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Gene: Gnas (GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus) Mus musculus
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Symbol: Gnas
Name: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Description: Predicted to have several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and signaling receptor binding activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; positive regulation of cell differentiation; and skeletal system development. Localizes to the dendrite and membrane. Predicted to colocalize with the Golgi apparatus and sarcolemma. Used to study Albright's hereditary osteodystrophy; pseudohypoparathyroidism; pseudopseudohypoparathyroidism; and schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including McCune Albright syndrome; cholangiocarcinoma; obesity; pituitary adenoma; and pseudohypoparathyroidism (multiple). Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; gonad; and somite. Orthologous to human GNAS (GNAS complex locus).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5530400H20Rik; A930027G11Rik; adenylate cyclase-stimulating G alpha protein; ALEX; alternative gene product encoded by XL-exon; C130027O20Rik; extra large alphas protein; Galphas; Gnas1; Gnasxl; GPSA; Gs alpha subunit; Gs-alpha; Gsa; GSP; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; MGC118029; Nesp; NESP55; Nespl; neuroendocrine secretory protein 55; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; SCG6; secretogranin VI; stimulatory G-protein alpha subunit
Orthologs:
Homo sapiens (human) : GNAS (GNAS complex locus)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gnas (GNAS complex locus)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : GNAS (GNAS complex locus)
Canis lupus familiaris (dog) : GNAS (GNAS complex locus)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnas (GNAS complex locus)
Sus scrofa (pig) : GNAS (GNAS complex locus)
more info ...
Related Pseudogenes: Gm8197  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382174,284,320 - 174,346,744 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372174,109,821 - 174,172,245 (+)NCBIGRCm37mm9NCBIm37
MGSCv362173,927,260 - 173,989,683 (+)NCBImm8
Celera2180,249,319 - 180,306,988 (+)NCBICelera
Cytogenetic Map2 H4NCBI
cM Map297.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Gnas
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10669
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.