Drd1 (dopamine receptor D1) - Rat Genome Database

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Gene: Drd1 (dopamine receptor D1) Mus musculus
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Symbol: Drd1
Name: dopamine receptor D1
RGD ID: 10485
MGI Page MGI
Description: Enables G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gs. Involved in adenylate cyclase-activating dopamine receptor signaling pathway; modification of postsynaptic structure; and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; endoplasmic reticulum; and nucleus. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C030036C15Rik; D(1A) dopamine receptor; D1 receptor; D1A dopamine receptor; dopamine D1 receptor; dopamine receptor D1A; Drd; Drd-; Drd-1; Drd1a; G protein-coupled receptor DRD1; Gpcr; Gpcr15
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,205,202 - 54,209,677 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,205,202 - 54,209,724 (-)EnsemblGRCm39 Ensembl
GRCm381354,051,183 - 54,055,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,051,183 - 54,055,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371354,146,552 - 54,151,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,061,276 - 54,065,279 (-)NCBIMGSCv36mm8
Celera1355,124,170 - 55,128,645 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (EXP,ISO)
1-bromopropane  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
3',5'-cyclic AMP  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amitriptyline  (ISO)
amlodipine  (EXP)
ammonium chloride  (ISO)
amoxapine  (EXP)
amphetamine  (EXP,ISO)
Anhydroecgonine methyl ester  (ISO)
apomorphine  (EXP,ISO)
aprindine  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
Bardoxolone methyl  (ISO)
benserazide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[ghi]perylene  (EXP)
Benzo[k]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Boldine  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
cyhalothrin  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diclofenac  (EXP)
diltiazem  (EXP)
dioxygen  (ISO)
dizocilpine maleate  (EXP)
domperidone  (EXP)
dopamine  (EXP,ISO)
etafenone  (EXP)
ethanol  (EXP,ISO)
ethyl acetate  (ISO)
eugenol  (ISO)
fenoldopam  (ISO)
flunarizine  (EXP)
flupenthixol  (ISO)
fonofos  (ISO)
formaldehyde  (EXP)
furan  (ISO)
gadolinium atom  (ISO)
gamma-aminobutyric acid  (ISO)
genistein  (ISO)
glyphosate  (ISO)
haloperidol  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoquinolines  (ISO)
lanthanum atom  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
loxapine  (ISO)
manganese(II) chloride  (EXP,ISO)
manidipine  (EXP)
melatonin  (EXP)
melevodopa  (ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methylphenidate  (ISO)
mirtazapine  (ISO)
morphine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (ISO)
nicotine  (EXP,ISO)
Nonylphenol  (ISO)
olanzapine  (EXP)
ouabain  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (EXP)
parathion  (ISO)
pentetrazol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
pergolide  (ISO)
phencyclidine  (EXP)
pioglitazone  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
procymidone  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
quinolinic acid  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SCH 23390  (EXP,ISO)
serotonin  (ISO)
sertraline  (ISO)
simvastatin  (ISO)
SKF 38393  (EXP,ISO)
sodium arsenite  (EXP,ISO)
spiperone  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
tetrahydropalmatine  (ISO)
tetraphene  (EXP)
valproic acid  (ISO)
verapamil  (EXP)
XL147  (EXP)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (IDA,ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-activating dopamine receptor signaling pathway  (IDA,IGI,IMP,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adult walking behavior  (IGI,IMP)
associative learning  (IMP,ISO)
astrocyte development  (IMP)
behavioral fear response  (IMP)
behavioral response to cocaine  (IMP,ISO)
calcium-mediated signaling  (ISO)
cell migration  (IMP)
cellular response to catecholamine stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cerebral cortex GABAergic interneuron migration  (IMP)
conditioned taste aversion  (IMP)
D-glucose import  (IMP)
dentate gyrus development  (IMP)
dopamine transport  (IMP)
eating behavior  (ISO)
feeding behavior  (IGI)
G protein-coupled dopamine receptor signaling pathway  (IBA,IGI,IMP)
G protein-coupled receptor signaling pathway  (IDA,IMP)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IEA,ISO)
grooming behavior  (IMP,ISO)
habituation  (IMP)
hippocampus development  (IMP)
intracellular protein transport  (ISO)
learning  (IMP)
locomotory behavior  (IGI,IMP,ISO)
long-term synaptic depression  (IMP)
long-term synaptic potentiation  (IMP)
maternal behavior  (IMP)
mating behavior  (IDA)
memory  (IMP)
modification of postsynaptic structure  (EXP,IDA)
muscle contraction  (IMP)
negative regulation of cell migration  (ISO)
negative regulation of cellular response to hypoxia  (ISO)
negative regulation of circadian sleep/wake cycle, sleep  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of synaptic transmission  (ISO)
neuron migration  (IMP)
neuronal action potential  (IMP)
operant conditioning  (IMP,ISO)
orbitofrontal cortex development  (ISO)
peristalsis  (IGI)
phospholipase C-activating dopamine receptor signaling pathway  (IDA,IGI,ISO)
positive regulation of feeding behavior  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of MAPK cascade  (IBA)
positive regulation of membrane potential  (ISO)
positive regulation of neuron migration  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (IMP)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prepulse inhibition  (IMP)
presynaptic modulation of chemical synaptic transmission  (EXP,IDA)
protein import into nucleus  (EXP,IMP)
protein phosphorylation  (IDA)
regulation of dopamine metabolic process  (IMP)
regulation of monoatomic ion transport  (ISO)
regulation of protein phosphorylation  (IMP)
regulation of vasoconstriction  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to amphetamine  (IGI,IMP,ISO)
response to cocaine  (IMP)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to nicotine  (ISO)
response to retinoic acid  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (IDA,IMP,ISO)
sensitization  (IGI)
social behavior  (ISO)
startle response  (IMP)
striatum development  (IMP,ISO)
synapse assembly  (ISO)
synaptic transmission, dopaminergic  (IMP)
synaptic transmission, glutamatergic  (IMP)
temperature homeostasis  (IMP)
transmission of nerve impulse  (IMP)
vasodilation  (IEA)
visual learning  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway   (ISO)
dopamine signaling pathway  (ISO)
dopamine signaling pathway via D1 family of receptors  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
G protein mediated signaling pathway via Galphas family  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavior  (IAGP)
abnormal brain wave pattern  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal digestive system development  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal eating behavior  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hypothalamus physiology  (IAGP)
abnormal inhibitory learning  (IAGP)
abnormal intestinal smooth muscle morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal long-term potentiation  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal operant conditioning behavior  (IAGP)
abnormal passive avoidance behavior  (IAGP)
abnormal posture  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal spatial learning  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal synaptic plasticity  (IAGP)
abnormal vision  (IAGP)
absent gastric milk in neonates  (IAGP)
aphagia  (IAGP)
astrocytosis  (IAGP)
behavioral despair  (IAGP)
bradykinesia  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased brain weight  (IAGP)
decreased fear-related response  (IAGP)
decreased forebrain size  (IAGP)
decreased forebrain volume  (IAGP)
decreased grip strength  (IAGP)
decreased hippocampus volume  (IAGP)
decreased locomotor activity  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased pulmonary respiratory rate  (IAGP)
decreased response to stress-induced hyperthermia  (IAGP)
decreased striatum size  (IAGP)
decreased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
decreased vertical activity  (IAGP)
disheveled coat  (IAGP)
dystonia  (IAGP)
enlarged lateral ventricles  (IAGP)
gastrointestinal hemorrhage  (IAGP)
gliosis  (IAGP)
hunched posture  (IAGP)
hyperactivity  (IAGP)
impaired balance  (IAGP)
impaired behavioral response to cocaine  (IAGP)
impaired behavioral response to xenobiotic  (IAGP)
impaired conditioned place preference behavior  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired coordination  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired righting response  (IAGP)
impaired swimming  (IAGP)
increased exploration in new environment  (IAGP)
increased locomotor activity  (IAGP)
increased startle reflex  (IAGP)
increased thigmotaxis  (IAGP)
increased vertical activity  (IAGP)
intestinal ulcer  (IAGP)
limb grasping  (IAGP)
loss of GABAergic neurons  (IAGP)
myoclonus  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
seizures  (IAGP)
small intestinal inflammation  (IAGP)
striatum atrophy  (IAGP)
trunk curl  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. Albrecht FE, etal., J Clin Invest 1996 May 15;97(10):2283-8.
2. Striatal neurochemical changes in transgenic models of Huntington's disease. Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29.
3. Acute sleep deprivation enhances avoidance learning and spatial memory and induces delayed alterations in neurochemical expression of GR, TH, DRD1, pCREB and Ki67 in rats. Azogu I, etal., Behav Brain Res. 2015 Feb 15;279:177-90. doi: 10.1016/j.bbr.2014.11.015. Epub 2014 Nov 26.
4. Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Banday AA, etal., Diabetes. 2005 Jul;54(7):2219-26.
5. Mitogen-activated protein kinase upregulation reduces renal D1 receptor affinity and G-protein coupling in obese rats. Banday AA, etal., Kidney Int. 2007 Mar;71(5):397-406. Epub 2006 Dec 27.
6. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
7. Dopamine receptors - IUPHAR Review 13. Beaulieu JM, etal., Br J Pharmacol. 2015 Jan;172(1):1-23.
8. Tracheal occlusion modulates the gene expression profile of the medial thalamus in anesthetized rats. Bernhardt V, etal., J Appl Physiol. 2011 Jul;111(1):117-24. doi: 10.1152/japplphysiol.01317.2010. Epub 2011 Apr 28.
9. Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA. Bjornebekk A, etal., Neuroreport. 2007 Jul 2;18(10):1039-43.
10. Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder. Chawla A, etal., Physiol Behav. 2017 Oct 15;180:78-90. doi: 10.1016/j.physbeh.2017.08.004. Epub 2017 Aug 15.
11. Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration. Conrad KL, etal., Neuroscience. 2010 Aug 11;169(1):182-94. doi: 10.1016/j.neuroscience.2010.04.056. Epub 2010 May 7.
12. Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease. Cummings DM, etal., Hum Mol Genet. 2006 Oct 1;15(19):2856-68. Epub 2006 Aug 11.
13. Loss of synaptic D1 dopamine/N-methyl-D-aspartate glutamate receptor complexes in L-DOPA-induced dyskinesia in the rat. Fiorentini C, etal., Mol Pharmacol. 2006 Mar;69(3):805-12. Epub 2005 Dec 19.
14. Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway. Floresco SB and Tse MT, J Neurosci. 2007 Feb 21;27(8):2045-57.
15. Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. Fung MM, etal., Kidney Int. 2009 Nov;76(10):1070-80. doi: 10.1038/ki.2009.306. Epub 2009 Aug 12.
16. The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking. Hamlin AS, etal., Neuroscience. 2007 May 11;146(2):525-36. doi: 10.1016/j.neuroscience.2007.01.063. Epub 2007 Mar 23.
17. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
18. Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats. Kumar TP, etal., J Biomed Sci. 2010 May 31;17:43. doi: 10.1186/1423-0127-17-43.
19. Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain. Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19.
20. Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. Lemon N and Manahan-Vaughan D, J Neurosci. 2006 Jul 19;26(29):7723-9.
21. The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
22. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Li Y, etal., Med Sci Monit. 2017 Jun 9;23:2805-2815.
23. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
24. MGDs mouse GO annotations MGD data from the GO Consortium
25. Glycaemic control with insulin prevents the reduced renal dopamine D1 receptor expression and function in streptozotocin-induced diabetes. Moreira-Rodrigues M, etal., Nephrol Dial Transplant. 2010 Sep;25(9):2945-53. doi: 10.1093/ndt/gfq150. Epub 2010 Mar 25.
26. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
27. Expression of the dopaminergic D1 and D2 receptors in the anterior cingulate cortex in a model of neuropathic pain. Ortega-Legaspi JM, etal., Mol Pain. 2011 Dec 15;7:97.
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking. Porras G, etal., J Clin Invest. 2012 Nov 1;122(11):3977-89. doi: 10.1172/JCI59426. Epub 2012 Oct 8.
30. Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism. Rao F, etal., Hypertension. 2007 May;49(5):1015-31. Epub 2007 Mar 12.
31. Mouse MP Annotation Import Pipeline RGD automated import pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry. Runne H, etal., J Neurosci. 2008 Sep 24;28(39):9723-31.
35. Brain D1 dopamine receptor in alloxan-induced diabetes. Salkovic M and Lackovic Z, Diabetes. 1992 Sep;41(9):1119-21.
36. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
37. Electroacupuncture inhibition of hyperalgesia in rats with adjuvant arthritis: involvement of cannabinoid receptor 1 and dopamine receptor subtypes in striatum. Shou Y, etal., Evid Based Complement Alternat Med. 2013;2013:393460. doi: 10.1155/2013/393460. Epub 2013 May 25.
38. Effect of UUO on D1aR expression reveals a link among dopamine, transforming growth factor-beta, and nitric oxide. Stern JM, etal., Am J Physiol Renal Physiol. 2004 Mar;286(3):F509-15. Epub 2003 Nov 11.
39. Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. Thomas M, etal., Synapse. 2009 Oct;63(10):881-94.
40. Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats. Trivedi M and Lokhandwala MF, Am J Physiol Renal Physiol. 2005 Aug;289(2):F298-304. Epub 2005 Mar 29.
41. Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats. Tu L, etal., Hum Gene Ther. 2008 Apr;19(4):318-30. doi: 10.1089/hum.2007.138.
42. Basal regulation of HPA and dopamine systems is altered differentially in males and females by prenatal alcohol exposure and chronic variable stress. Uban KA, etal., Psychoneuroendocrinology. 2013 Oct;38(10):1953-66. doi: 10.1016/j.psyneuen.2013.02.017. Epub 2013 Apr 8.
43. Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Xu M, etal., Cell 1994 Nov 18;79(4):729-42.
44. Effects of enteral nutrition on the barrier function of the intestinal mucosa and dopamine receptor expression in rats with traumatic brain injury. Zhang X and Jiang X, JPEN J Parenter Enteral Nutr. 2015 Jan;39(1):114-23. doi: 10.1177/0148607113501881. Epub 2013 Sep 18.
Additional References at PubMed
PMID:1354640   PMID:7549459   PMID:7566118   PMID:7637583   PMID:7719021   PMID:7809078   PMID:7959747   PMID:8001143   PMID:8094303   PMID:8288218   PMID:8294904   PMID:8521822  
PMID:8738226   PMID:8747144   PMID:8795639   PMID:8824814   PMID:8889548   PMID:8938453   PMID:8962158   PMID:9016340   PMID:9119405   PMID:9261820   PMID:9354330   PMID:9387887  
PMID:9427321   PMID:9692749   PMID:9749770   PMID:9822743   PMID:9829800   PMID:9886682   PMID:9988094   PMID:10222120   PMID:10349636   PMID:10366637   PMID:10501473   PMID:10585522  
PMID:10651856   PMID:10661513   PMID:10713301   PMID:10884517   PMID:10998124   PMID:11007776   PMID:11042159   PMID:11069937   PMID:11076861   PMID:11089973   PMID:11150348   PMID:11172752  
PMID:11251190   PMID:11274051   PMID:11404425   PMID:11409899   PMID:11423089   PMID:11438590   PMID:11567069   PMID:11823889   PMID:11823893   PMID:11923452   PMID:11985822   PMID:12097513  
PMID:12223546   PMID:12354293   PMID:12417685   PMID:12477932   PMID:12488442   PMID:12496944   PMID:12526890   PMID:12603275   PMID:12652349   PMID:12665504   PMID:12679517   PMID:12777963  
PMID:12860471   PMID:12867509   PMID:12930822   PMID:12949782   PMID:13679419   PMID:14681479   PMID:14712229   PMID:14769920   PMID:14960355   PMID:14981263   PMID:14997010   PMID:15016423  
PMID:15056714   PMID:15238444   PMID:15272078   PMID:15287892   PMID:15292232   PMID:15547113   PMID:15684065   PMID:15716360   PMID:15892099   PMID:15932618   PMID:16014726   PMID:16123762  
PMID:16141072   PMID:16141073   PMID:16189209   PMID:16197514   PMID:16364905   PMID:16388913   PMID:16476524   PMID:16525059   PMID:16602821   PMID:16633898   PMID:16855179   PMID:16865686  
PMID:16908842   PMID:16921022   PMID:16930410   PMID:16962565   PMID:16987237   PMID:17194762   PMID:17251429   PMID:17324452   PMID:17337702   PMID:17360497   PMID:17395606   PMID:17409246  
PMID:17509542   PMID:17712281   PMID:17984145   PMID:18045906   PMID:18045908   PMID:18083900   PMID:18279319   PMID:18288092   PMID:18313668   PMID:18337395   PMID:18363855   PMID:18380665  
PMID:18381284   PMID:18433738   PMID:18446092   PMID:18470912   PMID:18486343   PMID:18496528   PMID:18614680   PMID:18615733   PMID:18644244   PMID:18644790   PMID:18671743   PMID:18716204  
PMID:18760699   PMID:19012810   PMID:19017537   PMID:19030180   PMID:19074012   PMID:19117916   PMID:19139376   PMID:19204052   PMID:19228458   PMID:19261890   PMID:19274089   PMID:19279248  
PMID:19386638   PMID:19520364   PMID:19538708   PMID:19726707   PMID:19733597   PMID:19741115   PMID:19747903   PMID:19759531   PMID:19765599   PMID:19837142   PMID:19842069   PMID:19948956  
PMID:20018672   PMID:20023653   PMID:20038975   PMID:20092552   PMID:20132929   PMID:20346392   PMID:20347018   PMID:20451634   PMID:20456009   PMID:20543951   PMID:20600656   PMID:20616081  
PMID:20730802   PMID:20805489   PMID:20807772   PMID:20826661   PMID:20844125   PMID:20888914   PMID:20980993   PMID:21173143   PMID:21196914   PMID:21205893   PMID:21267068   PMID:21303698  
PMID:21308794   PMID:21368124   PMID:21412225   PMID:21491433   PMID:21521750   PMID:21677750   PMID:21746918   PMID:21813695   PMID:21873635   PMID:21982372   PMID:22033896   PMID:22034973  
PMID:22115942   PMID:22127145   PMID:22168837   PMID:22219295   PMID:22308372   PMID:22323706   PMID:22356538   PMID:22456324   PMID:22504960   PMID:22537018   PMID:22586226   PMID:22686291  
PMID:22764243   PMID:22776159   PMID:22820144   PMID:22884478   PMID:23000618   PMID:23152889   PMID:23242137   PMID:23278119   PMID:23305992   PMID:23319622   PMID:23357114   PMID:23538064  
PMID:23569242   PMID:23675505   PMID:23678109   PMID:23753418   PMID:23842570   PMID:23843993   PMID:23876451   PMID:24090101   PMID:24127594   PMID:24135007   PMID:24167564   PMID:24227722  
PMID:24260267   PMID:24351932   PMID:24441680   PMID:24496082   PMID:24529758   PMID:24550737   PMID:24599455   PMID:24830745   PMID:24843151   PMID:24952961   PMID:25071457   PMID:25076876  
PMID:25149631   PMID:25217530   PMID:25258080   PMID:25339698   PMID:25389395   PMID:25429131   PMID:25556545   PMID:25560761   PMID:25594175   PMID:25729269   PMID:25729949   PMID:25731884  
PMID:25772224   PMID:25781028   PMID:25865831   PMID:25933794   PMID:25990637   PMID:26053317   PMID:26174222   PMID:26182404   PMID:26256420   PMID:26314207   PMID:26319554   PMID:26332770  
PMID:26442961   PMID:26443442   PMID:26483399   PMID:26492471   PMID:26511239   PMID:26560700   PMID:26561599   PMID:26587737   PMID:26590421   PMID:26763483   PMID:26791202   PMID:26807952  
PMID:26831103   PMID:27035941   PMID:27194343   PMID:27422612   PMID:27452460   PMID:27460146   PMID:27460988   PMID:27568567   PMID:27658122   PMID:27678395   PMID:27733575   PMID:27811173  
PMID:27815417   PMID:28108253   PMID:28115522   PMID:28115704   PMID:28128287   PMID:28143767   PMID:28154160   PMID:28202411   PMID:28203148   PMID:28228269   PMID:28429261   PMID:28433741  
PMID:28473642   PMID:28582422   PMID:28781050   PMID:28860974   PMID:29027111   PMID:29043563   PMID:29089442   PMID:29183706   PMID:29217689   PMID:29407371   PMID:29540721   PMID:29541380  
PMID:29556031   PMID:29603470   PMID:29659809   PMID:29803941   PMID:29847232   PMID:29847669   PMID:29897417   PMID:29967281   PMID:30258218   PMID:30521930   PMID:30622165   PMID:30655356  
PMID:30804529   PMID:30915712   PMID:30919214   PMID:31060803   PMID:31242961   PMID:31326375   PMID:31387938   PMID:31413143   PMID:31491374   PMID:31665630   PMID:31708397   PMID:31711176  
PMID:31812651   PMID:31870855   PMID:31902720   PMID:31954621   PMID:32039920   PMID:32075716   PMID:32142670   PMID:32170006   PMID:32259353   PMID:32313025   PMID:32333845   PMID:32386544  
PMID:32399024   PMID:32433957   PMID:32513388   PMID:32561725   PMID:32610039   PMID:32643147   PMID:32833186   PMID:32868781   PMID:32891169   PMID:32941853   PMID:33047300   PMID:33094567  
PMID:33380525   PMID:33456556   PMID:33556069   PMID:33712552   PMID:33781778   PMID:33821423   PMID:34014554   PMID:34108486   PMID:34321999   PMID:34779492   PMID:34859931   PMID:34953210  
PMID:35172858   PMID:35177825   PMID:35415964   PMID:35467530   PMID:35501380   PMID:35615067   PMID:35666215   PMID:36012509   PMID:36081908   PMID:36450244   PMID:36464669   PMID:36494220  
PMID:36494350   PMID:36589737   PMID:36627054   PMID:36653189   PMID:36693372   PMID:36920928   PMID:36943865   PMID:37248637   PMID:37252844   PMID:37394124   PMID:37684522   PMID:37751999  
PMID:37922904   PMID:38048913   PMID:38322327   PMID:38658737   PMID:39438478  


Genomics

Comparative Map Data
Drd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,205,202 - 54,209,677 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,205,202 - 54,209,724 (-)EnsemblGRCm39 Ensembl
GRCm381354,051,183 - 54,055,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,051,183 - 54,055,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371354,146,552 - 54,151,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,061,276 - 54,065,279 (-)NCBIMGSCv36mm8
Celera1355,124,170 - 55,128,645 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.4NCBI
DRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385175,440,036 - 175,444,182 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5175,440,036 - 175,444,182 (-)EnsemblGRCh38hg38GRCh38
GRCh375174,867,039 - 174,871,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365174,800,281 - 174,803,769 (-)NCBINCBI36Build 36hg18NCBI36
Build 345174,800,642 - 174,803,769NCBI
Celera5170,906,676 - 170,910,164 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5169,967,086 - 169,970,574 (-)NCBIHuRef
CHM1_15174,300,099 - 174,303,587 (-)NCBICHM1_1
T2T-CHM13v2.05175,983,814 - 175,987,960 (-)NCBIT2T-CHM13v2.0
Drd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,545,488 - 10,550,029 (+)NCBIGRCr8
mRatBN7.21710,540,440 - 10,544,971 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,540,558 - 10,545,002 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,555,287 - 10,558,713 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01712,089,485 - 12,092,911 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,551,719 - 10,555,145 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01711,099,736 - 11,104,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,101,306 - 11,103,541 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,211,031 - 13,215,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,655,926 - 16,658,161 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,655,119 - 16,658,949 (+)NCBI
Celera1710,610,221 - 10,613,646 (+)NCBICelera
Cytogenetic Map17p14NCBI
Drd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,003,229 - 28,006,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,003,229 - 28,006,595 (-)NCBIChiLan1.0ChiLan1.0
DRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24170,570,821 - 170,577,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15168,710,364 - 168,717,128 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05170,787,115 - 170,792,383 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15177,687,201 - 177,691,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5177,688,917 - 177,690,257 (-)Ensemblpanpan1.1panPan2
DRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1437,550,454 - 37,554,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl437,549,708 - 37,553,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha437,496,619 - 37,501,286 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,916,432 - 37,921,101 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,916,400 - 37,921,094 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1437,741,033 - 37,745,149 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,928,336 - 37,933,009 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0438,438,479 - 38,443,142 (+)NCBIUU_Cfam_GSD_1.0
Drd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721392,067,956 - 92,072,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936609792,276 - 793,613 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936609790,647 - 795,187 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1649,189,602 - 49,191,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11649,189,555 - 49,193,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21653,333,853 - 53,338,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,587,340 - 77,591,434 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666034997,268 - 1,002,449 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473314,518,146 - 14,520,905 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473314,517,540 - 14,522,173 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Drd1
145 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:423
Count of miRNA genes:338
Interacting mature miRNAs:355
Transcripts:ENSMUST00000021932
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
25671382Hrsq4_mhost response to SARS QTL 4, vascular cuffing (mouse)135288165154992738Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse

Markers in Region
BB284642  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381354,051,309 - 54,051,449UniSTSGRCm38
MGSCv371354,146,678 - 54,146,818UniSTSGRCm37
Celera1355,124,296 - 55,124,436UniSTS
Cytogenetic Map13B1UniSTS
cM Map1332.0UniSTS
Whitehead/MRC_RH13582.89UniSTS
Drd1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381354,053,821 - 54,054,976UniSTSGRCm38
MGSCv371354,149,190 - 54,150,345UniSTSGRCm37
Celera1355,126,808 - 55,127,963UniSTS
Cytogenetic Map13B1UniSTS
cM Map1332.0UniSTS
cM Map1332.0UniSTS
Drd1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381354,053,494 - 54,053,596UniSTSGRCm38
MGSCv371354,148,863 - 54,148,965UniSTSGRCm37
Celera1355,126,481 - 55,126,583UniSTS
Cytogenetic Map13B1UniSTS
cM Map1332.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000021932   ⟹   ENSMUSP00000021932
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1354,205,205 - 54,209,677 (-)Ensembl
GRCm38.p6 Ensembl1354,051,186 - 54,055,658 (-)Ensembl
Ensembl Acc Id: ENSMUST00000221470   ⟹   ENSMUSP00000152768
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1354,205,202 - 54,209,724 (-)Ensembl
GRCm38.p6 Ensembl1354,051,183 - 54,055,705 (-)Ensembl
Ensembl Acc Id: ENSMUST00000222706
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1354,208,280 - 54,208,799 (-)Ensembl
GRCm38.p6 Ensembl1354,054,261 - 54,054,780 (-)Ensembl
RefSeq Acc Id: NM_001291801   ⟹   NP_001278730
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391354,205,202 - 54,208,799 (-)NCBI
GRCm381354,051,183 - 54,054,780 (-)NCBI
Celera1355,124,170 - 55,128,645 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010076   ⟹   NP_034206
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391354,205,202 - 54,209,677 (-)NCBI
GRCm381354,051,183 - 54,055,658 (-)ENTREZGENE
MGSCv371354,146,552 - 54,151,027 (-)RGD
Celera1355,124,170 - 55,128,645 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034206   ⟸   NM_010076
- UniProtKB: B2RPW8 (UniProtKB/Swiss-Prot),   Q8C8P8 (UniProtKB/Swiss-Prot),   Q61616 (UniProtKB/Swiss-Prot),   A0A1Y7VK92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278730   ⟸   NM_001291801
- UniProtKB: B2RPW8 (UniProtKB/Swiss-Prot),   Q8C8P8 (UniProtKB/Swiss-Prot),   Q61616 (UniProtKB/Swiss-Prot),   A0A1Y7VK92 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000021932   ⟸   ENSMUST00000021932
Ensembl Acc Id: ENSMUSP00000152768   ⟸   ENSMUST00000221470
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61616-F1-model_v2 AlphaFold Q61616 1-446 view protein structure

Promoters
RGD ID:8680372
Promoter ID:EPDNEW_M18217
Type:initiation region
Name:Drd1_1
Description:Mus musculus dopamine receptor D1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381354,055,658 - 54,055,718EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99578 AgrOrtholog
Ensembl Genes ENSMUSG00000021478 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021932 ENTREZGENE
  ENSMUST00000021932.6 UniProtKB/Swiss-Prot
  ENSMUST00000221470.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dopamine_D1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13488 UniProtKB/Swiss-Prot
MGD MGI:99578 ENTREZGENE
NCBI Gene 13488 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  D(1A) DOPAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DRD1 RGD
PhenoGen Drd1 PhenoGen
PRINTS DOPAMINED1AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOPAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VK92 ENTREZGENE, UniProtKB/TrEMBL
  B2RPW8 ENTREZGENE
  DRD1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q80T33_MOUSE UniProtKB/TrEMBL
  Q8C8P8 ENTREZGENE
UniProt Secondary B2RPW8 UniProtKB/Swiss-Prot
  Q8C8P8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-11-26 Drd1  dopamine receptor D1  Drd1a  dopamine receptor D1A  Symbol and/or name change 5135510 APPROVED