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Gene: Nefm (neurofilament medium) Rattus norvegicus
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Symbol: Nefm
Name: neurofilament medium
Description: Exhibits signaling receptor binding activity and toxic substance binding activity. Involved in several processes, including cellular response to estradiol stimulus; intermediate filament cytoskeleton organization; and nervous system development. Localizes to the axon; neurofilament; and perikaryon. Predicted to colocalize with the neuromuscular junction. Used to study amyotrophic lateral sclerosis and congenital hypothyroidism. Biomarker of hypothyroidism; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human NEFM (neurofilament medium); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH 2,5-hexanedione; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 160 kDa neurofilament protein; Nef3; neurofilament 3, medium; neurofilament medium polypeptide; neurofilament protein middle polypeptide; neurofilament protein, middle polypeptide; neurofilament triplet M protein; neurofilament, medium polypeptide; NF-M; Nfm
Orthologs:
Homo sapiens (human) : NEFM (neurofilament medium)  HGNC  Alliance
Mus musculus (house mouse) : Nefm (neurofilament, medium polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nefm (neurofilament medium)
Pan paniscus (bonobo/pygmy chimpanzee) : NEFM (neurofilament medium)
Canis lupus familiaris (dog) : NEFM (neurofilament medium)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nefm (neurofilament medium)
Sus scrofa (pig) : NEFM (neurofilament medium)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01544,855,307 - 44,860,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1544,855,310 - 44,860,604 (-)Ensembl
Rnor_5.01546,736,787 - 46,741,632 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41547,698,371 - 47,703,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11547,714,153 - 47,719,121 (-)NCBI
Celera1542,015,992 - 42,021,311 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nefm
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3160
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.