Drd3 (dopamine receptor D3) - Rat Genome Database

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Gene: Drd3 (dopamine receptor D3) Mus musculus
Analyze
Symbol: Drd3
Name: dopamine receptor D3
RGD ID: 735750
MGI Page MGI
Description: Exhibits dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including regulation of blood pressure; regulation of dopamine receptor signaling pathway; and response to alkaloid. Localizes to dopaminergic synapse and plasma membrane. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and sensory organ. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (S)-amphetamine; (S)-nicotine; apomorphine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D(3) dopamine receptor; D3; D3 receptor; D3R; dopamine D3 receptor; dopamine receptor 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,574,285 - 43,646,353 (+)NCBIGRCm39mm39
GRCm39 Ensembl1643,574,389 - 43,643,295 (+)Ensembl
GRCm381643,754,015 - 43,825,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1643,754,026 - 43,822,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv371643,762,355 - 43,822,952 (+)NCBIGRCm37mm9NCBIm37
MGSCv361643,681,574 - 43,742,171 (+)NCBImm8
Celera1644,116,581 - 44,178,828 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1628.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-butaclamol  (ISO)
(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin  (ISO)
(R,R)-tramadol  (ISO)
(S)-amphetamine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP)
1,2,3,4-tetrahydroisoquinoline  (ISO)
17beta-estradiol  (ISO)
2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
apomorphine  (EXP)
Aroclor 1254  (ISO)
atrazine  (ISO)
baclofen  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromocriptine  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
dieldrin  (ISO)
dopamine  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
FPL 64176  (ISO)
fucoxanthin  (ISO)
gamma-aminobutyric acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (ISO)
ionomycin  (ISO)
KN-93  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (EXP)
mirtazapine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (ISO)
nafadotride  (ISO)
nicotine  (EXP)
nifedipine  (ISO)
olanzapine  (ISO)
oxidopamine  (ISO)
piperidines  (ISO)
pramipexole  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinpirole  (ISO)
risperidone  (ISO)
ropinirole  (ISO)
SCH 23390  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
spiperone  (ISO)
tetrahydropalmatine  (ISO)
tramadol  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
U-73122  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-activating dopamine receptor signaling pathway  (IDA,ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IBA,ISO)
arachidonic acid secretion  (ISO)
autophagy  (ISO)
behavioral response to cocaine  (IMP,ISO)
cellular calcium ion homeostasis  (ISO)
circadian regulation of gene expression  (IMP)
G protein-coupled receptor internalization  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
gastric emptying  (ISO)
locomotory behavior  (IGI,IMP)
musculoskeletal movement, spinal reflex action  (IMP)
negative regulation of adenylate cyclase activity  (IBA)
negative regulation of apoptotic process  (ISO)
negative regulation of blood pressure  (IMP)
negative regulation of cytosolic calcium ion concentration  (IBA)
negative regulation of dopamine receptor signaling pathway  (IGI)
negative regulation of oligodendrocyte differentiation  (IDA)
negative regulation of protein kinase B signaling  (IMP)
negative regulation of protein secretion  (ISO)
negative regulation of sodium:proton antiporter activity  (ISO)
negative regulation of synaptic transmission, glutamatergic  (IBA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of voltage-gated calcium channel activity  (IBA)
phospholipase C-activating dopamine receptor signaling pathway  (IBA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IBA)
positive regulation of dopamine receptor signaling pathway  (IMP)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prepulse inhibition  (ISO)
regulation of blood volume by renin-angiotensin  (IGI,IMP)
regulation of circadian sleep/wake cycle, sleep  (ISO)
regulation of dopamine secretion  (IBA,IMP,ISO)
regulation of lipid metabolic process  (IMP)
regulation of locomotion  (ISO)
regulation of locomotion involved in locomotory behavior  (ISO)
regulation of multicellular organism growth  (IMP)
regulation of neurotransmitter uptake  (EXP,IDA)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of potassium ion transport  (IBA)
response to amphetamine  (IGI)
response to cocaine  (IMP,ISO)
response to drug  (ISO)
response to ethanol  (IMP)
response to histamine  (ISO)
response to morphine  (IMP)
signal transduction  (IEA)
visual learning  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavior  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal body water content  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal defecation  (IAGP)
abnormal dopamine level  (IAGP)
abnormal emotion/affect behavior  (IAGP)
abnormal food intake  (IAGP)
abnormal intestinal absorption  (IAGP)
abnormal intestinal transit time  (IAGP)
abnormal large intestinal transit time  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal reflex  (IAGP)
abnormal spatial learning  (IAGP)
behavioral despair  (IAGP)
cataract  (IEA)
decreased alcohol consumption  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased dopamine level  (IAGP)
decreased freezing behavior  (IEA)
decreased grooming behavior  (IAGP)
decreased startle reflex  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased urine flow rate  (IAGP)
decreased urine sodium level  (IAGP)
decreased vertical activity  (IAGP)
enhanced behavioral response to alcohol  (IAGP)
fused cornea and lens  (IEA)
head bobbing  (IAGP)
hunched posture  (IAGP)
hyperactivity  (IAGP)
hypoactivity  (IAGP)
impaired behavioral response to morphine  (IAGP)
impaired conditioned place preference behavior  (IAGP)
impaired coordination  (IAGP)
impaired swimming  (IAGP)
increased behavioral withdrawal response  (IAGP)
increased circulating leptin level  (IAGP)
increased defecation amount  (IAGP)
increased exploration in new environment  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased percent body fat/body weight  (IAGP)
increased renin activity  (IAGP)
increased stereotypic behavior  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased thigmotaxis  (IAGP)
increased total body fat amount  (IAGP)
increased vertical activity  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
References

References - curated
1. Accili D, etal., Proc Natl Acad Sci U S A 1996 Mar 5;93(5):1945-9.
2. Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29.
3. Asico LD, etal., J Clin Invest 1998 Aug 1;102(3):493-8.
4. Barbanti P, etal., Mov Disord. 1999 Sep;14(5):764-71.
5. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
6. Crocq MA, etal., J Med Genet. 1992 Dec;29(12):858-60.
7. Deransart C, etal., Brain Res Mol Brain Res. 2001 Oct 19;94(1-2):166-77.
8. Hehar H, etal., PLoS One. 2015 Oct 8;10(10):e0139842. doi: 10.1371/journal.pone.0139842. eCollection 2015.
9. Kosmowska B, etal., CNS Neurosci Ther. 2016 Jan;22(1):53-62. doi: 10.1111/cns.12467. Epub 2015 Oct 13.
10. Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19.
11. Laszy J, etal., Psychopharmacology (Berl). 2005 May;179(3):567-75. Epub 2004 Dec 24.
12. Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
13. Li Y, etal., Med Sci Monit. 2017 Jun 9;23:2805-2815.
14. Lucotte G, etal., Clin Genet. 2006 May;69(5):437-40.
15. MGD and Homologene mouse data transfer
16. MGD data from the GO Consortium
17. MGD IEA
18. Nagai Y, etal., Neurology. 1996 Mar;46(3):791-5.
19. Nanko S, etal., Hum Genet. 1993 Oct;92(4):336-8.
20. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
21. OMIM Disease Annotation Pipeline
22. RGD automated import pipeline
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Roberts C, etal., Eur J Pharmacol. 2006 Mar 18;534(1-3):108-14. Epub 2006 Feb 21.
26. Soma M, etal., Med Sci Monit. 2002 Jan;8(1):CR1-4.
27. Staner L, etal., Am J Med Genet 1998 Mar 28;81(2):192-4.
28. van Kampen JM and Stoessl AJ, Neuroscience 2003;116(1):307-14.
29. Wang Z, etal., Transplantation. 2015 Nov;99(11):2274-84. doi: 10.1097/TP.0000000000000762.
30. Zhang ZJ, etal., Psychiatr Genet. 2003 Sep;13(3):187-92.
Additional References at PubMed
PMID:7566118   PMID:7598803   PMID:7609622   PMID:7830039   PMID:8169823   PMID:8211130   PMID:8313980   PMID:8449953   PMID:8601467   PMID:8836575   PMID:9354330   PMID:9402626  
PMID:9430408   PMID:9482807   PMID:9651217   PMID:10029239   PMID:10221759   PMID:10341260   PMID:10391470   PMID:10432116   PMID:10506202   PMID:10828532   PMID:10884517   PMID:10943692  
PMID:10998124   PMID:11102473   PMID:11864730   PMID:11988344   PMID:12044470   PMID:12097513   PMID:12099907   PMID:12477932   PMID:12574430   PMID:12652349   PMID:12843272   PMID:12860471  
PMID:12873629   PMID:13129831   PMID:15016423   PMID:15056714   PMID:15084447   PMID:15197646   PMID:15371743   PMID:15537671   PMID:15601940   PMID:15878801   PMID:15998716   PMID:16176386  
PMID:16197514   PMID:16386234   PMID:16476524   PMID:16525059   PMID:16602821   PMID:16856172   PMID:16902178   PMID:17251429   PMID:17460376   PMID:17509542   PMID:17531156   PMID:17662480  
PMID:17784836   PMID:17942719   PMID:18083900   PMID:18380665   PMID:18402112   PMID:18410503   PMID:18612813   PMID:18644244   PMID:18644790   PMID:18797877   PMID:18799693   PMID:18832038  
PMID:18973551   PMID:19017537   PMID:19217379   PMID:19489048   PMID:19591935   PMID:19840852   PMID:19879251   PMID:20149873   PMID:20220117   PMID:20433900   PMID:20456009   PMID:20477937  
PMID:20584977   PMID:20600590   PMID:20600656   PMID:20849922   PMID:20938680   PMID:21040850   PMID:21168475   PMID:21170735   PMID:21209191   PMID:21267068   PMID:21354213   PMID:21737144  
PMID:21873635   PMID:21982372   PMID:22063631   PMID:22145570   PMID:22154407   PMID:22178719   PMID:22219295   PMID:22420045   PMID:22776159   PMID:22867038   PMID:22918877   PMID:22957735  
PMID:22995602   PMID:23001156   PMID:23045656   PMID:23242137   PMID:23322492   PMID:23357086   PMID:23410496   PMID:23429911   PMID:23506736   PMID:23511253   PMID:23589621   PMID:23643749  
PMID:23753418   PMID:23902361   PMID:23906635   PMID:24023697   PMID:24100927   PMID:24387821   PMID:24584330   PMID:24952961   PMID:24966815   PMID:25110304   PMID:25149631   PMID:25283483  
PMID:25393815   PMID:25444159   PMID:25482686   PMID:25511804   PMID:25729949   PMID:26025054   PMID:26228024   PMID:26238476   PMID:26483399   PMID:26561599   PMID:26619275   PMID:26718601  
PMID:27156126   PMID:27183640   PMID:27393374   PMID:27508444   PMID:27716994   PMID:27815417   PMID:28257894   PMID:28522735   PMID:28684358   PMID:29046641   PMID:29175029   PMID:29276054  
PMID:29510167   PMID:29713079   PMID:30233336   PMID:30244920   PMID:30292827   PMID:30919214   PMID:31127135   PMID:31810491   PMID:31900153   PMID:33153031  


Genomics

Comparative Map Data
Drd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,574,285 - 43,646,353 (+)NCBIGRCm39mm39
GRCm39 Ensembl1643,574,389 - 43,643,295 (+)Ensembl
GRCm381643,754,015 - 43,825,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1643,754,026 - 43,822,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv371643,762,355 - 43,822,952 (+)NCBIGRCm37mm9NCBIm37
MGSCv361643,681,574 - 43,742,171 (+)NCBImm8
Celera1644,116,581 - 44,178,828 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1628.44NCBI
DRD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3114,128,652 - 114,199,407 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3114,127,580 - 114,199,407 (-)EnsemblGRCh38hg38GRCh38
GRCh383114,127,580 - 114,199,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373113,846,427 - 113,918,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363115,330,247 - 115,380,589 (-)NCBINCBI36hg18NCBI36
Celera3112,255,976 - 112,306,017 (-)NCBI
Cytogenetic Map3q13.31NCBI
HuRef3111,221,547 - 111,271,509 (-)NCBIHuRef
CHM1_13113,810,844 - 113,881,272 (-)NCBICHM1_1
Drd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21156,879,689 - 56,931,901 (-)NCBI
Rnor_6.0 Ensembl1161,822,077 - 61,874,327 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01161,819,102 - 61,883,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01160,955,136 - 61,016,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,446,901 - 58,520,589 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,504,489 - 58,578,178 (-)NCBI
Celera1156,432,639 - 56,484,538 (-)NCBICelera
Cytogenetic Map11q21NCBI
Drd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542714,219,594 - 14,252,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542714,219,519 - 14,252,178 (-)NCBIChiLan1.0ChiLan1.0
DRD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13118,187,636 - 118,237,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3118,187,636 - 118,237,403 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03111,265,834 - 111,317,176 (-)NCBIMhudiblu_PPA_v0panPan3
DRD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13318,369,362 - 18,414,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3318,372,865 - 18,412,277 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3318,479,435 - 18,522,131 (-)NCBI
ROS_Cfam_1.03318,617,139 - 18,660,020 (-)NCBI
UMICH_Zoey_3.13318,420,282 - 18,463,050 (-)NCBI
UNSW_CanFamBas_1.03318,472,599 - 18,515,180 (-)NCBI
UU_Cfam_GSD_1.03319,017,562 - 19,060,421 (-)NCBI
Drd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602135,897,271 - 135,945,568 (+)NCBI
SpeTri2.0NW_0049365361,580,732 - 1,616,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13145,771,510 - 145,819,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113145,769,294 - 145,817,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213155,329,068 - 155,375,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12266,683,987 - 66,737,645 (+)NCBI
ChlSab1.1 Ensembl2266,691,177 - 66,736,690 (+)Ensembl
Drd3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473134,318,733 - 34,369,111 (+)NCBI

Position Markers
Drd3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381643,822,665 - 43,822,771UniSTSGRCm38
MGSCv371643,822,778 - 43,822,884UniSTSGRCm37
Celera1644,178,654 - 44,178,760UniSTS
Cytogenetic Map16B4UniSTS
cM Map1623.3UniSTS
DRD3-556F  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381643,821,451 - 43,822,730UniSTSGRCm38
MGSCv371643,821,564 - 43,822,843UniSTSGRCm37
Celera1644,177,440 - 44,178,719UniSTS
Cytogenetic Map16B4UniSTS
cM Map1623.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226768Tibl9_mtibia length 9, 5 week (mouse)16350000051600000Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16350000064800000Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16400000064800000Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16450000044700000Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16672511565669666Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16860000091100000Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined161006288144062881Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161203007246030171Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161240654246406653Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161498410348984214Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161570409149704294Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162020057985803938Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162211802156118212Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2295650257773713Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162897245062972589Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162897245062972589Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162897245062972589Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162897245062972589Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163249243266492570Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3270409165669666Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163562627392776120Mouse
10412263Gvhd6_mgraft-versus host disease 6 (mouse)Not determined163624048745690785Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163750000084900000Mouse
35673309Ari5_mantibody response to influenza 5, day 15, IgG1 (mouse)164000000044700000Mouse
4142112Skts-fp3_mskin tumor susceptibility in FVB and PWK 3 (mouse)Not determined164023351973127497Mouse
11522747Eae41_mexperimental allergic encephalomyelitis susceptibility 41 (mouse)164057877278218584Mouse
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164077356074773713Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164237745482534286Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir124a-2mmu-miR-124-3pMirtarbaseexternal_infoqRT-PCR//Western blotNon-Functional MTI19703567
Mirlet7dmmu-let-7d-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19703567

Predicted Target Of
Summary Value
Count of predictions:199
Count of miRNA genes:187
Interacting mature miRNAs:198
Transcripts:ENSMUST00000023390
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000023390   ⟹   ENSMUSP00000023390
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1643,762,221 - 43,822,932 (+)Ensembl
RefSeq Acc Id: ENSMUST00000229953   ⟹   ENSMUSP00000155033
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1643,754,026 - 43,822,932 (+)Ensembl
RefSeq Acc Id: NM_007877   ⟹   NP_031903
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391643,582,584 - 43,643,295 (+)NCBI
GRCm381643,762,221 - 43,822,932 (+)NCBI
MGSCv371643,762,355 - 43,822,952 (+)RGD
Celera1644,116,581 - 44,178,828 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521777   ⟹   XP_006521840
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391643,574,285 - 43,646,353 (+)NCBI
GRCm381643,754,015 - 43,825,982 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031903   ⟸   NM_007877
- UniProtKB: P30728 (UniProtKB/Swiss-Prot),   Q0VEC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006521840   ⟸   XM_006521777
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000155033   ⟸   ENSMUST00000229953
RefSeq Acc Id: ENSMUSP00000023390   ⟸   ENSMUST00000023390
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94925 AgrOrtholog
Ensembl Genes ENSMUSG00000022705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000023390 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000155033 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023390 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000229953 UniProtKB/TrEMBL
InterPro Dopamine_D3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:94925 ENTREZGENE
NCBI Gene 13490 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DRD3 RGD
PhenoGen Drd3 PhenoGen
PRINTS DOPAMINED3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOPAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R8VHF0_MOUSE UniProtKB/TrEMBL
  DRD3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0VEC4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Drd3  dopamine receptor D3  Drd3  dopamine receptor 3  Symbol and/or name change 5135510 APPROVED