RGD Reference Report - A study of the association between schizophrenia and the dopamine D3 receptor gene. - Rat Genome Database

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A study of the association between schizophrenia and the dopamine D3 receptor gene.

Authors: Nanko, S  Sasaki, T  Fukuda, R  Hattori, M  Dai, XY  Kazamatsuri, H  Kuwata, S  Juji, T  Gill, M 
Citation: Nanko S, etal., Hum Genet. 1993 Oct;92(4):336-8.
RGD ID: 1626358
Pubmed: PMID:8225313   (View Abstract at PubMed)

A study of the genetic association between schizophrenia and a BalI polymorphism in exon 1 of the dopamine D3 (DRD3) gene, a candidate gene for schizophrenia, was conducted. The polymorphism was examined in 91 patients whose symptoms satisfied DSM-III-R for schizophrenia and 90 controls. There were no significant differences between the groups in allele frequencies or genotype counts. Contrary to a previous report, the patients were no more likely to be homozygous than controls. Moreover, no association with the presence of illness could be demonstrated when the patients were grouped according to sex, age of onset, history of admission to psychiatric institutions or positive family history.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DRD3Humanschizophrenia no_associationIAGP DNA:polymorphism:CDS:BalI polymorphism more ...RGD 
Drd3Ratschizophrenia no_associationISODRD3 (Homo sapiens) RGD 
Drd3Mouseschizophrenia no_associationISODRD3 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd3  (dopamine receptor D3)

Genes (Mus musculus)
Drd3  (dopamine receptor D3)

Genes (Homo sapiens)
DRD3  (dopamine receptor D3)


Additional Information