RGD Reference Report - Dopamine D3 receptor modulation of dopamine efflux in the rat nucleus accumbens. - Rat Genome Database

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Dopamine D3 receptor modulation of dopamine efflux in the rat nucleus accumbens.

Authors: Roberts, C  Cummins, R  Gnoffo, Z  Kew, JN 
Citation: Roberts C, etal., Eur J Pharmacol. 2006 Mar 18;534(1-3):108-14. Epub 2006 Feb 21.
RGD ID: 1625068
Pubmed: PMID:16490190   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejphar.2006.01.014   (Journal Full-text)

The effect of antipsychotics on electrically evoked dopamine efflux in the rat nucleus accumbens core and shell was investigated, using in vitro fast cyclic voltammetry. In the nucleus accumbens core, the dopamine D2/D3 receptor agonist, (+/-)7-OH-DPAT ((+/-)-2-dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene), inhibited dopamine efflux with a pEC50 of 8.1. Clozapine, haloperidol, sulpiride and the selective dopamine D3 receptor antagonist, SB-277011-A, had no effect on dopamine efflux per se but all attenuated the (+/-)7-OH-DPAT-induced-inhibition of dopamine efflux, with pA2 values of 6.6, 7.9, 7.0 and 7.6, respectively. In the nucleus accumbens shell, (+/-)7-OH-DPAT inhibited dopamine efflux with a pEC50 of 8.3. Clozapine and SB-277011-A had no effect on dopamine efflux. In contrast, haloperidol and sulpiride significantly increased dopamine efflux through a D2 receptor-mediated mechanism. Clozapine, haloperidol, sulpiride and SB-277011-A attenuated the (+/-)7-OH-DPAT-induced inhibition with pA2 values of 7.3, 8.6, 7.6 and 8.2, respectively. These data demonstrate that dopamine efflux is modulated by both dopamine D2 and D3 receptors in the rat nucleus accumbens.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of dopamine secretion  IMP 1625068 RGD 
regulation of dopamine secretion  IMP 1625068 RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Drd2  (dopamine receptor D2)
Drd3  (dopamine receptor D3)

Genes (Mus musculus)
Drd2  (dopamine receptor D2)
Drd3  (dopamine receptor D3)

Genes (Homo sapiens)
DRD2  (dopamine receptor D2)
DRD3  (dopamine receptor D3)


Additional Information