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Gene: Drd1 (dopamine receptor D1) Rattus norvegicus
Symbol: Drd1
Name: dopamine receptor D1
Description: Exhibits several functions, including G protein-coupled receptor binding activity; G-protein alpha-subunit binding activity; and enzyme binding activity. Involved in several processes, including learning; modulation of chemical synaptic transmission; and response to alkaloid. Localizes to several cellular components, including caveola; dendrite; and integral component of synaptic membrane. Used to study Parkinson's disease; end stage renal failure; and obesity. Biomarker of several diseases, including heroin dependence; hyperglycemia; neurodegenerative disease (multiple); tracheal stenosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1); PARTICIPATES IN dopamine signaling pathway; long term depression; long term potentiation; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: d(1A) dopamine receptor; D1a; dopamine D1 receptor; dopamine receptor 1A; dopamine receptor D1A; Dopamine-1A receptor; Drd-1; Drd1a
Homo sapiens (human) : DRD1 (dopamine receptor D1)  HGNC  Alliance
Mus musculus (house mouse) : Drd1 (dopamine receptor D1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Drd1 (dopamine receptor D1)
Pan paniscus (bonobo/pygmy chimpanzee) : DRD1 (dopamine receptor D1)
Canis lupus familiaris (dog) : DRD1 (dopamine receptor D1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Drd1 (dopamine receptor D1)
Sus scrofa (pig) : DRD1 (dopamine receptor D1)
Chlorocebus sabaeus (African green monkey) : DRD1 (dopamine receptor D1)
Heterocephalus glaber (naked mole-rat) : Drd1 (dopamine receptor D1)
more info ...
Allele / Splice: Drd1em1Ionsz   Drd1em1(iCre)Berke  
Genetic Models: LE-Drd1em1(iCre)Berke SD-Drd1em1Ionsz
Is Marker For: Strains:   SD   LE-Tg(Drd1-icre)3Ottc   LE-Tg(Drd2-iCre)1Ottc  
QTLs:   BpQTLcluster14  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01711,099,736 - 11,104,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,211,031 - 13,215,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,655,926 - 16,658,161 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11716,655,119 - 16,658,949 (+)NCBI
Celera1710,610,221 - 10,613,646 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Drd1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2518
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.