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Gene: Gnas (GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus) Mus musculus
Symbol: Gnas
Name: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Description: Predicted to have several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and signaling receptor binding activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; positive regulation of cell differentiation; and skeletal system development. Localizes to the dendrite and membrane. Predicted to colocalize with the Golgi apparatus and sarcolemma. Used to study Albright's hereditary osteodystrophy; pseudohypoparathyroidism; pseudopseudohypoparathyroidism; and schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including McCune Albright syndrome; cholangiocarcinoma; obesity; pituitary adenoma; and pseudohypoparathyroidism (multiple). Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; gonad; and somite. Orthologous to human GNAS (GNAS complex locus).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5530400H20Rik; A930027G11Rik; adenylate cyclase-stimulating G alpha protein; ALEX; alternative gene product encoded by XL-exon; C130027O20Rik; extra large alphas protein; Galphas; Gnas1; Gnasxl; GPSA; Gs alpha subunit; Gs-alpha; Gsa; GSP; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; MGC118029; Nesp; NESP55; Nespl; neuroendocrine secretory protein 55; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; SCG6; secretogranin VI; stimulatory G-protein alpha subunit
Homo sapiens (human) : GNAS (GNAS complex locus)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gnas (GNAS complex locus)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : GNAS (GNAS complex locus)
Canis lupus familiaris (dog) : GNAS (GNAS complex locus)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnas (GNAS complex locus)
Sus scrofa (pig) : GNAS (GNAS complex locus)
more info ...
Related Pseudogenes: Gm8197  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382174,284,320 - 174,346,744 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372174,109,821 - 174,172,245 (+)NCBIGRCm37mm9NCBIm37
MGSCv362173,927,260 - 173,989,683 (+)NCBImm8
Celera2180,249,319 - 180,306,988 (+)NCBICelera
Cytogenetic Map2 H4NCBI
cM Map297.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gnas
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10669
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.