Drd3 (dopamine receptor D3) - Rat Genome Database

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Gene: Drd3 (dopamine receptor D3) Rattus norvegicus
Analyze
Symbol: Drd3
Name: dopamine receptor D3
RGD ID: 2521
Description: Enables D1 dopamine receptor binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and protein domain specific binding activity. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; regulation of secretion; and regulation of transcription by RNA polymerase II. Located in several cellular components, including apical part of cell; endocytic vesicle; and glutamatergic synapse. Is integral component of postsynaptic density membrane. Is active in GABA-ergic synapse. Used to study Parkinsonism; amnestic disorder; essential tremor; and hypertension. Biomarker of heroin dependence and visual epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (R,R)-tramadol; (S)-colchicine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D(3) dopamine receptor; D3 receptor; dopamine D3 receptor; dopamine D3 receptor isoform; dopaminergic receptor D3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21156,879,689 - 56,931,901 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1156,879,689 - 56,940,596 (-)Ensembl
Rnor_6.01161,819,102 - 61,883,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,822,077 - 61,874,327 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,955,136 - 61,016,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,446,901 - 58,520,589 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,504,489 - 58,578,178 (-)NCBI
Celera1156,432,639 - 56,484,538 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-butaclamol  (ISO)
(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin  (ISO)
(R,R)-tramadol  (EXP)
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,2,3,4-tetrahydroisoquinoline  (ISO)
17beta-estradiol  (EXP)
2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
4,4'-sulfonyldiphenol  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
apomorphine  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
baclofen  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromocriptine  (EXP)
C60 fullerene  (EXP)
cadmium atom  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
clozapine  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
dieldrin  (EXP)
dizocilpine maleate  (EXP)
dopamine  (EXP,ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
FPL 64176  (EXP)
fucoxanthin  (ISO)
gamma-aminobutyric acid  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
haloperidol  (ISO)
ionomycin  (EXP)
KN-93  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
mirtazapine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (EXP)
nafadotride  (ISO)
nicotine  (ISO)
nifedipine  (EXP)
olanzapine  (ISO)
oxidopamine  (EXP)
piperidines  (ISO)
pramipexole  (ISO)
propanal  (ISO)
quercetin  (EXP)
quinpirole  (EXP,ISO)
risperidone  (ISO)
ropinirole  (ISO)
SCH 23390  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
spiperone  (ISO)
tetrahydropalmatine  (EXP)
tramadol  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
U-73122  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (IDA)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-activating dopamine receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IBA,IDA,ISO)
arachidonic acid secretion  (ISO)
autophagy  (IMP)
behavioral response to cocaine  (IMP,ISO)
cellular calcium ion homeostasis  (ISO)
circadian regulation of gene expression  (ISO)
dopamine receptor signaling pathway  (TAS)
G protein-coupled receptor internalization  (IDA,ISO)
G protein-coupled receptor signaling pathway  (IMP,ISO)
gastric emptying  (IMP)
locomotory behavior  (ISO)
musculoskeletal movement, spinal reflex action  (ISO)
negative regulation of adenylate cyclase activity  (IBA)
negative regulation of apoptotic process  (IDA)
negative regulation of blood pressure  (ISO)
negative regulation of cytosolic calcium ion concentration  (IBA)
negative regulation of dopamine receptor signaling pathway  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of sodium:proton antiporter activity  (IMP)
negative regulation of synaptic transmission, glutamatergic  (IBA)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of voltage-gated calcium channel activity  (IBA)
phospholipase C-activating dopamine receptor signaling pathway  (IBA)
positive regulation of cell population proliferation  (IDA)
positive regulation of cytokinesis  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IBA)
positive regulation of dopamine receptor signaling pathway  (ISO)
positive regulation of mitotic nuclear division  (IMP)
positive regulation of renal sodium excretion  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA)
prepulse inhibition  (ISO)
regulation of blood volume by renin-angiotensin  (ISO)
regulation of circadian sleep/wake cycle, sleep  (IMP)
regulation of dopamine secretion  (IBA,IMP,ISO)
regulation of lipid metabolic process  (ISO)
regulation of locomotion  (IMP)
regulation of locomotion involved in locomotory behavior  (IMP)
regulation of multicellular organism growth  (ISO)
regulation of neurotransmitter uptake  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (EXP,IDA)
regulation of potassium ion transport  (IBA)
response to amphetamine  (ISO)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to histamine  (ISO)
response to morphine  (ISO)
response to xenobiotic stimulus  (IDA,TAS)
synaptic transmission, dopaminergic  (IEA)
visual learning  (ISO)

Cellular Component

References

References - curated
1. Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29.
2. Bahi A, etal., Eur J Neurosci. 2005 Jun;21(12):3415-26.
3. Barbanti P, etal., Mov Disord. 1999 Sep;14(5):764-71.
4. Barik S and de Beaurepaire R, Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):718-26.
5. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
6. Chen G, etal., J Neurosci. 2006 Mar 1;26(9):2513-21. doi: 10.1523/JNEUROSCI.4712-05.2006.
7. Chio CL, etal., Mol Pharmacol. 1994 Jan;45(1):51-60.
8. Coronas V, etal., J Neurochem. 2004 Dec;91(6):1292-301.
9. Crocq MA, etal., J Med Genet. 1992 Dec;29(12):858-60.
10. Deransart C, etal., Brain Res Mol Brain Res. 2001 Oct 19;94(1-2):166-77.
11. Duarte C, etal., Psychopharmacology (Berl) 2003 Feb;166(1):19-32.
12. Fernandes AR, etal., Eur J Neurosci. 2012 Apr;35(8):1344-53. doi: 10.1111/j.1460-9568.2012.08028.x. Epub 2012 Mar 7.
13. Fiorentini C, etal., Mol Pharmacol. 2008 Jul;74(1):59-69. doi: 10.1124/mol.107.043885. Epub 2008 Apr 18.
14. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Griffon N, etal., Brain Res Mol Brain Res 2003 Sep 10;117(1):47-57.
16. Hehar H, etal., PLoS One. 2015 Oct 8;10(10):e0139842. doi: 10.1371/journal.pone.0139842. eCollection 2015.
17. Jeanneteau F, etal., Mol Biol Cell. 2004 Feb;15(2):696-705. Epub 2003 Nov 14.
18. Kashyap P, etal., Dig Dis Sci. 2009 Jan;54(1):57-62. Epub 2008 Jul 4.
19. Kosmowska B, etal., CNS Neurosci Ther. 2016 Jan;22(1):53-62. doi: 10.1111/cns.12467. Epub 2015 Oct 13.
20. Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19.
21. Laszy J, etal., Psychopharmacology (Berl). 2005 May;179(3):567-75. Epub 2004 Dec 24.
22. Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
23. Li Y, etal., Med Sci Monit. 2017 Jun 9;23:2805-2815.
24. Lucotte G, etal., Clin Genet. 2006 May;69(5):437-40.
25. Luippold G, etal., Hypertens Res. 2003 Oct;26(10):855-61.
26. Luippold G, etal., J Am Soc Nephrol. 2001 Nov;12(11):2272-9.
27. MGD data from the GO Consortium
28. Nagai Y, etal., Neurology. 1996 Mar;46(3):791-5.
29. Nanko S, etal., Hum Genet. 1993 Oct;92(4):336-8.
30. NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. O'Connell DP, etal., Hypertension. 1998 Nov;32(5):886-95.
32. OMIM Disease Annotation Pipeline
33. Pedrosa R, etal., Br J Pharmacol. 2004 Aug;142(8):1343-53. Epub 2004 Jul 20.
34. Rajput PS, etal., Neurosci Res. 2009 Sep;65(1):53-63. Epub 2009 May 22.
35. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. RGD automated import pipeline for gene-chemical interactions
37. Roberts C, etal., Eur J Pharmacol. 2006 Mar 18;534(1-3):108-14. Epub 2006 Feb 21.
38. Snyder LA, etal., Biochem Biophys Res Commun 1991 Oct 31;180(2):1031-5.
39. Sokoloff P, etal., Nature 1990 Sep 13;347(6289):146-51.
40. Sokoloff P, etal., Naunyn Schmiedebergs Arch Pharmacol. 2013 Feb;386(2):107-24. doi: 10.1007/s00210-012-0797-0. Epub 2012 Sep 22.
41. Soma M, etal., Med Sci Monit. 2002 Jan;8(1):CR1-4.
42. Staner L, etal., Am J Med Genet 1998 Mar 28;81(2):192-4.
43. van Kampen JM and Stoessl AJ, Neuroscience 2003;116(1):307-14.
44. Wang JD, etal., Autophagy. 2015 Nov 2;11(11):2057-2073. doi: 10.1080/15548627.2015.1100930.
45. Wang Z, etal., Transplantation. 2015 Nov;99(11):2274-84. doi: 10.1097/TP.0000000000000762.
46. Zeng C, etal., Circ Res. 2006 Sep 1;99(5):494-500. Epub 2006 Aug 10.
47. Zeng C, etal., Hypertension. 2004 Mar;43(3):654-60. Epub 2004 Jan 19.
48. Zhang ZJ, etal., Psychiatr Genet. 2003 Sep;13(3):187-92.
Additional References at PubMed
PMID:1358063   PMID:2039532   PMID:7566118   PMID:7907363   PMID:7911712   PMID:8301582   PMID:8333859   PMID:8413587   PMID:8449953   PMID:8666994   PMID:8700864   PMID:8815892  
PMID:8836575   PMID:9354330   PMID:9402626   PMID:9482807   PMID:9651217   PMID:9691085   PMID:10221759   PMID:10415668   PMID:10432116   PMID:10884517   PMID:10943692   PMID:11864730  
PMID:11988344   PMID:12044470   PMID:12097513   PMID:12544452   PMID:12544838   PMID:12574430   PMID:12652349   PMID:12873629   PMID:13129831   PMID:14523624   PMID:15016423   PMID:15081599  
PMID:15084447   PMID:15140009   PMID:15197646   PMID:15319371   PMID:15601940   PMID:15878801   PMID:16197514   PMID:16386234   PMID:16574158   PMID:16839358   PMID:17077299   PMID:17187934  
PMID:17251429   PMID:17332411   PMID:17593530   PMID:17952413   PMID:17996231   PMID:18325483   PMID:18441198   PMID:18547994   PMID:18588536   PMID:20435100   PMID:20531939   PMID:20811714  
PMID:20888837   PMID:20936685   PMID:21054688   PMID:21215744   PMID:21228598   PMID:21389298   PMID:21633357   PMID:21896332   PMID:22297482   PMID:22888021   PMID:23192317   PMID:23399948  
PMID:23407782   PMID:23420100   PMID:23602989   PMID:25257287   PMID:25266122   PMID:25344317   PMID:25517101   PMID:25770092   PMID:25907750   PMID:26233608   PMID:26802971   PMID:27254310  
PMID:27393374   PMID:28096775   PMID:29510167   PMID:30261284   PMID:30489132   PMID:31535376   PMID:31695055   PMID:32646740   PMID:33249031  


Genomics

Comparative Map Data
Drd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21156,879,689 - 56,931,901 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1156,879,689 - 56,940,596 (-)Ensembl
Rnor_6.01161,819,102 - 61,883,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,822,077 - 61,874,327 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,955,136 - 61,016,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,446,901 - 58,520,589 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,504,489 - 58,578,178 (-)NCBI
Celera1156,432,639 - 56,484,538 (-)NCBICelera
Cytogenetic Map11q21NCBI
DRD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3114,127,580 - 114,199,407 (-)EnsemblGRCh38hg38GRCh38
GRCh383114,127,580 - 114,199,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373113,846,427 - 113,918,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363115,330,247 - 115,380,589 (-)NCBINCBI36hg18NCBI36
Celera3112,255,976 - 112,306,017 (-)NCBI
Cytogenetic Map3q13.31NCBI
HuRef3111,221,547 - 111,271,509 (-)NCBIHuRef
CHM1_13113,810,902 - 113,860,923 (-)NCBICHM1_1
Drd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,574,285 - 43,646,353 (+)NCBIGRCm39mm39
GRCm39 Ensembl1643,574,389 - 43,643,295 (+)Ensembl
GRCm381643,754,015 - 43,825,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1643,754,026 - 43,822,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv371643,762,355 - 43,822,952 (+)NCBIGRCm37mm9NCBIm37
MGSCv361643,681,574 - 43,742,171 (+)NCBImm8
Celera1644,116,581 - 44,178,828 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1628.44NCBI
Drd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542714,219,594 - 14,252,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542714,219,519 - 14,252,178 (-)NCBIChiLan1.0ChiLan1.0
DRD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13118,187,636 - 118,237,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3118,187,636 - 118,237,403 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03111,265,834 - 111,317,176 (-)NCBIMhudiblu_PPA_v0panPan3
DRD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13318,369,362 - 18,414,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3318,372,865 - 18,412,277 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3318,479,435 - 18,522,131 (-)NCBI
ROS_Cfam_1.03318,617,139 - 18,660,020 (-)NCBI
UMICH_Zoey_3.13318,420,282 - 18,463,050 (-)NCBI
UNSW_CanFamBas_1.03318,472,599 - 18,515,180 (-)NCBI
UU_Cfam_GSD_1.03319,017,562 - 19,060,421 (-)NCBI
Drd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602135,897,271 - 135,945,568 (+)NCBI
SpeTri2.0NW_0049365361,580,732 - 1,616,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13145,771,510 - 145,819,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113145,769,294 - 145,817,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213155,329,068 - 155,375,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12266,683,987 - 66,737,645 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2266,691,177 - 66,736,690 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604199,729,580 - 99,781,727 (-)NCBIVero_WHO_p1.0
Drd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473134,318,733 - 34,369,111 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D11Got110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,919,347 - 56,919,497 (+)MAPPERmRatBN7.2
Rnor_6.01161,861,776 - 61,861,923NCBIRnor6.0
Rnor_5.01160,994,847 - 60,994,994UniSTSRnor5.0
RGSC_v3.41158,508,038 - 58,508,185UniSTSRGSC3.4
Celera1156,471,987 - 56,472,134UniSTS
Cytogenetic Map11q21UniSTS
RH71216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,879,748 - 56,879,926 (+)MAPPERmRatBN7.2
Rnor_6.01161,822,137 - 61,822,314NCBIRnor6.0
Rnor_5.01160,956,033 - 60,956,210UniSTSRnor5.0
RGSC_v3.41158,446,961 - 58,447,138UniSTSRGSC3.4
Celera1156,432,699 - 56,432,876UniSTS
Cytogenetic Map11q21UniSTS
Drd3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,879,815 - 56,879,922 (+)MAPPERmRatBN7.2
Rnor_6.01161,822,204 - 61,822,310NCBIRnor6.0
Rnor_5.01160,956,100 - 60,956,206UniSTSRnor5.0
RGSC_v3.41158,447,028 - 58,447,134UniSTSRGSC3.4
Celera1156,432,766 - 56,432,872UniSTS
Cytogenetic Map11q21UniSTS
AU049053  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,918,309 - 56,918,584 (+)MAPPERmRatBN7.2
Rnor_6.01161,860,738 - 61,861,012NCBIRnor6.0
Rnor_5.01160,993,809 - 60,994,083UniSTSRnor5.0
RGSC_v3.41158,506,990 - 58,507,274UniSTSRGSC3.4
Celera1156,470,941 - 56,471,223UniSTS
Cytogenetic Map11q21UniSTS
AU049859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,919,224 - 56,919,495 (+)MAPPERmRatBN7.2
Rnor_6.01161,861,653 - 61,861,921NCBIRnor6.0
Rnor_5.01160,994,724 - 60,994,992UniSTSRnor5.0
RGSC_v3.41158,507,915 - 58,508,183UniSTSRGSC3.4
Celera1156,471,864 - 56,472,132UniSTS
Cytogenetic Map11q21UniSTS
DRD3-556F  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,879,856 - 56,881,140 (+)MAPPERmRatBN7.2
Rnor_6.01161,822,245 - 61,823,528NCBIRnor6.0
Rnor_5.01160,956,141 - 60,957,424UniSTSRnor5.0
RGSC_v3.41158,447,069 - 58,448,352UniSTSRGSC3.4
Celera1156,432,807 - 56,434,090UniSTS
Cytogenetic Map11q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:58
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000029474
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system nervous system reproductive system respiratory system
High
Medium
Low 19
Below cutoff 3 47 9 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000089057   ⟹   ENSRNOP00000073117
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,879,689 - 56,940,596 (-)Ensembl
Rnor_6.0 Ensembl1161,822,077 - 61,874,327 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,894,382 - 56,931,828 (-)Ensembl
Rnor_6.0 Ensembl1161,836,769 - 61,874,254 (-)Ensembl
RefSeq Acc Id: NM_017140   ⟹   NP_058836
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21156,879,689 - 56,931,901 (-)NCBI
Rnor_6.01161,822,077 - 61,874,327 (-)NCBI
Rnor_5.01160,955,136 - 61,016,058 (-)NCBI
RGSC_v3.41158,446,901 - 58,520,589 (-)RGD
Celera1156,432,639 - 56,484,538 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058836   ⟸   NM_017140
- UniProtKB: P19020 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073117   ⟸   ENSRNOT00000089057

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 56879893 56879894 G T snv WN/N (2020)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 61822281 61822282 G T snv WN/N (2020), WN/N (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 58447105 58447106 G T snv WN/N (KNAW)
11 58452279 58452280 G T snv FHL/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2521 AgrOrtholog
Ensembl Genes ENSRNOG00000060806 Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000073117 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000089057 UniProtKB/Swiss-Prot
InterPro Dopamine_D3_rcpt UniProtKB/Swiss-Prot
  Dopamine_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:29238 UniProtKB/Swiss-Prot
NCBI Gene 29238 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB DRD3 RGD
PhenoGen Drd3 PhenoGen
PRINTS DOPAMINED3R UniProtKB/Swiss-Prot
  DOPAMINER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt DRD3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P70647 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Drd3  dopamine receptor D3      Name updated 70584 APPROVED