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Gene: Gnas (GNAS complex locus) Rattus norvegicus
Symbol: Gnas
Name: GNAS complex locus
Description: Exhibits several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and signaling receptor binding activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; cellular response to prostaglandin E stimulus; and negative regulation of renal sodium excretion. Localizes to several cellular components, including cytoplasmic vesicle; heterotrimeric G-protein complex; and ruffle. Colocalizes with Golgi apparatus and sarcolemma. Biomarker of polycystic kidney disease. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; McCune Albright syndrome; obesity; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to human GNAS (GNAS complex locus); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; vasopressin signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adenylate cyclase-stimulating G alpha protein; ALEX; G-alpha-8; GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; GNAS complex locus XLas-like; Gnas1; Gnasxl; Gnpas; guanine nucleotide binding protein alpha s; guanine nucleotide binding protein alpha stimulating; guanine nucleotide binding protein alpha stimulating extra large; guanine nucleotide-binding protein G-s, alpha subunit; Guanine nucleotide-binding protein G-s, alpha subunit, Genbank no U51565; LOC100361691; LOC690994; Nesp55; SCG6; SCG6 (secretogranin VI); secretogranin VI; similar to XLalphas protein; XL alpha s; Xlas
Homo sapiens (human) : GNAS (GNAS complex locus)  HGNC  Alliance
Mus musculus (house mouse) : Gnas (GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100990650 (guanine nucleotide-binding protein G(s) subunit alpha)
Canis lupus familiaris (dog) : GNAS (GNAS complex locus)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnas (GNAS complex locus)
Sus scrofa (pig) : GNAS (GNAS complex locus)
Chlorocebus sabaeus (African green monkey) : GNAS (GNAS complex locus)
Heterocephalus glaber (naked mole-rat) : Gnas (GNAS complex locus)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03172,374,957 - 172,434,988 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,374,957 - 172,428,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,385,672 - 172,434,613 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,426,255 - 178,427,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03178,439,178 - 178,490,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43165,213,399 - 165,214,551 (+)NCBIRGSC3.4rn4RGSC3.4
Celera3162,244,932 - 162,311,413 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gnas
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2716
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.