Drd3 (dopamine receptor D3) - Rat Genome Database

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Gene: Drd3 (dopamine receptor D3) Mus musculus
Analyze
Symbol: Drd3
Name: dopamine receptor D3
RGD ID: 735750
MGI Page MGI
Description: Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in behavioral response to cocaine and regulation of neurotransmitter uptake. Acts upstream of or within several processes, including regulation of blood pressure; regulation of dopamine receptor signaling pathway; and response to alkaloid. Located in plasma membrane. Is active in dopaminergic synapse. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and sensory organ. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D(3) dopamine receptor; D3; D3 receptor; D3R; dopamine D3 receptor; dopamine receptor 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,574,285 - 43,646,353 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1643,574,389 - 43,643,295 (+)EnsemblGRCm39 Ensembl
GRCm381643,754,015 - 43,825,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1643,754,026 - 43,822,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv371643,762,355 - 43,822,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361643,681,574 - 43,742,171 (+)NCBIMGSCv36mm8
Celera1644,116,581 - 44,178,828 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1628.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-butaclamol  (ISO)
(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin  (ISO)
(R,R)-tramadol  (ISO)
(S)-amphetamine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP)
1,2,3,4-tetrahydroisoquinoline  (ISO)
17beta-estradiol  (ISO)
2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
apomorphine  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
baclofen  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromocriptine  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
dieldrin  (ISO)
diiodine  (EXP)
dimethylarsinic acid  (EXP)
dizocilpine maleate  (ISO)
dopamine  (ISO)
ethanol  (EXP)
eticlopride(1+)  (ISO)
fenvalerate  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
FPL 64176  (ISO)
fucoxanthin  (ISO)
gamma-aminobutyric acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (ISO)
ionomycin  (ISO)
KN-93  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methylarsonic acid  (EXP)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (EXP)
mirtazapine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (ISO)
N-Methylspiperone  (ISO)
nafadotride  (ISO)
nicotine  (EXP)
nifedipine  (ISO)
olanzapine  (ISO)
oxidopamine  (ISO)
piperidines  (ISO)
pramipexole  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinpirole  (ISO)
risperidone  (ISO)
ropinirole  (ISO)
SCH 23390  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
spiperone  (ISO)
tetrahydropalmatine  (ISO)
tramadol  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
U-73122  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-activating dopamine receptor signaling pathway  (IDA,ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IBA,ISO)
arachidonic acid secretion  (ISO)
autophagy  (ISO)
behavioral response to cocaine  (IMP,ISO)
circadian regulation of gene expression  (IMP)
dopamine receptor signaling pathway  (IGI,IMP)
G protein-coupled receptor internalization  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
intracellular calcium ion homeostasis  (ISO)
locomotory behavior  (IGI,IMP)
musculoskeletal movement, spinal reflex action  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of blood pressure  (IMP)
negative regulation of cytosolic calcium ion concentration  (IBA)
negative regulation of dopamine receptor signaling pathway  (IGI)
negative regulation of oligodendrocyte differentiation  (IDA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
negative regulation of protein secretion  (ISO)
negative regulation of sodium:proton antiporter activity  (ISO)
negative regulation of synaptic transmission, glutamatergic  (IBA)
negative regulation of transcription by RNA polymerase II  (ISO)
oligodendrocyte differentiation  (IDA)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
phospholipase C-activating dopamine receptor signaling pathway  (IBA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of dopamine receptor signaling pathway  (IMP)
positive regulation of MAPK cascade  (IBA)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prepulse inhibition  (ISO)
regulation of blood volume by renin-angiotensin  (IGI,IMP)
regulation of circadian sleep/wake cycle, sleep  (ISO)
regulation of dopamine secretion  (IBA,IMP,ISO)
regulation of lipid metabolic process  (IMP)
regulation of locomotion involved in locomotory behavior  (ISO)
regulation of multicellular organism growth  (IMP)
regulation of neurotransmitter uptake  (EXP,IDA)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of potassium ion transport  (IBA)
response to amphetamine  (IGI)
response to cocaine  (IMP,ISO)
response to ethanol  (IMP)
response to histamine  (ISO)
response to morphine  (IMP)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
visual learning  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavior  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal body water content  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal defecation  (IAGP)
abnormal dopamine level  (IAGP)
abnormal emotion/affect behavior  (IAGP)
abnormal food intake  (IAGP)
abnormal heart morphology  (IEA)
abnormal intestinal absorption  (IAGP)
abnormal intestinal transit time  (IAGP)
abnormal large intestinal transit time  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal reflex  (IAGP)
abnormal spatial learning  (IAGP)
behavioral despair  (IAGP)
decreased alcohol consumption  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased dopamine level  (IAGP)
decreased grooming behavior  (IAGP)
decreased locomotor activity  (IAGP)
decreased startle reflex  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased urine flow rate  (IAGP)
decreased urine sodium level  (IAGP)
decreased vertical activity  (IAGP)
enhanced behavioral response to alcohol  (IAGP)
head bobbing  (IAGP)
hunched posture  (IAGP)
hyperactivity  (IAGP)
impaired behavioral response to morphine  (IAGP)
impaired conditioned place preference behavior  (IAGP)
impaired coordination  (IAGP)
impaired swimming  (IAGP)
increased behavioral withdrawal response  (IAGP)
increased circulating leptin level  (IAGP)
increased defecation amount  (IAGP)
increased exploration in new environment  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased locomotor activity  (IAGP)
increased percent body fat/body weight  (IAGP)
increased renin activity  (IAGP)
increased stereotypic behavior  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased thigmotaxis  (IAGP)
increased total body fat amount  (IAGP)
increased vertical activity  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
small heart  (IEA)
small spleen  (IEA)
References

References - curated
# Reference Title Reference Citation
1. A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice. Accili D, etal., Proc Natl Acad Sci U S A 1996 Mar 5;93(5):1945-9.
2. Striatal neurochemical changes in transgenic models of Huntington's disease. Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29.
3. Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension. Asico LD, etal., J Clin Invest 1998 Aug 1;102(3):493-8.
4. Increased expression of dopamine receptors on lymphocytes in Parkinson's disease. Barbanti P, etal., Mov Disord. 1999 Sep;14(5):764-71.
5. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
6. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. Crocq MA, etal., J Med Genet. 1992 Dec;29(12):858-60.
7. Up-regulation of D3 dopaminergic receptor mRNA in the core of the nucleus accumbens accompanies the development of seizures in a genetic model of absence-epilepsy in the rat. Deransart C, etal., Brain Res Mol Brain Res. 2001 Oct 19;94(1-2):166-77.
8. Impulsivity and Concussion in Juvenile Rats: Examining Molecular and Structural Aspects of the Frontostriatal Pathway. Hehar H, etal., PLoS One. 2015 Oct 8;10(10):e0139842. doi: 10.1371/journal.pone.0139842. eCollection 2015.
9. Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats. Kosmowska B, etal., CNS Neurosci Ther. 2016 Jan;22(1):53-62. doi: 10.1111/cns.12467. Epub 2015 Oct 13.
10. Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain. Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19.
11. Dopamine D3 receptor antagonists improve the learning performance in memory-impaired rats. Laszy J, etal., Psychopharmacology (Berl). 2005 May;179(3):567-75. Epub 2004 Dec 24.
12. The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
13. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Li Y, etal., Med Sci Monit. 2017 Jun 9;23:2805-2815.
14. Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families. Lucotte G, etal., Clin Genet. 2006 May;69(5):437-40.
15. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease. Nagai Y, etal., Neurology. 1996 Mar;46(3):791-5.
19. A study of the association between schizophrenia and the dopamine D3 receptor gene. Nanko S, etal., Hum Genet. 1993 Oct;92(4):336-8.
20. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Mouse MP Annotation Import Pipeline RGD automated import pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Dopamine D3 receptor modulation of dopamine efflux in the rat nucleus accumbens. Roberts C, etal., Eur J Pharmacol. 2006 Mar 18;534(1-3):108-14. Epub 2006 Feb 21.
26. Ser9Gly polymorphism in the dopamine D3 receptor gene is not associated with essential hypertension in the Japanese. Soma M, etal., Med Sci Monit. 2002 Jan;8(1):CR1-4.
27. Association between novelty-seeking and the dopamine D3 receptor gene in bipolar patients: a preliminary report. Staner L, etal., Am J Med Genet 1998 Mar 28;81(2):192-4.
28. Effects of oligonucleotide antisense to dopamine D3 receptor mRNA in a rodent model of behavioural sensitization to levodopa. van Kampen JM and Stoessl AJ, Neuroscience 2003;116(1):307-14.
29. Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia-Reperfusion Injury via Increased Linkage With Ga12. Wang Z, etal., Transplantation. 2015 Nov;99(11):2274-84. doi: 10.1097/TP.0000000000000762.
30. Interaction between polymorphisms of the dopamine D3 receptor and manganese superoxide dismutase genes in susceptibility to tardive dyskinesia. Zhang ZJ, etal., Psychiatr Genet. 2003 Sep;13(3):187-92.
Additional References at PubMed
PMID:7566118   PMID:7598803   PMID:7609622   PMID:7830039   PMID:8169823   PMID:8211130   PMID:8313980   PMID:8449953   PMID:8601467   PMID:8836575   PMID:9354330   PMID:9402626  
PMID:9430408   PMID:9482807   PMID:9651217   PMID:10029239   PMID:10221759   PMID:10341260   PMID:10391470   PMID:10432116   PMID:10506202   PMID:10828532   PMID:10884517   PMID:10943692  
PMID:10998124   PMID:11102473   PMID:11864730   PMID:11988344   PMID:12044470   PMID:12097513   PMID:12099907   PMID:12477932   PMID:12574430   PMID:12652349   PMID:12843272   PMID:12860471  
PMID:12873629   PMID:13129831   PMID:15016423   PMID:15056714   PMID:15084447   PMID:15197646   PMID:15371743   PMID:15537671   PMID:15601940   PMID:15878801   PMID:15998716   PMID:16176386  
PMID:16197514   PMID:16386234   PMID:16476524   PMID:16525059   PMID:16602821   PMID:16856172   PMID:16902178   PMID:17251429   PMID:17460376   PMID:17509542   PMID:17531156   PMID:17662480  
PMID:17784836   PMID:17942719   PMID:18083900   PMID:18380665   PMID:18402112   PMID:18410503   PMID:18612813   PMID:18644244   PMID:18644790   PMID:18797877   PMID:18799693   PMID:18832038  
PMID:18973551   PMID:19017537   PMID:19217379   PMID:19489048   PMID:19591935   PMID:19840852   PMID:19879251   PMID:20149873   PMID:20220117   PMID:20433900   PMID:20456009   PMID:20477937  
PMID:20584977   PMID:20600590   PMID:20600656   PMID:20849922   PMID:20938680   PMID:21040850   PMID:21168475   PMID:21170735   PMID:21209191   PMID:21267068   PMID:21354213   PMID:21737144  
PMID:21873635   PMID:21982372   PMID:22063631   PMID:22145570   PMID:22154407   PMID:22178719   PMID:22219295   PMID:22420045   PMID:22776159   PMID:22867038   PMID:22918877   PMID:22957735  
PMID:22995602   PMID:23001156   PMID:23045656   PMID:23242137   PMID:23322492   PMID:23357086   PMID:23410496   PMID:23429911   PMID:23506736   PMID:23511253   PMID:23589621   PMID:23643749  
PMID:23753418   PMID:23902361   PMID:23906635   PMID:24023697   PMID:24100927   PMID:24387821   PMID:24584330   PMID:24952961   PMID:24966815   PMID:25110304   PMID:25149631   PMID:25283483  
PMID:25393815   PMID:25444159   PMID:25482686   PMID:25511804   PMID:25729949   PMID:26025054   PMID:26228024   PMID:26238476   PMID:26483399   PMID:26561599   PMID:26619275   PMID:26718601  
PMID:27156126   PMID:27183640   PMID:27393374   PMID:27508444   PMID:27716994   PMID:27815417   PMID:28257894   PMID:28522735   PMID:28684358   PMID:29046641   PMID:29175029   PMID:29276054  
PMID:29510167   PMID:29713079   PMID:30233336   PMID:30244920   PMID:30292827   PMID:30626912   PMID:30907042   PMID:30919214   PMID:31051233   PMID:31127135   PMID:31492942   PMID:31538542  
PMID:31626970   PMID:31810491   PMID:31900153   PMID:33153031   PMID:33799860   PMID:33803578   PMID:34048697   PMID:34070429   PMID:34370827   PMID:34708087   PMID:34920747   PMID:34971757  
PMID:35292659   PMID:35711471   PMID:35762652   PMID:36979407  


Genomics

Comparative Map Data
Drd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,574,285 - 43,646,353 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1643,574,389 - 43,643,295 (+)EnsemblGRCm39 Ensembl
GRCm381643,754,015 - 43,825,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1643,754,026 - 43,822,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv371643,762,355 - 43,822,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361643,681,574 - 43,742,171 (+)NCBIMGSCv36mm8
Celera1644,116,581 - 44,178,828 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1628.44NCBI
DRD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383114,127,580 - 114,199,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3114,127,580 - 114,199,407 (-)EnsemblGRCh38hg38GRCh38
GRCh373113,846,427 - 113,918,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363115,330,247 - 115,380,589 (-)NCBINCBI36Build 36hg18NCBI36
Celera3112,255,976 - 112,306,017 (-)NCBICelera
Cytogenetic Map3q13.31NCBI
HuRef3111,221,547 - 111,271,509 (-)NCBIHuRef
CHM1_13113,810,902 - 113,860,923 (-)NCBICHM1_1
T2T-CHM13v2.03116,848,840 - 116,920,342 (-)NCBIT2T-CHM13v2.0
Drd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81170,385,586 - 70,437,793 (-)NCBIGRCr8
mRatBN7.21156,879,689 - 56,931,901 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,879,689 - 56,940,596 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1165,692,856 - 65,745,058 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,355,096 - 58,407,302 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01157,403,823 - 57,463,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01161,819,102 - 61,883,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,822,077 - 61,874,327 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,955,136 - 61,016,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,446,901 - 58,520,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,504,489 - 58,578,178 (-)NCBI
Celera1156,432,639 - 56,484,538 (-)NCBICelera
Cytogenetic Map11q21NCBI
Drd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542714,219,594 - 14,252,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542714,219,519 - 14,252,178 (-)NCBIChiLan1.0ChiLan1.0
DRD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22112,119,170 - 112,171,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13112,123,944 - 112,175,818 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03111,265,834 - 111,317,176 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13118,187,636 - 118,237,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3118,187,636 - 118,237,403 (-)Ensemblpanpan1.1panPan2
DRD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13318,369,362 - 18,414,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3318,372,865 - 18,412,277 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3318,479,435 - 18,522,131 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03318,617,139 - 18,660,020 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3318,616,976 - 18,660,045 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13318,420,282 - 18,463,050 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03318,472,599 - 18,515,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03319,017,562 - 19,060,421 (-)NCBIUU_Cfam_GSD_1.0
Drd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602135,897,271 - 135,945,568 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365361,580,732 - 1,616,725 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365361,580,732 - 1,616,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13145,771,774 - 145,819,168 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113145,769,294 - 145,817,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213155,329,068 - 155,375,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12266,683,987 - 66,737,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2266,691,177 - 66,736,690 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604199,729,580 - 99,781,727 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473134,319,130 - 34,363,184 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473134,318,733 - 34,369,111 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Drd3
1488 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:199
Count of miRNA genes:187
Interacting mature miRNAs:198
Transcripts:ENSMUST00000023390
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
10412263Gvhd6_mgraft-versus host disease 6 (mouse)Not determined163606085745511148Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163732036284696888Mouse
35673309Ari5_mantibody response to influenza 5, day 15, IgG1 (mouse)163982036244520363Mouse
4142112Skts-fp3_mskin tumor susceptibility in FVB and PWK 3 (mouse)Not determined164005388172924385Mouse
11522747Eae41_mexperimental allergic encephalomyelitis susceptibility 41 (mouse)164039913478015472Mouse
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164059392374594076Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164219781782331174Mouse

Markers in Region
Drd3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381643,822,665 - 43,822,771UniSTSGRCm38
MGSCv371643,822,778 - 43,822,884UniSTSGRCm37
Celera1644,178,654 - 44,178,760UniSTS
Cytogenetic Map16B4UniSTS
cM Map1623.3UniSTS
DRD3-556F  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381643,821,451 - 43,822,730UniSTSGRCm38
MGSCv371643,821,564 - 43,822,843UniSTSGRCm37
Celera1644,177,440 - 44,178,719UniSTS
Cytogenetic Map16B4UniSTS
cM Map1623.3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000023390   ⟹   ENSMUSP00000023390
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1643,582,584 - 43,643,295 (+)Ensembl
GRCm38.p6 Ensembl1643,762,221 - 43,822,932 (+)Ensembl
RefSeq Acc Id: ENSMUST00000229953   ⟹   ENSMUSP00000155033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1643,574,389 - 43,643,295 (+)Ensembl
GRCm38.p6 Ensembl1643,754,026 - 43,822,932 (+)Ensembl
RefSeq Acc Id: NM_007877   ⟹   NP_031903
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391643,582,584 - 43,643,295 (+)NCBI
GRCm381643,762,221 - 43,822,932 (+)NCBI
MGSCv371643,762,355 - 43,822,952 (+)RGD
Celera1644,116,581 - 44,178,828 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521777   ⟹   XP_006521840
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391643,574,285 - 43,646,353 (+)NCBI
GRCm381643,754,015 - 43,825,982 (+)NCBI
Sequence:
RefSeq Acc Id: NP_031903   ⟸   NM_007877
- UniProtKB: P30728 (UniProtKB/Swiss-Prot),   Q0VEC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006521840   ⟸   XM_006521777
- Peptide Label: isoform X1
- UniProtKB: A0A2R8VHF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000155033   ⟸   ENSMUST00000229953
RefSeq Acc Id: ENSMUSP00000023390   ⟸   ENSMUST00000023390
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30728-F1-model_v2 AlphaFold P30728 1-446 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94925 AgrOrtholog
Ensembl Genes ENSMUSG00000022705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023390 ENTREZGENE
  ENSMUST00000023390.5 UniProtKB/Swiss-Prot
  ENSMUST00000229953 ENTREZGENE
  ENSMUST00000229953.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dopamine_D3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:94925 ENTREZGENE
NCBI Gene 13490 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  D(3) DOPAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DRD3 RGD
PhenoGen Drd3 PhenoGen
PRINTS DOPAMINED3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOPAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R8VHF0 ENTREZGENE, UniProtKB/TrEMBL
  DRD3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0VEC4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Drd3  dopamine receptor D3  Drd3  dopamine receptor 3  Symbol and/or name change 5135510 APPROVED