GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gnas | decreases response to substance | ISO | GNAS (Homo sapiens) | 6480464 | CTD | GNAS results in decreased susceptibility to Cisplatin | PMID:21849418 | Gnas | multiple interactions | ISO | GNAS (Homo sapiens) | 6480464 | CTD | [GNAS protein results in increased expression of XIAP protein] which results in decreased susceptibility to Cisplatin; Cisplatin inhibits the reaction [GNAS protein results in increased expression of XIAP mRNA]; GNAS protein inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] | PMID:21255191 | |
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