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Gene: Ppp1r1b (protein phosphatase 1, regulatory (inhibitor) subunit 1B) Rattus norvegicus
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Symbol: Ppp1r1b
Name: protein phosphatase 1, regulatory (inhibitor) subunit 1B
Description: Exhibits dopamine receptor binding activity. Involved in several processes, including memory; response to cocaine; and response to nicotine. Localizes to the dendritic spine; glutamatergic synapse; and nucleus. Used to study mental depression; schizophrenia; status epilepticus; and withdrawal disorder. Biomarker of Huntington's disease. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B); PARTICIPATES IN dopamine signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-methyl-6-(phenylethynyl)pyridine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Darpp-32; Darpp32; dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine- and cAMP-regulated phosphoprotein DARPP-32; neuronal phosphoprotein DARPP-32; protein phosphatase 1 regulatory subunit 1B
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01086,303,727 - 86,312,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01086,100,811 - 86,109,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,121,889 - 87,131,587 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11087,143,530 - 87,145,100 (+)NCBI
Celera1082,095,371 - 82,102,275 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ppp1r1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621859
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.