COL1A1 (collagen type I alpha 1 chain) - Rat Genome Database

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Gene: COL1A1 (collagen type I alpha 1 chain) Pan paniscus
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Symbol: COL1A1
Name: collagen type I alpha 1 chain
RGD ID: 11940872
Description: ENCODES a protein that exhibits extracellular matrix structural constituent (ortholog); identical protein binding (ortholog); platelet-derived growth factor binding (ortholog); INVOLVED IN blood vessel development (ortholog); bone trabecula formation (ortholog); cartilage development involved in endochondral bone morphogenesis (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH aggressive periodontitis (ortholog); alcoholic hepatitis (ortholog); aortic valve insufficiency (ortholog); FOUND IN collagen trimer (ortholog); collagen type I trimer (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: collagen alpha-1(I) chain; LOW QUALITY PROTEIN: collagen alpha-1(I) chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11749,149,277 - 49,166,833 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,150,677 - 49,166,677 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01744,274,349 - 44,291,764 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
aggressive periodontitis  (ISO)
alcoholic hepatitis  (ISO)
aortic valve insufficiency  (ISO)
Arteriovenous Fistula  (ISO)
autoimmune disease  (ISO)
beta thalassemia  (ISO)
Bisphosphonate-Associated Osteonecrosis of the Jaw  (ISO)
bladder neck obstruction  (ISO)
Bone Fractures  (ISO)
Caffey disease  (ISO)
calcinosis  (ISO)
Cardiac Fibrosis  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pancreatitis  (ISO)
Combined Osteogenesis Imperfecta and Ehlers-Danlos Syndrome 1  (ISO)
connective tissue disease  (ISO)
Contracture  (ISO)
cutaneous leishmaniasis  (ISO)
degenerative disc disease  (ISO)
dentinogenesis imperfecta  (ISO)
dermatofibrosarcoma protuberans  (ISO)
Diabetic Nephropathies  (ISO)
Dissecting Aneurysm  (ISO)
Ehlers-Danlos syndrome  (ISO)
Ehlers-Danlos syndrome arthrochalasia type 1  (ISO)
Ehlers-Danlos syndrome arthrochalasia type 2  (ISO)
Ehlers-Danlos syndrome cardiac valvular type  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
Ehlers-Danlos Syndrome Type 7  (ISO)
end stage renal disease  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
Femoral Fractures  (ISO)
Fibrosis  (ISO)
Fractures, Multiple  (ISO)
genetic disease  (ISO)
heart valve disease  (ISO)
hemorrhagic disease  (ISO)
Hernia, Ventral  (ISO)
High Myopia  (ISO)
Human Viral Hepatitis  (ISO)
Hypertelorism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
Intervertebral Disc Disease  (ISO)
Joint Instability  (ISO)
Keloid  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lipodermatosclerosis  (ISO)
liver benign neoplasm  (ISO)
liver cirrhosis  (ISO)
lupus nephritis  (ISO)
Metabolic Bone Diseases  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
myopia  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
ocular hypertension  (ISO)
open-angle glaucoma  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
Osteoarthritis, Hip  (ISO)
osteogenesis imperfecta  (ISO)
osteogenesis imperfecta type 1  (ISO)
osteogenesis imperfecta type 2  (ISO)
osteogenesis imperfecta type 2C  (ISO)
osteogenesis imperfecta type 3  (ISO)
osteogenesis imperfecta type 4  (ISO)
osteoporosis  (ISO)
otosclerosis  (ISO)
Postmenopausal Osteoporosis  (ISO)
primary biliary cholangitis  (ISO)
prostate cancer  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Spontaneous Abortions  (ISO)
systemic scleroderma  (ISO)
Tendon Injuries  (ISO)
thoracic aortic aneurysm  (ISO)
Trachomatous Trichiasis  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (ISO)
bone trabecula formation  (ISO)
cartilage development involved in endochondral bone morphogenesis  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to fluoride  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin E  (ISO)
collagen biosynthetic process  (ISO)
collagen fibril organization  (ISO)
collagen-activated tyrosine kinase receptor signaling pathway  (ISO)
embryonic skeletal system development  (ISO)
endochondral ossification  (ISO)
face morphogenesis  (ISO)
intramembranous ossification  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein localization to nucleus  (ISO)
protein transport  (ISO)
response to cAMP  (ISO)
response to corticosteroid  (ISO)
response to estradiol  (ISO)
response to fluoride  (ISO)
response to hydrogen peroxide  (ISO)
response to hyperoxia  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (ISO)
skeletal system development  (ISO)
skeletal system morphogenesis  (ISO)
skin development  (ISO)
skin morphogenesis  (ISO)
tooth eruption  (ISO)
tooth mineralization  (ISO)
visual perception  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
COL1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11749,149,277 - 49,166,833 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,150,677 - 49,166,677 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01744,274,349 - 44,291,764 (-)NCBIMhudiblu_PPA_v0panPan3
COL1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1750,184,101 - 50,201,632 (-)EnsemblGRCh38hg38GRCh38
GRCh381750,184,096 - 50,201,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371748,261,462 - 48,278,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,616,456 - 45,633,999 (-)NCBINCBI36hg18NCBI36
Build 341745,616,455 - 45,633,992NCBI
Celera1744,722,303 - 44,739,829 (-)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1743,630,129 - 43,647,463 (-)NCBIHuRef
CHM1_11748,325,754 - 48,343,284 (-)NCBICHM1_1
Col1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,827,050 - 94,843,868 (+)NCBIGRCm39mm39
GRCm39 Ensembl1194,827,050 - 94,843,868 (+)Ensembl
GRCm381194,936,224 - 94,953,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,936,224 - 94,953,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv371194,797,584 - 94,813,181 (+)NCBIGRCm37mm9NCBIm37
MGSCv361194,752,360 - 94,767,957 (+)NCBImm8
Celera11104,549,617 - 104,565,301 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Col1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21079,883,622 - 79,900,625 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1082,745,801 - 82,762,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01082,745,801 - 82,762,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01082,563,434 - 82,580,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,622,438 - 83,639,368 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11083,636,918 - 83,653,733 (+)NCBI
Celera1078,658,450 - 78,675,438 (+)NCBICelera
Cytogenetic Map10q26NCBI
Col1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,468,290 - 11,483,073 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,468,156 - 11,484,410 (+)NCBIChiLan1.0ChiLan1.0
COL1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,183,852 - 26,199,927 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,183,852 - 26,199,927 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,576,913 - 25,592,983 (-)NCBI
ROS_Cfam_1.0926,978,359 - 26,994,434 (-)NCBI
UMICH_Zoey_3.1925,746,094 - 25,762,176 (-)NCBI
UNSW_CanFamBas_1.0926,004,757 - 26,020,835 (-)NCBI
UU_Cfam_GSD_1.0926,134,702 - 26,150,789 (-)NCBI
Col1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,609,297 - 25,626,616 (-)NCBI
SpeTri2.0NW_00493649011,448,552 - 11,465,836 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COL1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,379,090 - 26,397,003 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,379,087 - 26,397,180 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
COL1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,134,648 - 43,152,313 (+)NCBI
ChlSab1.1 Ensembl1643,134,779 - 43,150,930 (+)Ensembl
Vero_WHO_p1.0NW_02366607713,850,099 - 13,867,746 (+)NCBI
Col1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247956,167,504 - 6,183,208 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003817459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000002118   ⟹   ENSPPAP00000000478
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1749,150,677 - 49,166,677 (-)Ensembl
RefSeq Acc Id: XM_003817459   ⟹   XP_003817507
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11749,149,277 - 49,166,833 (-)NCBI
Mhudiblu_PPA_v01744,274,349 - 44,291,764 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003817507 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003817507   ⟸   XM_003817459
- Sequence:
RefSeq Acc Id: ENSPPAP00000000478   ⟸   ENSPPAT00000002118


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000001294 Ensembl, ENTREZGENE
NCBI Gene COL1A1 ENTREZGENE