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Gene: Drd3 (dopamine receptor D3) Rattus norvegicus
Symbol: Drd3
Name: dopamine receptor D3
Description: Exhibits several functions, including D1 dopamine receptor binding activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; behavioral response to cocaine; and regulation of transcription by RNA polymerase II. Localizes to several cellular components, including GABA-ergic synapse; glutamatergic synapse; and integral component of postsynaptic density membrane. Used to study amnestic disorder; essential tremor; and hypertension. Biomarker of heroin dependence and visual epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (R,R)-tramadol; (S)-colchicine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D(3) dopamine receptor; D3 receptor; dopamine D3 receptor; dopamine D3 receptor isoform; dopaminergic receptor D3
Homo sapiens (human) : DRD3 (dopamine receptor D3)  HGNC  Alliance
Mus musculus (house mouse) : Drd3 (dopamine receptor D3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Drd3 (dopamine receptor D3)
Pan paniscus (bonobo/pygmy chimpanzee) : DRD3 (dopamine receptor D3)
Canis lupus familiaris (dog) : DRD3 (dopamine receptor D3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Drd3 (dopamine receptor D3)
Sus scrofa (pig) : DRD3 (dopamine receptor D3)
Chlorocebus sabaeus (African green monkey) : DRD3 (dopamine receptor D3)
Heterocephalus glaber (naked mole-rat) : Drd3 (dopamine receptor D3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01161,819,102 - 61,883,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,822,077 - 61,874,327 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,955,136 - 61,016,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,446,901 - 58,520,589 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,504,489 - 58,578,178 (-)NCBI
Celera1156,432,639 - 56,484,538 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Drd3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2521
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.