RGD Reference Report - Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. - Rat Genome Database

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Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.

Authors: Sokoloff, P  Giros, B  Martres, MP  Bouthenet, ML  Schwartz, JC 
Citation: Sokoloff P, etal., Nature 1990 Sep 13;347(6289):146-51.
RGD ID: 728430
Pubmed: PMID:1975644   (View Abstract at PubMed)
DOI: DOI:10.1038/347146a0   (Journal Full-text)

A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dopamine receptor signaling pathway  TAS 728430 RGD 
response to xenobiotic stimulus involved_inIDA 728430; 728430PMID:1975644BHF-UCL 
response to xenobiotic stimulus  TAS 728430 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dopamine neurotransmitter receptor activity  TAS 728430 RGD 
dopamine neurotransmitter receptor activity, coupled via Gi/Go enablesIDA 728430PMID:1975644BHF-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Drd2  (dopamine receptor D2)
Drd3  (dopamine receptor D3)


Additional Information