DRD1 (dopamine receptor D1) - Rat Genome Database

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Gene: DRD1 (dopamine receptor D1) Sus scrofa
Analyze
Symbol: DRD1
Name: dopamine receptor D1
RGD ID: 14075755
Description: ENCODES a protein that exhibits angiotensin receptor binding (ortholog); ATPase binding (ortholog); D3 dopamine receptor binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adult walking behavior (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); amphetamine abuse (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); caveola (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: D(1A) dopamine receptor; dopamine D1 receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1649,188,936 - 49,193,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11649,189,555 - 49,193,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21653,333,853 - 53,338,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (IEA,ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-activating dopamine receptor signaling pathway  (IEA,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA)
adult walking behavior  (ISO)
associative learning  (ISO)
astrocyte development  (ISO)
behavioral fear response  (ISO)
behavioral response to cocaine  (ISO)
calcium-mediated signaling  (ISO)
cellular response to catecholamine stimulus  (ISO)
cellular response to dopamine  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cerebral cortex GABAergic interneuron migration  (ISO)
conditioned taste aversion  (ISO)
dentate gyrus development  (ISO)
dopamine receptor signaling pathway  (IBA,IEA,ISO)
dopamine transport  (ISO)
eating behavior  (ISO)
feeding behavior  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IEA)
glucose import  (ISO)
grooming behavior  (ISO)
habituation  (ISO)
hippocampus development  (ISO)
histone H3-S10 phosphorylation  (ISO)
intracellular protein transport  (ISO)
learning  (ISO)
locomotory behavior  (ISO)
long-term synaptic depression  (ISO)
long-term synaptic potentiation  (ISO)
maternal behavior  (ISO)
mating behavior  (ISO)
memory  (ISO)
modification of postsynaptic structure  (ISO)
muscle contraction  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of circadian sleep/wake cycle, sleep  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of synaptic transmission  (ISO)
neuronal action potential  (ISO)
operant conditioning  (ISO)
orbitofrontal cortex development  (ISO)
peristalsis  (ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IEA)
positive regulation of feeding behavior  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of membrane potential  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (IEA)
positive regulation of synaptic transmission, glutamatergic  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prepulse inhibition  (ISO)
protein import into nucleus  (ISO)
regulation of dopamine metabolic process  (ISO)
regulation of ion transport  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
regulation of vasoconstriction  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to amphetamine  (ISO)
response to cocaine  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to morphine  (ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to retinoic acid  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensitization  (ISO)
social behavior  (ISO)
startle response  (ISO)
striatum development  (ISO)
synapse assembly  (ISO)
synaptic transmission, dopaminergic  (IEA,ISO)
temperature homeostasis  (ISO)
transmission of nerve impulse  (ISO)
vasodilation  (IEA)
visual learning  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
dopamine signaling pathway  (ISO)
dopamine signaling pathway via D1 family of receptors  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
G protein mediated signaling pathway via Galphas family  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:7900842   PMID:16217657  


Genomics

Comparative Map Data
DRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1649,188,936 - 49,193,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11649,189,555 - 49,193,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21653,333,853 - 53,338,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5175,440,036 - 175,444,182 (-)EnsemblGRCh38hg38GRCh38
GRCh385175,440,036 - 175,444,182 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375174,867,039 - 174,871,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365174,800,281 - 174,803,769 (-)NCBINCBI36hg18NCBI36
Build 345174,800,642 - 174,803,769NCBI
Celera5170,906,676 - 170,910,164 (-)NCBI
Cytogenetic Map5q35.2NCBI
HuRef5169,967,086 - 169,970,574 (-)NCBIHuRef
CHM1_15174,300,099 - 174,303,587 (-)NCBICHM1_1
Drd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,205,202 - 54,209,677 (-)NCBIGRCm39mm39
GRCm39 Ensembl1354,205,202 - 54,209,724 (-)Ensembl
GRCm381354,051,183 - 54,055,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,051,183 - 54,055,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371354,146,552 - 54,151,027 (-)NCBIGRCm37mm9NCBIm37
MGSCv361354,061,276 - 54,065,279 (-)NCBImm8
Celera1355,124,170 - 55,128,645 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.4NCBI
Drd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21710,540,440 - 10,544,971 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1710,540,558 - 10,545,002 (+)Ensembl
Rnor_6.01711,099,736 - 11,104,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,211,031 - 13,215,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,655,926 - 16,658,161 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11716,655,119 - 16,658,949 (+)NCBI
Celera1710,610,221 - 10,613,646 (+)NCBICelera
Cytogenetic Map17p14NCBI
Drd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,003,229 - 28,006,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,003,229 - 28,006,595 (-)NCBIChiLan1.0ChiLan1.0
DRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15177,687,201 - 177,691,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5177,688,917 - 177,690,257 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05170,787,115 - 170,792,383 (-)NCBIMhudiblu_PPA_v0panPan3
DRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1437,550,454 - 37,554,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl437,549,708 - 37,553,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha437,496,619 - 37,501,286 (+)NCBI
ROS_Cfam_1.0437,916,432 - 37,921,101 (+)NCBI
UMICH_Zoey_3.1437,741,033 - 37,745,149 (+)NCBI
UNSW_CanFamBas_1.0437,928,336 - 37,933,009 (+)NCBI
UU_Cfam_GSD_1.0438,438,479 - 38,443,142 (+)NCBI
Drd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721392,067,956 - 92,072,508 (+)NCBI
SpeTri2.0NW_004936609790,647 - 795,187 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,587,340 - 77,591,434 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666034997,268 - 1,002,449 (+)NCBIVero_WHO_p1.0
Drd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473314,517,540 - 14,522,173 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system reproductive system
High
Medium 4
Low 6 13 1
Below cutoff 1 2 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000025609   ⟹   ENSSSCP00000020447
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1649,188,936 - 49,193,709 (+)Ensembl
RefSeq Acc Id: NM_001123108   ⟹   NP_001116580
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11649,189,602 - 49,191,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021076520   ⟹   XP_020932179
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11649,189,555 - 49,193,722 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001116580 (Get FASTA)   NCBI Sequence Viewer  
  XP_020932179 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA79848 (Get FASTA)   NCBI Sequence Viewer  
  P50130 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020932179   ⟸   XM_021076520
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001116580   ⟸   NM_001123108
- UniProtKB: P50130 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000020447   ⟸   ENSSSCT00000025609
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029037 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070016149 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000020447 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070026410 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025609 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070031683 UniProtKB/TrEMBL
InterPro Dopamine_D1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100144487 UniProtKB/Swiss-Prot
NCBI Gene DRD1 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DOPAMINED1AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOPAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1UBS6_PIG UniProtKB/TrEMBL
  DRD1_PIG UniProtKB/Swiss-Prot
  I3L8T6_PIG UniProtKB/TrEMBL
  P50130 ENTREZGENE
VGNC ID VGNC:87443 ENTREZGENE