Drd1 (dopamine receptor D1) - Rat Genome Database

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Gene: Drd1 (dopamine receptor D1) Rattus norvegicus
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Symbol: Drd1
Name: dopamine receptor D1
RGD ID: 2518
Description: Enables several functions, including G protein-coupled receptor binding activity; G-protein alpha-subunit binding activity; and enzyme binding activity. Involved in several processes, including learning; modulation of chemical synaptic transmission; and regulation of protein phosphorylation. Located in several cellular components, including caveola; dendrite; and neuronal cell body. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Used to study Parkinson's disease; alcohol dependence; end stage renal disease; and obesity. Biomarker of several diseases, including heroin dependence; neurodegenerative disease (multiple); tracheal stenosis; traumatic brain injury; and ureteral obstruction. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1); PARTICIPATES IN dopamine signaling pathway; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: d(1A) dopamine receptor; D1a; dopamine D1 receptor; dopamine receptor 1A; dopamine receptor D1A; Dopamine-1A receptor; Drd-1; Drd1a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Drd1em1Ionsz   Drd1em1(iCre)Berke   Drd1m1Hubr  
Genetic Models: WI- Drd1m1Hubr LE-Drd1em1(iCre)Berke SD-Drd1em1Ionsz
Is Marker For: Strains:   SD   LE-Tg(Drd1-icre)3Ottc   LE-Tg(Drd2-iCre)1Ottc  
QTLs:   BpQTLcluster14  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,545,488 - 10,550,029 (+)NCBIGRCr8
mRatBN7.21710,540,440 - 10,544,971 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,540,558 - 10,545,002 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,555,287 - 10,558,713 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01712,089,485 - 12,092,911 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,551,719 - 10,555,145 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01711,099,736 - 11,104,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,211,031 - 13,215,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,655,926 - 16,658,161 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,655,119 - 16,658,949 (+)NCBI
Celera1710,610,221 - 10,613,646 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (EXP,ISO)
1-bromopropane  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amitriptyline  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
amoxapine  (ISO)
amphetamine  (EXP,ISO)
Anhydroecgonine methyl ester  (EXP)
apomorphine  (ISO)
aprindine  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
Bardoxolone methyl  (ISO)
benserazide  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Boldine  (EXP)
butanal  (ISO)
cadmium atom  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
diltiazem  (ISO)
dioxygen  (EXP)
dizocilpine maleate  (ISO)
domperidone  (ISO)
dopamine  (EXP,ISO)
etafenone  (ISO)
ethanol  (EXP,ISO)
ethyl acetate  (EXP)
eugenol  (EXP)
fenoldopam  (EXP)
flunarizine  (ISO)
flupenthixol  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gadolinium atom  (EXP)
gamma-aminobutyric acid  (EXP)
genistein  (EXP)
glyphosate  (EXP)
haloperidol  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoquinolines  (ISO)
lanthanum atom  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
loxapine  (EXP)
manganese(II) chloride  (EXP,ISO)
manidipine  (ISO)
melatonin  (ISO)
melevodopa  (EXP)
methamphetamine  (EXP,ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
mirtazapine  (EXP)
morphine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (ISO)
nicotine  (EXP,ISO)
Nonylphenol  (EXP)
olanzapine  (ISO)
ouabain  (EXP,ISO)
oxidopamine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
pentetrazol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
pergolide  (ISO)
phencyclidine  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
procymidone  (EXP)
Propiverine  (ISO)
quercetin  (EXP)
quinolinic acid  (EXP)
reserpine  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SCH 23390  (EXP,ISO)
serotonin  (EXP)
sertraline  (EXP)
simvastatin  (EXP)
SKF 38393  (EXP,ISO)
sodium arsenite  (EXP,ISO)
spiperone  (EXP)
sunitinib  (ISO)
terbufos  (ISO)
tetrahydropalmatine  (ISO)
tetraphene  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
XL147  (ISO)
zinc acetate  (EXP)
zinc dichloride  (EXP)
zinc sulfate  (EXP)
zonisamide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (IDA,IEA,IMP,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IBA)
adult walking behavior  (IEA,ISO)
associative learning  (IEP,IMP,ISO)
astrocyte development  (IEA,ISO)
behavioral fear response  (IEA,ISO)
behavioral response to cocaine  (IEA,IMP,ISO)
calcium-mediated signaling  (IDA)
cell migration  (ISO)
cellular response to catecholamine stimulus  (ISO)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cerebral cortex GABAergic interneuron migration  (IEA,ISO)
chemical synaptic transmission  (IBA)
conditioned taste aversion  (IEA,ISO)
D-glucose import  (IEA,ISO)
dentate gyrus development  (IEA,ISO)
dopamine transport  (IEA,ISO)
eating behavior  (IDA)
feeding behavior  (ISO)
G protein-coupled dopamine receptor signaling pathway  (ISO,TAS)
G protein-coupled receptor signaling pathway  (ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA,ISO)
G protein-coupled serotonin receptor signaling pathway  (IEA)
grooming behavior  (IDA,IEA,ISO)
habituation  (IEA,ISO)
hippocampus development  (ISO)
intracellular protein transport  (IMP)
learning  (ISO)
locomotory behavior  (IMP,ISO)
long-term synaptic depression  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
maternal behavior  (IEA,ISO)
mating behavior  (IEA,ISO)
memory  (IEA,ISO)
modification of postsynaptic structure  (IEA,ISO)
muscle contraction  (ISO)
negative regulation of cell migration  (IMP)
negative regulation of cellular response to hypoxia  (IMP)
negative regulation of circadian sleep/wake cycle, sleep  (IDA)
negative regulation of protein kinase activity  (IMP)
negative regulation of synaptic transmission  (IDA)
neuron migration  (ISO)
neuronal action potential  (IEA,ISO)
operant conditioning  (IEA,IMP,ISO)
orbitofrontal cortex development  (IEP)
peristalsis  (IEA,ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IEA,ISO)
positive regulation of feeding behavior  (IMP)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of membrane potential  (IMP)
positive regulation of neuron migration  (IEA,ISO)
positive regulation of protein phosphorylation  (IDA)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO)
postsynaptic modulation of chemical synaptic transmission  (EXP,IDA)
prepulse inhibition  (ISO)
presynaptic modulation of chemical synaptic transmission  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
protein phosphorylation  (ISO)
regulation of dopamine metabolic process  (IEA,ISO)
regulation of monoatomic ion transport  (IDA)
regulation of protein phosphorylation  (ISO)
regulation of vasoconstriction  (IMP)
response to activity  (IEP)
response to amino acid  (IEP)
response to amphetamine  (IEA,IEP,ISO)
response to cocaine  (ISO)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to food  (IEP)
response to nicotine  (IEP)
response to organic cyclic compound  (IEP)
response to retinoic acid  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (IEA,IEP,ISO)
sensitization  (IEA,ISO)
social behavior  (IMP)
startle response  (ISO)
striatum development  (IEA,IEP,ISO)
synapse assembly  (IEP)
synaptic transmission, dopaminergic  (IEA,ISO)
synaptic transmission, glutamatergic  (IEA,ISO)
temperature homeostasis  (IEA,ISO)
transmission of nerve impulse  (ISO)
vasodilation  (IEA)
visual learning  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway   (ISO)
dopamine signaling pathway  (IDA,ISO)
dopamine signaling pathway via D1 family of receptors  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
G protein mediated signaling pathway via Galphas family  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The role of dopamine in a model of trigeminovascular nociception. Akerman S and Goadsby PJ, J Pharmacol Exp Ther. 2005 Jul;314(1):162-9. Epub 2005 Mar 18.
2. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. Albrecht FE, etal., J Clin Invest 1996 May 15;97(10):2283-8.
3. Dopamine D1 receptor gene expression decreases in the nucleus accumbens upon long-term exposure to palatable food and differs depending on diet-induced obesity phenotype in rats. Alsio J, etal., Neuroscience. 2010 Dec 15;171(3):779-87. doi: 10.1016/j.neuroscience.2010.09.046. Epub 2010 Sep 26.
4. Correlation between genetic and cytogenetic maps of the rat. Andoh Y, etal., Mamm Genome 1998 Apr;9(4):287-93.
5. Striatal neurochemical changes in transgenic models of Huntington's disease. Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29.
6. Higher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats. Asghar M, etal., Am J Physiol Renal Physiol 2002 Aug;283(2):F350-5.
7. Acute sleep deprivation enhances avoidance learning and spatial memory and induces delayed alterations in neurochemical expression of GR, TH, DRD1, pCREB and Ki67 in rats. Azogu I, etal., Behav Brain Res. 2015 Feb 15;279:177-90. doi: 10.1016/j.bbr.2014.11.015. Epub 2014 Nov 26.
8. Transcription Factor Nrf2 Protects Renal Dopamine D1 Receptor Function During Oxidative Stress. Banday AA and Lokhandwala MF, Hypertension. 2013 Jul 22.
9. Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Banday AA, etal., Diabetes. 2005 Jul;54(7):2219-26.
10. Dopamine-mediated inhibition of renal Na,K-ATPase is reduced by insulin. Banday AA, etal., Hypertension. 2003 Jun;41(6):1353-8. Epub 2003 Apr 21.
11. Mitogen-activated protein kinase upregulation reduces renal D1 receptor affinity and G-protein coupling in obese rats. Banday AA, etal., Kidney Int. 2007 Mar;71(5):397-406. Epub 2006 Dec 27.
12. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
13. Dopamine receptors - IUPHAR Review 13. Beaulieu JM, etal., Br J Pharmacol. 2015 Jan;172(1):1-23.
14. Tracheal occlusion modulates the gene expression profile of the medial thalamus in anesthetized rats. Bernhardt V, etal., J Appl Physiol. 2011 Jul;111(1):117-24. doi: 10.1152/japplphysiol.01317.2010. Epub 2011 Apr 28.
15. Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine. Binienda ZK, etal., Neurosci Lett. 2006 Dec 13;410(1):62-5. Epub 2006 Oct 18.
16. The anabolic androgenic steroid nandrolone decanoate affects mRNA expression of dopaminergic but not serotonergic receptors. Birgner C, etal., Brain Res. 2008 Nov 13;1240:221-8. doi: 10.1016/j.brainres.2008.09.003. Epub 2008 Sep 13.
17. Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA. Bjornebekk A, etal., Neuroreport. 2007 Jul 2;18(10):1039-43.
18. Nearest neighbor analysis of dopamine D1 receptors and Na(+)-K(+)-ATPases in dendritic spines dissected by STED microscopy. Blom H, etal., Microsc Res Tech. 2012 Feb;75(2):220-8. doi: 10.1002/jemt.21046. Epub 2011 Aug 1.
19. Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV. Braszko JJ Peptides. 2004 Jul;25(7):1195-203.
20. Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder. Chawla A, etal., Physiol Behav. 2017 Oct 15;180:78-90. doi: 10.1016/j.physbeh.2017.08.004. Epub 2017 Aug 15.
21. Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex. Chen G, etal., Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2596-600.
22. Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. Chen J, etal., Eur J Neurosci. 2009 Jan;29(2):287-306.
23. Chronic stimulation of D1 dopamine receptors in human SK-N-MC neuroblastoma cells induces nitric-oxide synthase activation and cytotoxicity. Chen J, etal., J Biol Chem 2003 Jul 25;278(30):28089-100. Epub 2003 May 8.
24. Interaction of dopamine D1 receptor with N-ethylmaleimide-sensitive factor is important for the membrane localization of the receptor. Chen S and Liu F, J Neurosci Res. 2010 Aug 15;88(11):2504-12. doi: 10.1002/jnr.22401.
25. Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration. Conrad KL, etal., Neuroscience. 2010 Aug 11;169(1):182-94. doi: 10.1016/j.neuroscience.2010.04.056. Epub 2010 May 7.
26. Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease. Cummings DM, etal., Hum Mol Genet. 2006 Oct 1;15(19):2856-68. Epub 2006 Aug 11.
27. Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain. Dalton VS and Zavitsanou K, J Chem Neuroanat. 2010 Dec;40(4):272-80. doi: 10.1016/j.jchemneu.2010.07.005. Epub 2010 Jul 29.
28. Sindbis viral-mediated expression of eGFP-dopamine D1 receptors in situ with real-time two-photon microscopic detection. Diaz LM, etal., J Neurosci Methods. 2004 Oct 15;139(1):25-31.
29. Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration. Festa ED, etal., Brain Res Bull. 2006 Jan 15;68(4):277-84. Epub 2005 Sep 23.
30. Loss of synaptic D1 dopamine/N-methyl-D-aspartate glutamate receptor complexes in L-DOPA-induced dyskinesia in the rat. Fiorentini C, etal., Mol Pharmacol. 2006 Mar;69(3):805-12. Epub 2005 Dec 19.
31. Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Fiorentini C, etal., Mol Pharmacol. 2008 Jul;74(1):59-69. doi: 10.1124/mol.107.043885. Epub 2008 Apr 18.
32. Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease. Fiorentini C, etal., Neurobiol Dis. 2013 Jun;54:339-48. doi: 10.1016/j.nbd.2013.01.005. Epub 2013 Jan 14.
33. Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway. Floresco SB and Tse MT, J Neurosci. 2007 Feb 21;27(8):2045-57.
34. Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. Fung MM, etal., Kidney Int. 2009 Nov;76(10):1070-80. doi: 10.1038/ki.2009.306. Epub 2009 Aug 12.
35. Adolescent changes in dopamine D1 receptor expression in orbitofrontal cortex and piriform cortex accompany an associative learning deficit. Garske AK, etal., PLoS One. 2013;8(2):e56191. doi: 10.1371/journal.pone.0056191. Epub 2013 Feb 21.
36. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
37. Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats. George L, etal., Am J Physiol Renal Physiol. 2009 Nov;297(5):F1174-80. doi: 10.1152/ajprenal.00397.2009. Epub 2009 Sep 16.
38. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
39. The epigenetic effect of nicotine on dopamine D1 receptor expression in rat prefrontal cortex. Gozen O, etal., Synapse. 2013 Sep;67(9):545-52. doi: 10.1002/syn.21659. Epub 2013 Mar 27.
40. Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization. Ha CM, etal., J Biol Chem. 2012 Sep 14;287(38):31813-22. doi: 10.1074/jbc.M112.370601. Epub 2012 Jul 26.
41. Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking. Hallett PJ, etal., J Neurosci. 2006 Apr 26;26(17):4690-700.
42. The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking. Hamlin AS, etal., Neuroscience. 2007 May 11;146(2):525-36. doi: 10.1016/j.neuroscience.2007.01.063. Epub 2007 Mar 23.
43. Overlapping intracellular and differential synaptic distributions of dopamine D1 and glutamate N-methyl-D-aspartate receptors in rat nucleus accumbens. Hara Y and Pickel VM, J Comp Neurol. 2005 Nov 28;492(4):442-55.
44. The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model. Homberg JR, etal., Dis Model Mech. 2016 Oct 1;9(10):1147-1158. doi: 10.1242/dmm.024752. Epub 2016 May 19.
45. Repeated treatment with antidepressants enhances dopamine D1 receptor gene expression in the rat brain. Huzarska M, etal., Eur J Pharmacol. 2006 Feb 27;532(3):208-13.
46. Wake-promoting actions of dopamine D1 and D2 receptor stimulation. Isaac SO and Berridge CW, J Pharmacol Exp Ther. 2003 Oct;307(1):386-94. Epub 2003 Aug 27.
47. Localization of D1a dopamine receptors on cell bodies and axonal endings in the substantia nigra pars reticulata of the rat. Jan C, etal., J Neural Transm. 2007;114(12):1509-17. Epub 2007 Jun 18.
48. Neurofilament-M interacts with the D1 dopamine receptor to regulate cell surface expression and desensitization. Kim OJ, etal., J Neurosci. 2002 Jul 15;22(14):5920-30.
49. Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal. Krishnan B, etal., Eur J Neurosci. 2010 Mar;31(6):1027-42. Epub 2010 Mar 8.
50. Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats. Kumar TP, etal., J Biomed Sci. 2010 May 31;17:43. doi: 10.1186/1423-0127-17-43.
51. Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain. Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19.
52. Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Lee FJ, etal., Cell. 2002 Oct 18;111(2):219-30.
53. Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. Lemon N and Manahan-Vaughan D, J Neurosci. 2006 Jul 19;26(29):7723-9.
54. Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation. Li D, etal., J Am Soc Nephrol. 2012 Mar;23(3):421-8. doi: 10.1681/ASN.2011040344. Epub 2011 Dec 22.
55. MicroRNA expression profile and functional analysis reveal that miR-382 is a critical novel gene of alcohol addiction. Li J, etal., EMBO Mol Med. 2013 Jul 22. doi: 10.1002/emmm.201201900.
56. The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
57. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Li Y, etal., Med Sci Monit. 2017 Jun 9;23:2805-2815.
58. Dopaminergic and cholinergic regulation of Fyn tyrosine kinase phosphorylation in the rat striatum in vivo. Mao LM and Wang JQ, Neuropharmacology. 2015 Dec;99:491-9. doi: 10.1016/j.neuropharm.2015.08.017. Epub 2015 Aug 13.
59. D1 and D4 dopaminergic receptor interplay mediates coincident G protein-independent and dependent regulation of glutamate NMDA receptors in the lateral amygdala. Martina M and Bergeron R, J Neurochem. 2008 Sep;106(6):2421-35. doi: 10.1111/j.1471-4159.2008.05584.x. Epub 2008 Jul 24.
60. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
61. Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation. Monsma FJ Jr, etal., Proc Natl Acad Sci U S A 1990 Sep;87(17):6723-7.
62. Glycaemic control with insulin prevents the reduced renal dopamine D1 receptor expression and function in streptozotocin-induced diabetes. Moreira-Rodrigues M, etal., Nephrol Dial Transplant. 2010 Sep;25(9):2945-53. doi: 10.1093/ndt/gfq150. Epub 2010 Mar 25.
63. Amphetamine-induced changes in dopamine receptors in early postnatal rat brain. Mukda S, etal., Dev Neurosci. 2009;31(3):193-201. Epub 2009 Jan 15.
64. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
65. Expression of the dopaminergic D1 and D2 receptors in the anterior cingulate cortex in a model of neuropathic pain. Ortega-Legaspi JM, etal., Mol Pain. 2011 Dec 15;7:97.
66. Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats. Perreault ML, etal., Neuroscience. 2012 Dec 6;225:130-9. doi: 10.1016/j.neuroscience.2012.08.042. Epub 2012 Sep 15.
67. Ultrastructural analysis of prefrontal cortical inputs to the rat amygdala: spatial relationships to presumed dopamine axons and D1 and D2 receptors. Pinto A and Sesack SR, Brain Struct Funct. 2008 Sep;213(1-2):159-75. doi: 10.1007/s00429-008-0180-6. Epub 2008 Mar 14.
68. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
69. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
70. PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking. Porras G, etal., J Clin Invest. 2012 Nov 1;122(11):3977-89. doi: 10.1172/JCI59426. Epub 2012 Oct 8.
71. Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling. Raghuraman G, etal., J Neurochem. 2010 Dec;115(6):1568-78. doi: 10.1111/j.1471-4159.2010.07063.x. Epub 2010 Nov 19.
72. Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain. Rajput PS, etal., Neurosci Res. 2009 Sep;65(1):53-63. Epub 2009 May 22.
73. Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism. Rao F, etal., Hypertension. 2007 May;49(5):1015-31. Epub 2007 Mar 12.
74. GOA pipeline RGD automated data pipeline
75. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
76. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
77. Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry. Runne H, etal., J Neurosci. 2008 Sep 24;28(39):9723-31.
78. Brain D1 dopamine receptor in alloxan-induced diabetes. Salkovic M and Lackovic Z, Diabetes. 1992 Sep;41(9):1119-21.
79. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
80. Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats. Sarvari M, etal., Endocrinology. 2010 Aug;151(8):3847-62. doi: 10.1210/en.2010-0375. Epub 2010 Jun 9.
81. Dopamine D1 receptor gene polymorphism is associated with essential hypertension. Sato M, etal., Hypertension. 2000 Aug;36(2):183-6.
82. Hypothalamic dopaminergic receptor expressions in anorexia of tumor-bearing rats. Sato T, etal., Am J Physiol Regul Integr Comp Physiol 2001 Dec;281(6):R1907-16.
83. Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation. Scott L, etal., Proc Natl Acad Sci U S A 2002 Feb 5;99(3):1661-4.
84. Electroacupuncture inhibition of hyperalgesia in rats with adjuvant arthritis: involvement of cannabinoid receptor 1 and dopamine receptor subtypes in striatum. Shou Y, etal., Evid Based Complement Alternat Med. 2013;2013:393460. doi: 10.1155/2013/393460. Epub 2013 May 25.
85. Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat. Sillivan SE and Konradi C, Neuroscience. 2011 Dec 29;199:501-14. doi: 10.1016/j.neuroscience.2011.10.004. Epub 2011 Oct 8.
86. Effect of UUO on D1aR expression reveals a link among dopamine, transforming growth factor-beta, and nitric oxide. Stern JM, etal., Am J Physiol Renal Physiol. 2004 Mar;286(3):F509-15. Epub 2003 Nov 11.
87. Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal. Sun L, etal., Brain Struct Funct. 2013 Jun 18.
88. Up-regulation of dopamine D1 receptor in the hippocampus after establishment of conditioned place preference by cocaine. Tanaka T, etal., Neuropharmacology. 2011 Sep;61(4):842-8. doi: 10.1016/j.neuropharm.2011.05.032. Epub 2011 Jun 12.
89. Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D1and D2Dopamine Receptor Agonists. Tapia-Bustos A, etal., Neurotox Res. 2017 Jan;31(1):109-121. doi: 10.1007/s12640-016-9669-6. Epub 2016 Sep 16.
90. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
91. Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. Thomas M, etal., Synapse. 2009 Oct;63(10):881-94.
92. Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats. Trivedi M and Lokhandwala MF, Am J Physiol Renal Physiol. 2005 Aug;289(2):F298-304. Epub 2005 Mar 29.
93. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules. Trivedi M, etal., Am J Physiol Renal Physiol. 2004 Nov;287(5):F921-31. Epub 2004 Jul 20.
94. Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms. Tseng KY and O'Donnell P, J Neurosci. 2004 Jun 2;24(22):5131-9. doi: 10.1523/JNEUROSCI.1021-04.2004.
95. Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats. Tu L, etal., Hum Gene Ther. 2008 Apr;19(4):318-30. doi: 10.1089/hum.2007.138.
96. Basal regulation of HPA and dopamine systems is altered differentially in males and females by prenatal alcohol exposure and chronic variable stress. Uban KA, etal., Psychoneuroendocrinology. 2013 Oct;38(10):1953-66. doi: 10.1016/j.psyneuen.2013.02.017. Epub 2013 Apr 8.
97. Regulation of multiple dopamine signal transduction molecules by retinoids in the developing striatum. Wang HF and Liu FC, Neuroscience. 2005;134(1):97-105.
98. Evidence for the coupling of Gq protein to D1-like dopamine sites in rat striatum: possible role in dopamine-mediated inositol phosphate formation. Wang HY, etal., Mol Pharmacol. 1995 Dec;48(6):988-94.
99. D1- and D2-like dopamine receptors are co-localized on the presynaptic varicosities of striatal and nucleus accumbens neurons in vitro. Wong AC, etal., Neuroscience. 1999 Mar;89(1):221-33.
100. Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Xu M, etal., Cell 1994 Nov 18;79(4):729-42.
101. Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors. Yasunari K, etal., J Cardiovasc Pharmacol. 2003 Jan;41 Suppl 1:S33-8.
102. Dopamine D1A receptor regulation of phospholipase C isoform. Yu PY, etal., J Biol Chem. 1996 Aug 9;271(32):19503-8.
103. Cellular mechanisms for dopamine D4 receptor-induced homeostatic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Yuen EY and Yan Z, J Biol Chem. 2011 Jul 15;286(28):24957-65. doi: 10.1074/jbc.M111.221416. Epub 2011 May 27.
104. Aberrant D1 and D3 dopamine receptor transregulation in hypertension. Zeng C, etal., Hypertension. 2004 Mar;43(3):654-60. Epub 2004 Jan 19.
105. Requirement for the endocannabinoid system in social interaction impairment induced by coactivation of dopamine D1 and D2 receptors in the piriform cortex. Zenko M, etal., J Neurosci Res. 2011 Aug;89(8):1245-58. doi: 10.1002/jnr.22580. Epub 2011 May 6.
106. Effects of enteral nutrition on the barrier function of the intestinal mucosa and dopamine receptor expression in rats with traumatic brain injury. Zhang X and Jiang X, JPEN J Parenter Enteral Nutr. 2015 Jan;39(1):114-23. doi: 10.1177/0148607113501881. Epub 2013 Sep 18.
107. Characterization of gene organization and promoter region of the rat dopamine D1 receptor gene. Zhou QY, etal., J Neurochem 1992 Nov;59(5):1875-83.
Additional References at PubMed
PMID:1282671   PMID:1831904   PMID:2138567   PMID:2144334   PMID:2168520   PMID:7549459   PMID:7566118   PMID:7809078   PMID:7838121   PMID:8001143   PMID:8294904   PMID:8738226  
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PMID:21078371   PMID:21113156   PMID:21173143   PMID:21368124   PMID:21593319   PMID:21593325   PMID:21653722   PMID:21720753   PMID:21768371   PMID:21846496   PMID:21903142   PMID:21942433  
PMID:22022509   PMID:22038910   PMID:22081646   PMID:22236063   PMID:22308372   PMID:22411927   PMID:22428025   PMID:22580374   PMID:22586226   PMID:22707255   PMID:23138234   PMID:23149555  
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PMID:35478421   PMID:36191805   PMID:37252844  


Genomics

Comparative Map Data
Drd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,545,488 - 10,550,029 (+)NCBIGRCr8
mRatBN7.21710,540,440 - 10,544,971 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,540,558 - 10,545,002 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,555,287 - 10,558,713 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01712,089,485 - 12,092,911 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,551,719 - 10,555,145 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01711,099,736 - 11,104,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,211,031 - 13,215,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,655,926 - 16,658,161 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,655,119 - 16,658,949 (+)NCBI
Celera1710,610,221 - 10,613,646 (+)NCBICelera
Cytogenetic Map17p14NCBI
DRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385175,440,036 - 175,444,182 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5175,440,036 - 175,444,182 (-)EnsemblGRCh38hg38GRCh38
GRCh375174,867,039 - 174,871,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365174,800,281 - 174,803,769 (-)NCBINCBI36Build 36hg18NCBI36
Build 345174,800,642 - 174,803,769NCBI
Celera5170,906,676 - 170,910,164 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5169,967,086 - 169,970,574 (-)NCBIHuRef
CHM1_15174,300,099 - 174,303,587 (-)NCBICHM1_1
T2T-CHM13v2.05175,983,814 - 175,987,960 (-)NCBIT2T-CHM13v2.0
Drd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,205,202 - 54,209,677 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,205,202 - 54,209,724 (-)EnsemblGRCm39 Ensembl
GRCm381354,051,183 - 54,055,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,051,183 - 54,055,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371354,146,552 - 54,151,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,061,276 - 54,065,279 (-)NCBIMGSCv36mm8
Celera1355,124,170 - 55,128,645 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.4NCBI
Drd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,003,229 - 28,006,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,003,229 - 28,006,595 (-)NCBIChiLan1.0ChiLan1.0
DRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24170,570,821 - 170,577,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15168,710,364 - 168,717,128 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05170,787,115 - 170,792,383 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15177,687,201 - 177,691,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5177,688,917 - 177,690,257 (-)Ensemblpanpan1.1panPan2
DRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1437,550,454 - 37,554,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl437,549,708 - 37,553,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha437,496,619 - 37,501,286 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,916,432 - 37,921,101 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,916,400 - 37,921,094 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1437,741,033 - 37,745,149 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,928,336 - 37,933,009 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0438,438,479 - 38,443,142 (+)NCBIUU_Cfam_GSD_1.0
Drd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721392,067,956 - 92,072,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936609792,276 - 793,613 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936609790,647 - 795,187 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1649,189,602 - 49,191,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11649,189,555 - 49,193,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21653,333,853 - 53,338,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,587,340 - 77,591,434 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666034997,268 - 1,002,449 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473314,518,146 - 14,520,905 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473314,517,540 - 14,522,173 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Drd1
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:89
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000030893
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat

Markers in Region
D17Mco4  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map17110.9RGD
D17Mgh11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21710,538,985 - 10,539,099 (+)MAPPERmRatBN7.2
Rnor_6.01711,098,367 - 11,098,480NCBIRnor6.0
Rnor_5.01713,209,596 - 13,209,709UniSTSRnor5.0
RGSC_v3.41716,652,986 - 16,653,100RGDRGSC3.4
RGSC_v3.41716,652,987 - 16,653,100UniSTSRGSC3.4
RGSC_v3.11716,652,986 - 16,653,100RGD
Celera1710,607,651 - 10,607,762UniSTS
RH 3.4 Map17108.1UniSTS
RH 3.4 Map17108.1RGD
RH 2.0 Map1767.4RGD
SHRSP x BN Map178.3RGD
Cytogenetic Map17p14UniSTS
D17Mco4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21710,539,904 - 10,540,108 (+)MAPPERmRatBN7.2
Rnor_6.01711,099,286 - 11,099,489NCBIRnor6.0
Rnor_5.01713,210,515 - 13,210,718UniSTSRnor5.0
RGSC_v3.41716,653,849 - 16,654,190RGDRGSC3.4
RGSC_v3.41716,653,906 - 16,654,109UniSTSRGSC3.4
RGSC_v3.11716,653,905 - 16,654,109RGD
Celera1710,608,568 - 10,608,783UniSTS
RH 3.4 Map17110.9UniSTS
Cytogenetic Map17p14UniSTS
D17Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21710,543,391 - 10,543,617 (+)MAPPERmRatBN7.2
Rnor_6.01711,102,773 - 11,102,998NCBIRnor6.0
Rnor_5.01713,214,002 - 13,214,227UniSTSRnor5.0
RGSC_v3.41716,657,393 - 16,657,618UniSTSRGSC3.4
Celera1710,612,067 - 10,612,292UniSTS
Cytogenetic Map17p14UniSTS
RH131896  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21710,544,693 - 10,544,875 (+)MAPPERmRatBN7.2
Rnor_6.01711,104,075 - 11,104,256NCBIRnor6.0
Rnor_5.01713,215,304 - 13,215,485UniSTSRnor5.0
RGSC_v3.41716,658,695 - 16,658,876UniSTSRGSC3.4
Celera1710,613,369 - 10,613,550UniSTS
RH 3.4 Map17106.3UniSTS
Cytogenetic Map17p14UniSTS
Drd1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21710,542,580 - 10,542,683 (+)MAPPERmRatBN7.2
Rnor_6.01711,101,962 - 11,102,064NCBIRnor6.0
Rnor_5.01713,213,191 - 13,213,293UniSTSRnor5.0
RGSC_v3.41716,656,582 - 16,656,684UniSTSRGSC3.4
Celera1710,611,256 - 10,611,358UniSTS
Cytogenetic Map17p14UniSTS


Related Rat Strains
The following Strains have been annotated to Drd1
LE-Tg(Drd1-icre)3Ottc     LE-Tg(Drd2-iCre)1Ottc     SD    


Genetic Models
This gene Drd1 is modified in the following models/strains:
WI- Drd1m1Hubr     LE-Drd1em1(iCre)Berke     SD-Drd1em1Ionsz    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 4 34 111 41 37 13 18 13 6 136 68 91 44 40 24

Sequence


Ensembl Acc Id: ENSRNOT00000030893   ⟹   ENSRNOP00000034820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1710,540,558 - 10,545,002 (+)Ensembl
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117894   ⟹   ENSRNOP00000081268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1710,541,059 - 10,545,002 (+)Ensembl
RefSeq Acc Id: NM_012546   ⟹   NP_036678
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,546,604 - 10,550,029 (+)NCBI
mRatBN7.21710,541,546 - 10,544,971 (+)NCBI
Rnor_6.01711,100,927 - 11,104,352 (+)NCBI
Rnor_5.01713,211,031 - 13,215,581 (+)NCBI
RGSC_v3.41716,655,926 - 16,658,161 (+)RGD
Celera1710,610,221 - 10,613,646 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253599   ⟹   XP_006253661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,545,697 - 10,550,029 (+)NCBI
mRatBN7.21710,540,657 - 10,544,971 (+)NCBI
Rnor_6.01711,100,096 - 11,104,352 (+)NCBI
Rnor_5.01713,211,031 - 13,215,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253600   ⟹   XP_006253662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,545,488 - 10,550,029 (+)NCBI
mRatBN7.21710,540,440 - 10,544,971 (+)NCBI
Rnor_6.01711,099,736 - 11,104,352 (+)NCBI
Rnor_5.01713,211,031 - 13,215,581 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036678   ⟸   NM_012546
- UniProtKB: P21669 (UniProtKB/Swiss-Prot),   P18901 (UniProtKB/Swiss-Prot),   G3V933 (UniProtKB/TrEMBL),   A6KB08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253662   ⟸   XM_006253600
- Peptide Label: isoform X1
- UniProtKB: P21669 (UniProtKB/Swiss-Prot),   P18901 (UniProtKB/Swiss-Prot),   G3V933 (UniProtKB/TrEMBL),   A6KB08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253661   ⟸   XM_006253599
- Peptide Label: isoform X1
- UniProtKB: P21669 (UniProtKB/Swiss-Prot),   P18901 (UniProtKB/Swiss-Prot),   G3V933 (UniProtKB/TrEMBL),   A6KB08 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034820   ⟸   ENSRNOT00000030893
Ensembl Acc Id: ENSRNOP00000081268   ⟸   ENSRNOT00000117894
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18901-F1-model_v2 AlphaFold P18901 1-446 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2518 AgrOrtholog
BioCyc Gene G2FUF-10155 BioCyc
Ensembl Genes ENSRNOG00000023688 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030893.4 UniProtKB/TrEMBL
  ENSRNOT00000117894.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dopamine_D1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24316 UniProtKB/TrEMBL
NCBI Gene 24316 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  D(1A) DOPAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DRD1 RGD
PhenoGen Drd1 PhenoGen
PRINTS DOPAMINED1AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOPAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023688 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC215195
UniProt A6KB08 ENTREZGENE, UniProtKB/TrEMBL
  DRD1_RAT UniProtKB/Swiss-Prot
  G3V933 ENTREZGENE, UniProtKB/TrEMBL
  P18901 ENTREZGENE
  P21669 ENTREZGENE
UniProt Secondary P21669 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-14 Drd1  dopamine receptor D1  Drd1a  dopamine receptor D1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Drd1a  dopamine receptor D1A    dopamine receptor 1A  Name updated 1299863 APPROVED
2003-04-09 Drd1a  dopamine receptor 1A    Dopamine-1A receptor  Name updated 629478 APPROVED
2002-06-10 Drd1a  Dopamine-1A receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in schizophrenia 70242
gene_disease mRNA level is high in the hypothalamus in anorectic animals 68908
gene_expression expressed in the brain 68908
gene_process has a role in dopamine-sensitive adenyl cyclase activity 70242
gene_process may be involved in a G-protein coupled receptor protein signaling pathway 70242
gene_process stimulates adenylyl cyclase activity 68908
gene_process plays a role in regulating food intake 628466