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Gene: Prpf8 (pre-mRNA processing factor 8) Rattus norvegicus
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Symbol: Prpf8
Name: pre-mRNA processing factor 8
Description: Predicted to have K63-linked polyubiquitin modification-dependent protein binding activity; RNA binding activity; and second spliceosomal transesterification activity. Involved in cellular response to lipopolysaccharide and cellular response to tumor necrosis factor. Localizes to the small nuclear ribonucleoprotein complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 13. Orthologous to human PRPF8 (pre-mRNA processing factor 8); PARTICIPATES IN retinitis pigmentosa pathway; spliceosome pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC287530; pre-mRNA-processing-splicing factor 8; PRP8 pre-mRNA processing factor 8 homolog; PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
Orthologs:
Homo sapiens (human) : PRPF8 (pre-mRNA processing factor 8)  HGNC  Alliance
Mus musculus (house mouse) : Prpf8 (pre-mRNA processing factor 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prpf8 (pre-mRNA processing factor 8)
Pan paniscus (bonobo/pygmy chimpanzee) : PRPF8 (pre-mRNA processing factor 8)
Canis lupus familiaris (dog) : PRPF8 (pre-mRNA processing factor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prpf8 (pre-mRNA processing factor 8)
Sus scrofa (pig) : PRPF8 (pre-mRNA processing factor 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01063,635,239 - 63,658,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01064,348,558 - 64,371,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,786,225 - 62,830,939 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11062,821,711 - 62,844,405 (+)NCBI
Celera1059,359,820 - 59,382,932 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Prpf8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305467
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-05-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.