Prpf8 (pre-mRNA processing factor 8) - Rat Genome Database

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Gene: Prpf8 (pre-mRNA processing factor 8) Rattus norvegicus
Analyze
Symbol: Prpf8
Name: pre-mRNA processing factor 8
RGD ID: 1305467
Description: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; pre-mRNA intronic binding activity; and snRNA binding activity. Involved in cellular response to lipopolysaccharide and cellular response to tumor necrosis factor. Part of small nuclear ribonucleoprotein complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 13. Orthologous to human PRPF8 (pre-mRNA processing factor 8); PARTICIPATES IN retinitis pigmentosa pathway; spliceosome pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC287530; pre-mRNA-processing-splicing factor 8; PRP8 pre-mRNA processing factor 8 homolog; PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21060,331,494 - 60,354,606 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,331,494 - 60,354,606 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1064,978,414 - 65,001,760 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01064,483,841 - 64,507,188 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01059,946,410 - 59,969,757 (+)NCBIRnor_WKY
Rnor_6.01063,635,239 - 63,658,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,635,219 - 63,658,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,348,558 - 64,371,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,786,225 - 62,830,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,821,711 - 62,844,405 (+)NCBI
Celera1059,359,820 - 59,382,932 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A novel 40S multi-snRNP complex isolated from rat liver nuclei. Guialis A, etal., Nucleic Acids Res. 1991 Jan 25;19(2):287-96.
4. Lipopolysaccharide stimulates phosphorylation of eukaryotic initiation factor-4F in macrophages and tumor necrosis factor participates in this event. Haas DW, etal., Second Messengers Phosphoproteins. 1992-1993;14(3):163-71.
5. Mutations in the pre-mRNA splicing factor gene PRPC8 in autosomal dominant retinitis pigmentosa (RP13). McKie AB, etal., Hum Mol Genet. 2001 Jul 15;10(15):1555-62.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Structural analyses of the pre-mRNA splicing machinery. Zhang L, etal., Protein Sci. 2013 Jun;22(6):677-92. doi: 10.1002/pro.2266. Epub 2013 May 8.
Additional References at PubMed
PMID:11991638   PMID:12477932   PMID:19946888   PMID:20595234   PMID:22206666   PMID:22658674   PMID:22681889   PMID:22720776   PMID:23793891   PMID:24625528   PMID:28076346   PMID:28781166  
PMID:29301961   PMID:29361316   PMID:30315277  


Genomics

Comparative Map Data
Prpf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21060,331,494 - 60,354,606 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,331,494 - 60,354,606 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1064,978,414 - 65,001,760 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01064,483,841 - 64,507,188 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01059,946,410 - 59,969,757 (+)NCBIRnor_WKY
Rnor_6.01063,635,239 - 63,658,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,635,219 - 63,658,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,348,558 - 64,371,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,786,225 - 62,830,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,821,711 - 62,844,405 (+)NCBI
Celera1059,359,820 - 59,382,932 (+)NCBICelera
Cytogenetic Map10q24NCBI
PRPF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,650,629 - 1,684,867 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl171,650,629 - 1,684,867 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,553,923 - 1,588,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,500,673 - 1,534,926 (-)NCBINCBI36Build 36hg18NCBI36
Build 34171,500,673 - 1,534,850NCBI
Celera171,569,279 - 1,603,532 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,453,297 - 1,487,547 (-)NCBIHuRef
CHM1_1171,562,693 - 1,596,948 (-)NCBICHM1_1
T2T-CHM13v2.0171,539,419 - 1,573,657 (-)NCBIT2T-CHM13v2.0
Prpf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,377,603 - 75,400,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,377,642 - 75,400,275 (+)EnsemblGRCm39 Ensembl
GRCm381175,486,777 - 75,509,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,486,816 - 75,509,449 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,300,279 - 75,322,949 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,303,285 - 75,325,578 (+)NCBIMGSCv36mm8
Celera1182,995,186 - 83,017,855 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Prpf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,499,634 - 1,530,670 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,499,634 - 1,530,670 (+)NCBIChiLan1.0ChiLan1.0
PRPF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1171,532,579 - 1,565,254 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,532,579 - 1,565,254 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0171,635,991 - 1,669,703 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRPF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,797,882 - 45,827,365 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,797,959 - 45,828,071 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha944,948,795 - 44,978,151 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,624,977 - 46,654,363 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,624,983 - 46,654,304 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,395,072 - 45,424,429 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,689,610 - 45,718,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,744,054 - 45,773,421 (-)NCBIUU_Cfam_GSD_1.0
Prpf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560244,902,077 - 44,936,620 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,780,022 - 7,814,575 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365387,780,022 - 7,814,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRPF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,861,043 - 47,895,190 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,861,041 - 47,895,286 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,746,647 - 49,777,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRPF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,321,568 - 1,352,775 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl161,321,416 - 1,352,466 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605920,627,886 - 20,660,154 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prpf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,355,993 - 4,393,243 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,356,481 - 4,392,594 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prpf8
67 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:30
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000005016
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat

Markers in Region
RH127343  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q24UniSTS
RH132395  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21060,309,421 - 60,309,629 (+)MAPPERmRatBN7.2
Rnor_6.01062,301,975 - 62,302,182NCBIRnor6.0
Rnor_5.01062,016,025 - 62,016,232UniSTSRnor5.0
RGSC_v3.41062,785,106 - 62,785,313UniSTSRGSC3.4
Celera1059,337,859 - 59,338,066UniSTS
Cytogenetic Map10q24UniSTS
PRPF8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21060,351,480 - 60,352,626 (+)MAPPERmRatBN7.2
Rnor_6.01063,655,235 - 63,656,380NCBIRnor6.0
Rnor_5.01064,350,538 - 64,351,683UniSTSRnor5.0
RGSC_v3.41062,827,814 - 62,828,959UniSTSRGSC3.4
Celera1059,379,807 - 59,380,952UniSTS
Cytogenetic Map10q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005016   ⟹   ENSRNOP00000005016
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,331,494 - 60,354,606 (+)Ensembl
Rnor_6.0 Ensembl1063,635,251 - 63,658,360 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081813   ⟹   ENSRNOP00000073574
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,331,494 - 60,354,606 (+)Ensembl
Rnor_6.0 Ensembl1063,635,219 - 63,658,361 (+)Ensembl
RefSeq Acc Id: NM_001191590   ⟹   NP_001178519
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21060,331,494 - 60,354,606 (+)NCBI
Rnor_6.01063,635,251 - 63,658,360 (+)NCBI
Rnor_5.01064,348,558 - 64,371,667 (-)NCBI
Celera1059,359,820 - 59,382,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246892   ⟹   XP_006246954
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21060,331,499 - 60,354,600 (+)NCBI
Rnor_6.01063,635,239 - 63,658,360 (+)NCBI
Rnor_5.01064,348,558 - 64,371,667 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001178519   ⟸   NM_001191590
- UniProtKB: G3V6H2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246954   ⟸   XM_006246892
- Peptide Label: isoform X1
- UniProtKB: G3V6H2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005016   ⟸   ENSRNOT00000005016
RefSeq Acc Id: ENSRNOP00000073574   ⟸   ENSRNOT00000081813
Protein Domains
MPN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6H2-F1-model_v2 AlphaFold G3V6H2 1-2335 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697437
Promoter ID:EPDNEW_R7961
Type:initiation region
Name:Prpf8_1
Description:pre-mRNA processing factor 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01063,635,264 - 63,635,324EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305467 AgrOrtholog
BioCyc Gene G2FUF-24198 BioCyc
Ensembl Genes ENSRNOG00000003495 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005016 ENTREZGENE
  ENSRNOP00000005016.3 UniProtKB/TrEMBL
  ENSRNOP00000073574.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005016 ENTREZGENE
  ENSRNOT00000005016.6 UniProtKB/TrEMBL
  ENSRNOT00000081813.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.40 UniProtKB/TrEMBL
  3.30.420.230 UniProtKB/TrEMBL
  3.30.43.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7383791 IMAGE-MGC_LOAD
InterPro JAB1_Mov34_MPN_PAD1 UniProtKB/TrEMBL
  MPN UniProtKB/TrEMBL
  Pre-mRNA-splicing_factor-8 UniProtKB/TrEMBL
  PRO_C UniProtKB/TrEMBL
  PROCN UniProtKB/TrEMBL
  PRP8 UniProtKB/TrEMBL
  PRP8_domainIV UniProtKB/TrEMBL
  Prp8_domainIV_fingers UniProtKB/TrEMBL
  Prp8_domainIV_palm UniProtKB/TrEMBL
  Prp8_U5-snRNA-bd UniProtKB/TrEMBL
  Prp8_U5-snRNA-bd_sf UniProtKB/TrEMBL
  Prp8_U6-snRNA-bd UniProtKB/TrEMBL
  RNaseH-like_dom UniProtKB/TrEMBL
  RRM_spliceosomal_PrP8 UniProtKB/TrEMBL
KEGG Report rno:287530 UniProtKB/TrEMBL
MGC_CLONE MGC:116370 IMAGE-MGC_LOAD
NCBI Gene 287530 ENTREZGENE
PANTHER PTHR11140 UniProtKB/TrEMBL
Pfam JAB UniProtKB/TrEMBL
  PRO8NT UniProtKB/TrEMBL
  PROCN UniProtKB/TrEMBL
  PROCT UniProtKB/TrEMBL
  PRP8_domainIV UniProtKB/TrEMBL
  RRM_4 UniProtKB/TrEMBL
  U5_2-snRNA_bdg UniProtKB/TrEMBL
  U6-snRNA_bdg UniProtKB/TrEMBL
PhenoGen Prpf8 PhenoGen
PROSITE MPN UniProtKB/TrEMBL
SMART JAB_MPN UniProtKB/TrEMBL
Superfamily-SCOP SSF53098 UniProtKB/TrEMBL
UniProt A0A0G2K5V6_RAT UniProtKB/TrEMBL
  G3V6H2 ENTREZGENE, UniProtKB/TrEMBL
  Q4FZS3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Prpf8  pre-mRNA processing factor 8  Prpf8  PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Prpf8  PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)  Prpf8  pre-mRNA processing factor 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Prpf8  pre-mRNA processing factor 8  Prpf8_predicted  pre-mRNA processing factor 8 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Prpf8_predicted  pre-mRNA processing factor 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED