RGD Reference Report - Gene expression in distinct regions of rat tendons in response to jump training combined with anabolic androgenic steroid administration. - Rat Genome Database

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Gene expression in distinct regions of rat tendons in response to jump training combined with anabolic androgenic steroid administration.

Authors: Marqueti, RC  Heinemeier, KM  Durigan, JL  De Andrade Perez, SE  Schjerling, P  Kjaer, M  Carvalho, HF  Selistre-de-Araujo, HS 
Citation: Marqueti RC, etal., Eur J Appl Physiol. 2012 Apr;112(4):1505-15. doi: 10.1007/s00421-011-2114-x. Epub 2011 Aug 14.
RGD ID: 8552703
Pubmed: PMID:21842416   (View Abstract at PubMed)
DOI: DOI:10.1007/s00421-011-2114-x   (Journal Full-text)

The aim of this study was to evaluate the expression of key genes responsible for tendon remodeling of the proximal and distal regions of calcaneal tendon (CT), intermediate and distal region of superficial flexor tendon (SFT) and proximal, intermediate and distal region of deep flexor tendon (DFT) submitted to 7 weeks of jumping water load exercise in combination with AAS administration. Wistar male rats were grouped as follows: sedentary (S), trained (jumping water load exercise) (T), sedentary animals treated with AAS (5 mg/kg, twice a week) and animals treated with AAS and trained (AAST). mRNA levels of COL1A1, COL3A1, TIMP-1, TIMP-2, MMP-2, IGF-IEa, GAPDH, CTGF and TGF-beta-1 were evaluated by quantitative PCR. Our main results indicated that mRNA levels alter in different regions in each tendon of sedentary animals. The training did not alter the expression of COL1A1, COL3A, IGF-IEa and MMP-2 genes, while AAS administration or its combination with training reduced their expression. This study indicated that exercise did not alter the expression of collagen and related growth factors in different regions of rat tendon. Moreover, the pattern of gene expression was distinct in the different tendon regions of sedentary animals. Although, the RNA yield levels of CT, SFT and DFT were not distinct in each region, these regions possess not only the structural and biochemical difference, but also divergence in the expression of key genes involved in tendon adaptation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to steroid hormone  IEP 8552703nandrolone decanoateRGD 

Objects Annotated

Genes (Rattus norvegicus)
Col1a1  (collagen type I alpha 1 chain)


Additional Information