Col1a1 (collagen, type I, alpha 1) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Col1a1 (collagen, type I, alpha 1) Mus musculus
Symbol: Col1a1
Name: collagen, type I, alpha 1
RGD ID: 62109
Description: Enables identical protein binding activity. An extracellular matrix structural constituent. Involved in cellular response to mechanical stimulus and osteoblast differentiation. Acts upstream of or within several processes, including face morphogenesis; intramembranous ossification; and skeletal system morphogenesis. Located in collagen-containing extracellular matrix; cytoplasm; and extracellular space. Part of collagen type I trimer. Is expressed in several structures, including alimentary system; embryo mesenchyme; eye; heart and pericardium; and skeleton. Used to study several diseases, including D-2-hydroxyglutaric aciduria; Diamond-Blackfan anemia; hepatocellular carcinoma; lung cancer (multiple); and osteogenesis imperfecta (multiple). Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: alpha-1 type 1 collagen; alpha-1 type I collagen; Co; Col; Col1; Col1a-1; Cola-1; Cola1; collagen alpha-1(I) chain; Mov-; Mov-13; Mov13; procollagen, type I, alpha 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391194,827,050 - 94,843,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,827,050 - 94,843,868 (+)EnsemblGRCm39 Ensembl
GRCm381194,936,224 - 94,953,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,936,224 - 94,953,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv371194,797,584 - 94,813,181 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,752,360 - 94,767,957 (+)NCBIMGSCv36mm8
Celera11104,549,617 - 104,565,301 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
aggressive periodontitis  (ISO)
alcoholic hepatitis  (ISO)
aortic valve insufficiency  (ISO)
Arteriovenous Fistula  (ISO)
asphyxia neonatorum  (ISO)
autoimmune disease  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2D  (ISO)
beta thalassemia  (ISO)
Bisphosphonate-Associated Osteonecrosis of the Jaw  (ISO)
bladder neck obstruction  (ISO)
Bone Fractures  (ISO)
bone structure disease  (ISO)
Caffey disease  (ISO)
calcinosis  (ISO)
Cardiac Fibrosis  (ISO)
cholangitis  (ISO)
cholestasis  (IEP,ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pancreatitis  (ISO)
Combined Osteogenesis Imperfecta and Ehlers-Danlos Syndrome 1  (ISO)
congenital heart disease  (ISO)
connective tissue disease  (ISO)
Contracture  (ISO)
cutaneous leishmaniasis  (ISO)
degenerative disc disease  (ISO)
dentinogenesis imperfecta  (ISO)
dermatofibrosarcoma protuberans  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Dissecting Aneurysm  (ISO)
Ehlers-Danlos syndrome  (IAGP,ISO)
Ehlers-Danlos syndrome arthrochalasia type 1  (ISO)
Ehlers-Danlos syndrome arthrochalasia type 2  (ISO)
Ehlers-Danlos syndrome cardiac valvular type  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
end stage renal disease  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
Femoral Fractures  (ISO)
Fetal Nutrition Disorders  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
heart valve disease  (ISO)
hemorrhagic disease  (ISO)
High Myopia  (ISO)
Human Viral Hepatitis  (ISO)
Hypertelorism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
Intervertebral Disc Disease  (ISO)
Joint Instability  (ISO)
Keloid  (ISO)
keratoconus  (ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (ISO)
Lipodermatosclerosis  (ISO)
liver benign neoplasm  (ISO)
liver cirrhosis  (ISO)
Lung Reperfusion Injury  (IEP)
lupus nephritis  (IDA,IEP,ISO)
Metabolic Bone Diseases  (ISO)
multiple epiphyseal dysplasia 1  (ISO)
multiple sclerosis  (ISO)
Muscle Hypotonia  (ISO)
myocardial infarction  (ISO)
myocarditis  (IDA)
myopia  (IEP)
Nephrogenic Fibrosing Dermopathy  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (IDA,ISO)
non-alcoholic steatohepatitis  (IEP)
ocular hypertension  (IMP)
open-angle glaucoma  (IMP)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
Osteoarthritis, Hip  (ISO)
osteochondrodysplasia  (ISO)
osteogenesis imperfecta  (IAGP,IMP,ISO)
osteogenesis imperfecta type 1  (IAGP,ISO)
osteogenesis imperfecta type 2  (IAGP,ISO)
osteogenesis imperfecta type 2C  (ISO)
osteogenesis imperfecta type 3  (IAGP,ISO)
osteogenesis imperfecta type 4  (IAGP,ISO)
osteoporosis  (ISO)
otosclerosis  (ISO)
phenylketonuria  (ISO)
Postmenopausal Osteoporosis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
prostate cancer  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
rheumatic heart disease  (ISO)
Spontaneous Abortions  (ISO)
Spontaneous Fractures  (ISO)
systemic scleroderma  (ISO)
Tendon Injuries  (ISO)
thoracic aortic aneurysm  (ISO)
Trachomatous Trichiasis  (ISO)
Tubulointerstitial Fibrosis  (IEP)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
Ventral Hernia  (ISO)
Wiedemann-Rautenstrauch syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (EXP)
(1->4)-beta-D-glucan  (EXP)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (EXP)
(R)-carnitine  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
1-stearoyl-2-arachidonoyl-sn-glycerol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
2-hydroxyethyl methacrylate  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-HETE  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5'-S-methyl-5'-thioadenosine  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9,10-epoxy-12-octadecenoic acid  (EXP)
9-cis-retinoic acid  (ISO)
acetaldehyde  (EXP,ISO)
acetic acid  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
Activin A  (ISO)
adenine  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
allyl isothiocyanate  (EXP)
Allylamine  (ISO)
alpha-pinene  (ISO)
aluminium atom  (EXP)
aluminium oxide  (ISO)
aluminium(0)  (EXP)
AM-251  (ISO)
ambroxol  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
amlodipine  (ISO)
Ammothamnine  (EXP)
amosite asbestos  (ISO)
amphetamine  (ISO)
amphibole asbestos  (EXP)
andrographolide  (EXP,ISO)
anthocyanin  (ISO)
antimycin A  (ISO)
Archazolid B  (ISO)
argatroban  (EXP)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
azelastine  (ISO)
baicalein  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[ghi]perylene  (EXP)
berberine  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boron atom  (ISO)
boron nitride  (ISO)
BQ 123  (EXP)
bromochloroacetic acid  (EXP)
bucladesine  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium dichloride  (ISO)
calcium dihydroxide  (ISO)
calcium silicate  (EXP)
camostat  (ISO)
cannabidiol  (ISO)
cantharidin  (EXP)
capsaicin  (ISO)
carbamazepine  (ISO)
Carbaprostacyclin  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
carvedilol  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceruletide  (EXP,ISO)
chenodeoxycholic acid  (EXP,ISO)
chloramphenicol  (ISO)
chlorogenic acid  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cholate  (ISO)
choline  (EXP,ISO)
chromium(6+)  (EXP)
chrysene  (EXP)
ciglitazone  (ISO)
cisplatin  (ISO)
clodronic acid  (EXP)
clofibrate  (EXP)
clofibric acid  (ISO)
Clofop  (ISO)
clorgyline  (EXP)
clothianidin  (ISO)
clotrimazole  (ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cortisol  (ISO)
crocidolite asbestos  (EXP,ISO)
cucurbitacin B  (EXP)
cucurbitacin E  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cystamine  (ISO)
cytarabine  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
Didecyldimethylammonium  (EXP,ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
diiodine  (ISO)
diltiazem  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
diminazene diaceturate  (ISO)
Diosbulbin B  (EXP)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
diquat  (EXP)
disodium selenite  (EXP)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
EC (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (EXP)
elemental boron  (ISO)
elemental selenium  (EXP)
emodin  (ISO)
enalapril  (EXP)
endosulfan  (ISO)
entinostat  (EXP,ISO)
enzacamene  (ISO)
epalrestat  (EXP)
eplerenone  (ISO)
eprosartan  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylisopropylamiloride  (ISO)
excitatory amino acid agonist  (ISO)
fasudil  (EXP)
fenofibrate  (EXP,ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (EXP)
fingolimod hydrochloride  (EXP)
folic acid  (EXP)
folpet  (EXP)
fomepizole  (ISO)
fonofos  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gefitinib  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
glucagon  (EXP)
glucose  (ISO)
glyburide  (EXP)
glycerol 2-phosphate  (EXP,ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyoxal  (ISO)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
griseofulvin  (EXP)
guaiazulene  (ISO)
GW 4064  (ISO)
heptachlor  (ISO)
hesperetin  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexadecanoic acid  (EXP,ISO)
Honokiol  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron dextran  (EXP)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (EXP)
JTE-013  (ISO)
kainic acid  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
leukotriene B4  (EXP)
levonorgestrel  (ISO)
linoleic acid  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
lithocholic acid  (EXP)
losartan  (EXP,ISO)
LY-2157299  (EXP)
magnesium atom  (ISO)
malonaldehyde  (ISO)
maneb  (EXP)
mangiferin  (ISO)
manidipine  (ISO)
maraviroc  (EXP)
marinobufagenin  (ISO)
menadione  (ISO)
menaquinone  (ISO)
mercaptopurine  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
methylparaben  (ISO)
metoprolol  (EXP,ISO)
mevalonic acid  (ISO)
miconazole  (EXP)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
mirtazapine  (EXP,ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
Morroniside  (ISO)
myricitrin  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-oleoyldopamine  (ISO)
N-palmitoyl dopamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naphthalene  (EXP)
naringin  (EXP)
neoeriocitrin  (EXP)
nickel atom  (ISO)
nickel sulfate  (EXP)
niclosamide  (EXP,ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nimodipine  (EXP)
nitrofen  (ISO)
obeticholic acid  (EXP,ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
olaparib  (EXP)
oleamide  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (ISO)
Osajin  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
pamidronate  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paricalcitol  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phosphatidylcholine  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
picoxystrobin  (ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
Plantamajoside  (EXP)
poly(ethylene)  (ISO)
poly(guanylic acid)  (ISO)
Pomiferin  (ISO)
potassium dichromate  (EXP,ISO)
prednisolone  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
Ptaquiloside  (EXP)
puerarin  (EXP)
purine-6-thiol  (ISO)
pyrazinecarboxamide  (ISO)
pyrogallol  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quartz  (EXP,ISO)
quercetin  (EXP,ISO)
ramipril  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rifaximin  (ISO)
rimonabant  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
rutin  (ISO)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saralasin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP)
serpentine asbestos  (EXP)
Shikonin  (ISO)
sildenafil citrate  (EXP)
silibinin  (ISO)
silicon atom  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
stattic  (EXP,ISO)
streptozocin  (EXP)
sulfadimethoxine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
teprenone  (EXP)
terbufos  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
Tetramethylthiourea  (ISO)
tetraphene  (EXP)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (EXP,ISO)
titanium atom  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
tranexamic acid  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
troglitazone  (EXP,ISO)
uranium atom  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadium atom  (ISO)
vanadium(0)  (ISO)
verapamil  (EXP,ISO)
vildagliptin  (EXP)
vitamin D  (EXP,ISO)
vitamin E  (ISO)
vitamin K  (ISO)
warfarin  (EXP,ISO)
Y-27632  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (IBA,IMP,ISO)
bone trabecula formation  (IGI)
cartilage development involved in endochondral bone morphogenesis  (IMP)
cellular response to amino acid stimulus  (IDA)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to fluoride  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to mechanical stimulus  (IEP,ISO)
cellular response to retinoic acid  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin E  (ISO)
collagen biosynthetic process  (ISO)
collagen fibril organization  (ISO,NAS)
collagen-activated tyrosine kinase receptor signaling pathway  (ISO)
embryonic skeletal system development  (ISO)
endochondral ossification  (IMP)
extracellular matrix organization  (IBA)
face morphogenesis  (IGI)
intramembranous ossification  (IGI)
negative regulation of cell-substrate adhesion  (IDA)
ossification  (IBA,ISO)
osteoblast differentiation  (IEP)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
protein localization to nucleus  (ISO)
protein transport  (IMP)
response to cAMP  (ISO)
response to estradiol  (ISO)
response to fluoride  (ISO)
response to hydrogen peroxide  (ISO)
response to hyperoxia  (ISO)
response to insulin  (ISO)
response to mechanical stimulus  (IBA,ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (ISO)
skeletal system development  (IBA,IMP,ISO)
skeletal system morphogenesis  (IGI)
skin development  (IBA,IMP)
skin morphogenesis  (ISO)
tooth mineralization  (ISO)
visual perception  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension. Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21.
2. Lack of association between osteoarthritis of the hip and gene polymorphisms of VDR, COL1A1, and COL2A1 in postmenopausal women. Aerssens J, etal., Arthritis Rheum. 1998 Nov;41(11):1946-50.
3. Combination of ADMSCs and chondrocytes reduces hypertrophy and improves the functional properties of osteoarthritic cartilage. Ahmed MR, etal., Osteoarthritis Cartilage. 2014 Nov;22(11):1894-901. doi: 10.1016/j.joca.2014.07.028. Epub 2014 Aug 13.
4. Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil: role of COL1A1. Almeida L, etal., Infect Genet Evol. 2015 Mar;30:225-9. doi: 10.1016/j.meegid.2014.12.034. Epub 2015 Jan 3.
5. Albumin and procollagen type I gene regulation in alcohol and viral-induced human liver disease. Annoni G, etal., Boll Ist Sieroter Milan. 1991-1992;70(1-2):391-7.
6. Polymorphism analysis in the COLIA1 gene of patients with thalassemia major and intermedia. Arisal O, etal., Haematologia (Budap). 2002;32(4):475-82.
7. Alteration of type I collagen in the radial artery of patients with end-stage renal disease. Bai Y, etal., Am J Med Sci. 2015 Apr;349(4):292-7. doi: 10.1097/MAJ.0000000000000408.
8. A novel, non-functional, COL1A1 polymorphism is not associated with lumbar disk disease in young male Greek subjects unlike that of the Sp1 site. Bei T, etal., Hormones (Athens). 2008 Jul-Sep;7(3):251-4.
9. Prevention of glomerulosclerosis by early cyclosporine treatment of experimental lupus nephritis. Bergijk EC, etal., Kidney Int. 1994 Dec;46(6):1663-73.
10. Ehlers-Danlos syndrome type VIIA and VIIB result from splice-junction mutations or genomic deletions that involve exon 6 in the COL1A1 and COL1A2 genes of type I collagen. Byers PH, etal., Am J Med Genet 1997 Oct 3;72(1):94-105.
11. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
12. MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension. Castoldi G, etal., J Cell Physiol. 2012 Feb;227(2):850-6. doi: 10.1002/jcp.22939.
13. First mouse model for combined osteogenesis imperfecta and Ehlers-Danlos syndrome. Chen F, etal., J Bone Miner Res. 2014 Jun;29(6):1412-23. doi: 10.1002/jbmr.2177.
14. A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation. Chen JY, etal., J Ethnopharmacol. 2012 Aug 1;142(3):811-8. doi: 10.1016/j.jep.2012.06.005. Epub 2012 Jun 15.
15. Single-nucleotide polymorphisms in the COL1A1 regulatory regions are associated with otosclerosis. Chen W, etal., Clin Genet. 2007 May;71(5):406-14.
16. High-flow-induced arterial remodeling in rats with different susceptibilities to cerebral aneurysms. Coutard M, etal., J Vasc Res. 2006;43(3):217-28. Epub 2006 Jan 20.
17. Outflow facility in mice with a targeted type I collagen mutation. Dai Y, etal., Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5749-53. doi: 10.1167/iovs.08-3367. Epub 2009 Sep 24.
18. Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis. Degiorgio-Miller AM, etal., Br J Dermatol. 2005 Feb;152(2):242-9.
19. TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways. Fang L, etal., Toxicol Appl Pharmacol. 2013 Nov 1;272(3):713-25. doi: 10.1016/j.taap.2013.08.009. Epub 2013 Aug 16.
20. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
21. In vivo low-intensity pulsed ultrasound (LIPUS) following tendon injury promotes repair during granulation but suppresses decorin and biglycan expression during remodeling. Fu SC, etal., J Orthop Sports Phys Ther. 2010 Jul;40(7):422-9. doi: 10.2519/jospt.2010.3254.
22. A novel COL1A1 mutation in infantile cortical hyperostosis (Caffey disease) expands the spectrum of collagen-related disorders. Gensure RC, etal., J Clin Invest. 2005 May;115(5):1250-7.
23. Dermatofibrosarcoma protuberans of the vulva and groin: detection of COL1A1-PDGFB fusion transcripts by RT-PCR. Gokden N, etal., J Cutan Pathol. 2003 Mar;30(3):190-5.
24. Relationship between SP1 polymorphism and osteoporosis in beta-thalassemia major patients. Guzeloglu-Kayisli O, etal., Pediatr Int. 2008 Aug;50(4):474-6. doi: 10.1111/j.1442-200X.2008.02609.x.
25. Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation. Han JM, etal., Food Chem Toxicol. 2012 Oct;50(10):3505-13. doi: 10.1016/j.fct.2012.07.018. Epub 2012 Jul 20.
26. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. He H, etal., Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10.
27. A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats. Hermida N, etal., Cardiovasc Res. 2009 Feb 15;81(3):601-9. doi: 10.1093/cvr/cvn315. Epub 2008 Nov 19.
28. Pathway-focused arrays reveal increased matrix metalloproteinase-7 (matrilysin) transcription in trachomatous trichiasis. Holland MJ, etal., Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3893-902. doi: 10.1167/iovs.09-5054. Epub 2010 Apr 7.
29. Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
30. The COL1A1 gene and high myopia susceptibility in Japanese. Inamori Y, etal., Hum Genet. 2007 Sep;122(2):151-7. Epub 2007 Jun 8.
31. Comparison of antioxidative and antifibrotic effects of alpha-tocopherol with those of tocotrienol-rich fraction in a rat model of chronic pancreatitis. Jiang F, etal., Pancreas. 2011 Oct;40(7):1091-6. doi: 10.1097/MPA.0b013e31821b59c6.
32. Preventing effects of joint contracture by high molecular weight hyaluronan injections in a rat immobilized knee model. Kanazawa K, etal., Int J Clin Exp Pathol. 2015 Apr 1;8(4):3426-40. eCollection 2015.
33. Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw. Katz J, etal., Int J Oral Maxillofac Surg. 2011 Jun;40(6):605-11. doi: 10.1016/j.ijom.2011.02.002. Epub 2011 Mar 10.
34. Multicentric dermatofibrosarcoma protuberans in patients with adenosine deaminase-deficient severe combined immune deficiency. Kesserwan C, etal., J Allergy Clin Immunol. 2011 Dec 6.
35. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
36. Prevention of liver fibrosis by triple helix-forming oligodeoxyribonucleotides targeted to the promoter region of type I collagen gene. Koilan S, etal., Oligonucleotides. 2010 Oct;20(5):231-7. Epub 2010 Sep 6.
37. Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis. Kulozik M, etal., J Clin Invest. 1990 Sep;86(3):917-22.
38. Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNFalpha-signaling due to oxidative cellular stress in rats. Kuwata K, etal., Toxicology. 2011 Apr 28;283(1):8-17. Epub 2011 Feb 2.
39. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Lai CF, etal., Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92. doi: 10.1152/ajprenal.00670.2013. Epub 2014 Jun 11.
40. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
41. Type I collagen alpha1 Sp1 transcription factor binding site polymorphism is associated with reduced risk of hip osteoarthritis defined by severe joint space narrowing in elderly women. Lian K, etal., Arthritis Rheum. 2005 May;52(5):1431-6.
42. ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. Lisse TS, etal., PLoS Genet. 2008 Feb;4(2):e7. doi: 10.1371/journal.pgen.0040007.
43. Association analysis of the vitamin D receptor gene, the type I collagen gene COL1A1, and the estrogen receptor gene in idiopathic osteoarthritis. Loughlin J, etal., J Rheumatol. 2000 Mar;27(3):779-84.
44. Optic nerve damage in mice with a targeted type I collagen mutation. Mabuchi F, etal., Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1841-5.
45. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
46. MGDs mouse GO annotations MGD data from the GO Consortium
48. Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Mohan H, etal., Brain Pathol. 2010 Sep;20(5):966-75. Epub 2010 Mar 25.
49. Variable expressivity of osteogenesis imperfecta in a Brazilian family due to p.G1079S mutation in the COL1A1 gene. Moraes MV, etal., Genet Mol Res. 2012 Sep 13;11(3):3246-55. doi: 10.4238/2012.September.12.7.
50. Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). Nakajima A, etal., J Bone Miner Res. 2002 Nov;17(11):2038-47.
51. Effect of a specific endothelin A receptor antagonist on murine lupus nephritis. Nakamura T, etal., Kidney Int. 1995 Feb;47(2):481-9.
52. Absence of association between COL1A1 polymorphisms and high myopia in the Japanese population. Nakanishi H, etal., Invest Ophthalmol Vis Sci. 2009 Feb;50(2):544-50. doi: 10.1167/iovs.08-2425. Epub 2008 Oct 3.
53. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Ning W, etal., Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14895-900. Epub 2004 Oct 5.
54. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
55. Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Ota T, etal., Gastroenterology. 2007 Jan;132(1):282-93. Epub 2006 Oct 12.
56. Novel COL1A1 mutation (G559C) [correction of G599C] associated with mild osteogenesis imperfecta and dentinogenesis imperfecta. Pallos D, etal., Arch Oral Biol. 2001 May;46(5):459-70.
57. A novel splicing mutation in COL1A1 gene caused type I osteogenesis imperfecta in a Chinese family. Peng H, etal., Gene. 2012 Jul 10;502(2):168-71. doi: 10.1016/j.gene.2012.04.023. Epub 2012 Apr 29.
58. Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral. Pereira R, etal., J Clin Invest 1993 Feb;91(2):709-16.
59. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Pereira RF, etal., Proc Natl Acad Sci U S A 1998 Feb 3;95(3):1142-7.
60. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
61. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
62. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
63. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Popov Y, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi: 10.1152/ajpgi.00394.2009. Epub 2010 Jan 7.
64. Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis. Reich HN, etal., J Mol Diagn. 2011 Mar;13(2):143-51.
65. Mouse MP Annotation Import Pipeline RGD automated import pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. Schroder A, etal., J Urol. 2013 Jun;189(6):2377-84. doi: 10.1016/j.juro.2012.12.110. Epub 2013 Jan 9.
69. Involvement of renal corpuscle microRNA expression on epithelial-to-mesenchymal transition in maternal low protein diet in adult programmed rats. Sene Lde B, etal., PLoS One. 2013 Aug 19;8(8):e71310. doi: 10.1371/journal.pone.0071310. eCollection 2013.
70. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
71. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Staels B, etal., Hepatology. 2013 Dec;58(6):1941-52. doi: 10.1002/hep.26461. Epub 2013 Oct 29.
72. Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice. Sullivan BP, etal., Toxicol Sci. 2012 Mar;126(1):267-74. doi: 10.1093/toxsci/kfr311. Epub 2011 Nov 17.
73. Expanding the phenotypic spectrum of Caffey disease. Suphapeetiporn K, etal., Clin Genet. 2007 Mar;71(3):280-4.
74. Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. Suzuki A, etal., Biochem Biophys Res Commun. 2004 May 7;317(3):887-92.
75. Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host. Szalay G, etal., Circ Res. 2009 Apr 10;104(7):851-9. doi: 10.1161/CIRCRESAHA.109.193805. Epub 2009 Feb 26.
76. Thalidomide prevents bleomycin-induced pulmonary fibrosis in mice. Tabata C, etal., J Immunol. 2007 Jul 1;179(1):708-14.
77. Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis. Tao H, etal., Cardiovasc Pathol. 2016 Sep-Oct;25(5):381-9. doi: 10.1016/j.carpath.2016.05.005. Epub 2016 Jun 2.
78. Novel ActRIIB ligand trap increases muscle mass and improves bone geometry in a mouse model of severe osteogenesis imperfecta. Tauer JT and Rauch F, Bone. 2019 Nov;128:115036. doi: 10.1016/j.bone.2019.115036. Epub 2019 Aug 13.
79. A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats. Terashima H, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F792-801. Epub 2010 Jul 21.
80. Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits. Tilkeridis C, etal., J Med Genet. 2005 Jul;42(7):e44.
81. Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients. Truong LH, etal., Arthritis Res Ther. 2006;8(6):R188.
82. Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women. Tural S, etal., Gene. 2013 Feb 15;515(1):167-72. doi: 10.1016/j.gene.2012.10.041. Epub 2012 Nov 5.
83. Complete COL1A1 allele deletions in osteogenesis imperfecta. van Dijk FS, etal., Genet Med. 2010 Nov;12(11):736-41. doi: 10.1097/GIM.0b013e3181f01617.
84. Decreased hernia recurrence using autologous platelet-rich plasma (PRP) with Strattice mesh in a rodent ventral hernia model. Van Eps J, etal., Surg Endosc. 2015 Nov 17.
85. Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing. Videman T, etal., Arthritis Rheum. 2009 Feb;60(2):470-81.
86. Effects of angiotensin II intervention on MMP-2, MMP-9, TIMP-1, and collagen expression in rats with pulmonary hypertension. Wang XM, etal., Genet Mol Res. 2015 Mar 6;14(1):1707-17. doi: 10.4238/2015.March.6.17.
87. [Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis] Wang XN, etal., Zhong Xi Yi Jie He Xue Bao. 2005 Jul;3(4):286-9.
88. Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression. Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329.
89. A novel RNA-splicing mutation in COL1A1 gene causing osteogenesis imperfecta type I in a Chinese family. Xia XY, etal., Clin Chim Acta. 2008 Dec;398(1-2):148-51. doi: 10.1016/j.cca.2008.07.030. Epub 2008 Aug 5.
90. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. Xian S, etal., Mol Med Rep. 2021 Jan;23(1):10. doi: 10.3892/mmr.2020.11648. Epub 2020 Nov 12.
91. microRNA-29b Mediates the Antifibrotic Effect of Tanshinone IIA in Postinfarct Cardiac Remodeling. Yang F, etal., J Cardiovasc Pharmacol. 2015 May;65(5):456-64. doi: 10.1097/FJC.0000000000000214.
92. Mutation characteristics in type I collagen genes in Chinese patients with osteogenesis imperfecta. Yang Z, etal., Genet Mol Res. 2011 Feb 8;10(1):177-85. doi: 10.4238/vol10-1gmr984.
93. Wnt pathway-related gene expression in inflammatory bowel disease. You J, etal., Dig Dis Sci. 2008 Apr;53(4):1013-9. Epub 2007 Oct 16.
94. In situ hybridization analysis of rat lung alpha 1(I) and alpha 2(I) collagen gene expression in pulmonary fibrosis induced by endotracheal bleomycin injection. Zhang K, etal., Lab Invest. 1994 Feb;70(2):192-202.
95. Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway. Zhang L, etal., J Mol Histol. 2020 Feb;51(1):77-87. doi: 10.1007/s10735-020-09859-8. Epub 2020 Feb 17.
96. Gene expression profiling in glomeruli of diabetic nephropathy rat. Zhang Q, etal., Exp Biol Med (Maywood). 2012 Aug;237(8):903-11. doi: 10.1258/ebm.2012.012032. Epub 2012 Aug 17.
97. Lipopolysaccharide induced activin A-follistatin imbalance affects cardiac fibrosis. Zhang WQ, etal., Chin Med J (Engl). 2012 Jun;125(12):2205-12.
98. Experimental murine myopia induces collagen type Ialpha1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera. Zhou X, etal., Mol Vis. 2012;18:1312-24. Epub 2012 May 30.
99. Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. Zou M, etal., Oncotarget. 2017 Jul 5;8(47):81825-81837. doi: 10.18632/oncotarget.18998. eCollection 2017 Oct 10.
Additional References at PubMed
PMID:1524678   PMID:1537326   PMID:1618338   PMID:1744131   PMID:1761577   PMID:1794049   PMID:1879336   PMID:1879363   PMID:1916105   PMID:2054384   PMID:2097519   PMID:2209468  
PMID:2387241   PMID:2402497   PMID:2450280   PMID:2567264   PMID:2824282   PMID:3116273   PMID:3172346   PMID:3340560   PMID:3467899   PMID:3502995   PMID:3841523   PMID:3960120  
PMID:6219867   PMID:6298597   PMID:6308457   PMID:6324198   PMID:6825169   PMID:6857446   PMID:7237558   PMID:7573384   PMID:7574488   PMID:7589890   PMID:7593259   PMID:7598807  
PMID:7629088   PMID:7704020   PMID:7754814   PMID:7775585   PMID:7790374   PMID:7813775   PMID:7873289   PMID:7919967   PMID:7924138   PMID:7937772   PMID:7964480   PMID:7964554  
PMID:8018053   PMID:8022775   PMID:8026631   PMID:8065328   PMID:8096090   PMID:8096378   PMID:8097422   PMID:8106463   PMID:8113105   PMID:8130375   PMID:8146196   PMID:8163675  
PMID:8204907   PMID:8240330   PMID:8268229   PMID:8328969   PMID:8369292   PMID:8373351   PMID:8408623   PMID:8449498   PMID:8524319   PMID:8535610   PMID:8563024   PMID:8569173  
PMID:8577708   PMID:8619363   PMID:8683100   PMID:8686743   PMID:8702912   PMID:8747929   PMID:8783182   PMID:8785585   PMID:8806434   PMID:8851045   PMID:8853993   PMID:8900172  
PMID:8906420   PMID:8944545   PMID:8952549   PMID:8984825   PMID:8986815   PMID:8988177   PMID:9030551   PMID:9101290   PMID:9164858   PMID:9213002   PMID:9286593   PMID:9390635  
PMID:9415455   PMID:9426396   PMID:9556061   PMID:9584177   PMID:9614124   PMID:9664687   PMID:9755172   PMID:9796779   PMID:9801322   PMID:9832566   PMID:9853961   PMID:9880236  
PMID:9880238   PMID:9887097   PMID:9922384   PMID:10021460   PMID:10072783   PMID:10213384   PMID:10349636   PMID:10357935   PMID:10429947   PMID:10473125   PMID:10545953   PMID:10608859  
PMID:10633870   PMID:10780854   PMID:10878613   PMID:10922068   PMID:10970885   PMID:10995453   PMID:11032854   PMID:11042159   PMID:11076861   PMID:11124519   PMID:11180952   PMID:11217851  
PMID:11230154   PMID:11358497   PMID:11566859   PMID:11606467   PMID:11685542   PMID:11702786   PMID:11705995   PMID:11713230   PMID:11784073   PMID:11792318   PMID:11804779   PMID:11813254  
PMID:11839810   PMID:11882659   PMID:11900462   PMID:11934855   PMID:11969258   PMID:12192060   PMID:12434152   PMID:12438746   PMID:12466851   PMID:12477932   PMID:12524684   PMID:12540776  
PMID:12571105   PMID:12592609   PMID:12657595   PMID:12755333   PMID:12756187   PMID:12807961   PMID:12837285   PMID:12855673   PMID:12878728   PMID:12933685   PMID:14499643   PMID:14559231  
PMID:14614858   PMID:14617570   PMID:14627958   PMID:14630726   PMID:14660441   PMID:14688224   PMID:14758483   PMID:14980515   PMID:15005849   PMID:15022335   PMID:15030764   PMID:15039145  
PMID:15042706   PMID:15107406   PMID:15121863   PMID:15162503   PMID:15175265   PMID:15207743   PMID:15246109   PMID:15383546   PMID:15451791   PMID:15456762   PMID:15489334   PMID:15536133  
PMID:15537544   PMID:15548578   PMID:15576404   PMID:15578713   PMID:15653467   PMID:15659034   PMID:15689378   PMID:15741244   PMID:15781699   PMID:15782199   PMID:15866163   PMID:15866164  
PMID:15866165   PMID:15882627   PMID:15963767   PMID:15975938   PMID:15993878   PMID:16007336   PMID:16049333   PMID:16109715   PMID:16141072   PMID:16141073   PMID:16183868   PMID:16192629  
PMID:16311053   PMID:16326388   PMID:16356873   PMID:16368934   PMID:16400644   PMID:16446138   PMID:16452166   PMID:16537906   PMID:16556917   PMID:16602821   PMID:16751105   PMID:16813523  
PMID:16815385   PMID:16971509   PMID:17014841   PMID:17018525   PMID:17024418   PMID:17029294   PMID:17050674   PMID:17099713   PMID:17135260   PMID:17141628   PMID:17142326   PMID:17143598  
PMID:17177285   PMID:17194222   PMID:17204263   PMID:17330941   PMID:17336904   PMID:17430895   PMID:17440987   PMID:17449229   PMID:17453912   PMID:17510195   PMID:17510210   PMID:17544391  
PMID:17548469   PMID:17554301   PMID:17595534   PMID:17654495   PMID:17662583   PMID:17705049   PMID:17764670   PMID:17881772   PMID:17950069   PMID:17980593   PMID:17986615   PMID:18025304  
PMID:18052755   PMID:18056424   PMID:18061568   PMID:18067859   PMID:18211825   PMID:18234177   PMID:18285337   PMID:18297083   PMID:18299419   PMID:18313657   PMID:18371336   PMID:18414679  
PMID:18424556   PMID:18442412   PMID:18487609   PMID:18554416   PMID:18556780   PMID:18559979   PMID:18606782   PMID:18612084   PMID:18639653   PMID:18667463   PMID:18684089   PMID:18684439  
PMID:18759297   PMID:18779865   PMID:18799693   PMID:18816857   PMID:18819932   PMID:18832069   PMID:18973680   PMID:19008372   PMID:19041753   PMID:19060879   PMID:19153555   PMID:19162043  
PMID:19185060   PMID:19189321   PMID:19191514   PMID:19196966   PMID:19197242   PMID:19217425   PMID:19224984   PMID:19235716   PMID:19235726   PMID:19304887   PMID:19307728   PMID:19356224  
PMID:19357194   PMID:19378260   PMID:19389359   PMID:19414862   PMID:19418583   PMID:19419310   PMID:19423573   PMID:19458888   PMID:19469869   PMID:19560165   PMID:19590010   PMID:19605502  
PMID:19653325   PMID:19690389   PMID:19734317   PMID:19737917   PMID:19762422   PMID:19820996   PMID:19853894   PMID:19933329   PMID:19948490   PMID:20010698   PMID:20010831   PMID:20010832  
PMID:20025746   PMID:20059955   PMID:20059976   PMID:20080568   PMID:20085738   PMID:20142103   PMID:20179096   PMID:20193675   PMID:20200944   PMID:20218816   PMID:20223936   PMID:20237296  
PMID:20368361   PMID:20430747   PMID:20440000   PMID:20458143   PMID:20463013   PMID:20498044   PMID:20499347   PMID:20512147   PMID:20515681   PMID:20541046   PMID:20548288   PMID:20551517  
PMID:20616797   PMID:20654714   PMID:20696843   PMID:20708079   PMID:20830701   PMID:20852040   PMID:20858856   PMID:20864640   PMID:20877012   PMID:20881014   PMID:20881139   PMID:20944625  
PMID:20952506   PMID:20970343   PMID:21067603   PMID:21095332   PMID:21148188   PMID:21150166   PMID:21170031   PMID:21173153   PMID:21185280   PMID:21193410   PMID:21289056   PMID:21308778  
PMID:21351141   PMID:21364421   PMID:21367821   PMID:21376238   PMID:21425413   PMID:21447555   PMID:21458673   PMID:21467034   PMID:21478499   PMID:21482754   PMID:21494559   PMID:21511879  
PMID:21512159   PMID:21557453   PMID:21571217   PMID:21606205   PMID:21613984   PMID:21625049   PMID:21643937   PMID:21659474   PMID:21677750   PMID:21707943   PMID:21718087   PMID:21746880  
PMID:21775118   PMID:21779369   PMID:21788370   PMID:21807129   PMID:21873635   PMID:21907137   PMID:21907695   PMID:21911092   PMID:21934140   PMID:21939397   PMID:21944754   PMID:21949390  
PMID:21962509   PMID:21979435   PMID:21987724   PMID:21989989   PMID:22020333   PMID:22022457   PMID:22093826   PMID:22096492   PMID:22113163   PMID:22152476   PMID:22155508   PMID:22158707  
PMID:22159717   PMID:22171010   PMID:22194864   PMID:22206865   PMID:22207275   PMID:22232675   PMID:22301776   PMID:22308401   PMID:22318228   PMID:22325288   PMID:22342532   PMID:22354840  
PMID:22363786   PMID:22427063   PMID:22432025   PMID:22434869   PMID:22437311   PMID:22438570   PMID:22464334   PMID:22469981   PMID:22492985   PMID:22493482   PMID:22508542   PMID:22511244  
PMID:22546693   PMID:22560297   PMID:22561987   PMID:22564414   PMID:22573318   PMID:22573622   PMID:22589248   PMID:22589746   PMID:22669820   PMID:22673621   PMID:22682244   PMID:22687751  
PMID:22791294   PMID:22843502   PMID:22843703   PMID:22869368   PMID:22869756   PMID:22883231   PMID:22885149   PMID:22886599   PMID:22902753   PMID:23022097   PMID:23023126   PMID:23034633  
PMID:23064687   PMID:23133399   PMID:23143395   PMID:23149718   PMID:23188710   PMID:23222438   PMID:23237810   PMID:23243279   PMID:23254193   PMID:23273220   PMID:23274346   PMID:23281395  
PMID:23311625   PMID:23322385   PMID:23322734   PMID:23325759   PMID:23326559   PMID:23333738   PMID:23371561   PMID:23376422   PMID:23377784   PMID:23378032   PMID:23423975   PMID:23452852  
PMID:23533084   PMID:23544078   PMID:23567158   PMID:23583181   PMID:23604553   PMID:23615282   PMID:23635313   PMID:23650387   PMID:23653374   PMID:23658023   PMID:23666760   PMID:23680150  
PMID:23680479   PMID:23684612   PMID:23684984   PMID:23703832   PMID:23715551   PMID:23720048   PMID:23762363   PMID:23774443   PMID:23791176   PMID:23791530   PMID:23824573   PMID:23827711  
PMID:23827712   PMID:23830207   PMID:23848320   PMID:23863479   PMID:23895934   PMID:23907538   PMID:23918805   PMID:23937658   PMID:23946498   PMID:23957394   PMID:23966707   PMID:23991045  
PMID:24006456   PMID:24012677   PMID:24019537   PMID:24022296   PMID:24029918   PMID:24046351   PMID:24046454   PMID:24114659   PMID:24192035   PMID:24209617   PMID:24209762   PMID:24248941  
PMID:24284212   PMID:24336202   PMID:24349142   PMID:24361262   PMID:24385915   PMID:24401838   PMID:24411941   PMID:24419316   PMID:24440599   PMID:24446491   PMID:24451543   PMID:24489749  
PMID:24491691   PMID:24497554   PMID:24529372   PMID:24563484   PMID:24581491   PMID:24583261   PMID:24589777   PMID:24604556   PMID:24711581   PMID:24715455   PMID:24732380   PMID:24743337  
PMID:24743474   PMID:24776885   PMID:24805232   PMID:24805236   PMID:24825348   PMID:24840544   PMID:24906150   PMID:24927920   PMID:24930703   PMID:24939936   PMID:24952082   PMID:24952428  
PMID:24952961   PMID:24979572   PMID:24988319   PMID:24996922   PMID:25035393   PMID:25043045   PMID:25043474   PMID:25068460   PMID:25086405   PMID:25087979   PMID:25090092   PMID:25092332  
PMID:25159328   PMID:25171833   PMID:25173427   PMID:25242322   PMID:25249460   PMID:25262205   PMID:25262822   PMID:25281715   PMID:25296256   PMID:25300579   PMID:25310984   PMID:25344368  
PMID:25363458   PMID:25382630   PMID:25395457   PMID:25395662   PMID:25411251   PMID:25422423   PMID:25428889   PMID:25432534   PMID:25433207   PMID:25437874   PMID:25445450   PMID:25453901  
PMID:25456127   PMID:25464126   PMID:25527076   PMID:25547114   PMID:25564625   PMID:25572963   PMID:25575822   PMID:25605327   PMID:25615642   PMID:25655194   PMID:25689619   PMID:25690852  
PMID:25691658   PMID:25695629   PMID:25715398   PMID:25734811   PMID:25736226   PMID:25746793   PMID:25774828   PMID:25775525   PMID:25808752   PMID:25812847   PMID:25843629   PMID:25848867  
PMID:25865501   PMID:25866973   PMID:25886697   PMID:25919951   PMID:25921090   PMID:25956904   PMID:25965570   PMID:25977369   PMID:25978185   PMID:25985393   PMID:25987251   PMID:25987256  
PMID:25988972   PMID:26020233   PMID:26051322   PMID:26058078   PMID:26062940   PMID:26091037   PMID:26091038   PMID:26094741   PMID:26096209   PMID:26100884   PMID:26134413   PMID:26139524  
PMID:26140606   PMID:26192994   PMID:26222436   PMID:26244796   PMID:26258302   PMID:26264579   PMID:26277094   PMID:26283861   PMID:26362410   PMID:26362633   PMID:26376991   PMID:26378152  
PMID:26383724   PMID:26390284   PMID:26395480   PMID:26411367   PMID:26438359   PMID:26439301   PMID:26445246   PMID:26446156   PMID:26447190   PMID:26494538   PMID:26498761   PMID:26511924  
PMID:26551465   PMID:26553654   PMID:26642357   PMID:26673327   PMID:26681395   PMID:26701347   PMID:26729896   PMID:26731471   PMID:26739452   PMID:26769006   PMID:26794256   PMID:26801741  
PMID:26808549   PMID:26821812   PMID:26890219   PMID:26898884   PMID:26899202   PMID:26909318   PMID:26910059   PMID:26924503   PMID:26925839   PMID: