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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2521
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd3
Name: dopamine receptor D3
Acc ID: CHEBI:64117
Term: (1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin
Definition: A secondary amino compound that consists of tetralin bearing methyl, propylamino and methoxy groups at positions 1, 2 and 5 respectively. Dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively).
Chemical ID: MESH:C051171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd3multiple interactionsISODRD3 (Homo sapiens)6480464CTD5-methoxy-1-methyl-2-(n-propylamino)tetralin binds to and results in decreased activity of DRD3 proteinPMID:10728880
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