Drd3 (dopamine receptor D3) - Rat Genome Database

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Gene: Drd3 (dopamine receptor D3) Ictidomys tridecemlineatus
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Symbol: Drd3
Name: dopamine receptor D3
RGD ID: 12648217
Description: ENCODES a protein that exhibits D1 dopamine receptor binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN acid secretion (ortholog); adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); autophagy (ortholog); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH Alzheimer's disease (ortholog); amnestic disorder (ortholog); amphetamine abuse (ortholog); FOUND IN apical part of cell (ortholog); cell projection (ortholog); dopaminergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: D(3) dopamine receptor; dopamine receptor D3, transcript variant X1; dopamine receptor D3, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602135,897,271 - 135,945,568 (+)NCBI
SpeTri2.0NW_0049365361,580,732 - 1,616,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (IEA,ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IEA)
arachidonic acid secretion  (IEA)
autophagy  (ISO)
behavioral response to cocaine  (IEA,ISO)
cellular calcium ion homeostasis  (IEA)
circadian regulation of gene expression  (ISO)
G protein-coupled receptor internalization  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
gastric emptying  (ISO)
locomotory behavior  (ISO)
musculoskeletal movement, spinal reflex action  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of dopamine receptor signaling pathway  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein secretion  (IEA)
negative regulation of sodium:proton antiporter activity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokinesis  (IEA)
positive regulation of dopamine receptor signaling pathway  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prepulse inhibition  (IEA)
regulation of biological quality  (IEA)
regulation of blood volume by renin-angiotensin  (ISO)
regulation of circadian sleep/wake cycle, sleep  (ISO)
regulation of dopamine secretion  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of locomotion  (ISO)
regulation of locomotion involved in locomotory behavior  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of neurotransmitter uptake  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
response to amphetamine  (ISO)
response to cocaine  (IEA,ISO)
response to ethanol  (ISO)
response to histamine  (IEA)
response to morphine  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
synaptic transmission, dopaminergic  (IEA)
visual learning  (ISO)

References

Genomics

Comparative Map Data
Drd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602135,897,271 - 135,945,568 (+)NCBI
SpeTri2.0NW_0049365361,580,732 - 1,616,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3114,127,580 - 114,199,407 (-)EnsemblGRCh38hg38GRCh38
GRCh383114,127,580 - 114,199,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373113,846,427 - 113,918,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363115,330,247 - 115,380,589 (-)NCBINCBI36hg18NCBI36
Celera3112,255,976 - 112,306,017 (-)NCBI
Cytogenetic Map3q13.31NCBI
HuRef3111,221,547 - 111,271,509 (-)NCBIHuRef
CHM1_13113,810,902 - 113,860,923 (-)NCBICHM1_1
Drd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,574,285 - 43,646,353 (+)NCBIGRCm39mm39
GRCm39 Ensembl1643,574,389 - 43,643,295 (+)Ensembl
GRCm381643,754,015 - 43,825,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1643,754,026 - 43,822,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv371643,762,355 - 43,822,952 (+)NCBIGRCm37mm9NCBIm37
MGSCv361643,681,574 - 43,742,171 (+)NCBImm8
Celera1644,116,581 - 44,178,828 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1628.44NCBI
Drd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21156,879,689 - 56,931,901 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1156,879,689 - 56,940,596 (-)Ensembl
Rnor_6.01161,819,102 - 61,883,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,822,077 - 61,874,327 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,955,136 - 61,016,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,446,901 - 58,520,589 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,504,489 - 58,578,178 (-)NCBI
Celera1156,432,639 - 56,484,538 (-)NCBICelera
Cytogenetic Map11q21NCBI
Drd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542714,219,594 - 14,252,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542714,219,519 - 14,252,178 (-)NCBIChiLan1.0ChiLan1.0
DRD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13118,187,636 - 118,237,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3118,187,636 - 118,237,403 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03111,265,834 - 111,317,176 (-)NCBIMhudiblu_PPA_v0panPan3
DRD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13318,369,362 - 18,414,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3318,372,865 - 18,412,277 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3318,479,435 - 18,522,131 (-)NCBI
ROS_Cfam_1.03318,617,139 - 18,660,020 (-)NCBI
ROS_Cfam_1.0 Ensembl3318,616,976 - 18,660,045 (-)Ensembl
UMICH_Zoey_3.13318,420,282 - 18,463,050 (-)NCBI
UNSW_CanFamBas_1.03318,472,599 - 18,515,180 (-)NCBI
UU_Cfam_GSD_1.03319,017,562 - 19,060,421 (-)NCBI
DRD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13145,771,510 - 145,819,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113145,769,294 - 145,817,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213155,329,068 - 155,375,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12266,683,987 - 66,737,645 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2266,691,177 - 66,736,690 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604199,729,580 - 99,781,727 (-)NCBIVero_WHO_p1.0
Drd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473134,318,733 - 34,369,111 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005327606   ⟹   XP_005327663
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602135,897,275 - 135,945,568 (+)NCBI
SpeTri2.0NW_0049365361,580,732 - 1,616,726 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040270346   ⟹   XP_040126280
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602135,897,271 - 135,945,568 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005327663 (Get FASTA)   NCBI Sequence Viewer  
  XP_040126280 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3271428 (Get FASTA)   NCBI Sequence Viewer  
  KAG3271429 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005327663   ⟸   XM_005327606
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040126280   ⟸   XM_040270346
- Peptide Label: isoform X1
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000307 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000016310 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000028325 UniProtKB/TrEMBL
InterPro Dopamine_D3_rcpt UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene Drd3 ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS DOPAMINED3R UniProtKB/TrEMBL
  DOPAMINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
UniProt I3MW15_ICTTR UniProtKB/TrEMBL