Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | increases expression | ISO | Clic6 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of CLIC6 mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | affects expression | ISO | Clic6 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of CLIC6 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of CLIC6 mRNA | CTD | PMID:29097150 | 17beta-estradiol | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | Estradiol results in increased expression of CLIC6 mRNA | CTD | PMID:16474171 | 2,3,7,8-tetrachlorodibenzodioxine | decreases methylation | ISO | Clic6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased methylation of CLIC6 gene | CTD | PMID:21212295 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Clic6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CLIC6 mRNA | CTD | PMID:33956508 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CLIC6 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Clic6 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of CLIC6 gene and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CLIC6 promoter] | CTD | PMID:19654925 and PMID:21212295 | 2-palmitoylglycerol | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of CLIC6 mRNA | CTD | PMID:37199045 | 4,4'-sulfonyldiphenol | increases methylation | ISO | Clic6 (Mus musculus) | 6480464 | bisphenol S results in increased methylation of CLIC6 exon | CTD | PMID:33297965 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Clic6 (Mus musculus) | 6480464 | bisphenol S affects the methylation of CLIC6 gene | CTD | PMID:31683443 | 4-hydroxyphenyl retinamide | increases expression | ISO | Clic6 (Mus musculus) | 6480464 | Fenretinide results in increased expression of CLIC6 mRNA | CTD | PMID:28973697 | 5-aza-2'-deoxycytidine | affects expression | ISO | CLIC6 (Homo sapiens) | 6480464 | Decitabine affects the expression of CLIC6 mRNA | CTD | PMID:23300844 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | Decitabine inhibits the reaction [Smoke results in decreased expression of CLIC6 mRNA] | CTD | PMID:21095227 | acrylamide | decreases expression | ISO | Clic6 (Mus musculus) | 6480464 | Acrylamide results in decreased expression of CLIC6 mRNA | CTD | PMID:35032568 | aflatoxin B1 | increases methylation | ISO | CLIC6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of CLIC6 gene | CTD | PMID:27153756 | aldehydo-D-glucose | multiple interactions | ISO | Clic6 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of CLIC6 mRNA | CTD | PMID:37567420 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CLIC6 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | Clic6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of CLIC6 mRNA | CTD | PMID:27195522 | benzo[a]pyrene | increases methylation | ISO | CLIC6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CLIC6 exon | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | CLIC6 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of CLIC6 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | Clic6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of CLIC6 mRNA | CTD | PMID:22228805 | bisphenol A | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of CLIC6 mRNA | CTD | PMID:16474171 | bisphenol A | increases expression | ISO | Clic6 (Mus musculus) | 6480464 | bisphenol A results in increased expression of CLIC6 mRNA | CTD | PMID:34585602 and PMID:37392660 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CLIC6 mRNA | CTD | PMID:30816183 | bisphenol A | decreases expression | ISO | Clic6 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of CLIC6 mRNA | CTD | PMID:26063408 more ... | bisphenol F | increases methylation | ISO | CLIC6 (Homo sapiens) | 6480464 | bisphenol F results in increased methylation of CLIC6 gene | CTD | PMID:31601247 | cadmium atom | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CLIC6 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CLIC6 mRNA | CTD | PMID:35301059 | CGP 52608 | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CLIC6 gene] | CTD | PMID:28238834 | choline | multiple interactions | ISO | Clic6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLIC6 mRNA | CTD | PMID:20938992 | cisplatin | affects expression | ISO | CLIC6 (Homo sapiens) | 6480464 | Cisplatin affects the expression of CLIC6 mRNA | CTD | PMID:23300844 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of CLIC6 mRNA | CTD | PMID:30556269 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of CLIC6 mRNA | CTD | PMID:30556269 | D-glucose | multiple interactions | ISO | Clic6 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of CLIC6 mRNA | CTD | PMID:37567420 | dorsomorphin | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | entinostat results in increased expression of CLIC6 mRNA | CTD | PMID:26272509 and PMID:27188386 | entinostat | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA | CTD | PMID:27188386 | ethanol | affects splicing | ISO | Clic6 (Mus musculus) | 6480464 | Ethanol affects the splicing of CLIC6 mRNA | CTD | PMID:30319688 | ethanol | affects expression | ISO | Clic6 (Mus musculus) | 6480464 | Ethanol affects the expression of CLIC6 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Clic6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLIC6 mRNA | CTD | PMID:20938992 | fonofos | increases methylation | ISO | CLIC6 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of CLIC6 promoter | CTD | PMID:22847954 | fructose | multiple interactions | ISO | Clic6 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of CLIC6 mRNA | CTD | PMID:37567420 | genistein | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | Genistein results in increased expression of CLIC6 mRNA | CTD | PMID:16474171 | genistein | decreases expression | ISO | Clic6 (Mus musculus) | 6480464 | Genistein results in decreased expression of CLIC6 mRNA | CTD | PMID:32186404 | glucose | multiple interactions | ISO | Clic6 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of CLIC6 mRNA | CTD | PMID:37567420 | glycidol | increases expression | EXP | | 6480464 | glycidol results in increased expression of CLIC6 mRNA | CTD | PMID:24395379 | L-methionine | multiple interactions | ISO | Clic6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLIC6 mRNA | CTD | PMID:20938992 | lead diacetate | affects expression | EXP | | 6480464 | lead acetate affects the expression of CLIC6 mRNA | CTD | PMID:21864555 | lipopolysaccharide | decreases methylation | ISO | Clic6 (Mus musculus) | 6480464 | Lipopolysaccharides results in decreased methylation of CLIC6 gene | CTD | PMID:21212295 | lipopolysaccharide | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CLIC6 mRNA | CTD | PMID:35811015 | lipopolysaccharide | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of CLIC6 mRNA | CTD | PMID:35811015 | lipopolysaccharide | multiple interactions | ISO | Clic6 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of CLIC6 gene | CTD | PMID:21212295 | Mesaconitine | increases expression | EXP | | 6480464 | mesaconitine results in increased expression of CLIC6 protein | CTD | PMID:37182599 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of CLIC6 gene | CTD | PMID:35440735 | methylmercury chloride | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of CLIC6 mRNA | CTD | PMID:23179753 and PMID:26272509 | methylmercury chloride | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA | CTD | PMID:27188386 | Monobutylphthalate | decreases expression | ISO | Clic6 (Mus musculus) | 6480464 | monobutyl phthalate results in decreased expression of CLIC6 protein | CTD | PMID:20553848 | panobinostat | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | panobinostat results in increased expression of CLIC6 mRNA | CTD | PMID:26272509 | panobinostat | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA | CTD | PMID:27188386 | parathion | increases methylation | ISO | CLIC6 (Homo sapiens) | 6480464 | Parathion results in increased methylation of CLIC6 promoter | CTD | PMID:22847954 | permethrin | decreases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | Permethrin results in decreased expression of CLIC6 mRNA | CTD | PMID:37047231 | phenylmercury acetate | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of CLIC6 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA | CTD | PMID:27188386 | progesterone | decreases expression | ISO | Clic6 (Mus musculus) | 6480464 | Progesterone results in decreased expression of CLIC6 mRNA | CTD | PMID:22238285 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CLIC6 mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of CLIC6 protein | CTD | PMID:29459688 | sulforaphane | increases expression | ISO | Clic6 (Mus musculus) | 6480464 | sulforaphane results in increased expression of CLIC6 mRNA | CTD | PMID:30529165 | terbufos | increases methylation | ISO | CLIC6 (Homo sapiens) | 6480464 | terbufos results in increased methylation of CLIC6 promoter | CTD | PMID:22847954 | titanium dioxide | affects expression | ISO | Clic6 (Mus musculus) | 6480464 | titanium dioxide affects the expression of CLIC6 mRNA | CTD | PMID:23557971 | trichostatin A | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA | CTD | PMID:27188386 | trichostatin A | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of CLIC6 mRNA | CTD | PMID:24935251 more ... | triptonide | increases expression | ISO | Clic6 (Mus musculus) | 6480464 | triptonide results in increased expression of CLIC6 mRNA | CTD | PMID:33045310 | valproic acid | increases expression | ISO | Clic6 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of CLIC6 mRNA | CTD | PMID:21427059 | valproic acid | increases expression | ISO | CLIC6 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of CLIC6 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | CLIC6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA | CTD | PMID:27188386 | valproic acid | increases methylation | ISO | CLIC6 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of CLIC6 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | CLIC6 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CLIC6 mRNA | CTD | PMID:25979313 | zinc atom | increases expression | ISO | Clic6 (Mus musculus) | 6480464 | Zinc deficiency results in increased expression of CLIC6 mRNA | CTD | PMID:20857495 | zinc(0) | increases expression | ISO | Clic6 (Mus musculus) | 6480464 | Zinc deficiency results in increased expression of CLIC6 mRNA | CTD | PMID:20857495 | |