Igf1r (insulin-like growth factor 1 receptor) - Rat Genome Database
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Gene: Igf1r (insulin-like growth factor 1 receptor) Rattus norvegicus
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Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
RGD ID: 2869
Description: Exhibits G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Localizes to several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor); PARTICIPATES IN insulin-like growth factor signaling pathway; E-cadherin signaling pathway; endocytosis pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (S)-nicotine; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IGF-1 receptor; IGF-I receptor; IGFIRC; Igfr1; insulin-like growth factor I receptor; JTK13; type-I IGF receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHRSP.WKY-(Igf1r-D1Rat36)/IzmTkyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21121,549,839 - 121,838,545 (+)NCBI
Rnor_6.0 Ensembl1128,924,966 - 129,206,516 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01128,924,921 - 129,213,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01129,985,761 - 130,272,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41122,704,976 - 122,990,007 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11122,783,318 - 123,068,350 (+)NCBI
Celera1113,751,636 - 114,029,884 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP)
adrenocortical carcinoma  (ISO)
alcoholic neuropathy  (IEP)
Alzheimer's disease  (IEP,IMP,ISO)
amyotrophic lateral sclerosis  (IEP)
atrial fibrillation  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Burns  (IEP)
Cardiomegaly  (ISO)
cardiomyopathy  (IEP)
Carotid Artery Injuries  (IEP)
Choroidal Neovascularization  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital diaphragmatic hernia  (ISO)
coronary stenosis  (IEP)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
cryptorchidism  (IEP)
dementia  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (IEP)
Endometrial Neoplasms  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP)
fetal alcohol spectrum disorder  (IEP)
Fetal Growth Retardation  (IEP,ISO)
gastrinoma  (ISO)
gastroschisis  (IEP)
genetic disease  (ISO)
gestational diabetes  (IEP)
Graves' disease  (ISO)
Growth Disorders  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperphagia  (IMP)
hypertension  (IEP)
hyperthyroidism  (IEP)
hypertrophic cardiomyopathy  (ISO)
IgA glomerulonephritis  (ISO)
Insulin-Like Growth Factor I, Resistance To  (ISO)
intellectual disability  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Reperfusion Injury  (IEP)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
lung disease  (ISO)
Malocclusion  (IEP)
Metabolic Bone Diseases  (IEP)
myocardial infarction  (IEP)
NATURAL KILLER CELL ENTEROPATHY  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
non-alcoholic fatty liver disease  (IEP)
obesity  (IEP)
Optic Nerve Injuries  (IEP,IMP)
osteoarthritis  (ISO)
osteoporosis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (IMP,ISO)
peripheral nervous system disease  (ISO)
portal vein thrombosis  (ISO)
Premature Aging  (ISO)
prostate adenocarcinoma  (IMP,ISO)
prostate cancer  (ISO)
prostate carcinoma  (IEP)
prostatic hypertrophy  (ISO)
renal cell carcinoma  (IEP)
respiratory failure  (ISO)
Right Ventricular Hypertrophy  (IDA)
Skin Neoplasms  (ISO)
Stroke  (ISO)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (IEP)
ulcerative colitis  (ISO)
vascular dementia  (ISO)
vesicoureteral reflux  (ISO)
Zollinger-Ellison syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(S)-nicotine  (EXP)
(Z)-ligustilide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5,6,7,8-tetrahydrofolic acid  (ISO)
5-fluorouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
acetazolamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
amino acid  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
AP20187  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
BMS-754807  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
Chimaphylin  (ISO)
chitin  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP)
cisplatin  (ISO)
clodronic acid  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
dapsone  (ISO)
Deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dihydrofolic acid  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzacamene  (EXP)
equol  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
everolimus  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
herbicide  (EXP)
hexachlorobenzene  (EXP,ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (EXP)
isoflurane  (EXP)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
leuprolide  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP)
lovastatin  (EXP)
lycopene  (ISO)
manganese(II) chloride  (EXP)
maslinic acid  (ISO)
masoprocol  (ISO)
menadione  (ISO)
metformin  (EXP,ISO)
methcathinone  (ISO)
methimazole  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (EXP,ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
monosodium L-glutamate  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
nicotine  (EXP)
nilutamide  (EXP)
nitrofen  (EXP)
nitrogen mustard  (ISO)
ochratoxin A  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorododecanoic acid  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picolinic acid  (EXP)
picropodophyllotoxin  (ISO)
piperine  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
RU 58668  (ISO)
rutin  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sophoraflavanone B  (EXP)
sorafenib  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tanespimycin  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (ISO)
thyroxine  (EXP)
trichostatin A  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
aging  (IEP)
amyloid-beta clearance  (IEA,ISO)
animal organ morphogenesis  (ISO)
axonogenesis  (IMP)
brain development  (ISO)
cardiac atrium development  (IEP)
cellular response to aldosterone  (IEP)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to angiotensin  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to glucose stimulus  (IBA,IEP,ISO)
cellular response to insulin stimulus  (IEP,ISO)
cellular response to insulin-like growth factor stimulus  (IEP,IPI)
cellular response to mechanical stimulus  (IEP)
cellular response to progesterone stimulus  (IEP)
cellular response to testosterone stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IPI)
cellular senescence  (IEP)
cerebellum development  (IEP,IMP)
dendritic spine maintenance  (IGI)
epidermis development  (ISO)
establishment of cell polarity  (IMP)
estrous cycle  (IMP)
exocrine pancreas development  (ISO)
glucose homeostasis  (IBA)
hippocampus development  (IEP)
immune response  (IEA,ISO)
inactivation of MAPKK activity  (IEA,ISO,ISS)
insulin receptor signaling pathway  (IMP)
insulin-like growth factor receptor signaling pathway  (IBA,IEA,ISO,ISS)
male sex determination  (ISO)
mammary gland development  (ISO)
multicellular organism development  (IBA)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of cholangiocyte apoptotic process  (IMP)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of hepatocyte apoptotic process  (IMP)
negative regulation of MAPK cascade  (ISO)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of protein kinase B signaling  (ISO)
neuron projection development  (IDA)
peptidyl-tyrosine autophosphorylation  (IEA,ISO)
phosphatidylinositol-mediated signaling  (IEA,ISO)
positive regulation of axon regeneration  (IMP)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytokinesis  (IMP)
positive regulation of developmental growth  (ISO)
positive regulation of DNA metabolic process  (IMP)
positive regulation of kinase activity  (IBA)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of meiotic cell cycle  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA,IMP)
positive regulation of protein kinase B signaling  (IBA,ISO)
positive regulation of protein-containing complex disassembly  (IGI)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of steroid hormone biosynthetic process  (IMP)
positive regulation of transcription, DNA-templated  (ISO)
prostate gland epithelium morphogenesis  (ISO)
protein autophosphorylation  (ISO,ISS)
protein phosphorylation  (ISO)
regulation of JNK cascade  (IBA,IEA,ISO,ISS)
response to ethanol  (IDA,IEP)
response to insulin  (IEP)
response to L-glutamate  (IDA)
response to nicotine  (IEP)
response to nutrient levels  (IEP)
response to vitamin E  (IEP)
transcytosis  (IEA,ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:1530648   PMID:1846292   PMID:2163625   PMID:2477843   PMID:7541045   PMID:7679099   PMID:7692086   PMID:7758167   PMID:7931420   PMID:8452530   PMID:10100151   PMID:11162456  
PMID:11448933   PMID:11884589   PMID:12101187   PMID:12105987   PMID:12138094   PMID:12556535   PMID:12970367   PMID:14566968   PMID:14628051   PMID:14644152   PMID:14767998   PMID:15358140  
PMID:15567334   PMID:15609625   PMID:15616026   PMID:15638388   PMID:15796760   PMID:16052330   PMID:16236484   PMID:16306401   PMID:16322063   PMID:16516162   PMID:16803852   PMID:16886151  
PMID:17088403   PMID:17241280   PMID:17317782   PMID:17480015   PMID:17510240   PMID:17545147   PMID:17586502   PMID:17662267   PMID:17900863   PMID:17940216   PMID:18021255   PMID:18039791  
PMID:18216249   PMID:18451178   PMID:18458087   PMID:18615585   PMID:19122171   PMID:19220583   PMID:19545541   PMID:19578119   PMID:19672727   PMID:19696229   PMID:20097715   PMID:20100694  
PMID:20200966   PMID:20605618   PMID:20620343   PMID:21179204   PMID:21411721   PMID:21433279   PMID:21447702   PMID:21645859   PMID:21677284   PMID:22341695   PMID:22342912   PMID:22367207  
PMID:22429571   PMID:22635104   PMID:22781651   PMID:23046980   PMID:23300479   PMID:23322319   PMID:23382219   PMID:23457189   PMID:23603302   PMID:23695157   PMID:23906066   PMID:24106410  
PMID:24287499   PMID:24530896   PMID:24617524   PMID:24782617   PMID:25500890   PMID:25514442   PMID:25875646   PMID:26170015   PMID:26286172   PMID:26534869   PMID:26556536   PMID:27036326  
PMID:27350269   PMID:27626839   PMID:28290552   PMID:28438613   PMID:28668953   PMID:28937244   PMID:29090346   PMID:29412813   PMID:29556095   PMID:29663740   PMID:29865254   PMID:30248386  
PMID:30404731   PMID:31271053   PMID:32236698  


Genomics

Comparative Map Data
Igf1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21121,549,839 - 121,838,545 (+)NCBI
Rnor_6.0 Ensembl1128,924,966 - 129,206,516 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01128,924,921 - 129,213,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01129,985,761 - 130,272,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41122,704,976 - 122,990,007 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11122,783,318 - 123,068,350 (+)NCBI
Celera1113,751,636 - 114,029,884 (+)NCBICelera
Cytogenetic Map1q22NCBI
IGF1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1598,648,539 - 98,964,530 (+)EnsemblGRCh38hg38GRCh38
GRCh381598,648,539 - 98,964,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371599,191,768 - 99,507,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361597,010,284 - 97,325,282 (+)NCBINCBI36hg18NCBI36
Build 341597,010,287 - 97,319,034NCBI
Celera1575,609,678 - 75,924,704 (+)NCBI
Cytogenetic Map15q26.3NCBI
HuRef1575,320,348 - 75,635,223 (+)NCBIHuRef
CHM1_11599,033,296 - 99,349,171 (+)NCBICHM1_1
Igf1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39767,601,486 - 67,883,416 (+)NCBIGRCm39mm39
GRCm39 Ensembl767,602,575 - 67,883,416 (+)Ensembl
GRCm38767,952,257 - 68,233,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl767,952,827 - 68,233,668 (+)EnsemblGRCm38mm10GRCm38
MGSCv37775,097,143 - 75,378,553 (+)NCBIGRCm37mm9NCBIm37
MGSCv36767,826,372 - 68,100,293 (+)NCBImm8
Celera765,407,649 - 65,690,413 (+)NCBICelera
Cytogenetic Map7CNCBI
cM Map737.27NCBI
Igf1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541626,102,628 - 26,382,666 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541626,101,090 - 26,382,660 (-)NCBIChiLan1.0ChiLan1.0
IGF1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11596,576,930 - 96,832,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1596,535,164 - 96,832,974 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01577,332,926 - 77,648,474 (+)NCBIMhudiblu_PPA_v0panPan3
IGF1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl341,794,623 - 42,090,387 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1341,795,337 - 42,096,255 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Igf1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364834,563,995 - 4,860,231 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1137,387,925 - 137,690,666 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11137,383,623 - 137,691,038 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21153,523,944 - 153,853,776 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q17-q21NCBI
IGF1R
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12917,212,206 - 17,534,036 (+)NCBI
ChlSab1.1 Ensembl2917,459,404 - 17,526,930 (+)Ensembl
Igf1r
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247685,396,027 - 5,688,435 (+)NCBI

Position Markers
D1Hmgc5  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01128,924,376 - 128,924,502NCBIRnor6.0
Rnor_5.01129,985,259 - 129,985,385UniSTSRnor5.0
RGSC_v3.41122,704,429 - 122,704,555UniSTSRGSC3.4
Celera1113,751,091 - 113,751,217UniSTS
RH 3.4 Map11447.71RGD
RH 3.4 Map11447.71UniSTS
Cytogenetic Map1q22UniSTS
RH143949  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01128,985,452 - 128,985,581NCBIRnor6.0
Rnor_5.01130,045,545 - 130,045,674UniSTSRnor5.0
RGSC_v3.41122,765,365 - 122,765,494UniSTSRGSC3.4
Celera1113,808,998 - 113,809,127UniSTS
RH 3.4 Map11447.51UniSTS
Cytogenetic Map1q22UniSTS
D1Bda23  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01129,206,658 - 129,207,016NCBIRnor6.0
Rnor_5.01130,265,431 - 130,265,789UniSTSRnor5.0
RGSC_v3.41122,989,611 - 122,989,969UniSTSRGSC3.4
Celera1114,029,488 - 114,029,846UniSTS
Cytogenetic Map1q22UniSTS
BE111364  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01128,992,243 - 128,992,393NCBIRnor6.0
Rnor_5.01130,052,395 - 130,052,545UniSTSRnor5.0
RGSC_v3.41122,772,244 - 122,772,394UniSTSRGSC3.4
Celera1113,815,808 - 113,815,958UniSTS
RH 3.4 Map11447.01UniSTS
Cytogenetic Map1q22UniSTS
RH135226  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01129,053,503 - 129,053,695NCBIRnor6.0
Rnor_5.01130,113,131 - 130,113,323UniSTSRnor5.0
RGSC_v3.41122,832,903 - 122,833,095UniSTSRGSC3.4
Celera1113,877,067 - 113,877,259UniSTS
RH 3.4 Map11447.21UniSTS
Cytogenetic Map1q22UniSTS
BE119057  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01128,960,536 - 128,960,691NCBIRnor6.0
Rnor_5.01130,020,629 - 130,020,784UniSTSRnor5.0
RGSC_v3.41122,740,218 - 122,740,373UniSTSRGSC3.4
Celera1113,786,256 - 113,786,411UniSTS
RH 3.4 Map11450.09UniSTS
Cytogenetic Map1q22UniSTS
BM384925  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01129,043,490 - 129,043,691NCBIRnor6.0
Rnor_5.01130,103,642 - 130,103,843UniSTSRnor5.0
RGSC_v3.41122,823,240 - 122,823,441UniSTSRGSC3.4
Celera1113,866,780 - 113,866,981UniSTS
RH 3.4 Map11445.91UniSTS
Cytogenetic Map1q22UniSTS
Igf1r  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01129,142,678 - 129,142,807NCBIRnor6.0
Rnor_5.01130,201,338 - 130,201,467UniSTSRnor5.0
RGSC_v3.41122,924,226 - 122,924,355UniSTSRGSC3.4
Celera1113,965,994 - 113,966,123UniSTS
Cytogenetic Map1q22UniSTS
GDB:187366  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01128,924,422 - 128,924,523NCBIRnor6.0
Rnor_5.01129,985,305 - 129,985,406UniSTSRnor5.0
RGSC_v3.41122,704,475 - 122,704,576UniSTSRGSC3.4
Celera1113,751,137 - 113,751,238UniSTS
Cytogenetic Map1q22UniSTS
TAMU_PKR0001  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01129,162,783 - 129,162,963NCBIRnor6.0
Rnor_5.01130,221,443 - 130,221,623UniSTSRnor5.0
RGSC_v3.41122,944,321 - 122,944,501UniSTSRGSC3.4
Celera1113,985,952 - 113,986,132UniSTS
Cytogenetic Map1q22UniSTS
IGF1R  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01129,162,783 - 129,162,963NCBIRnor6.0
Rnor_5.01130,221,443 - 130,221,623UniSTSRnor5.0
RGSC_v3.41122,944,321 - 122,944,501UniSTSRGSC3.4
Celera1113,985,952 - 113,986,132UniSTS
Cytogenetic Map1q22UniSTS
Igf1r  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01128,978,121 - 128,978,513NCBIRnor6.0
Rnor_5.01130,038,214 - 130,038,606UniSTSRnor5.0
RGSC_v3.41122,757,817 - 122,758,209UniSTSRGSC3.4
Celera1113,801,551 - 113,801,943UniSTS
Cytogenetic Map1q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185779320130779320Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185917265130917265Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)186776571131776571Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)190804143161321256Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)191093646136093646Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)194225372130917265Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194364073153076991Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)195304961156446783Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100354344145354344Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1106002252202571904Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1108057233167517487Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1108417193153417193Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1108417193153417193Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1108986301161784422Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1108986301219232156Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1108986301219232156Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1109634374154634374Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1110620749155620749Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1110620749155620749Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1111446783156446783Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1111446783156446783Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1113593576129209407Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1113593576158593576Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1122614824201146953Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1124090312169090312Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1124603592188289386Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1126240667217054291Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1129208943174208943Rat


Related Rat Strains
The following Strains have been annotated to Igf1r

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir378rno-miR-378a-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI22367207

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:36
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000019267
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 17 2 9 2 1 1 49 31 34 8 1
Low 3 19 32 31 10 31 7 10 25 4 7 3 7
Below cutoff 8 8 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019267   ⟹   ENSRNOP00000019267
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1128,924,966 - 129,206,516 (+)Ensembl
RefSeq Acc Id: NM_052807   ⟹   NP_434694
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21121,550,741 - 121,831,786 (+)NCBI
Rnor_6.01128,924,921 - 129,207,054 (+)NCBI
Rnor_5.01129,985,761 - 130,272,589 (+)NCBI
RGSC_v3.41122,704,976 - 122,990,007 (+)RGD
Celera1113,751,636 - 114,029,884 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229324   ⟹   XP_006229386
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21121,549,843 - 121,838,545 (+)NCBI
Rnor_6.01128,924,921 - 129,213,816 (+)NCBI
Rnor_5.01129,985,761 - 130,272,589 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759500   ⟹   XP_008757722
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21121,549,842 - 121,838,545 (+)NCBI
Rnor_6.01128,924,923 - 129,213,816 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102217   ⟹   XP_038958145
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21121,549,841 - 121,838,545 (+)NCBI
RefSeq Acc Id: XM_039102225   ⟹   XP_038958153
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21121,549,839 - 121,801,744 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_434694   ⟸   NM_052807
- Peptide Label: precursor
- UniProtKB: P24062 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006229386   ⟸   XM_006229324
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008757722   ⟸   XM_008759500
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000019267   ⟸   ENSRNOT00000019267
RefSeq Acc Id: XP_038958153   ⟸   XM_039102225
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038958145   ⟸   XM_039102217
- Peptide Label: isoform X3
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690112
Promoter ID:EPDNEW_R635
Type:single initiation site
Name:Igf1r_1
Description:insulin-like growth factor 1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01128,924,935 - 128,924,995EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2869 AgrOrtholog
Ensembl Genes ENSRNOG00000014187 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019267 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019267 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.20.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin-like_Cys-rich_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_insulin-like_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25718 UniProtKB/Swiss-Prot
NCBI Gene 25718 ENTREZGENE
Pfam Furin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igf1r PhenoGen
PIRSF Insulin_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00261 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAB8_RAT UniProtKB/TrEMBL
  IGF1R_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-06 Igf1r  insulin-like growth factor 1 receptor  Igf1r  insulin-like growth factor I receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Igf1r  insulin-like growth factor I receptor  Igf1r  insulin-like growth factor 1 receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Igf1r  insulin-like growth factor 1 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease overexpressed in most malignant tissues 61526
gene_disease overexpressed in most malignant tissues 70266
gene_process plays a role in transformation events 61526
gene_process plays a role in transformation events 70266
gene_process functions as an anti-apoptotic agent in malignant tissues 61526
gene_process functions as an anti-apoptotic agent in malignant tissues 70266
gene_regulation tyrosine phosphorylated by epidermal growth factor (EGF) 727470