Drd1 (dopamine receptor D1) - Rat Genome Database

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Gene: Drd1 (dopamine receptor D1) Rattus norvegicus
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Symbol: Drd1
Name: dopamine receptor D1
RGD ID: 2518
Description: Exhibits several functions, including G protein-coupled receptor binding activity; G-protein alpha-subunit binding activity; and enzyme binding activity. Involved in several processes, including learning; modulation of chemical synaptic transmission; and response to alkaloid. Localizes to several cellular components, including caveola; dendrite; and integral component of synaptic membrane. Used to study Parkinson's disease; end stage renal disease; and obesity. Biomarker of several diseases, including heroin dependence; hyperglycemia; neurodegenerative disease (multiple); tracheal stenosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1); PARTICIPATES IN dopamine signaling pathway; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: d(1A) dopamine receptor; D1a; dopamine D1 receptor; dopamine receptor 1A; dopamine receptor D1A; Dopamine-1A receptor; Drd-1; Drd1a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Drd1em1Ionsz   Drd1em1(iCre)Berke  
Genetic Models: LE-Drd1em1(iCre)Berke SD-Drd1em1Ionsz
Is Marker For: Strains:   SD   LE-Tg(Drd1-icre)3Ottc   LE-Tg(Drd2-iCre)1Ottc  
QTLs:   BpQTLcluster14  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21710,540,440 - 10,544,971 (+)NCBI
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01711,099,736 - 11,104,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01713,211,031 - 13,215,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,655,926 - 16,658,161 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11716,655,119 - 16,658,949 (+)NCBI
Celera1710,610,221 - 10,613,646 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (EXP,ISO)
1-bromopropane  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amitriptyline  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
amoxapine  (ISO)
amphetamine  (EXP,ISO)
apomorphine  (ISO)
aprindine  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
benserazide  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Boldine  (EXP)
butanal  (ISO)
cadmium atom  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
diltiazem  (ISO)
domperidone  (ISO)
dopamine  (EXP,ISO)
etafenone  (ISO)
ethanol  (EXP,ISO)
ethyl acetate  (EXP)
eugenol  (EXP)
fenoldopam  (EXP)
flunarizine  (ISO)
flupenthixol  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gadolinium atom  (EXP)
gamma-aminobutyric acid  (EXP)
genistein  (EXP)
glyphosate  (EXP)
haloperidol  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoquinolines  (ISO)
lanthanum atom  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
loxapine  (EXP)
manganese(II) chloride  (EXP,ISO)
manidipine  (ISO)
melatonin  (ISO)
melevodopa  (EXP)
methamphetamine  (EXP,ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
mirtazapine  (EXP)
morphine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (ISO)
nicotine  (EXP,ISO)
Nonylphenol  (EXP)
olanzapine  (ISO)
ouabain  (EXP,ISO)
oxidopamine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
pentetrazol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
pergolide  (ISO)
phencyclidine  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
procymidone  (EXP)
Propiverine  (ISO)
quercetin  (EXP)
quinolinic acid  (EXP)
reserpine  (EXP)
rotenone  (EXP)
SCH 23390  (EXP,ISO)
serotonin  (EXP)
sertraline  (EXP)
simvastatin  (EXP)
SKF 38393  (EXP,ISO)
sodium arsenite  (EXP)
spiperone  (EXP)
sunitinib  (ISO)
terbufos  (ISO)
tetrahydropalmatine  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
XL147  (ISO)
zinc acetate  (EXP)
zinc dichloride  (EXP)
zinc sulfate  (EXP)
zonisamide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (IEA,ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (IDA,IEA,IMP,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adult walking behavior  (IEA,ISO)
associative learning  (IEP,IMP,ISO)
astrocyte development  (IEA,ISO)
behavioral fear response  (IEA,ISO)
behavioral response to cocaine  (IEA,IMP,ISO)
calcium-mediated signaling  (IDA)
cellular response to catecholamine stimulus  (ISO)
cellular response to dopamine  (ISO)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cerebral cortex GABAergic interneuron migration  (IEA,ISO)
chemical synaptic transmission  (IBA)
conditioned taste aversion  (IEA,ISO)
dentate gyrus development  (IEA,ISO)
dopamine receptor signaling pathway  (ISO,TAS)
dopamine transport  (IEA,ISO)
eating behavior  (IDA)
feeding behavior  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA,IEA,ISO)
G protein-coupled serotonin receptor signaling pathway  (IEA)
glucose import  (IEA,ISO)
grooming behavior  (IDA,IEA,ISO)
habituation  (IEA,ISO)
hippocampus development  (ISO)
histone H3-S10 phosphorylation  (IEA,ISO)
intracellular protein transport  (IMP)
learning  (ISO)
locomotory behavior  (IMP,ISO)
long-term synaptic depression  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
maternal behavior  (IEA,ISO)
mating behavior  (IEA,ISO)
memory  (IEA,ISO)
modification of postsynaptic structure  (ISO)
muscle contraction  (ISO)
negative regulation of cell death  (IDA)
negative regulation of cell migration  (IMP)
negative regulation of circadian sleep/wake cycle, sleep  (IDA)
negative regulation of protein kinase activity  (IMP)
negative regulation of synaptic transmission  (IDA)
neuronal action potential  (IEA,ISO)
operant conditioning  (IEA,IMP,ISO)
orbitofrontal cortex development  (IEP)
peristalsis  (IEA,ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IEA,ISO)
positive regulation of feeding behavior  (IMP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of membrane potential  (IMP)
positive regulation of protein phosphorylation  (IDA)
positive regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO)
postsynaptic modulation of chemical synaptic transmission  (EXP,IDA)
prepulse inhibition  (ISO)
protein import into nucleus  (IEA,ISO)
regulation of dopamine metabolic process  (IEA,ISO)
regulation of ion transport  (IDA)
regulation of protein phosphorylation  (IEA,ISO)
regulation of synaptic vesicle exocytosis  (IEA,ISO)
regulation of vasoconstriction  (IMP)
response to activity  (IEP)
response to amino acid  (IEP)
response to amphetamine  (IEA,IEP,ISO)
response to cocaine  (ISO)
response to drug  (IEA,IEP,ISO)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to food  (IEP)
response to morphine  (IEP)
response to nicotine  (IEP)
response to organic cyclic compound  (IEP)
response to organonitrogen compound  (IEP)
response to retinoic acid  (IEP)
response to steroid hormone  (IEP)
sensitization  (IEA,ISO)
social behavior  (IMP)
startle response  (ISO)
striatum development  (IEA,IEP,ISO)
synapse assembly  (IEP)
synaptic transmission, dopaminergic  (IEA,ISO)
temperature homeostasis  (IEA,ISO)
transmission of nerve impulse  (ISO)
vasodilation  (IEA)
visual learning  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
dopamine signaling pathway  (IDA,ISO)
dopamine signaling pathway via D1 family of receptors  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
G protein mediated signaling pathway via Galphas family  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

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Additional References at PubMed
PMID:1282671   PMID:1831904   PMID:2138567   PMID:2144334   PMID:2168520   PMID:7549459   PMID:7566118   PMID:7809078   PMID:7838121   PMID:8001143   PMID:8294904   PMID:8738226  
PMID:8795639   PMID:9016340   PMID:9261820   PMID:9354330   PMID:9387887   PMID:9427321   PMID:9603210   PMID:9692749   PMID:9749770   PMID:9829800   PMID:9988094   PMID:10222120  
PMID:10585522   PMID:10661513   PMID:10884517   PMID:11069937   PMID:11089973   PMID:11150348   PMID:11172752   PMID:11251190   PMID:11331877   PMID:11404425   PMID:11409899   PMID:11438590  
PMID:11500503   PMID:11823893   PMID:11914579   PMID:11923452   PMID:11985822   PMID:12097513   PMID:12223546   PMID:12354293   PMID:12417685   PMID:12452531   PMID:12488442   PMID:12603275  
PMID:12634922   PMID:12646556   PMID:12652349   PMID:12665504   PMID:12867509   PMID:12930822   PMID:13679419   PMID:14660631   PMID:14712229   PMID:14981263   PMID:15016423   PMID:15033440  
PMID:15272078   PMID:15328036   PMID:15328529   PMID:15569306   PMID:15684065   PMID:15932618   PMID:16000622   PMID:16014726   PMID:16033882   PMID:16126181   PMID:16172423   PMID:16217657  
PMID:16408587   PMID:16413126   PMID:16549270   PMID:16636192   PMID:16757732   PMID:16758365   PMID:16855179   PMID:16908842   PMID:16962565   PMID:17047670   PMID:17064765   PMID:17116755  
PMID:17132536   PMID:17194762   PMID:17264308   PMID:17293055   PMID:17320758   PMID:17324452   PMID:17360497   PMID:17409246   PMID:17409305   PMID:17634393   PMID:17712281   PMID:17760784  
PMID:17845833   PMID:17936656   PMID:18003845   PMID:18045908   PMID:18052983   PMID:18077190   PMID:18097763   PMID:18158345   PMID:18185106   PMID:18288091   PMID:18336564   PMID:18343588  
PMID:18403039   PMID:18410175   PMID:18435423   PMID:18442937   PMID:18455307   PMID:18486343   PMID:18489579   PMID:18496528   PMID:18535281   PMID:18538938   PMID:18554296   PMID:18671743  
PMID:18675324   PMID:18685027   PMID:18701624   PMID:18785628   PMID:18975071   PMID:19132528   PMID:19139376   PMID:19258519   PMID:19262467   PMID:19275776   PMID:19293728   PMID:19318466  
PMID:19320634   PMID:19321949   PMID:19399396   PMID:19419427   PMID:19564919   PMID:19578995   PMID:19614979   PMID:19690230   PMID:19747509   PMID:19794106   PMID:19940196   PMID:20034231  
PMID:20149807   PMID:20395553   PMID:20412313   PMID:20521380   PMID:20531939   PMID:20569495   PMID:20599592   PMID:20646048   PMID:20718855   PMID:20732358   PMID:20837135   PMID:20962767  
PMID:21078371   PMID:21113156   PMID:21173143   PMID:21368124   PMID:21593319   PMID:21593325   PMID:21653722   PMID:21720753   PMID:21768371   PMID:21846496   PMID:21903142   PMID:21942433  
PMID:22022509   PMID:22038910   PMID:22081646   PMID:22236063   PMID:22308372   PMID:22411927   PMID:22428025   PMID:22580374   PMID:22586226   PMID:22707255   PMID:23138234   PMID:23149555  
PMID:23151613   PMID:23192317   PMID:23201252   PMID:23270858   PMID:23276732   PMID:23336973   PMID:23403122   PMID:23470804   PMID:23598433   PMID:23626827   PMID:23672849   PMID:23701913  
PMID:23842570   PMID:23896530   PMID:23956981   PMID:24040266   PMID:24120554   PMID:24133208   PMID:24136195   PMID:24167564   PMID:24199666   PMID:24236888   PMID:24239691   PMID:24262750  
PMID:24408208   PMID:24550737   PMID:24559270   PMID:24733061   PMID:24915967   PMID:25171081   PMID:25172664   PMID:25258080   PMID:25344317   PMID:25444866   PMID:25505330   PMID:25733244  
PMID:25775606   PMID:25797492   PMID:25865831   PMID:26256420   PMID:26277743   PMID:26345345   PMID:26452359   PMID:26656274   PMID:26658514   PMID:26784516   PMID:26826585   PMID:26892296  
PMID:27035941   PMID:27164043   PMID:27179937   PMID:27374160   PMID:27483345   PMID:27894877   PMID:28065827   PMID:28115219   PMID:28116523   PMID:28154160   PMID:28259782   PMID:28336436  
PMID:28429261   PMID:28546312   PMID:28828729   PMID:28887183   PMID:29229410   PMID:29229557   PMID:29246771   PMID:29498008   PMID:29508439   PMID:29537707   PMID:29569008   PMID:30165079  
PMID:30172845   PMID:30261284   PMID:30622165   PMID:30656366   PMID:31029071   PMID:31142084   PMID:31358512   PMID:31940660   PMID:31972244   PMID:31972963   PMID:32039920   PMID:32087746  
PMID:32215915   PMID:32246242  


Genomics

Comparative Map Data
Drd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21710,540,440 - 10,544,971 (+)NCBI
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01711,099,736 - 11,104,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01713,211,031 - 13,215,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,655,926 - 16,658,161 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11716,655,119 - 16,658,949 (+)NCBI
Celera1710,610,221 - 10,613,646 (+)NCBICelera
Cytogenetic Map17p14NCBI
DRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5175,440,036 - 175,444,182 (-)EnsemblGRCh38hg38GRCh38
GRCh385175,440,036 - 175,444,182 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375174,867,039 - 174,871,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365174,800,281 - 174,803,769 (-)NCBINCBI36hg18NCBI36
Build 345174,800,642 - 174,803,769NCBI
Celera5170,906,676 - 170,910,164 (-)NCBI
Cytogenetic Map5q35.2NCBI
HuRef5169,967,086 - 169,970,574 (-)NCBIHuRef
CHM1_15174,300,099 - 174,303,587 (-)NCBICHM1_1
Drd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,205,202 - 54,209,677 (-)NCBIGRCm39mm39
GRCm39 Ensembl1354,205,202 - 54,209,724 (-)Ensembl
GRCm381354,051,183 - 54,055,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,051,183 - 54,055,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371354,146,552 - 54,151,027 (-)NCBIGRCm37mm9NCBIm37
MGSCv361354,061,276 - 54,065,279 (-)NCBImm8
Celera1355,124,170 - 55,128,645 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.4NCBI
Drd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,003,229 - 28,006,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,003,229 - 28,006,595 (-)NCBIChiLan1.0ChiLan1.0
DRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15177,687,201 - 177,691,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5177,688,917 - 177,690,257 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05170,787,115 - 170,792,383 (-)NCBIMhudiblu_PPA_v0panPan3
DRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1437,550,454 - 37,554,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl437,549,708 - 37,553,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha437,496,619 - 37,501,286 (+)NCBI
ROS_Cfam_1.0437,916,432 - 37,921,101 (+)NCBI
UMICH_Zoey_3.1437,741,033 - 37,745,149 (+)NCBI
UNSW_CanFamBas_1.0437,928,336 - 37,933,009 (+)NCBI
UU_Cfam_GSD_1.0438,438,479 - 38,443,142 (+)NCBI
Drd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721392,067,956 - 92,072,508 (+)NCBI
SpeTri2.0NW_004936609790,647 - 795,187 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1649,188,936 - 49,193,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11649,189,555 - 49,193,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21653,333,853 - 53,338,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,587,340 - 77,591,434 (-)NCBI
Drd1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473314,517,540 - 14,522,173 (+)NCBI

Position Markers
D17Mco4  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map17110.9RGD
D17Mgh11  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01711,098,367 - 11,098,480NCBIRnor6.0
Rnor_5.01713,209,596 - 13,209,709UniSTSRnor5.0
RGSC_v3.41716,652,987 - 16,653,100UniSTSRGSC3.4
RGSC_v3.41716,652,986 - 16,653,100RGDRGSC3.4
RGSC_v3.11716,652,986 - 16,653,100RGD
Celera1710,607,651 - 10,607,762UniSTS
RH 3.4 Map17108.1RGD
RH 3.4 Map17108.1UniSTS
RH 2.0 Map1767.4RGD
SHRSP x BN Map178.3RGD
Cytogenetic Map17p14UniSTS
D17Mco4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01711,099,286 - 11,099,489NCBIRnor6.0
Rnor_5.01713,210,515 - 13,210,718UniSTSRnor5.0
RGSC_v3.41716,653,849 - 16,654,190RGDRGSC3.4
RGSC_v3.41716,653,906 - 16,654,109UniSTSRGSC3.4
RGSC_v3.11716,653,905 - 16,654,109RGD
Celera1710,608,568 - 10,608,783UniSTS
RH 3.4 Map17110.9UniSTS
Cytogenetic Map17p14UniSTS
D17Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01711,102,773 - 11,102,998NCBIRnor6.0
Rnor_5.01713,214,002 - 13,214,227UniSTSRnor5.0
RGSC_v3.41716,657,393 - 16,657,618UniSTSRGSC3.4
Celera1710,612,067 - 10,612,292UniSTS
Cytogenetic Map17p14UniSTS
RH131896  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01711,104,075 - 11,104,256NCBIRnor6.0
Rnor_5.01713,215,304 - 13,215,485UniSTSRnor5.0
RGSC_v3.41716,658,695 - 16,658,876UniSTSRGSC3.4
Celera1710,613,369 - 10,613,550UniSTS
RH 3.4 Map17106.3UniSTS
Cytogenetic Map17p14UniSTS
Drd1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01711,101,962 - 11,102,064NCBIRnor6.0
Rnor_5.01713,213,191 - 13,213,293UniSTSRnor5.0
RGSC_v3.41716,656,582 - 16,656,684UniSTSRGSC3.4
Celera1710,611,256 - 10,611,358UniSTS
Cytogenetic Map17p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17124787908Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17132230361Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17133303755Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138243814Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17163676140Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17173413148Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17173413148Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1751977023422380Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1751977036283402Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17333697224030841Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17333697224030841Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17333697237790462Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17333697263676140Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17333697273413148Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17333697273413148Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17333697273413148Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17341403928073589Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17471606727691136Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17471606727691136Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17519104750191047Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17519104750191047Rat
1581553Pur14Proteinuria QTL 145.30.0001total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17842446716620067Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17973026321491085Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17973026321491085Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17973026321491085Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17973026321491085Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17973026321491085Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17973026321491085Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17973026321491085Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17973026321491085Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17982730454827304Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)171052970942542027Rat


Related Rat Strains
The following Strains have been annotated to Drd1


Genetic Models
This gene Drd1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:89
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000030893
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22
Low 2 4 4 4 42 14 9
Below cutoff 1 26 17 3 12 3 4 4 10 20 20 6 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000030893   ⟹   ENSRNOP00000034820
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)Ensembl
RefSeq Acc Id: NM_012546   ⟹   NP_036678
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21710,541,546 - 10,544,971 (+)NCBI
Rnor_6.01711,100,927 - 11,104,352 (+)NCBI
Rnor_5.01713,211,031 - 13,215,581 (+)NCBI
RGSC_v3.41716,655,926 - 16,658,161 (+)RGD
Celera1710,610,221 - 10,613,646 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253599   ⟹   XP_006253661
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21710,540,657 - 10,544,971 (+)NCBI
Rnor_6.01711,100,096 - 11,104,352 (+)NCBI
Rnor_5.01713,211,031 - 13,215,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253600   ⟹   XP_006253662
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21710,540,440 - 10,544,971 (+)NCBI
Rnor_6.01711,099,736 - 11,104,352 (+)NCBI
Rnor_5.01713,211,031 - 13,215,581 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036678   ⟸   NM_012546
- UniProtKB: G3V933 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253662   ⟸   XM_006253600
- Peptide Label: isoform X1
- UniProtKB: G3V933 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253661   ⟸   XM_006253599
- Peptide Label: isoform X1
- UniProtKB: G3V933 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034820   ⟸   ENSRNOT00000030893
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2518 AgrOrtholog
Ensembl Genes ENSRNOG00000023688 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034820 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030893 ENTREZGENE, UniProtKB/TrEMBL
InterPro Dopamine_D1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24316 UniProtKB/TrEMBL
NCBI Gene 24316 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DRD1 RGD
PhenoGen Drd1 PhenoGen
PRINTS DOPAMINED1AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOPAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC215195
UniProt DRD1_RAT UniProtKB/Swiss-Prot
  G3V933 ENTREZGENE, UniProtKB/TrEMBL
  P18901 ENTREZGENE
UniProt Secondary P21669 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-14 Drd1  dopamine receptor D1  Drd1a  dopamine receptor D1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Drd1a  dopamine receptor D1A    dopamine receptor 1A  Name updated 1299863 APPROVED
2003-04-09 Drd1a  dopamine receptor 1A    Dopamine-1A receptor  Name updated 629478 APPROVED
2002-06-10 Drd1a  Dopamine-1A receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in schizophrenia 70242
gene_disease mRNA level is high in the hypothalamus in anorectic animals 68908
gene_expression expressed in the brain 68908
gene_process has a role in dopamine-sensitive adenyl cyclase activity 70242
gene_process may be involved in a G-protein coupled receptor protein signaling pathway 70242
gene_process stimulates adenylyl cyclase activity 68908
gene_process plays a role in regulating food intake 628466