RGD Reference Report - Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA. - Rat Genome Database

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Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA.

Authors: Bjornebekk, A  Mathe, AA  Brene, S 
Citation: Bjornebekk A, etal., Neuroreport. 2007 Jul 2;18(10):1039-43.
RGD ID: 2311588
Pubmed: PMID:17558292   (View Abstract at PubMed)
DOI: DOI:10.1097/WNR.0b013e3281668bf7   (Journal Full-text)

Social isolation has profound effects on animal behavior and dopamine systems. We investigated the effect of social isolation on the dopamine receptor and neuropeptide mRNAs in the brain reward system in an animal model of depression, the Flinders Sensitive Line rats and Sprague-Dawley controls. We demonstrate that socially isolated but not group housed Flinders sensitive line rats had lower dopamine D2 receptor mRNA levels compared with Sprague-Dawley rats. Isolated and group housed Flinders Sensitive Line rats had higher levels of dopamine D1 receptor and substance P and enkephalin but not dynorphin mRNAs when compared with Sprague-Dawley rats. Our findings of decreased dopamine D2 receptor levels in socially isolated Flinders Sensitive Line rats suggest that low D2 receptor expression may play a role in pathophysiology of depression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
depressive disorder  ISODrd1 (Rattus norvegicus)2311588; 2311588mRNA:increased expression:caudate putamen (rat)RGD 
depressive disorder  IEP 2311588mRNA:increased expression:caudate putamen (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd1  (dopamine receptor D1)

Genes (Mus musculus)
Drd1  (dopamine receptor D1)

Genes (Homo sapiens)
DRD1  (dopamine receptor D1)

Objects referenced in this article
Gene DRD2 dopamine receptor D2 Homo sapiens
Gene Drd2 dopamine receptor D2 Mus musculus
Gene Drd2 dopamine receptor D2 Rattus norvegicus

Additional Information