RGD Reference Report - The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology.

Authors: Hillhouse, EW  Grammatopoulos, DK 
Citation: Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
RGD ID: 5147387
Pubmed: PMID:16484629   (View Abstract at PubMed)
DOI: DOI:10.1210/er.2005-0034   (Journal Full-text)

The CRH receptor (CRH-R) is a member of the secretin family of G protein-coupled receptors. Wide expression of CRH-Rs in the central nervous system and periphery ensures that their cognate agonists, the family of CRH-like peptides, are capable of exerting a wide spectrum of actions that underpin their critical role in integrating the stress response and coordinating the activity of fundamental physiological functions, such as the regulation of the cardiovascular system, energy balance, and homeostasis. Two types of mammal CRH-R exist, CRH-R1 and CRH-R2, each with unique splicing patterns and remarkably distinct pharmacological properties, but similar signaling properties, probably reflecting their distinct and sometimes contrasting biological functions. The regulation of CRH-R expression and activity is not fully elucidated, and we only now begin to fully understand the impact on mammalian pathophysiology. The focus of this review is the current and evolving understanding of the molecular mechanisms controlling CRH-R biological activity and functional flexibility. This shows notable tissue-specific characteristics, highlighted by their ability to couple to distinct G proteins and activate tissue-specific signaling cascades. The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CRHHumancorticotropin-releasing hormone signaling pathway   TAS  RGD 
CRHBPHumancorticotropin-releasing hormone signaling pathway   TAS  RGD 
CRHR1Humancorticotropin-releasing hormone signaling pathway   TAS  RGD 
CRHR2Humancorticotropin-releasing hormone signaling pathway   TAS  RGD 
CrhRatcorticotropin-releasing hormone signaling pathway   ISOCRH (Homo sapiens) RGD 
CrhMousecorticotropin-releasing hormone signaling pathway   ISOCRH (Homo sapiens) RGD 
CrhbpRatcorticotropin-releasing hormone signaling pathway   ISOCRHBP (Homo sapiens) RGD 
CrhbpMousecorticotropin-releasing hormone signaling pathway   ISOCRHBP (Homo sapiens) RGD 
Crhr1Mousecorticotropin-releasing hormone signaling pathway   ISOCRHR1 (Homo sapiens) RGD 
Crhr1Ratcorticotropin-releasing hormone signaling pathway   ISOCRHR1 (Homo sapiens) RGD 
Crhr2Mousecorticotropin-releasing hormone signaling pathway   ISOCRHR2 (Homo sapiens) RGD 
Crhr2Ratcorticotropin-releasing hormone signaling pathway   ISOCRHR2 (Homo sapiens) RGD 
GNASHumancorticotropin-releasing hormone signaling pathway   TAS  RGD 
GRK3Humancorticotropin-releasing hormone signaling pathway   TAS  RGD 
GRK6Humancorticotropin-releasing hormone signaling pathway   TAS  RGD 
GnasRatcorticotropin-releasing hormone signaling pathway   ISOGNAS (Homo sapiens) RGD 
GnasMousecorticotropin-releasing hormone signaling pathway   ISOGNAS (Homo sapiens) RGD 
Grk3Ratcorticotropin-releasing hormone signaling pathway   ISOGRK3 (Homo sapiens) RGD 
Grk3Mousecorticotropin-releasing hormone signaling pathway   ISOGRK3 (Homo sapiens) RGD 
Grk6Ratcorticotropin-releasing hormone signaling pathway   ISOGRK6 (Homo sapiens) RGD 
Grk6Mousecorticotropin-releasing hormone signaling pathway   ISOGRK6 (Homo sapiens) RGD 
UCNHumancorticotropin-releasing hormone signaling pathway   TAS  RGD 
UCN2Humancorticotropin-releasing hormone signaling pathway   TAS  RGD 
UCN3Humancorticotropin-releasing hormone signaling pathway   TAS  RGD 
UcnRatcorticotropin-releasing hormone signaling pathway   ISOUCN (Homo sapiens) RGD 
UcnMousecorticotropin-releasing hormone signaling pathway   ISOUCN (Homo sapiens) RGD 
Ucn2Ratcorticotropin-releasing hormone signaling pathway   ISOUCN2 (Homo sapiens) RGD 
Ucn2Mousecorticotropin-releasing hormone signaling pathway   ISOUCN2 (Homo sapiens) RGD 
Ucn3Ratcorticotropin-releasing hormone signaling pathway   ISOUCN3 (Homo sapiens) RGD 
Ucn3Mousecorticotropin-releasing hormone signaling pathway   ISOUCN3 (Homo sapiens) RGD 
CRHR1HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
CRHR2HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
Crhr1RatG protein mediated signaling pathway via Galphas family  ISOCRHR1 (Homo sapiens) RGD 
Crhr1MouseG protein mediated signaling pathway via Galphas family  ISOCRHR1 (Homo sapiens) RGD 
Crhr2RatG protein mediated signaling pathway via Galphas family  ISOCRHR2 (Homo sapiens) RGD 
Crhr2MouseG protein mediated signaling pathway via Galphas family  ISOCRHR2 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Crh  (corticotropin releasing hormone)
Crhbp  (corticotropin releasing hormone binding protein)
Crhr1  (corticotropin releasing hormone receptor 1)
Crhr2  (corticotropin releasing hormone receptor 2)
Gnas  (GNAS complex locus)
Grk3  (G protein-coupled receptor kinase 3)
Grk6  (G protein-coupled receptor kinase 6)
Ucn  (urocortin)
Ucn2  (urocortin 2)
Ucn3  (urocortin 3)

Genes (Mus musculus)
Crh  (corticotropin releasing hormone)
Crhbp  (corticotropin releasing hormone binding protein)
Crhr1  (corticotropin releasing hormone receptor 1)
Crhr2  (corticotropin releasing hormone receptor 2)
Gnas  (GNAS complex locus)
Grk3  (G protein-coupled receptor kinase 3)
Grk6  (G protein-coupled receptor kinase 6)
Ucn  (urocortin)
Ucn2  (urocortin 2)
Ucn3  (urocortin 3)

Genes (Homo sapiens)
CRH  (corticotropin releasing hormone)
CRHBP  (corticotropin releasing hormone binding protein)
CRHR1  (corticotropin releasing hormone receptor 1)
CRHR2  (corticotropin releasing hormone receptor 2)
GNAS  (GNAS complex locus)
GRK3  (G protein-coupled receptor kinase 3)
GRK6  (G protein-coupled receptor kinase 6)
UCN  (urocortin)
UCN2  (urocortin 2)
UCN3  (urocortin 3)


Additional Information