Ppp1r1b (protein phosphatase 1, regulatory (inhibitor) subunit 1B) - Rat Genome Database

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Gene: Ppp1r1b (protein phosphatase 1, regulatory (inhibitor) subunit 1B) Rattus norvegicus
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Symbol: Ppp1r1b
Name: protein phosphatase 1, regulatory (inhibitor) subunit 1B
RGD ID: 621859
Description: Enables dopamine receptor binding activity. Involved in several processes, including memory; response to cocaine; and response to nicotine. Located in dendritic spine head; dendritic spine neck; and nucleus. Is active in glutamatergic synapse and postsynapse. Used to study mental depression; schizophrenia; status epilepticus; and withdrawal disorder. Biomarker of Huntington's disease. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B); PARTICIPATES IN dopamine signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Darpp-32; Darpp32; dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine- and cAMP-regulated phosphoprotein DARPP-32; neuronal phosphoprotein DARPP-32; protein phosphatase 1 regulatory subunit 1B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21083,347,731 - 83,356,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,347,731 - 83,356,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,292,064 - 88,301,109 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01087,790,149 - 87,799,194 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01083,182,801 - 83,191,846 (+)NCBIRnor_WKY
Rnor_6.01086,303,727 - 86,312,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,303,727 - 86,312,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,100,811 - 86,109,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,121,889 - 87,131,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,143,530 - 87,145,100 (+)NCBI
Celera1082,095,371 - 82,102,275 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-methoxytryptamine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clorgyline  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
corticosterone  (ISO)
corticotropin  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyhalothrin  (EXP)
DDE  (EXP)
deguelin  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
eticlopride(1+)  (ISO)
fluoxetine  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
graphite  (EXP)
haloperidol  (ISO)
indole-3-methanol  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
ketamine  (EXP)
ketanserin  (ISO)
linuron  (EXP)
LY294002  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
microcystin  (EXP)
morphine  (EXP,ISO)
nickel atom  (ISO)
oxidopamine  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
Pargyline  (ISO)
PCB138  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quinpirole  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
wortmannin  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neuronal replacement from endogenous precursors in the adult brain after stroke. Arvidsson A, etal., Nat Med. 2002 Sep;8(9):963-70. doi: 10.1038/nm747. Epub 2002 Aug 5.
2. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
3. DARPP-32 binds to tra2-beta1 and influences alternative splicing. Benderska N, etal., Biochim Biophys Acta. 2010 May-Jun;1799(5-6):448-53. doi: 10.1016/j.bbagrm.2010.01.003. Epub 2010 Jan 13.
4. Spatial distribution of DARPP-32 in dendritic spines. Blom H, etal., PLoS One. 2013 Sep 10;8(9):e75155. doi: 10.1371/journal.pone.0075155. eCollection 2013.
5. Sex differences in a transgenic rat model of Huntington's disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males. Bode FJ, etal., Hum Mol Genet. 2008 Sep 1;17(17):2595-609. doi: 10.1093/hmg/ddn159. Epub 2008 May 23.
6. Chronic hyperdopaminergic activity of schizophrenia is associated with increased ┬┐FosB levels and cdk-5 signaling in the nucleus accumbens. Cantrup R, etal., Neuroscience. 2012 Oct 11;222:124-35. doi: 10.1016/j.neuroscience.2012.07.027. Epub 2012 Jul 20.
7. Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32. Flores-Hernandez J, etal., J Neurophysiol 2002 Dec;88(6):3010-20.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Environmental enrichment alters nicotine-mediated locomotor sensitization and phosphorylation of DARPP-32 and CREB in rat prefrontal cortex. Gomez AM, etal., PLoS One. 2012;7(8):e44149. doi: 10.1371/journal.pone.0044149. Epub 2012 Aug 31.
10. Intrastriatal injection of ionomycin profoundly changes motor response to l-DOPA and its underlying molecular mechanisms. Han C, etal., Neuroscience. 2017 Jan 6;340:23-33. doi: 10.1016/j.neuroscience.2016.10.033. Epub 2016 Oct 19.
11. D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex. Hotte M, etal., Behav Brain Res. 2006 Jul 15;171(1):127-33. Epub 2006 May 9.
12. Nanotherapeutic approach for opiate addiction using DARPP-32 gene silencing in an animal model of opiate addiction. Ignatowski TA, etal., J Neuroimmune Pharmacol. 2015 Mar;10(1):136-52. doi: 10.1007/s11481-015-9585-1. Epub 2015 Jan 22.
13. DARPP-32 to quantify intracerebral hemorrhage-induced neuronal death in basal ganglia. Jin H, etal., Transl Stroke Res. 2013 Feb;4(1):130-4. doi: 10.1007/s12975-012-0232-3. Epub 2012 Dec 12.
14. Activation of Protein Kinases and Phosphatases Coupled to Glutamate Receptors Regulates the Phosphorylation State of DARPP32 at Threonine 75 After Repeated Exposure to Cocaine in the Rat Dorsal Striatum in a Ca2+-Dependent Manner. Kim J, etal., Int J Neuropsychopharmacol. 2015 Jul 4;18(12). pii: pyv075. doi: 10.1093/ijnp/pyv075.
15. Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression. Kunii Y, etal., Mol Psychiatry. 2014 Feb;19(2):192-9. doi: 10.1038/mp.2012.174. Epub 2013 Jan 8.
16. Decreased calcineurin and increased phosphothreonine-DARPP-32 in the striatum of rats behaviorally sensitized to methamphetamine. Lin XH, etal., Synapse 2002 Jun 1;44(3):181-7.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain. Rajput PS, etal., Neurosci Res. 2009 Sep;65(1):53-63. Epub 2009 May 22.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Proteomic analysis of alterations induced by perinatal hypoxic-ischemic brain injury. Rosenkranz K, etal., J Proteome Res. 2012 Dec 7;11(12):5794-803. doi: 10.1021/pr3005869. Epub 2012 Nov 27.
23. PPARa modulation of mesolimbic dopamine transmission rescues depression-related behaviors. Scheggi S, etal., Neuropharmacology. 2016 Nov;110(Pt A):251-259. doi: 10.1016/j.neuropharm.2016.07.024. Epub 2016 Jul 22.
24. [Research on expression and function of phosphorylated DARPP-32 on pentylenetetrazol-induced epilepsy model of rat]. Wang W, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Jun;31(3):637-41.
25. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:10669419   PMID:10807923   PMID:10854268   PMID:12409216   PMID:12477932   PMID:15287884   PMID:15515184   PMID:15536496   PMID:16020482   PMID:16428298   PMID:17008016   PMID:17010100  
PMID:17552992   PMID:17680995   PMID:17693396   PMID:17884291   PMID:17919461   PMID:17953657   PMID:18415674   PMID:18496528   PMID:18923023   PMID:18954090   PMID:18985320   PMID:19041388  
PMID:19474310   PMID:19782104   PMID:22116741   PMID:22301787   PMID:22462413   PMID:23250204   PMID:24978930   PMID:26119931   PMID:26463938   PMID:26639316   PMID:27998980   PMID:28257887  
PMID:30181585   PMID:33096475  


Genomics

Comparative Map Data
Ppp1r1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21083,347,731 - 83,356,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,347,731 - 83,356,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,292,064 - 88,301,109 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01087,790,149 - 87,799,194 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01083,182,801 - 83,191,846 (+)NCBIRnor_WKY
Rnor_6.01086,303,727 - 86,312,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,303,727 - 86,312,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,100,811 - 86,109,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,121,889 - 87,131,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,143,530 - 87,145,100 (+)NCBI
Celera1082,095,371 - 82,102,275 (+)NCBICelera
Cytogenetic Map10q31NCBI
PPP1R1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,626,707 - 39,636,624 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1739,626,740 - 39,636,626 (+)EnsemblGRCh38hg38GRCh38
GRCh371737,783,205 - 37,792,877 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,036,705 - 35,046,404 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,038,278 - 35,046,405NCBI
Celera1734,442,912 - 34,452,611 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,576,900 - 33,586,601 (+)NCBIHuRef
CHM1_11738,019,003 - 38,028,704 (+)NCBICHM1_1
T2T-CHM13v2.01740,490,522 - 40,500,194 (+)NCBIT2T-CHM13v2.0
Ppp1r1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,239,232 - 98,248,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,239,230 - 98,248,622 (+)EnsemblGRCm39 Ensembl
GRCm381198,348,406 - 98,357,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,348,404 - 98,357,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,210,052 - 98,219,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,164,828 - 98,173,885 (+)NCBIMGSCv36mm8
Celera11108,003,018 - 108,012,075 (+)NCBICelera
Cytogenetic Map11DNCBI
Ppp1r1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,389,533 - 14,394,169 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,378,186 - 14,394,910 (+)NCBIChiLan1.0ChiLan1.0
PPP1R1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11717,868,965 - 17,878,116 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,868,965 - 17,878,120 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01717,652,216 - 17,662,085 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PPP1R1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,838,198 - 22,847,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,838,576 - 22,848,142 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,310,605 - 22,319,844 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,631,857 - 23,641,339 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,631,868 - 23,641,337 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,404,434 - 22,413,913 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,665,479 - 22,674,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,790,595 - 22,800,065 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,243,802 - 22,252,420 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,822,213 - 14,831,349 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493649014,822,246 - 14,831,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,680,980 - 22,690,952 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,681,244 - 22,690,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,071,451 - 23,079,039 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,530,640 - 66,541,025 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,530,488 - 66,541,242 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,442,205 - 37,453,029 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,431,689 - 3,439,545 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,432,179 - 3,439,490 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r1b
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:82
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000037752
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat

Markers in Region
RH130479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,356,520 - 83,356,705 (+)MAPPERmRatBN7.2
Rnor_6.01086,312,516 - 86,312,700NCBIRnor6.0
Rnor_5.01086,109,600 - 86,109,784UniSTSRnor5.0
RGSC_v3.41087,131,335 - 87,131,519UniSTSRGSC3.4
RH 3.4 Map10809.6UniSTS
Cytogenetic Map10q31UniSTS
AU040756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,356,375 - 83,356,612 (+)MAPPERmRatBN7.2
Rnor_6.01086,312,371 - 86,312,607NCBIRnor6.0
Rnor_5.01086,109,455 - 86,109,691UniSTSRnor5.0
RGSC_v3.41087,131,190 - 87,131,426UniSTSRGSC3.4
Cytogenetic Map10q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 51 13 10 10
Low 31 13 11 1 11 3 3 13 22 28 1 3
Below cutoff 12 33 22 16 22 5 8 6 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037752   ⟹   ENSRNOP00000034614
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,347,731 - 83,356,767 (+)Ensembl
Rnor_6.0 Ensembl1086,303,727 - 86,312,762 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107401   ⟹   ENSRNOP00000077715
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,347,731 - 83,356,767 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109859   ⟹   ENSRNOP00000094600
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,353,422 - 83,356,775 (+)Ensembl
RefSeq Acc Id: NM_138521   ⟹   NP_612530
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21083,347,731 - 83,356,773 (+)NCBI
Rnor_6.01086,303,727 - 86,312,768 (+)NCBI
Rnor_5.01086,100,811 - 86,109,854 (+)NCBI
RGSC_v3.41087,121,889 - 87,131,587 (+)RGD
Celera1082,095,371 - 82,102,275 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247344   ⟹   XP_006247406
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21083,353,017 - 83,356,775 (+)NCBI
Rnor_6.01086,308,710 - 86,312,770 (+)NCBI
Rnor_5.01086,100,811 - 86,109,854 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_612530   ⟸   NM_138521
- UniProtKB: Q6J4I0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247406   ⟸   XM_006247344
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GL91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034614   ⟸   ENSRNOT00000037752
RefSeq Acc Id: ENSRNOP00000094600   ⟸   ENSRNOT00000109859
RefSeq Acc Id: ENSRNOP00000077715   ⟸   ENSRNOT00000107401

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6J4I0-F1-model_v2 AlphaFold Q6J4I0 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697657
Promoter ID:EPDNEW_R8181
Type:initiation region
Name:Ppp1r1b_1
Description:protein phosphatase 1, regulatory subunit 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01086,303,773 - 86,303,833EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621859 AgrOrtholog
BioCyc Gene G2FUF-23373 BioCyc
Ensembl Genes ENSRNOG00000028404 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034614 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000077715.1 UniProtKB/TrEMBL
  ENSRNOP00000094600 ENTREZGENE
  ENSRNOP00000094600.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037752 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000107401.1 UniProtKB/TrEMBL
  ENSRNOT00000109859 ENTREZGENE
  ENSRNOT00000109859.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110316 IMAGE-MGC_LOAD
InterPro DARPP-32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPP1R1A/B/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360616 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93809 IMAGE-MGC_LOAD
NCBI Gene 360616 ENTREZGENE
PANTHER PTHR15417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15417:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DARPP-32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r1b PhenoGen
UniProt A0A8I5YCG8_RAT UniProtKB/TrEMBL
  A0A8I6GL91 ENTREZGENE, UniProtKB/TrEMBL
  PPR1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Ppp1r1b  protein phosphatase 1, regulatory (inhibitor) subunit 1B      Symbol and Name updated 629477 APPROVED
2003-03-19 Ppp1r1b  protein phosphatase 1, regulatory (inhibitor) subunit 1B  Darpp32  neuronal phosphoprotein DARPP-32  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-08-07 Darpp32  neuronal phosphoprotein DARPP-32      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 32 kDa 724660
gene_regulation phosphorylated by cAMP-dependent PKA 724660