Col1a1 (collagen type I alpha 1 chain) - Rat Genome Database

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Gene: Col1a1 (collagen type I alpha 1 chain) Rattus norvegicus
Symbol: Col1a1
Name: collagen type I alpha 1 chain
RGD ID: 61817
Description: Predicted to enable identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent. Involved in several processes, including cellular response to growth factor stimulus; cellular response to mechanical stimulus; and cellular response to retinoic acid. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and secretory granule. Used to study cholestasis and non-alcoholic fatty liver disease. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; liver disease (multiple); pulmonary fibrosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (R)-carnitine; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-1 type I collagen; COLIA1; collagen alpha-1(I) chain; collagen, type 1, alpha 1; collagen, type I, alpha 1; procollagen type I alpha 1; procollagen type I, alpha 1; procollagen, type 1, alpha 1; procollagen, type I, alpha 1 ; type I-alpha 1 collagen
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21079,883,622 - 79,900,625 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1079,883,622 - 79,900,624 (+)Ensembl
Rnor_6.01082,745,801 - 82,762,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,745,801 - 82,762,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,563,434 - 82,580,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,622,438 - 83,639,368 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11083,636,918 - 83,653,733 (+)NCBI
Celera1078,658,450 - 78,675,438 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
aggressive periodontitis  (ISO)
alcoholic hepatitis  (ISO)
aortic valve insufficiency  (ISO)
Arteriovenous Fistula  (IEP)
autoimmune disease  (ISO)
beta thalassemia  (ISO)
Bisphosphonate-Associated Osteonecrosis of the Jaw  (ISO)
bladder neck obstruction  (IEP)
Bone Fractures  (ISO)
Caffey disease  (ISO)
calcinosis  (ISO)
Cardiac Fibrosis  (IDA,IEP)
cholangitis  (ISO)
cholestasis  (IDA,IEP,ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pancreatitis  (IDA)
Combined Osteogenesis Imperfecta and Ehlers-Danlos Syndrome 1  (ISO)
connective tissue disease  (ISO)
Contracture  (IEP)
cutaneous leishmaniasis  (ISO)
degenerative disc disease  (ISO)
dentinogenesis imperfecta  (ISO)
dermatofibrosarcoma protuberans  (ISO)
Diabetic Nephropathies  (IEP)
Dissecting Aneurysm  (ISO)
Ehlers-Danlos syndrome  (ISO,ISS)
Ehlers-Danlos syndrome arthrochalasia type 1  (ISO)
Ehlers-Danlos syndrome arthrochalasia type 2  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
end stage renal disease  (ISO)
Experimental Liver Cirrhosis  (IDA,IEP,IMP,ISO)
extrahepatic cholestasis  (ISO)
Femoral Fractures  (IDA)
Fibrosis  (ISO)
Fractures, Multiple  (ISO)
genetic disease  (ISO)
heart valve disease  (ISO)
hemorrhagic disease  (ISO)
Hernia, Ventral  (IDA)
High Myopia  (ISO)
Human Viral Hepatitis  (ISO)
Hypertelorism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (IEP)
Intervertebral Disc Disease  (ISO)
Joint Instability  (ISO)
Keloid  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lipodermatosclerosis  (ISO)
liver benign neoplasm  (IEP)
liver cirrhosis  (ISO)
lupus nephritis  (ISO)
Metabolic Bone Diseases  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IEP)
myocarditis  (ISO)
myopia  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (IDA,ISO)
non-alcoholic steatohepatitis  (ISO)
ocular hypertension  (ISO)
open-angle glaucoma  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (IEP)
Osteoarthritis, Hip  (ISO)
osteogenesis imperfecta  (ISO)
osteogenesis imperfecta type 1  (ISO)
osteogenesis imperfecta type 2  (ISO)
osteogenesis imperfecta type 2C  (ISO)
osteogenesis imperfecta type 3  (ISO)
osteogenesis imperfecta type 4  (ISO)
osteoporosis  (ISO)
otosclerosis  (ISO)
Postmenopausal Osteoporosis  (ISO)
primary biliary cholangitis  (IEP)
prostate cancer  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP)
Spontaneous Abortions  (ISO)
systemic scleroderma  (ISO)
Tendon Injuries  (IDA)
thoracic aortic aneurysm  (ISO)
Trachomatous Trichiasis  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP,ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-stearoyl-2-arachidonoyl-sn-glycerol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP,ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (EXP,ISO)
acetic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenine  (EXP)
aflatoxin B1  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allyl isothiocyanate  (ISO)
alpha-pinene  (ISO)
aluminium oxide  (ISO)
AM-251  (ISO)
ambroxol  (EXP)
aminoguanidine  (EXP)
amlodipine  (EXP)
amosite asbestos  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
andrographolide  (EXP,ISO)
anthocyanin  (EXP)
antimycin A  (ISO)
argatroban  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
azelastine  (ISO)
baicalein  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boron atom  (ISO)
boron nitride  (ISO)
BQ 123  (ISO)
bromochloroacetic acid  (ISO)
bucladesine  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium dichloride  (ISO)
calcium dihydroxide  (ISO)
camostat  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carvedilol  (EXP)
casticin  (ISO)
celastrol  (EXP)
celecoxib  (EXP)
ceruletide  (EXP,ISO)
chenodeoxycholic acid  (EXP,ISO)
chloramphenicol  (ISO)
chlorogenic acid  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholate  (EXP)
choline  (EXP,ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
Clofop  (EXP)
clothianidin  (ISO)
cocaine  (EXP)
coenzyme Q10  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (EXP)
crocidolite asbestos  (ISO)
cucurbitacin B  (ISO)
cucurbitacin E  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cystamine  (EXP)
cytarabine  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
diiodine  (ISO)
diltiazem  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (ISO)
diminazene diaceturate  (ISO)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
EC (peptidyl-dipeptidase A) inhibitor  (EXP)
elemental boron  (ISO)
elemental selenium  (ISO)
emodin  (EXP)
enalapril  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
epalrestat  (ISO)
eplerenone  (EXP)
eprosartan  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylisopropylamiloride  (EXP)
excitatory amino acid agonist  (ISO)
fasudil  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (ISO)
fingolimod hydrochloride  (ISO)
folic acid  (ISO)
folpet  (ISO)
fomepizole  (EXP)
fonofos  (ISO)
fulvestrant  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
geraniol  (EXP)
glucagon  (ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyoxal  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
guaiazulene  (ISO)
GW 4064  (EXP)
heptachlor  (ISO)
hesperetin  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
iron atom  (EXP)
iron dextran  (ISO)
iron(0)  (EXP)
iron(III) nitrilotriacetate  (EXP)
isoflavones  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isotretinoin  (EXP)
kainic acid  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leukotriene B4  (ISO)
levonorgestrel  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
losartan  (EXP,ISO)
LY 364947  (ISO)
LY-2157299  (ISO)
magnesium atom  (ISO)
malonaldehyde  (ISO)
mangiferin  (EXP)
manidipine  (EXP)
maraviroc  (ISO)
marinobufagenin  (EXP)
menadione  (ISO)
menaquinone  (ISO)
mercaptopurine  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
metoprolol  (EXP,ISO)
miconazole  (ISO)
mifepristone  (EXP)
monocrotaline  (EXP)
monosodium L-glutamate  (EXP)
myricitrin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-oleoyldopamine  (ISO)
N-palmitoyl dopamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
naphthalene  (ISO)
naringin  (ISO)
neoeriocitrin  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nimodipine  (ISO)
nitrofen  (EXP)
obeticholic acid  (EXP,ISO)
okadaic acid  (EXP)
olanzapine  (ISO)
olaparib  (ISO)
oleamide  (ISO)
oleanolic acid  (EXP)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
Osajin  (ISO)
ouabain  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
pamidronate  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paricalcitol  (ISO)
pentanal  (ISO)
Pentoxifylline  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP)
phenol  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phosphatidylcholine  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
picoxystrobin  (ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
Plantamajoside  (ISO)
poly(ethylene)  (ISO)
poly(guanylic acid)  (EXP)
Pomiferin  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
Ptaquiloside  (ISO)
puerarin  (ISO)
purine-6-thiol  (EXP)
pyrazinecarboxamide  (EXP)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
ramipril  (EXP)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
rifaximin  (ISO)
rimonabant  (EXP)
rosmarinic acid  (EXP,ISO)
rotenone  (EXP)
rottlerin  (ISO)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
saralasin  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
sildenafil citrate  (ISO)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (EXP)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
sorafenib  (EXP,ISO)
stattic  (ISO)
streptozocin  (ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sunitinib  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
tetraphene  (ISO)
thalidomide  (EXP)
theophylline  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
tranexamic acid  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
uranium atom  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
verapamil  (ISO)
vildagliptin  (ISO)
vitamin D  (ISO)
vitamin E  (EXP)
vitamin K  (EXP)
warfarin  (EXP,ISO)
Y-27632  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (IBA,ISO)
bone trabecula formation  (ISO)
cartilage development involved in endochondral bone morphogenesis  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to fluoride  (IEP)
cellular response to mechanical stimulus  (IEP,ISO)
cellular response to retinoic acid  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to vitamin E  (IEP)
collagen biosynthetic process  (ISO)
collagen fibril organization  (ISO)
collagen-activated tyrosine kinase receptor signaling pathway  (IDA)
embryonic skeletal system development  (ISO)
endochondral ossification  (ISO)
extracellular matrix organization  (IBA)
face morphogenesis  (ISO)
intramembranous ossification  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
ossification  (IBA,IEP)
osteoblast differentiation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein localization to nucleus  (ISO)
protein transport  (ISO)
response to cAMP  (IEP)
response to corticosteroid  (IEP)
response to estradiol  (IEP)
response to fluoride  (IEP)
response to hydrogen peroxide  (IEP)
response to hyperoxia  (IEP)
response to mechanical stimulus  (IBA,IEP)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to peptide hormone  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (IEP)
sensory perception of sound  (ISO)
skeletal system development  (IBA,ISO)
skeletal system morphogenesis  (ISO)
skin development  (IBA,ISO)
skin morphogenesis  (ISO)
tooth eruption  (IEP)
tooth mineralization  (ISO)
visual perception  (ISO)
wound healing  (IMP)

Cellular Component

Molecular Function


References - curated
1. Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21.
2. Aerssens J, etal., Arthritis Rheum. 1998 Nov;41(11):1946-50.
3. Ahmed MR, etal., Osteoarthritis Cartilage. 2014 Nov;22(11):1894-901. doi: 10.1016/j.joca.2014.07.028. Epub 2014 Aug 13.
4. Almeida L, etal., Infect Genet Evol. 2015 Mar;30:225-9. doi: 10.1016/j.meegid.2014.12.034. Epub 2015 Jan 3.
5. Annoni G, etal., Boll Ist Sieroter Milan. 1991-1992;70(1-2):391-7.
6. Arisal O, etal., Haematologia (Budap). 2002;32(4):475-82.
7. Bai Y, etal., Am J Med Sci. 2015 Apr;349(4):292-7. doi: 10.1097/MAJ.0000000000000408.
8. Bei T, etal., Hormones (Athens). 2008 Jul-Sep;7(3):251-4.
9. Bergijk EC, etal., Kidney Int. 1994 Dec;46(6):1663-73.
10. Bhatt RS, etal., Genes Dev. 2000 Sep 1;14(17):2216-28.
11. Bhatti FU, etal., Inflamm Res. 2013 Aug;62(8):781-9. doi: 10.1007/s00011-013-0635-y. Epub 2013 May 31.
12. Bogdanovic Z, etal., J Cell Biochem. 2000 Feb;77(1):149-58.
13. Braut A, etal., Int J Dev Biol 2003 May;47(4):281-92.
14. Byers PH, etal., Am J Med Genet 1997 Oct 3;72(1):94-105.
15. Castoldi G, etal., J Cell Physiol. 2012 Feb;227(2):850-6. doi: 10.1002/jcp.22939.
16. Chen F, etal., J Bone Miner Res. 2014 Jun;29(6):1412-23. doi: 10.1002/jbmr.2177.
17. Chen JY, etal., J Ethnopharmacol. 2012 Aug 1;142(3):811-8. doi: 10.1016/j.jep.2012.06.005. Epub 2012 Jun 15.
18. Chen W, etal., Clin Genet. 2007 May;71(5):406-14.
19. Coutard M, etal., J Vasc Res. 2006;43(3):217-28. Epub 2006 Jan 20.
20. Dai Y, etal., Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5749-53. doi: 10.1167/iovs.08-3367. Epub 2009 Sep 24.
21. Degiorgio-Miller AM, etal., Br J Dermatol. 2005 Feb;152(2):242-9.
22. Delella FK, etal., Life Sci. 2012 Dec 17;91(25-26):1281-7. doi: 10.1016/j.lfs.2012.09.017. Epub 2012 Oct 12.
23. Espira L, etal., J Mol Cell Cardiol. 2009 Aug;47(2):188-95. doi: 10.1016/j.yjmcc.2009.03.024. Epub 2009 Apr 10.
24. Fang L, etal., Toxicol Appl Pharmacol. 2013 Nov 1;272(3):713-25. doi: 10.1016/j.taap.2013.08.009. Epub 2013 Aug 16.
25. Federspiel SJ, etal., Lab Invest. 1991 Apr;64(4):463-73.
26. Federspiel SJ, etal., Lab Invest. 1991 Oct;65(4):441-50.
27. Flentke GR, etal., Dev Dyn. 2004 Apr;229(4):886-98.
28. Frankel FR, etal., DNA 1988 Jun;7(5):347-54.
29. Fu SC, etal., J Orthop Sports Phys Ther. 2010 Jul;40(7):422-9. doi: 10.2519/jospt.2010.3254.
30. Garcia-Trevijano ER, etal., Hepatology. 1999 Mar;29(3):960-70.
31. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
32. Gensure RC, etal., J Clin Invest. 2005 May;115(5):1250-7.
33. GOA data from the GO Consortium
34. Gokden N, etal., J Cutan Pathol. 2003 Mar;30(3):190-5.
35. Guzeloglu-Kayisli O, etal., Pediatr Int. 2008 Aug;50(4):474-6. doi: 10.1111/j.1442-200X.2008.02609.x.
36. Han JM, etal., Food Chem Toxicol. 2012 Oct;50(10):3505-13. doi: 10.1016/j.fct.2012.07.018. Epub 2012 Jul 20.
37. He H, etal., Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10.
38. Heinemeier KM, etal., J Appl Physiol. 2009 Jan;106(1):178-86. Epub 2008 Nov 6.
39. Hermida N, etal., Cardiovasc Res. 2009 Feb 15;81(3):601-9. doi: 10.1093/cvr/cvn315. Epub 2008 Nov 19.
40. Holland MJ, etal., Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3893-902. doi: 10.1167/iovs.09-5054. Epub 2010 Apr 7.
41. Horino Y, etal., Life Sci 2002 Nov 15;71(26):3031-45.
42. Hsieh AH, etal., J Orthop Res 2002 Mar;20(2):325-31.
43. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
44. Imai C, etal., Clin Exp Hypertens 2005 Jan;27(1):59-69.
45. Inamori Y, etal., Hum Genet. 2007 Sep;122(2):151-7. Epub 2007 Jun 8.
46. Ishii Y, etal., J Orthop Res. 2002 Mar;20(2):353-6.
47. Jiang F, etal., Pancreas. 2011 Oct;40(7):1091-6. doi: 10.1097/MPA.0b013e31821b59c6.
48. Kanazawa K, etal., Int J Clin Exp Pathol. 2015 Apr 1;8(4):3426-40. eCollection 2015.
49. Katz J, etal., Int J Oral Maxillofac Surg. 2011 Jun;40(6):605-11. doi: 10.1016/j.ijom.2011.02.002. Epub 2011 Mar 10.
50. Kesserwan C, etal., J Allergy Clin Immunol. 2011 Dec 6.
51. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
52. Koilan S, etal., Oligonucleotides. 2010 Oct;20(5):231-7. Epub 2010 Sep 6.
53. Kulozik M, etal., J Clin Invest. 1990 Sep;86(3):917-22.
54. Kuwata K, etal., Toxicology. 2011 Apr 28;283(1):8-17. Epub 2011 Feb 2.
55. Leheup BP, etal., Lab Invest. 1989 Jun;60(6):791-807.
56. Lian K, etal., Arthritis Rheum. 2005 May;52(5):1431-6.
57. Lindahl GE, etal., J Biol Chem. 2002 Feb 22;277(8):6153-61. Epub 2001 Dec 17.
58. Ling L, etal., J Cell Physiol. 2006 Dec;209(3):811-25.
59. Lisse TS, etal., PLoS Genet. 2008 Feb;4(2):e7. doi: 10.1371/journal.pgen.0040007.
60. Loughlin J, etal., J Rheumatol. 2000 Mar;27(3):779-84.
61. Mabuchi F, etal., Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1841-5.
62. Marqueti RC, etal., Eur J Appl Physiol. 2012 Apr;112(4):1505-15. doi: 10.1007/s00421-011-2114-x. Epub 2011 Aug 14.
63. MGD data from the GO Consortium
64. Mohan H, etal., Brain Pathol. 2010 Sep;20(5):966-75. Epub 2010 Mar 25.
65. Moraes MV, etal., Genet Mol Res. 2012 Sep 13;11(3):3246-55. doi: 10.4238/2012.September.12.7.
66. Nakajima A, etal., J Bone Miner Res. 2002 Nov;17(11):2038-47.
67. Nakamura T, etal., Kidney Int. 1995 Feb;47(2):481-9.