Gnas (GNAS complex locus) - Rat Genome Database
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Gene: Gnas (GNAS complex locus) Rattus norvegicus
Analyze
Symbol: Gnas
Name: GNAS complex locus
RGD ID: 2716
Description: Exhibits several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and signaling receptor binding activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; cellular response to prostaglandin E stimulus; and negative regulation of renal sodium excretion. Localizes to several cellular components, including cytoplasmic vesicle; heterotrimeric G-protein complex; and ruffle. Colocalizes with Golgi apparatus and sarcolemma. Biomarker of polycystic kidney disease. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; McCune Albright syndrome; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to human GNAS (GNAS complex locus); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; vasopressin signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adenylate cyclase-stimulating G alpha protein; ALEX; G-alpha-8; GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; GNAS complex locus XLas-like; Gnas1; Gnasxl; Gnpas; guanine nucleotide binding protein alpha s; guanine nucleotide binding protein alpha stimulating; guanine nucleotide binding protein alpha stimulating extra large; guanine nucleotide-binding protein G-s, alpha subunit; Guanine nucleotide-binding protein G-s, alpha subunit, Genbank no U51565; LOC100361691; LOC690994; Nesp55; SCG6; SCG6 (secretogranin VI); secretogranin VI; similar to XLalphas protein; XL alpha s; Xlas
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23163,071,003 - 163,136,350 (+)NCBI
Rnor_6.0 Ensembl3172,385,672 - 172,434,613 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,374,957 - 172,428,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03172,374,957 - 172,434,988 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03178,439,178 - 178,490,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03178,426,255 - 178,427,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43165,213,399 - 165,214,551 (+)NCBIRGSC3.4rn4RGSC3.4
Celera3162,244,932 - 162,311,413 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acromegaly  (ISO)
ACTH Syndrome, Ectopic  (ISO)
ACTH-independent macronodular adrenal hyperplasia  (ISO)
ACTH-independent macronodular adrenal hyperplasia 1  (ISO)
adrenal carcinoma  (ISO)
adrenal gland hyperfunction  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
adult hepatocellular carcinoma  (ISO)
Albright's hereditary osteodystrophy  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis type 8  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
brachydactyly  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Cafe-au-Lait Spots  (ISO)
cholangiocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Cushing Syndrome  (ISO)
disease of cellular proliferation  (ISO)
endocrine system disease  (ISO)
Gallstones  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
Heterotopic Ossification  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
liver cancer  (ISO)
lung adenocarcinoma  (ISO)
McCune Albright syndrome  (ISO)
melanoma  (ISO)
Metabolic Bone Diseases  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Orthostatic Hypotension  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
Parasitic Liver Diseases  (ISO)
pituitary adenoma 3  (ISO)
Pituitary Neoplasms  (ISO)
polycystic kidney disease  (IEP)
polycystic ovary syndrome  (ISO)
Precocious Puberty  (ISO)
primary hyperaldosteronism  (ISO)
Primary Pigmented Nodular Adrenocortical Disease, 1  (ISO)
progressive osseous heteroplasia  (ISO)
Prolonged Bleeding Time, Brachydactyly, and Mental Retardation  (ISO)
pseudohypoaldosteronism  (ISO)
pseudohypoparathyroidism  (ISO)
pseudohypoparathyroidism type IB  (ISO)
Pseudohypoparathyroidism Type IC  (ISO)
pseudopseudohypoparathyroidism  (ISO)
Respiration Disorders  (ISO)
schizophrenia  (ISS)
sex cord-gonadal stromal tumor  (ISO)
skin melanoma  (ISO)
Tachycardia  (ISO)
Uterine Cervical Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3',5'-cyclic AMP  (ISO)
3,3'-diindolylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alprenolol  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
cholesterol  (ISO)
cicaprost  (ISO)
cisplatin  (ISO)
citronellal  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (EXP)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
genistein  (EXP,ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
ICI 118551  (ISO)
indometacin  (EXP)
isoprenaline  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
mercury dibromide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
morphine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
oleanolic acid  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pentobarbital  (EXP)
phencyclidine  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chloride  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propranolol  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (ISO)
theophylline  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc sulfate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO,ISS)
adenylate cyclase-activating dopamine receptor signaling pathway  (IBA,IDA,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA,IMP,ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IBA)
bone development  (ISO)
calcium ion homeostasis  (IMP)
cartilage development  (ISO)
cellular response to catecholamine stimulus  (IDA)
cellular response to prostaglandin E stimulus  (IDA)
cognition  (ISO)
developmental growth  (ISO)
DNA methylation  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (ISO)
endochondral ossification  (ISO)
energy reserve metabolic process  (ISO)
G protein-coupled receptor signaling pathway  (IEA,IMP)
genetic imprinting  (ISO)
hair follicle placode formation  (ISO)
multicellular organism growth  (ISO)
negative regulation of blood pressure  (IMP)
negative regulation of multicellular organism growth  (ISO)
negative regulation of renal sodium excretion  (IMP)
platelet aggregation  (ISO)
positive regulation of cAMP-mediated signaling  (ISO,ISS)
positive regulation of cell population proliferation  (IDA)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of GTPase activity  (ISO,ISS)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of sodium ion transport  (IMP)
post-embryonic body morphogenesis  (ISO)
post-embryonic development  (ISO)
regulation of catalytic activity  (IEA)
regulation of parathyroid hormone secretion  (ISO)
regulation of signal transduction  (ISO)
regulation of transcription by RNA polymerase II  (IMP)
response to drug  (ISO)
response to parathyroid hormone  (IEA,ISO)
sensory perception of chemical stimulus  (IBA)
skeletal system development  (ISO)
skin development  (ISO)
tissue homeostasis  (ISO)

References

References - curated
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Additional References at PubMed
PMID:799727   PMID:2499043   PMID:2826231   PMID:3092218   PMID:7500342   PMID:8347607   PMID:8679006   PMID:8889548   PMID:9016340   PMID:9322912   PMID:10675785   PMID:10712433  
PMID:10931823   PMID:10931851   PMID:11438605   PMID:12221292   PMID:12391161   PMID:12719376   PMID:14767559   PMID:15057822   PMID:15148396   PMID:15381255   PMID:15489334   PMID:15496483  
PMID:15546818   PMID:15579796   PMID:15797856   PMID:15811946   PMID:15972823   PMID:16379030   PMID:16478979   PMID:16631471   PMID:17110384   PMID:17194762   PMID:18067150   PMID:19199708  
PMID:19237344   PMID:19946888   PMID:19966281   PMID:20427744   PMID:20458337   PMID:20862257   PMID:21584660   PMID:21606326   PMID:21890629   PMID:22573829   PMID:22871113   PMID:23376485  
PMID:23533145   PMID:23839232   PMID:25691569   PMID:27432886   PMID:28260721   PMID:29476059   PMID:30053369   PMID:31374326  


Genomics

Comparative Map Data
Gnas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23163,071,003 - 163,136,350 (+)NCBI
Rnor_6.0 Ensembl3172,385,672 - 172,434,613 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,374,957 - 172,428,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03172,374,957 - 172,434,988 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03178,439,178 - 178,490,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03178,426,255 - 178,427,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43165,213,399 - 165,214,551 (+)NCBIRGSC3.4rn4RGSC3.4
Celera3162,244,932 - 162,311,413 (+)NCBICelera
Cytogenetic Map3q43NCBI
GNAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2058,839,718 - 58,911,192 (+)EnsemblGRCh38hg38GRCh38
GRCh382058,839,681 - 58,911,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372057,414,803 - 57,486,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,848,190 - 56,919,645 (+)NCBINCBI36hg18NCBI36
Build 342056,900,129 - 56,919,640NCBI
Celera2054,155,257 - 54,226,691 (+)NCBI
Cytogenetic Map20q13.32NCBI
HuRef2054,201,757 - 54,273,094 (+)NCBIHuRef
CHM1_12057,316,663 - 57,387,668 (+)NCBICHM1_1
Gnas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,126,113 - 174,188,537 (+)NCBIGRCm39mm39
GRCm39 Ensembl2174,126,113 - 174,188,537 (+)Ensembl
GRCm382174,284,320 - 174,346,744 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,284,320 - 174,346,744 (+)EnsemblGRCm38mm10GRCm38
MGSCv372174,109,821 - 174,172,245 (+)NCBIGRCm37mm9NCBIm37
MGSCv362173,927,260 - 173,989,683 (+)NCBImm8
Celera2180,249,319 - 180,306,988 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.89NCBI
LOC100990650
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12056,460,906 - 56,620,313 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02055,190,607 - 55,262,245 (+)NCBIMhudiblu_PPA_v0panPan3
GNAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2443,643,405 - 43,658,657 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12443,643,409 - 43,658,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gnas
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365301,353,432 - 1,407,437 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1758,998,981 - 59,053,021 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11758,985,580 - 59,053,022 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,303,970 - 66,356,738 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21766,408,660 - 66,423,431 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap17qNCBI
LOC103243509
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.125,233,893 - 5,303,433 (-)NCBI
Gnas
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474125,138,678 - 25,197,194 (+)NCBI

Position Markers
D3Wox4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3162,307,581 - 162,307,759UniSTS
Cytogenetic Map3q42UniSTS
RH11717  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03172,434,614 - 172,434,774NCBIRnor6.0
Rnor_5.03178,489,913 - 178,490,073UniSTSRnor5.0
Celera3162,311,039 - 162,311,199UniSTS
Cytogenetic Map3q42UniSTS
RH132134  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03172,428,172 - 172,428,383NCBIRnor6.0
Rnor_5.03178,481,664 - 178,481,875UniSTSRnor5.0
Celera3162,301,092 - 162,301,303UniSTS
Cytogenetic Map3q42UniSTS
BF395949  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03172,384,449 - 172,384,630NCBIRnor6.0
Rnor_5.03178,437,955 - 178,438,136UniSTSRnor5.0
Celera3162,260,412 - 162,260,593UniSTS
RH 3.4 Map31498.5UniSTS
Cytogenetic Map3q42UniSTS
BF389724  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03172,390,966 - 172,391,198NCBIRnor6.0
Rnor_5.03178,444,411 - 178,444,643UniSTSRnor5.0
Celera3162,267,544 - 162,267,776UniSTS
RH 3.4 Map31499.49UniSTS
Cytogenetic Map3q42UniSTS
BF398043  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3162,307,324 - 162,307,509UniSTS
RH 3.4 Map31496.8UniSTS
Cytogenetic Map3q42UniSTS
RH94424  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03172,434,699 - 172,434,858NCBIRnor6.0
Rnor_5.03178,489,998 - 178,490,157UniSTSRnor5.0
Celera3162,311,124 - 162,311,283UniSTS
Cytogenetic Map3q42UniSTS
RH139191  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03172,379,285 - 172,379,446NCBIRnor6.0
Rnor_5.03178,430,583 - 178,430,744UniSTSRnor5.0
RGSC_v3.43165,217,727 - 165,217,888UniSTSRGSC3.4
Celera3162,249,260 - 162,249,421UniSTS
RH 3.4 Map31496.8UniSTS
Cytogenetic Map3q42UniSTS
AI230657  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03172,423,921 - 172,424,132NCBIRnor6.0
Rnor_5.03178,477,413 - 178,477,624UniSTSRnor5.0
Celera3162,296,842 - 162,297,053UniSTS
RH 3.4 Map31496.9UniSTS
Cytogenetic Map3q42UniSTS
Gnas  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3162,308,221 - 162,309,788UniSTS
Cytogenetic Map3q42UniSTS
UniSTS:496676  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03172,433,980 - 172,434,725NCBIRnor6.0
Rnor_5.03178,489,279 - 178,490,024UniSTSRnor5.0
Celera3162,310,405 - 162,311,150UniSTS
Cytogenetic Map3q42UniSTS
Gnas  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3162,310,126 - 162,310,977UniSTS
Cytogenetic Map3q42UniSTS
PMC22380P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03172,387,604 - 172,387,950NCBIRnor6.0
Rnor_5.03178,441,110 - 178,441,395UniSTSRnor5.0
Cytogenetic Map3q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3138374177177699992Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3150368003177699992Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3138374177177699992Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3153918022177699992Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128986468173986468Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3146232777177699992Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153381237174632112Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3156381661176418101Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3170428815177699992Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3132875075176418101Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3139578365177699992Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3153412455177699992Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3148034701177699992Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3153381237174632112Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3153381237174632112Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3130006659175006659Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3153381237174632112Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3153381237174632112Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3153381237174632112Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3153381237174632112Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:117
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000035916, ENSRNOT00000071215
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 47 69 45 19 45 10 13 130 35 64 11 10
Low 3 34 39 31 19 31 6 9 18 35 17 11 6
Below cutoff 5 6 6 6 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001024823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001159653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001159656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01026999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF093569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF105254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF107844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF107845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF184151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC168156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF394587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB770483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X84047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000035916   ⟹   ENSRNOP00000033065
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3172,374,957 - 172,428,483 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071215   ⟹   ENSRNOP00000066164
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3172,420,591 - 172,434,613 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090989   ⟹   ENSRNOP00000069800
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3172,385,672 - 172,433,441 (+)Ensembl
RefSeq Acc Id: NM_001024823   ⟹   NP_001019994
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,085,014 - 163,136,350 (+)NCBI
Rnor_6.03172,385,672 - 172,434,988 (+)NCBI
Rnor_5.03178,439,178 - 178,490,287 (+)NCBI
Celera3162,261,635 - 162,311,413 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001159653   ⟹   NP_001153125
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,071,417 - 163,136,350 (+)NCBI
Rnor_6.03172,374,957 - 172,434,988 (+)NCBI
Rnor_5.03178,426,255 - 178,427,409 (+)NCBI
Rnor_5.03178,439,178 - 178,490,287 (+)NCBI
RGSC_v3.43165,213,399 - 165,214,551 (+)RGD
Celera3162,244,932 - 162,311,413 (+)RGD
Sequence:
RefSeq Acc Id: NM_001159656   ⟹   NP_001153128
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,071,417 - 163,127,264 (+)NCBI
Rnor_6.03172,374,957 - 172,428,485 (+)NCBI
Rnor_5.03178,426,255 - 178,427,409 (+)NCBI
Rnor_5.03178,439,178 - 178,490,287 (+)NCBI
RGSC_v3.43165,213,399 - 165,214,551 (+)RGD
Celera3162,244,932 - 162,301,405 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001359867   ⟹   NP_001346796
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,119,113 - 163,136,350 (+)NCBI
RefSeq Acc Id: NM_019132   ⟹   NP_062005
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,119,113 - 163,136,350 (+)NCBI
Rnor_6.03172,420,409 - 172,434,984 (+)NCBI
Rnor_5.03178,439,178 - 178,490,287 (+)NCBI
Celera3162,297,458 - 162,311,409 (+)NCBI
Sequence:
RefSeq Acc Id: NM_021845   ⟹   NP_068617
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,085,014 - 163,136,350 (+)NCBI
Rnor_6.03172,385,672 - 172,434,988 (+)NCBI
Rnor_5.03178,439,178 - 178,490,287 (+)NCBI
Celera3162,261,635 - 162,311,413 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104293   ⟹   XP_038960221
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,085,002 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104294   ⟹   XP_038960222
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,085,002 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104295   ⟹   XP_038960223
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,085,002 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104296   ⟹   XP_038960224
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,085,002 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104297   ⟹   XP_038960225
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,085,002 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104298   ⟹   XP_038960226
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,085,002 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104299   ⟹   XP_038960227
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,085,002 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104300   ⟹   XP_038960228
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,083,030 - 163,091,563 (+)NCBI
RefSeq Acc Id: XM_039104301   ⟹   XP_038960229
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,083,441 - 163,127,264 (+)NCBI
RefSeq Acc Id: XM_039104302   ⟹   XP_038960230
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,116,988 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104303   ⟹   XP_038960231
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,119,119 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104304   ⟹   XP_038960232
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,119,119 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104305   ⟹   XP_038960233
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,072,442 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104306   ⟹   XP_038960234
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,072,442 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104307   ⟹   XP_038960235
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,072,442 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104309   ⟹   XP_038960237
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,116,821 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104310   ⟹   XP_038960238
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,117,012 - 163,136,350 (+)NCBI
RefSeq Acc Id: XM_039104311   ⟹   XP_038960239
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,071,004 - 163,123,107 (+)NCBI
RefSeq Acc Id: XR_005501783
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,083,030 - 163,096,260 (+)NCBI
RefSeq Acc Id: XR_005501784
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,071,003 - 163,136,345 (+)NCBI
RefSeq Acc Id: XR_005501785
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,071,005 - 163,131,534 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001019994 (Get FASTA)   NCBI Sequence Viewer  
  NP_001153125 (Get FASTA)   NCBI Sequence Viewer  
  NP_001153128 (Get FASTA)   NCBI Sequence Viewer  
  NP_001346796 (Get FASTA)   NCBI Sequence Viewer  
  NP_062005 (Get FASTA)   NCBI Sequence Viewer  
  NP_068617 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960221 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960222 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960223 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960224 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960225 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960226 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960227 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960228 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960229 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960230 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960231 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960232 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960233 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960234 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960235 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960237 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960238 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960239 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40827 (Get FASTA)   NCBI Sequence Viewer  
  AAA41261 (Get FASTA)   NCBI Sequence Viewer  
  AAA41664 (Get FASTA)   NCBI Sequence Viewer  
  AAD03032 (Get FASTA)   NCBI Sequence Viewer  
  AAD03033 (Get FASTA)   NCBI Sequence Viewer  
  AAD11801 (Get FASTA)   NCBI Sequence Viewer  
  AAD11802 (Get FASTA)   NCBI Sequence Viewer  
  AAD11803 (Get FASTA)   NCBI Sequence Viewer  
  AAF37806 (Get FASTA)   NCBI Sequence Viewer  
  AAF63227 (Get FASTA)   NCBI Sequence Viewer  
  AAH61967 (Get FASTA)   NCBI Sequence Viewer  
  AAI58590 (Get FASTA)   NCBI Sequence Viewer  
  AAI68156 (Get FASTA)   NCBI Sequence Viewer  
  AAZ23814 (Get FASTA)   NCBI Sequence Viewer  
  AAZ23815 (Get FASTA)   NCBI Sequence Viewer  
  CAC39211 (Get FASTA)   NCBI Sequence Viewer  
  CAC39212 (Get FASTA)   NCBI Sequence Viewer  
  EDL85091 (Get FASTA)   NCBI Sequence Viewer  
  P63095 (Get FASTA)   NCBI Sequence Viewer  
  Q63803 (Get FASTA)   NCBI Sequence Viewer  
  Q792G6 (Get FASTA)   NCBI Sequence Viewer  
  Q9Z213 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_068617   ⟸   NM_021845
- Peptide Label: isoform XLas
- UniProtKB: B4F771 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001019994   ⟸   NM_001024823
- Peptide Label: isoform Alex
- UniProtKB: B4F771 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_062005   ⟸   NM_019132
- Peptide Label: isoform GNASL
- UniProtKB: P63095 (UniProtKB/Swiss-Prot),   B0BMW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153125   ⟸   NM_001159653
- Peptide Label: isoform SCG6 precursor
- UniProtKB: Q792G6 (UniProtKB/Swiss-Prot),   B4F771 (UniProtKB/TrEMBL),   G3V916 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153128   ⟸   NM_001159656
- Peptide Label: isoform SCG6 precursor
- UniProtKB: Q792G6 (UniProtKB/Swiss-Prot),   B4F771 (UniProtKB/TrEMBL),   G3V916 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033065   ⟸   ENSRNOT00000035916
RefSeq Acc Id: ENSRNOP00000069800   ⟸   ENSRNOT00000090989
RefSeq Acc Id: ENSRNOP00000066164   ⟸   ENSRNOT00000071215
RefSeq Acc Id: XP_038960239   ⟸   XM_039104311
- Peptide Label: isoform X17
RefSeq Acc Id: XP_038960233   ⟸   XM_039104305
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038960234   ⟸   XM_039104306
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038960235   ⟸   XM_039104307
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038960228   ⟸   XM_039104300
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038960229   ⟸   XM_039104301
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038960221   ⟸   XM_039104293
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038960224   ⟸   XM_039104296
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038960225   ⟸   XM_039104297
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038960222   ⟸   XM_039104294
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960226   ⟸   XM_039104298
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038960223   ⟸   XM_039104295
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038960227   ⟸   XM_039104299
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038960237   ⟸   XM_039104309
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038960230   ⟸   XM_039104302
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038960238   ⟸   XM_039104310
- Peptide Label: isoform X16
RefSeq Acc Id: NP_001346796   ⟸   NM_001359867
- Peptide Label: isoform b
RefSeq Acc Id: XP_038960231   ⟸   XM_039104303
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038960232   ⟸   XM_039104304
- Peptide Label: isoform X12
Protein Domains
G-alpha

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692719
Promoter ID:EPDNEW_R3243
Type:single initiation site
Name:Gnas_1
Description:GNAS complex locus
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03172,374,943 - 172,375,003EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2716 AgrOrtholog
Ensembl Genes ENSRNOG00000025889 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000047374 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000033065 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000066164 UniProtKB/TrEMBL
  ENSRNOP00000069800 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035916 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000071215 UniProtKB/TrEMBL
  ENSRNOT00000090989 UniProtKB/TrEMBL
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9099119 IMAGE-MGC_LOAD
InterPro Gprotein_alpha_S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NESP55 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24896 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187374 IMAGE-MGC_LOAD
NCBI Gene 24896 ENTREZGENE
PANTHER PTHR10218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NESP55 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GNAS RGD
PhenoGen Gnas PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART G_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWA1_RAT UniProtKB/TrEMBL
  ALEX_RAT UniProtKB/Swiss-Prot
  B0BMW4 ENTREZGENE, UniProtKB/TrEMBL
  B4F771 ENTREZGENE, UniProtKB/TrEMBL
  G3V916 ENTREZGENE, UniProtKB/TrEMBL
  GNAS1_RAT UniProtKB/Swiss-Prot
  GNAS2_RAT UniProtKB/Swiss-Prot
  GNAS3_RAT UniProtKB/Swiss-Prot
  M0R9J4_RAT UniProtKB/TrEMBL
  P63095 ENTREZGENE
  Q63803 ENTREZGENE
  Q792G6 ENTREZGENE
  Q792H3_RAT UniProtKB/TrEMBL
  Q9Z213 ENTREZGENE
UniProt Secondary P04894 UniProtKB/Swiss-Prot
  P08755 UniProtKB/Swiss-Prot
  Q05087 UniProtKB/Swiss-Prot
  Q45QM7 UniProtKB/Swiss-Prot
  Q924W1 UniProtKB/Swiss-Prot
  Q9Z1R8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-15 Gnas  GNAS complex locus  LOC100361691  GNAS complex locus XLas-like  Data Merged 737654 APPROVED
2010-05-05 LOC100361691  GNAS complex locus XLas-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-06-15 Gnas  GNAS complex locus  LOC690994  similar to XLalphas protein  Data Merged 737654 PROVISIONAL
2009-01-12 Gnas  GNAS complex locus  Gnas  GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Gnas  GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus  Gnas  GNAS complex locus  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-01-18 Gnas  GNAS complex locus  Xlas  XLas protein  Data Merged 737654 APPROVED
2006-11-20 LOC690994  similar to XLalphas protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Gnas  GNAS complex locus    Guanine nucleotide-binding protein G-s, alpha subunit, Genbank no U51565  Name updated 625702 APPROVED
2002-08-07 Xlas  XLas protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Gnas  Guanine nucleotide-binding protein G-s, alpha subunit, Genbank no U51565      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes pseudohypoparathyroidism (PHP) type Ia 730810
gene_function couple extracellular signals in signal transduction pathway, neurotransmission and synaptic vesicle life cycle 1357908