Col1a1 (collagen, type I, alpha 1) - Rat Genome Database

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Gene: Col1a1 (collagen, type I, alpha 1) Mus musculus
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Symbol: Col1a1
Name: collagen, type I, alpha 1
RGD ID: 62109
MGI Page MGI
Description: Enables identical protein binding activity. An extracellular matrix structural constituent. Involved in cellular response to mechanical stimulus and osteoblast differentiation. Acts upstream of or within several processes, including face morphogenesis; intramembranous ossification; and skeletal system morphogenesis. Located in collagen-containing extracellular matrix; cytoplasm; and extracellular space. Part of collagen type I trimer. Is expressed in several structures, including alimentary system; embryo mesenchyme; heart and pericardium; limb; and skeleton. Used to study several diseases, including D-2-hydroxyglutaric aciduria; Diamond-Blackfan anemia; hepatocellular carcinoma; lung cancer (multiple); and osteogenesis imperfecta (multiple). Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: alpha-1 type 1 collagen; alpha-1 type I collagen; Co; Col; Col1; Col1a-1; Cola-1; Cola1; collagen alpha-1(I) chain; Mov-; Mov-13; Mov13; procollagen, type I, alpha 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,827,050 - 94,843,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,827,050 - 94,843,868 (+)EnsemblGRCm39 Ensembl
GRCm381194,936,224 - 94,953,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,936,224 - 94,953,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv371194,797,584 - 94,813,181 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,752,360 - 94,767,957 (+)NCBIMGSCv36mm8
Celera11104,549,617 - 104,565,301 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
aggressive periodontitis  (ISO)
alcoholic hepatitis  (ISO)
aortic valve insufficiency  (ISO)
Arteriovenous Fistula  (ISO)
asphyxia neonatorum  (ISO)
autoimmune disease  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2D  (ISO)
beta thalassemia  (ISO)
Bisphosphonate-Associated Osteonecrosis of the Jaw  (ISO)
bladder neck obstruction  (ISO)
Bone Fractures  (ISO)
Caffey disease  (ISO)
calcinosis  (ISO)
Cardiac Fibrosis  (ISO)
cholangitis  (ISO)
cholestasis  (IEP,ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pancreatitis  (ISO)
Combined Osteogenesis Imperfecta and Ehlers-Danlos Syndrome 1  (ISO)
congenital heart disease  (ISO)
connective tissue disease  (ISO)
Contracture  (ISO)
cutaneous leishmaniasis  (ISO)
degenerative disc disease  (ISO)
dentinogenesis imperfecta  (ISO)
dermatofibrosarcoma protuberans  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Dissecting Aneurysm  (ISO)
Ehlers-Danlos syndrome  (IAGP,ISO)
Ehlers-Danlos syndrome arthrochalasia type 1  (ISO)
Ehlers-Danlos syndrome arthrochalasia type 2  (ISO)
Ehlers-Danlos syndrome cardiac valvular type  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
end stage renal disease  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
Femoral Fractures  (ISO)
Fetal Nutrition Disorders  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
heart valve disease  (ISO)
hemorrhagic disease  (ISO)
High Myopia  (ISO)
Human Viral Hepatitis  (ISO)
Hypertelorism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
Intervertebral Disc Disease  (ISO)
Joint Instability  (ISO)
Keloid  (ISO)
keratoconus  (ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (ISO)
Lipodermatosclerosis  (ISO)
liver benign neoplasm  (ISO)
liver cirrhosis  (ISO)
Lung Reperfusion Injury  (IEP)
lupus nephritis  (IDA,IEP,ISO)
Metabolic Bone Diseases  (ISO)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IDA,ISO)
multiple epiphyseal dysplasia 1  (ISO)
multiple sclerosis  (ISO)
Muscle Hypotonia  (ISO)
myocardial infarction  (ISO)
myocarditis  (IDA)
myopia  (IEP)
Nephrogenic Fibrosing Dermopathy  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
ocular hypertension  (IMP)
open-angle glaucoma  (IMP)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
Osteoarthritis, Hip  (ISO)
osteochondrodysplasia  (ISO)
osteogenesis imperfecta  (IAGP,IMP,ISO)
osteogenesis imperfecta type 1  (IAGP,ISO)
osteogenesis imperfecta type 2  (IAGP,ISO)
osteogenesis imperfecta type 2C  (ISO)
osteogenesis imperfecta type 3  (IAGP,ISO)
osteogenesis imperfecta type 4  (IAGP,ISO)
osteoporosis  (ISO)
otosclerosis  (ISO)
phenylketonuria  (ISO)
Postmenopausal Osteoporosis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
prostate cancer  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
rheumatic heart disease  (ISO)
Spontaneous Abortions  (ISO)
Spontaneous Fractures  (ISO)
systemic scleroderma  (ISO)
Tendon Injuries  (ISO)
thoracic aortic aneurysm  (ISO)
Trachomatous Trichiasis  (ISO)
trichodontoosseous syndrome  (ISO)
Tubulointerstitial Fibrosis  (IEP)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
Ventral Hernia  (ISO)
Wiedemann-Rautenstrauch syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (EXP)
(1->4)-beta-D-glucan  (EXP)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (EXP)
(R)-camphor  (ISO)
(R)-carnitine  (ISO)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1,8-cineole  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
1-stearoyl-2-arachidonoyl-sn-glycerol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (EXP)
2-hydroxyethyl methacrylate  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-HETE  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5'-S-methyl-5'-thioadenosine  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP)
5-Hydroxycapric acid  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9,10-epoxy-12-octadecenoic acid  (EXP)
9-cis-retinoic acid  (ISO)
acetaldehyde  (EXP,ISO)
acetic acid  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
Activin A  (ISO)
adenine  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
Alisol B  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
allyl isothiocyanate  (EXP)
Allylamine  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
aluminium atom  (EXP)
aluminium oxide  (ISO)
aluminium(0)  (EXP)
AM-251  (ISO)
ambroxol  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
amlodipine  (ISO)
Ammothamnine  (EXP)
amosite asbestos  (ISO)
amphetamine  (ISO)
amphibole asbestos  (EXP)
andrographolide  (EXP,ISO)
angiotensin II  (EXP)
anthocyanin  (ISO)
antimycin A  (ISO)
Archazolid B  (ISO)
argatroban  (EXP)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (ISO)
aucubin  (EXP,ISO)
azathioprine  (ISO)
azelastine  (ISO)
baicalein  (EXP,ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[ghi]perylene