.1093/toxsci/kfr311. Epub 2011 Nov 17.
103. Expanding the phenotypic spectrum of Caffey disease. Suphapeetiporn K, etal., Clin Genet. 2007 Mar;71(3):280-4.
104. Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. Suzuki A, etal., Biochem Biophys Res Commun. 2004 May 7;317(3):887-92.
105. Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host. Szalay G, etal., Circ Res. 2009 Apr 10;104(7):851-9. doi: 10.1161/CIRCRESAHA.109.193805. Epub 2009 Feb 26.
106. Thalidomide prevents bleomycin-induced pulmonary fibrosis in mice. Tabata C, etal., J Immunol. 2007 Jul 1;179(1):708-14.
107. Gene expression for extracellular matrix proteins in shockwave-induced osteogenesis in rats. Takahashi K, etal., Calcif Tissue Int. 2004 Feb;74(2):187-93. Epub 2003 Nov 6.
108. Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis. Tao H, etal., Cardiovasc Pathol. 2016 Sep-Oct;25(5):381-9. doi: 10.1016/j.carpath.2016.05.005. Epub 2016 Jun 2.
109. Novel ActRIIB ligand trap increases muscle mass and improves bone geometry in a mouse model of severe osteogenesis imperfecta. Tauer JT and Rauch F, Bone. 2019 Nov;128:115036. doi: 10.1016/j.bone.2019.115036. Epub 2019 Aug 13.
110. A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats. Terashima H, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F792-801. Epub 2010 Jul 21.
111. Endo180 binds to the C-terminal region of type I collagen. Thomas EK, etal., J Biol Chem. 2005 Jun 17;280(24):22596-605. Epub 2005 Apr 6.
112. Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits. Tilkeridis C, etal., J Med Genet. 2005 Jul;42(7):e44.
113. Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients. Truong LH, etal., Arthritis Res Ther. 2006;8(6):R188.
114. Expression of MMP-8 and MMP-13 mRNAs in rat periodontium during tooth eruption. Tsubota M, etal., J Dent Res. 2002 Oct;81(10):673-8.
115. Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. Tsybouleva N, etal., Circulation. 2004 Mar 16;109(10):1284-91. Epub 2004 Mar 1.
116. Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women. Tural S, etal., Gene. 2013 Feb 15;515(1):167-72. doi: 10.1016/j.gene.2012.10.041. Epub 2012 Nov 5.
117. Complete COL1A1 allele deletions in osteogenesis imperfecta. van Dijk FS, etal., Genet Med. 2010 Nov;12(11):736-41. doi: 10.1097/GIM.0b013e3181f01617.
118. Decreased hernia recurrence using autologous platelet-rich plasma (PRP) with Strattice mesh in a rodent ventral hernia model. Van Eps J, etal., Surg Endosc. 2015 Nov 17.
119. Glutathione depletion is involved in the inhibition of procollagen alpha1(I) mRNA levels caused by TNF-alpha on hepatic stellate cells. Varela-Rey M, etal., Cytokine. 2007 Mar;37(3):212-7. Epub 2007 May 7.
120. p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells(1). Varela-Rey M, etal., FEBS Lett 2002 Sep 25;528(1-3):133-8.
121. Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing. Videman T, etal., Arthritis Rheum. 2009 Feb;60(2):470-81.
122. Effects of angiotensin II intervention on MMP-2, MMP-9, TIMP-1, and collagen expression in rats with pulmonary hypertension. Wang XM, etal., Genet Mol Res. 2015 Mar 6;14(1):1707-17. doi: 10.4238/2015.March.6.17.
123. [Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis] Wang XN, etal., Zhong Xi Yi Jie He Xue Bao. 2005 Jul;3(4):286-9.
124. Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression. Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329.
125. A novel RNA-splicing mutation in COL1A1 gene causing osteogenesis imperfecta type I in a Chinese family. Xia XY, etal., Clin Chim Acta. 2008 Dec;398(1-2):148-51. doi: 10.1016/j.cca.2008.07.030. Epub 2008 Aug 5.
126. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. Xian S, etal., Mol Med Rep. 2021 Jan;23(1):10. doi: 10.3892/mmr.2020.11648. Epub 2020 Nov 12.
127. High-fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin. Yamane T, etal., Mol Nutr Food Res. 2010 May;54 Suppl 1:S53-61. doi: 10.1002/mnfr.201000022.
128. Fluoride induces apoptosis and alters collagen I expression in rat osteoblasts. Yan X, etal., Toxicol Lett. 2011 Feb 5;200(3):133-8. doi: 10.1016/j.toxlet.2010.11.005. Epub 2010 Nov 18.
129. microRNA-29b Mediates the Antifibrotic Effect of Tanshinone IIA in Postinfarct Cardiac Remodeling. Yang F, etal., J Cardiovasc Pharmacol. 2015 May;65(5):456-64. doi: 10.1097/FJC.0000000000000214.
130. Mutation characteristics in type I collagen genes in Chinese patients with osteogenesis imperfecta. Yang Z, etal., Genet Mol Res. 2011 Feb 8;10(1):177-85. doi: 10.4238/vol10-1gmr984.
131. All-trans retinoic acid diminishes collagen production in a hepatic stellate cell line via suppression of active protein-1 and c-Jun N-terminal kinase signal. Ye Y and Dan Z, J Huazhong Univ Sci Technolog Med Sci. 2010 Dec;30(6):726-33. doi: 10.1007/s11596-010-0648-5. Epub 2010 Dec 22.
132. Wnt pathway-related gene expression in inflammatory bowel disease. You J, etal., Dig Dis Sci. 2008 Apr;53(4):1013-9. Epub 2007 Oct 16.
133. The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension. Yuan Y, etal., PLoS One. 2020 Dec 14;15(12):e0243846. doi: 10.1371/journal.pone.0243846. eCollection 2020.
134. In situ hybridization analysis of rat lung alpha 1(I) and alpha 2(I) collagen gene expression in pulmonary fibrosis induced by endotracheal bleomycin injection. Zhang K, etal., Lab Invest. 1994 Feb;70(2):192-202.
135. Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway. Zhang L, etal., J Mol Histol. 2020 Feb;51(1):77-87. doi: 10.1007/s10735-020-09859-8. Epub 2020 Feb 17.
136. Gene expression profiling in glomeruli of diabetic nephropathy rat. Zhang Q, etal., Exp Biol Med (Maywood). 2012 Aug;237(8):903-11. doi: 10.1258/ebm.2012.012032. Epub 2012 Aug 17.
137. Lipopolysaccharide induced activin A-follistatin imbalance affects cardiac fibrosis. Zhang WQ, etal., Chin Med J (Engl). 2012 Jun;125(12):2205-12.
138. Experimental murine myopia induces collagen type Ialpha1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera. Zhou X, etal., Mol Vis. 2012;18:1312-24. Epub 2012 May 30.
139. Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. Zou M, etal., Oncotarget. 2017 Jul 5;8(47):81825-81837. doi: 10.18632/oncotarget.18998. eCollection 2017 Oct 10.
Additional References at PubMed
PMID:1874719   PMID:2209468   PMID:2779548   PMID:4126850   PMID:4290711   PMID:4327399   PMID:4335087   PMID:4342027   PMID:4366532   PMID:4636751   PMID:5337886   PMID:5411206  
PMID:5777344   PMID:6395893   PMID:7573384   PMID:7589890   PMID:7629088   PMID:7704020   PMID:7790374   PMID:8018053   PMID:8097422   PMID:8130375   PMID:8163675   PMID:8686743  
PMID:8889548   PMID:8900172   PMID:8906420   PMID:8984825   PMID:9213002   PMID:10065941   PMID:10608859   PMID:10878613   PMID:12199527   PMID:12477932   PMID:12647294   PMID:14630726  
PMID:14749390   PMID:14976317   PMID:15095409   PMID:15383546   PMID:15647278   PMID:15677443   PMID:15703183   PMID:16306131   PMID:16311053   PMID:16751282   PMID:16938497   PMID:16971509  
PMID:17018525   PMID:17029294   PMID:17118335   PMID:17156988   PMID:17206378   PMID:17211858   PMID:17440987   PMID:17485851   PMID:17576241   PMID:17616939   PMID:17662583   PMID:17924680  
PMID:18041732   PMID:18095594   PMID:18348167   PMID:18375391   PMID:18471258   PMID:18553566   PMID:18726071   PMID:18727865   PMID:18782537   PMID:19393425   PMID:19418583   PMID:19426591  
PMID:19667256   PMID:19679517   PMID:19932771   PMID:20006603   PMID:20018240   PMID:20149607   PMID:20388018   PMID:20548288   PMID:20551380   PMID:20603131   PMID:20875682   PMID:21055467  
PMID:21166192   PMID:21625049   PMID:21645221   PMID:21729992   PMID:22206666   PMID:22847422   PMID:23093703   PMID:23200051   PMID:23508044   PMID:23633075   PMID:23658023   PMID:23959432  
PMID:24006456   PMID:24036265   PMID:24116223   PMID:24735795   PMID:25655816   PMID:25784725   PMID:25931508   PMID:26049074   PMID:26567337   PMID:26674152   PMID:26702050   PMID:26807691  
PMID:27031437   PMID:27068509   PMID:27108411   PMID:27155082   PMID:27351590   PMID:27559042   PMID:27756197   PMID:28031326   PMID:28320405   PMID:28713909   PMID:28731181   PMID:28849131  
PMID:29286102   PMID:29733741   PMID:30053369   PMID:31186140   PMID:32328952   PMID:33450132   PMID:33497804  


Genomics

Comparative Map Data
Col1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,380,458 - 80,397,461 (+)NCBIGRCr8
mRatBN7.21079,883,622 - 79,900,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,832,832 - 84,849,838 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,330,903 - 84,347,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,723,993 - 79,740,998 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,745,801 - 82,762,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,745,801 - 82,762,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,563,434 - 82,580,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,622,438 - 83,639,368 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,636,918 - 83,653,733 (+)NCBI
Celera1078,658,450 - 78,675,438 (+)NCBICelera
Cytogenetic Map10q26NCBI
COL1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,184,101 - 50,201,631 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,184,101 - 50,201,632 (-)EnsemblGRCh38hg38GRCh38
GRCh371748,261,462 - 48,278,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,616,456 - 45,633,999 (-)NCBINCBI36Build 36hg18NCBI36
Build 341745,616,455 - 45,633,992NCBI
Celera1744,722,303 - 44,739,829 (-)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,630,129 - 43,647,463 (-)NCBIHuRef
CHM1_11748,325,754 - 48,343,284 (-)NCBICHM1_1
T2T-CHM13v2.01751,051,162 - 51,068,680 (-)NCBIT2T-CHM13v2.0
Col1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,827,050 - 94,843,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,827,050 - 94,843,868 (+)EnsemblGRCm39 Ensembl
GRCm381194,936,224 - 94,953,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,936,224 - 94,953,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv371194,797,584 - 94,813,181 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,752,360 - 94,767,957 (+)NCBIMGSCv36mm8
Celera11104,549,617 - 104,565,301 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Col1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,468,290 - 11,483,073 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,468,156 - 11,484,410 (+)NCBIChiLan1.0ChiLan1.0
COL1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,373,893 - 66,390,381 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,180,391 - 71,196,792 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01744,274,349 - 44,291,764 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11749,149,277 - 49,166,833 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,150,677 - 49,166,677 (-)Ensemblpanpan1.1panPan2
COL1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,183,852 - 26,199,927 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,183,852 - 26,199,927 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,576,913 - 25,592,983 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,978,359 - 26,994,434 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,978,317 - 26,994,453 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,746,094 - 25,762,176 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,004,757 - 26,020,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,134,702 - 26,150,789 (-)NCBIUU_Cfam_GSD_1.0
Col1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,609,297 - 25,626,616 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,448,654 - 11,464,444 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,448,552 - 11,465,836 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COL1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,379,090 - 26,397,004 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,379,087 - 26,397,180 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
COL1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,134,648 - 43,152,313 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,134,779 - 43,150,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,850,099 - 13,867,746 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Col1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,168,797 - 6,183,071 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,167,504 - 6,183,208 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Col1a1
124 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:504
Count of miRNA genes:227
Interacting mature miRNAs:291
Transcripts:ENSRNOT00000005311
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
PMC151926P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,899,135 - 79,899,468 (+)MAPPERmRatBN7.2
Rnor_6.01082,761,301 - 82,761,633NCBIRnor6.0
Rnor_5.01082,578,875 - 82,579,207UniSTSRnor5.0
RGSC_v3.41083,637,879 - 83,638,211UniSTSRGSC3.4
Celera1078,673,949 - 78,674,281UniSTS
Cytogenetic Map10q31UniSTS
PMC34669P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,898,190 - 79,898,850 (+)MAPPERmRatBN7.2
Rnor_6.01082,760,356 - 82,761,015NCBIRnor6.0
Rnor_5.01082,577,930 - 82,578,589UniSTSRnor5.0
RGSC_v3.41083,636,934 - 83,637,593UniSTSRGSC3.4
Celera1078,673,004 - 78,673,663UniSTS
Cytogenetic Map10q31UniSTS
RH128280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,900,370 - 79,900,613 (+)MAPPERmRatBN7.2
Rnor_6.01082,762,536 - 82,762,778NCBIRnor6.0
Rnor_5.01082,580,110 - 82,580,352UniSTSRnor5.0
RGSC_v3.41083,639,114 - 83,639,356UniSTSRGSC3.4
Celera1078,675,184 - 78,675,426UniSTS
RH 3.4 Map10723.7UniSTS
Cytogenetic Map10q31UniSTS
PMC275467P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,883,057 - 79,883,318 (+)MAPPERmRatBN7.2
Rnor_6.01082,745,237 - 82,745,497NCBIRnor6.0
Rnor_5.01082,562,870 - 82,563,130UniSTSRnor5.0
RGSC_v3.41083,621,874 - 83,622,134UniSTSRGSC3.4
Celera1078,657,886 - 78,658,146UniSTS
Cytogenetic Map10q31UniSTS
COL1A1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,895,336 - 79,895,601 (+)MAPPERmRatBN7.2
Rnor_6.01082,757,500 - 82,757,764NCBIRnor6.0
Rnor_5.01082,575,074 - 82,575,338UniSTSRnor5.0
RGSC_v3.41083,634,078 - 83,634,342UniSTSRGSC3.4
Celera1078,670,150 - 78,670,414UniSTS
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005311   ⟹   ENSRNOP00000005311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)Ensembl
Rnor_6.0 Ensembl1082,745,801 - 82,762,789 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114204   ⟹   ENSRNOP00000088255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,883,623 - 79,900,624 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115096   ⟹   ENSRNOP00000081061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115180   ⟹   ENSRNOP00000081946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)Ensembl
RefSeq Acc Id: NM_053304   ⟹   NP_445756
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,380,458 - 80,397,461 (+)NCBI
mRatBN7.21079,883,622 - 79,900,625 (+)NCBI
Rnor_6.01082,745,801 - 82,762,790 (+)NCBI
Rnor_5.01082,563,434 - 82,580,364 (+)NCBI
RGSC_v3.41083,622,438 - 83,639,368 (+)RGD
Celera1078,658,450 - 78,675,438 (+)RGD
Sequence:
RefSeq Acc Id: NP_445756   ⟸   NM_053304
- Peptide Label: precursor
- UniProtKB: P02455 (UniProtKB/Swiss-Prot),   A3KNA1 (UniProtKB/Swiss-Prot),   Q63079 (UniProtKB/Swiss-Prot),   P02454 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005311   ⟸   ENSRNOT00000005311
Ensembl Acc Id: ENSRNOP00000081061   ⟸   ENSRNOT00000115096
Ensembl Acc Id: ENSRNOP00000081946   ⟸   ENSRNOT00000115180
Ensembl Acc Id: ENSRNOP00000088255   ⟸   ENSRNOT00000114204
Protein Domains
Fibrillar collagen NC1   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02454-F1-model_v2 AlphaFold P02454 1-1453 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697611
Promoter ID:EPDNEW_R8136
Type:multiple initiation site
Name:Col1a1_1
Description:collagen type I alpha 1 chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01082,745,796 - 82,745,856EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61817 AgrOrtholog
BioCyc Gene G2FUF-23579 BioCyc
Ensembl Genes ENSRNOG00000003897 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032354 UniProtKB/Swiss-Prot
  ENSRNOG00060019866 UniProtKB/Swiss-Prot
  ENSRNOG00065020003 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005311.7 UniProtKB/Swiss-Prot
  ENSRNOT00000114204.1 UniProtKB/TrEMBL
  ENSRNOT00000115096.1 UniProtKB/TrEMBL
  ENSRNOT00000115180.1 UniProtKB/TrEMBL
  ENSRNOT00055055926 UniProtKB/Swiss-Prot
  ENSRNOT00060034429 UniProtKB/Swiss-Prot
  ENSRNOT00065033789 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6-Phosphogluconate Dehydrogenase, domain 3 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125649 IMAGE-MGC_LOAD
InterPro Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen_superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fib_collagen_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29393 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156780 IMAGE-MGC_LOAD
NCBI Gene 29393 ENTREZGENE
PANTHER COLLAGEN ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COLLAGEN ALPHA-1(I) CHAIN UniProtKB/TrEMBL
  ENDOSTATIN DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COLFI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB COL1A1 RGD
PhenoGen Col1a1 PhenoGen
PROSITE NC1_FIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003897 RatGTEx
  ENSRNOG00055032354 RatGTEx
  ENSRNOG00060019866 RatGTEx
  ENSRNOG00065020003 RatGTEx
SMART COLFI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A068F650_RAT UniProtKB/TrEMBL
  A0A8I5ZRN2_RAT UniProtKB/TrEMBL
  A0A8I6G8P4_RAT UniProtKB/TrEMBL
  A0A8I6GG08_RAT UniProtKB/TrEMBL
  A3KNA1 ENTREZGENE
  A6HI72_RAT UniProtKB/TrEMBL
  CO1A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P02455 ENTREZGENE
  Q63079 ENTREZGENE
UniProt Secondary A3KNA1 UniProtKB/Swiss-Prot
  P02455 UniProtKB/Swiss-Prot
  Q63079 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Col1a1  collagen type I alpha 1 chain  Col1a1  collagen, type I, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Col1a1  collagen, type I, alpha 1  Col1a1  procollagen, type 1, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Col1a1  procollagen, type 1, alpha 1    collagen, type 1, alpha 1   Name updated 1299863 APPROVED
2002-06-10 Col1a1  collagen, type 1, alpha 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is higher in unstimulated, cultured cardiac fibroblasts from adult SHR rats than in those from WKY rats. 1358958
gene_regulation expression levels in knee are modulated by mechanical load 1299105
gene_regulation steady state transcript levels in cultured fetal lung fibroblasts are not changed by prolonged hypoxia 1299106
gene_regulation expression in hepatic stellate cells is downregulated upon treatment with TNF-alpha and this effect may be mediated by p38 MAP kinase 1299107
gene_regulation Bradykinin attenuates mRNA expression in cultured cardiac fibroblasts from SHR but not WKY rats 1358958