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Gene: Drd3 (dopamine receptor D3) Mus musculus
Symbol: Drd3
Name: dopamine receptor D3
Description: Exhibits dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including regulation of blood pressure; regulation of dopamine receptor signaling pathway; and response to alkaloid. Localizes to the dopaminergic synapse and plasma membrane. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; and schizophrenia. Is expressed in several structures, including brain; exocrine gland; eye; genitourinary system; and gut. Orthologous to human DRD3 (dopamine receptor D3); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (S)-amphetamine; apomorphine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D(3) dopamine receptor; D3 receptor; D3R; dopamine D3 receptor; dopamine receptor 3
Homo sapiens (human) : DRD3 (dopamine receptor D3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Drd3 (dopamine receptor D3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Drd3 (dopamine receptor D3)
Pan paniscus (bonobo/pygmy chimpanzee) : DRD3 (dopamine receptor D3)
Canis lupus familiaris (dog) : DRD3 (dopamine receptor D3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Drd3 (dopamine receptor D3)
Sus scrofa (pig) : DRD3 (dopamine receptor D3)
Chlorocebus sabaeus (green monkey) : DRD3 (dopamine receptor D3)
Heterocephalus glaber (naked mole-rat) : Drd3 (dopamine receptor D3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1643,754,026 - 43,822,932 (+)Ensembl
GRCm381643,754,015 - 43,825,982 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371643,762,355 - 43,822,952 (+)NCBIGRCm37mm9NCBIm37
MGSCv361643,681,574 - 43,742,171 (+)NCBImm8
Celera1644,116,581 - 44,178,828 (+)NCBICelera
Cytogenetic Map16 B4NCBI
cM Map1628.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Drd3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735750
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.