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Gene: Oprm1 (opioid receptor, mu 1) Rattus norvegicus
Symbol: Oprm1
Name: opioid receptor, mu 1
Description: Exhibits several functions, including G-protein beta-subunit binding activity; filamin binding activity; and morphine receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of signal transduction; and response to alkaloid. Localizes to several cellular components, including dendrite; focal adhesion; and integral component of synaptic membrane. Colocalizes with sarcolemma. Biomarker of brain ischemia and human immunodeficiency virus infectious disease. Orthologous to human OPRM1 (opioid receptor mu 1); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (3,4-dihydroxyphenyl)acetic acid; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: M-OR-1; MOR-1; MORA; mu opioid receptor; mu opioid receptor splice variant rMOR-1S; mu opioid receptor splice variant rMOR-1Z; mu-type opioid receptor; MUOR1; opioid receptor B; Oprm; Oprrm1
Homo sapiens (human) : OPRM1 (opioid receptor mu 1)  HGNC  Alliance
Mus musculus (house mouse) : Oprm1 (opioid receptor, mu 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Oprm1 (opioid receptor mu 1)
Pan paniscus (bonobo/pygmy chimpanzee) : OPRM1 (opioid receptor mu 1)
Canis lupus familiaris (dog) : OPRM1 (opioid receptor mu 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Oprm1 (opioid receptor mu 1)
Sus scrofa (pig) : OPRM1 (opioid receptor mu 1)
Chlorocebus sabaeus (African green monkey) : OPRM1 (opioid receptor mu 1)
Heterocephalus glaber (naked mole-rat) : Oprm1 (opioid receptor mu 1)
more info ...
Allele / Splice: Oprm1_v3   Oprm1_v1   Oprm1_v2   Oprm1_v4  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0143,454,803 - 43,704,948 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,454,803 - 43,704,948 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0144,804,181 - 45,034,145 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4137,535,416 - 37,779,392 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1137,538,384 - 37,591,800 (+)NCBI
Celera138,804,246 - 39,057,359 (+)NCBICelera
Cytogenetic Map1q11NCBI
RH 3.4 Map1468.6RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Oprm1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3234
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.