DRD1 (dopamine receptor D1) - Rat Genome Database

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Pathways
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Gene: DRD1 (dopamine receptor D1) Chlorocebus sabaeus
Analyze
Symbol: DRD1
Name: dopamine receptor D1
RGD ID: 18392219
Description: ENCODES a protein that exhibits angiotensin receptor binding (ortholog); ATPase binding (ortholog); D3 dopamine receptor binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adult walking behavior (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Albuminuria (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); caveola (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: D(1A) dopamine receptor; LOC103245014; uncharacterized LOC103245014; uncharacterized protein LOC103245014
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,587,340 - 77,591,434 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666034997,268 - 1,002,449 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IEA)
adenylate cyclase-activating dopamine receptor signaling pathway  (IEA,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA)
adult walking behavior  (IEA,ISO)
associative learning  (IEA,ISO)
astrocyte development  (IEA,ISO)
behavioral fear response  (IEA,ISO)
behavioral response to cocaine  (IEA,ISO)
calcium-mediated signaling  (ISO)
cell migration  (IEA,ISO)
cellular response to catecholamine stimulus  (IEA)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cerebral cortex GABAergic interneuron migration  (IEA,ISO)
conditioned taste aversion  (IEA,ISO)
D-glucose import  (IEA,ISO)
dentate gyrus development  (IEA,ISO)
dopamine transport  (IEA,ISO)
eating behavior  (ISO)
feeding behavior  (IEA,ISO)
G protein-coupled dopamine receptor signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IEA)
grooming behavior  (IEA,ISO)
habituation  (IEA,ISO)
hippocampus development  (IEA,ISO)
intracellular protein transport  (ISO)
learning  (IEA,ISO)
locomotory behavior  (IEA,ISO)
long-term synaptic depression  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
maternal behavior  (IEA,ISO)
mating behavior  (IEA,ISO)
memory  (IEA,ISO)
modification of postsynaptic structure  (IEA)
muscle contraction  (IEA,ISO)
negative regulation of cell migration  (ISO)
negative regulation of cellular response to hypoxia  (ISO)
negative regulation of circadian sleep/wake cycle, sleep  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of synaptic transmission  (ISO)
neuron migration  (IEA,ISO)
neuronal action potential  (IEA,ISO)
operant conditioning  (IEA,ISO)
orbitofrontal cortex development  (ISO)
peristalsis  (IEA,ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IEA,ISO)
positive regulation of feeding behavior  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of MAPK cascade  (IEA)
positive regulation of membrane potential  (ISO)
positive regulation of neuron migration  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (IEA)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prepulse inhibition  (ISO)
presynaptic modulation of chemical synaptic transmission  (IEA)
protein import into nucleus  (IEA,ISO)
protein phosphorylation  (ISO)
regulation of dopamine metabolic process  (IEA,ISO)
regulation of monoatomic ion transport  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of vasoconstriction  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to amphetamine  (IEA,ISO)
response to cocaine  (IEA,ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to nicotine  (ISO)
response to retinoic acid  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
sensitization  (IEA,ISO)
social behavior  (ISO)
startle response  (ISO)
striatum development  (IEA,ISO)
synapse assembly  (ISO)
synaptic transmission, dopaminergic  (IEA,ISO)
synaptic transmission, glutamatergic  (IEA,ISO)
temperature homeostasis  (IEA,ISO)
transmission of nerve impulse  (IEA,ISO)
vasodilation  (IEA)
visual learning  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway   (ISO)
dopamine signaling pathway  (ISO)
dopamine signaling pathway via D1 family of receptors  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
G protein mediated signaling pathway via Galphas family  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:32087746  


Genomics

Comparative Map Data
DRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,587,340 - 77,591,434 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666034997,268 - 1,002,449 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385175,440,036 - 175,444,182 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5175,440,036 - 175,444,182 (-)EnsemblGRCh38hg38GRCh38
GRCh375174,867,039 - 174,871,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365174,800,281 - 174,803,769 (-)NCBINCBI36Build 36hg18NCBI36
Build 345174,800,642 - 174,803,769NCBI
Celera5170,906,676 - 170,910,164 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5169,967,086 - 169,970,574 (-)NCBIHuRef
CHM1_15174,300,099 - 174,303,587 (-)NCBICHM1_1
T2T-CHM13v2.05175,983,814 - 175,987,960 (-)NCBIT2T-CHM13v2.0
Drd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,205,202 - 54,209,677 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,205,202 - 54,209,724 (-)EnsemblGRCm39 Ensembl
GRCm381354,051,183 - 54,055,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,051,183 - 54,055,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371354,146,552 - 54,151,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,061,276 - 54,065,279 (-)NCBIMGSCv36mm8
Celera1355,124,170 - 55,128,645 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.4NCBI
Drd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,545,488 - 10,550,029 (+)NCBIGRCr8
mRatBN7.21710,540,440 - 10,544,971 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,540,558 - 10,545,002 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,555,287 - 10,558,713 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01712,089,485 - 12,092,911 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,551,719 - 10,555,145 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01711,099,736 - 11,104,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,211,031 - 13,215,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,655,926 - 16,658,161 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,655,119 - 16,658,949 (+)NCBI
Celera1710,610,221 - 10,613,646 (+)NCBICelera
Cytogenetic Map17p14NCBI
Drd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,003,229 - 28,006,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,003,229 - 28,006,595 (-)NCBIChiLan1.0ChiLan1.0
DRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24170,570,821 - 170,577,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15168,710,364 - 168,717,128 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05170,787,115 - 170,792,383 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15177,687,201 - 177,691,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5177,688,917 - 177,690,257 (-)Ensemblpanpan1.1panPan2
DRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1437,550,454 - 37,554,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl437,549,708 - 37,553,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha437,496,619 - 37,501,286 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,916,432 - 37,921,101 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,916,400 - 37,921,094 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1437,741,033 - 37,745,149 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,928,336 - 37,933,009 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0438,438,479 - 38,443,142 (+)NCBIUU_Cfam_GSD_1.0
Drd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721392,067,956 - 92,072,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936609792,276 - 793,613 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936609790,647 - 795,187 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1649,189,602 - 49,191,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11649,189,555 - 49,193,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21653,333,853 - 53,338,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Drd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473314,518,146 - 14,520,905 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473314,517,540 - 14,522,173 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_008015340   ⟹   XP_008013531
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12377,587,340 - 77,591,434 (-)NCBI
Vero_WHO_p1.0NW_023666034998,323 - 1,002,449 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038010265   ⟹   XP_037866193
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666034997,268 - 1,002,449 (+)NCBI
RefSeq Acc Id: XM_038010271   ⟹   XP_037866199
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666034997,268 - 1,002,449 (+)NCBI
RefSeq Acc Id: XM_038010274   ⟹   XP_037866202
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666034997,665 - 1,002,449 (+)NCBI
RefSeq Acc Id: XM_038010281   ⟹   XP_037866209
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666034997,268 - 1,002,449 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008013531 (Get FASTA)   NCBI Sequence Viewer  
  XP_037866193 (Get FASTA)   NCBI Sequence Viewer  
  XP_037866199 (Get FASTA)   NCBI Sequence Viewer  
  XP_037866202 (Get FASTA)   NCBI Sequence Viewer  
  XP_037866209 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005749.1
RefSeq Acc Id: XP_008013531   ⟸   XM_008015340
- UniProtKB: A0A0D9RAW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037866199   ⟸   XM_038010271
- UniProtKB: A0A0D9RAW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037866193   ⟸   XM_038010265
- UniProtKB: A0A0D9RAW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037866209   ⟸   XM_038010281
- UniProtKB: A0A0D9RAW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037866202   ⟸   XM_038010274
- UniProtKB: A0A0D9RAW0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009491 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007578.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Dopamine_D1_rcpt UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene DRD1 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  D(1A) DOPAMINE RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS DOPAMINED1AR UniProtKB/TrEMBL
  DOPAMINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0D9RAW0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-03 DRD1  dopamine receptor D1  LOC103245014  uncharacterized LOC103245014  Data merged from RGD:18754232 737654 PROVISIONAL