LOC101971027 (neuroendocrine secretory protein 55) - Rat Genome Database

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Gene: LOC101971027 (neuroendocrine secretory protein 55) Ictidomys tridecemlineatus
Analyze
Symbol: LOC101971027
Name: neuroendocrine secretory protein 55
RGD ID: 12644515
Description: ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); alkylglycerophosphoethanolamine phosphodiesterase activity (ortholog); alpha-tubulin binding (ortholog); INVOLVED IN adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN adenosine signaling pathway; corticotropin-releasing hormone signaling pathway; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH acromegaly (ortholog); ACTH-independent macronodular adrenal hyperplasia (ortholog); ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); FOUND IN COPI-coated Golgi to ER transport vesicle (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: Gnas; GNAS complex locus
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,895,749 - 181,952,790 (-)NCBI
SpeTri2.0NW_0049365301,353,432 - 1,407,437 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acromegaly  (ISO)
ACTH-independent macronodular adrenal hyperplasia  (ISO)
ACTH-independent macronodular adrenal hyperplasia 1  (ISO)
adrenal carcinoma  (ISO)
adrenal gland hyperfunction  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
adult hepatocellular carcinoma  (ISO)
Albright's hereditary osteodystrophy  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis type 8  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
brachydactyly  (ISO)
Breast Neoplasms  (ISO)
Cafe-au-Lait Spots  (ISO)
cholangiocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Cushing Syndrome  (ISO)
disease of cellular proliferation  (ISO)
endocrine system disease  (ISO)
Gallstones  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
Heterotopic Ossification  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
lung adenocarcinoma  (ISO)
McCune Albright syndrome  (ISO)
melanoma  (ISO)
Metabolic Bone Diseases  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Orthostatic Hypotension  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
Parasitic Liver Diseases  (ISO)
pituitary adenoma 3  (ISO)
Pituitary Neoplasms  (ISO)
polycystic kidney disease  (ISO)
polycystic ovary syndrome  (ISO)
Precocious Puberty  (ISO)
primary hyperaldosteronism  (ISO)
Primary Pigmented Nodular Adrenocortical Disease, 1  (ISO)
progressive osseous heteroplasia  (ISO)
Prolonged Bleeding Time, Brachydactyly, and Mental Retardation  (ISO)
pseudohypoaldosteronism  (ISO)
pseudohypoparathyroidism  (ISO)
pseudohypoparathyroidism type IB  (ISO)
Pseudohypoparathyroidism Type IC  (ISO)
pseudopseudohypoparathyroidism  (ISO)
Respiration Disorders  (ISO)
sex cord-gonadal stromal tumor  (ISO)
skin melanoma  (ISO)
Tachycardia  (ISO)
Uterine Cervical Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
bone development  (ISO)
calcium ion homeostasis  (ISO)
cartilage development  (ISO)
cellular response to catecholamine stimulus  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cognition  (ISO)
developmental growth  (ISO)
DNA methylation  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (ISO)
endochondral ossification  (ISO)
energy reserve metabolic process  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
genetic imprinting  (ISO)
hair follicle placode formation  (ISO)
multicellular organism growth  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of multicellular organism growth  (ISO)
negative regulation of renal sodium excretion  (ISO)
platelet aggregation  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of sodium ion transport  (ISO)
post-embryonic body morphogenesis  (ISO)
post-embryonic development  (ISO)
regulation of parathyroid hormone secretion  (ISO)
regulation of signal transduction  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to drug  (ISO)
response to parathyroid hormone  (ISO)
skeletal system development  (ISO)
skin development  (ISO)
tissue homeostasis  (ISO)

References

Genomics

Comparative Map Data
LOC101971027
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,895,749 - 181,952,790 (-)NCBI
SpeTri2.0NW_0049365301,353,432 - 1,407,437 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2058,839,718 - 58,911,192 (+)EnsemblGRCh38hg38GRCh38
GRCh382058,839,681 - 58,911,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372057,414,803 - 57,486,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,848,190 - 56,919,645 (+)NCBINCBI36hg18NCBI36
Build 342056,900,129 - 56,919,640NCBI
Celera2054,155,257 - 54,226,691 (+)NCBI
Cytogenetic Map20q13.32NCBI
HuRef2054,201,757 - 54,273,094 (+)NCBIHuRef
CHM1_12057,316,663 - 57,387,668 (+)NCBICHM1_1
Gnas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,126,113 - 174,188,537 (+)NCBIGRCm39mm39
GRCm39 Ensembl2174,126,113 - 174,188,537 (+)Ensembl
GRCm382174,284,320 - 174,346,744 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,284,320 - 174,346,744 (+)EnsemblGRCm38mm10GRCm38
MGSCv372174,109,821 - 174,172,245 (+)NCBIGRCm37mm9NCBIm37
MGSCv362173,927,260 - 173,989,683 (+)NCBImm8
Celera2180,249,319 - 180,306,988 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.89NCBI
Gnas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23163,071,003 - 163,136,350 (+)NCBI
Rnor_6.0 Ensembl3172,385,672 - 172,434,613 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,374,957 - 172,428,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03172,374,957 - 172,434,988 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03178,439,178 - 178,490,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.03178,426,255 - 178,427,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43165,213,399 - 165,214,551 (+)NCBIRGSC3.4rn4RGSC3.4
Celera3162,244,932 - 162,311,413 (+)NCBICelera
Cytogenetic Map3q43NCBI
LOC100990650
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12056,460,906 - 56,620,313 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02055,190,607 - 55,262,245 (+)NCBIMhudiblu_PPA_v0panPan3
GNAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12443,643,409 - 43,658,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2443,643,405 - 43,658,657 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2442,885,440 - 42,905,085 (+)NCBI
ROS_Cfam_1.02444,469,667 - 44,524,884 (+)NCBI
UMICH_Zoey_3.12443,609,062 - 43,628,699 (+)NCBI
UNSW_CanFamBas_1.02443,727,472 - 43,747,093 (+)NCBI
UU_Cfam_GSD_1.02444,387,669 - 44,407,318 (+)NCBI
GNAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1758,998,981 - 59,053,021 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11758,985,580 - 59,053,022 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,303,970 - 66,356,738 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21766,408,660 - 66,423,431 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap17qNCBI
LOC103243509
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.125,233,893 - 5,303,433 (-)NCBI
Gnas
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474125,138,678 - 25,197,194 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021727594   ⟹   XP_021583269
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365301,353,432 - 1,407,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040275053   ⟹   XP_040130987
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640181,895,749 - 181,952,790 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040130987 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_021583269   ⟸   XM_021727594
- Sequence:
RefSeq Acc Id: XP_040130987   ⟸   XM_040275053


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000033348 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000026819 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000040583 UniProtKB/TrEMBL
InterPro NESP55 UniProtKB/TrEMBL
NCBI Gene LOC101971027 ENTREZGENE
Pfam NESP55 UniProtKB/TrEMBL
UniProt A0A287D000_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 LOC101971027  neuroendocrine secretory protein 55  Gnas  GNAS complex locus  Symbol and/or name change 5135510 APPROVED
2017-07-13 Gnas  GNAS complex locus  LOC101971027  neuroendocrine secretory protein 55  Symbol and/or name change 5135510 APPROVED