Gnas (GNAS complex locus) - Rat Genome Database

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Pathways
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Gene: Gnas (GNAS complex locus) Heterocephalus glaber
Analyze
Symbol: Gnas
Name: GNAS complex locus
RGD ID: 18929567
Description: ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase regulator activity (ortholog); alkylglycerophosphoethanolamine phosphodiesterase activity (ortholog); INVOLVED IN adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN adenosine signaling pathway; corticotropin-releasing hormone signaling pathway; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH acromegaly (ortholog); ACTH-independent macronodular adrenal hyperplasia (ortholog); ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); FOUND IN COPI-coated Golgi to ER transport vesicle (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: guanine nucleotide-binding protein G(s) subunit alpha; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; stimulatory G-protein alpha subunit
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474125,183,329 - 25,196,880 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474125,138,678 - 25,197,194 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acromegaly  (ISO)
ACTH-independent macronodular adrenal hyperplasia  (ISO)
ACTH-independent macronodular adrenal hyperplasia 1  (ISO)
adrenal gland hyperfunction  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
Albright's hereditary osteodystrophy  (ISO)
Alzheimer's disease  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
brachydactyly  (ISO)
Breast Neoplasms  (ISO)
Cafe-au-Lait Spots  (ISO)
cholangiocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Cushing Syndrome  (ISO)
disease of cellular proliferation  (ISO)
Duane retraction syndrome  (ISO)
endocrine system disease  (ISO)
Gallstones  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary spastic paraplegia 4  (ISO)
Heterotopic Ossification  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
lung adenocarcinoma  (ISO)
McCune Albright syndrome  (ISO)
melanoma  (ISO)
Metabolic Bone Diseases  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Orthostatic Hypotension  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
Parasitic Liver Diseases  (ISO)
pituitary adenoma 3  (ISO)
Pituitary Neoplasms  (ISO)
polycystic kidney disease  (ISO)
polycystic ovary syndrome  (ISO)
Precocious Puberty  (ISO)
primary hyperaldosteronism  (ISO)
Primary Pigmented Nodular Adrenocortical Disease, 1  (ISO)
progressive osseous heteroplasia  (ISO)
pseudohypoaldosteronism  (ISO)
pseudohypoparathyroidism  (ISO)
pseudohypoparathyroidism type IB  (ISO)
Pseudohypoparathyroidism Type IC  (ISO)
pseudopseudohypoparathyroidism  (ISO)
Respiration Disorders  (ISO)
sex cord-gonadal stromal tumor  (ISO)
skin melanoma  (ISO)
Tachycardia  (ISO)
Uterine Cervical Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (IEA,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
bone development  (ISO)
cartilage development  (ISO)
cellular response to catecholamine stimulus  (ISO)
cellular response to glucagon stimulus  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cognition  (ISO)
developmental growth  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (ISO)
endochondral ossification  (ISO)
energy reserve metabolic process  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
genomic imprinting  (ISO)
hair follicle placode formation  (ISO)
multicellular organism growth  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of multicellular organism growth  (ISO)
platelet aggregation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of sodium ion transport  (ISO)
post-embryonic body morphogenesis  (ISO)
post-embryonic development  (ISO)
regulation of parathyroid hormone secretion  (ISO)
regulation of signal transduction  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to parathyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of chemical stimulus  (IEA)
signal transduction  (IEA)
skeletal system development  (ISO)
skin development  (ISO)
tissue homeostasis  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gnas
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474125,183,329 - 25,196,880 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474125,138,678 - 25,197,194 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GNAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,839,748 - 58,911,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,839,718 - 58,911,192 (+)EnsemblGRCh38hg38GRCh38
GRCh372057,414,803 - 57,486,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,848,190 - 56,919,645 (+)NCBINCBI36Build 36hg18NCBI36
Build 342056,900,129 - 56,919,640NCBI
Celera2054,155,257 - 54,226,691 (+)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,201,757 - 54,273,094 (+)NCBIHuRef
CHM1_12057,316,685 - 57,387,667 (+)NCBICHM1_1
T2T-CHM13v2.02060,622,888 - 60,694,319 (+)NCBIT2T-CHM13v2.0
Gnas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,126,113 - 174,188,537 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2174,126,113 - 174,188,537 (+)EnsemblGRCm39 Ensembl
GRCm382174,284,320 - 174,346,744 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,284,320 - 174,346,744 (+)EnsemblGRCm38mm10GRCm38
MGSCv372174,109,821 - 174,172,245 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362173,927,260 - 173,989,683 (+)NCBIMGSCv36mm8
Celera2180,249,319 - 180,306,988 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.89NCBI
Gnas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,489,648 - 183,554,570 (+)NCBIGRCr8
mRatBN7.23163,071,003 - 163,136,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,071,417 - 163,136,350 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl3163,071,417 - 163,127,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3166,870,185 - 166,935,111 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,366,829 - 175,431,728 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,111,029 - 173,175,955 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,374,957 - 172,434,988 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,385,672 - 172,434,613 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,374,957 - 172,428,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,426,255 - 178,427,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03178,439,178 - 178,490,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43165,213,399 - 165,214,551 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3162,244,932 - 162,311,413 (+)NCBICelera
Cytogenetic Map3q43NCBI
GNAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22164,603,402 - 64,674,018 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12064,596,523 - 64,667,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02055,190,607 - 55,262,245 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12056,460,906 - 56,620,313 (+)NCBIpanpan1.1PanPan1.1panPan2
GNAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12443,643,409 - 43,658,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2443,643,405 - 43,658,657 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2442,885,440 - 42,905,085 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02444,469,667 - 44,524,884 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2444,457,089 - 44,540,809 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12443,609,062 - 43,628,699 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02443,727,472 - 43,747,093 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02444,387,669 - 44,407,318 (+)NCBIUU_Cfam_GSD_1.0
LOC101971027
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,895,749 - 181,952,790 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365301,353,432 - 1,407,437 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1758,998,981 - 59,053,021 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11758,985,580 - 59,053,022 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,303,970 - 66,356,738 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21766,408,660 - 66,423,431 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap17qNCBI
LOC103243509
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.125,233,893 - 5,303,433 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl25,233,874 - 5,249,192 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605053,288,032 - 53,358,025 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000008259   ⟹   ENSHGLP00000008170
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474125,183,329 - 25,196,880 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000008260   ⟹   ENSHGLP00000008171
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474125,183,329 - 25,196,880 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000008261   ⟹   ENSHGLP00000008172
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474125,183,344 - 25,196,880 (+)Ensembl
RefSeq Acc Id: XM_004840958   ⟹   XP_004841015
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474125,138,678 - 25,197,194 (+)NCBI
RefSeq Acc Id: XM_004840959   ⟹   XP_004841016
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474125,138,678 - 25,197,194 (+)NCBI
RefSeq Acc Id: XM_021255169   ⟹   XP_021110828
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474125,138,678 - 25,197,194 (+)NCBI
RefSeq Acc Id: XM_021255171   ⟹   XP_021110830
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474125,138,678 - 25,197,194 (+)NCBI
RefSeq Acc Id: XM_021255172   ⟹   XP_021110831
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474125,177,253 - 25,197,162 (+)NCBI
RefSeq Acc Id: XM_021255173   ⟹   XP_021110832
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474125,177,257 - 25,197,162 (+)NCBI
RefSeq Acc Id: XM_021255174   ⟹   XP_021110833
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474125,177,258 - 25,197,162 (+)NCBI
RefSeq Acc Id: XM_021255175   ⟹   XP_021110834
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474125,177,253 - 25,197,162 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004841015   ⟸   XM_004840958
- Peptide Label: isoform X1
- UniProtKB: G5AKZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110828   ⟸   XM_021255169
- Peptide Label: isoform X2
- UniProtKB: G5AKZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004841016   ⟸   XM_004840959
- Peptide Label: isoform X3
- UniProtKB: G5AKZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110830   ⟸   XM_021255171
- Peptide Label: isoform X4
- UniProtKB: G5AKZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110831   ⟸   XM_021255172
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021110834   ⟸   XM_021255175
- Peptide Label: isoform X8
RefSeq Acc Id: XP_021110832   ⟸   XM_021255173
- Peptide Label: isoform X6
RefSeq Acc Id: XP_021110833   ⟸   XM_021255174
- Peptide Label: isoform X7
RefSeq Acc Id: ENSHGLP00000008171   ⟸   ENSHGLT00000008260
RefSeq Acc Id: ENSHGLP00000008170   ⟸   ENSHGLT00000008259
RefSeq Acc Id: ENSHGLP00000008172   ⟸   ENSHGLT00000008261


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005914 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000008259 ENTREZGENE
  ENSHGLT00000008260 ENTREZGENE
Gene3D-CATH GI Alpha 1, domain 2-like UniProtKB/TrEMBL
  P-loop containing nucleotide triphosphate hydrolases UniProtKB/TrEMBL
InterPro Gprotein_alpha_S UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Gnas ENTREZGENE
PANTHER GTP-BINDING PROTEIN ALPHA SUBUNIT UniProtKB/TrEMBL
  GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) SUBUNIT ALPHA ISOFORMS XLAS UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/TrEMBL
PRINTS GPROTEINA UniProtKB/TrEMBL
  GPROTEINAS UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/TrEMBL
SMART G_alpha UniProtKB/TrEMBL
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL
  Transducin (alpha subunit), insertion domain UniProtKB/TrEMBL
UniProt G5AKZ3 ENTREZGENE, UniProtKB/TrEMBL