Ppp1r1b (protein phosphatase 1, regulatory inhibitor subunit 1B) - Rat Genome Database

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Gene: Ppp1r1b (protein phosphatase 1, regulatory inhibitor subunit 1B) Mus musculus
Analyze
Symbol: Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
RGD ID: 736949
MGI Page MGI
Description: Predicted to enable dopamine receptor binding activity and protein phosphatase inhibitor activity. Acts upstream of or within several processes, including negative regulation of female receptivity; response to cocaine; and visual learning. Located in cytoplasm; neuronal cell body; and nucleus. Is expressed in central nervous system; limb mesenchyme; nucleus pulposus; retina; and ureteric tip. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AU040756; Dar; DARP; DARPP-32; Darpp32; dopamine- and cAMP-regulated neuronal phosphoprotein; protein phosphatase 1 regulatory subunit 1B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,239,232 - 98,248,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,239,230 - 98,248,622 (+)EnsemblGRCm39 Ensembl
GRCm381198,348,406 - 98,357,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,348,404 - 98,357,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,210,052 - 98,219,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,164,828 - 98,173,885 (+)NCBIMGSCv36mm8
Celera11108,003,018 - 108,012,075 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Ppp1r1bMouseCatalepsy  ISOPPP1R1B (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:20682746
Ppp1r1bMouseDyskinesias  ISOPPP1R1B (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:20682746

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Original Reference(s)
Ppp1r1bMouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PPP1R1B mRNACTDPMID:36331819
Ppp1r1bMouse1,2-dichloroethane decreases expressionEXP 6480464ethylene dichloride results in decreased expression of PPP1R1B mRNACTDPMID:28189721 and PMID:28960355
Ppp1r1bMouse1,2-dimethylhydrazine increases expressionEXP 64804641 and 2-Dimethylhydrazine results in increased expression of PPP1R1B mRNACTDPMID:22206623
Ppp1r1bMouse17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of PPP1R1B mRNACTDPMID:17942748
Ppp1r1bMouse17beta-estradiol increases expressionISOPpp1r1b (Rattus norvegicus)6480464Estradiol results in increased expression of PPP1R1B mRNACTDPMID:20068009
Ppp1r1bMouse17beta-estradiol increases expressionISOPPP1R1B (Homo sapiens)6480464Estradiol results in increased expression of PPP1R1B mRNACTDPMID:23019147
Ppp1r1bMouse2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Ppp1r1bMouse2,2',5,5'-tetrachlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Ppp1r1bMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPpp1r1b (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of PPP1R1B mRNACTDPMID:18465118
Ppp1r1bMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPpp1r1b (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of PPP1R1B mRNACTDPMID:32109520
Ppp1r1bMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PPP1R1B mRNACTDPMID:26290441 and PMID:33956508
Ppp1r1bMouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PPP1R1B mRNACTDPMID:26377647
Ppp1r1bMouse2,3,7,8-Tetrachlorodibenzofuran decreases expressionISOPpp1r1b (Rattus norvegicus)64804642 more ...CTDPMID:32109520
Ppp1r1bMouse2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionEXP 64804642 more ...CTDPMID:38648751
Ppp1r1bMouse2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine increases phosphorylationEXP 64804644-iodo-2 and 5-dimethoxyphenylisopropylamine results in increased phosphorylation of PPP1R1B proteinCTDPMID:11880652
Ppp1r1bMouse2-methyl-6-(phenylethynyl)pyridine multiple interactionsISOPpp1r1b (Rattus norvegicus)64804646-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of PPP1R1B protein]CTDPMID:17680995
Ppp1r1bMouse3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide increases phosphorylationEXP 6480464Raclopride results in increased phosphorylation of PPP1R1B proteinCTDPMID:12064480
Ppp1r1bMouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of PPP1R1B mRNACTDPMID:30951980
Ppp1r1bMouse4,4'-sulfonyldiphenol decreases methylationEXP 6480464bisphenol S results in decreased methylation of PPP1R1B promoterCTDPMID:33297965
Ppp1r1bMouse4-hydroxyphenyl retinamide increases expressionEXP 6480464Fenretinide results in increased expression of PPP1R1B mRNACTDPMID:28973697

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Biological Process
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Original Reference(s)
Ppp1r1bMousebehavioral response to cocaine acts_upstream_of_or_withinIMPMGI:37992912290270 PMID:18496528MGIPMID:18496528
Ppp1r1bMousecellular response to cocaine acts_upstream_of_or_withinIMPMGI:37992912290270 PMID:18496528MGIPMID:18496528
Ppp1r1bMouseDNA-templated transcription acts_upstream_of_or_withinIMP 2290270 PMID:10854268MGIPMID:10854268
Ppp1r1bMouseintracellular signal transduction involved_inISOPpp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppp1r1bMouseintracellular signal transduction involved_inIBAPANTHER:PTN000395915 and Ppp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000033
Ppp1r1bMouseintracellular signal transduction  ISOPpp1r1b (Rattus norvegicus)9068941 RGDPMID:12466426 and REF_RGD_ID:724660
Ppp1r1bMouselocomotory behavior  ISOPpp1r1b (Rattus norvegicus)9068941 RGDPMID:22952905 and REF_RGD_ID:10059420
Ppp1r1bMouselocomotory behavior acts_upstream_of_or_withinIMPMGI:37992912290270 PMID:18496528MGIPMID:18496528
Ppp1r1bMouselocomotory behavior involved_inISOPpp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppp1r1bMousememory involved_inISOPpp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppp1r1bMousememory  ISOPpp1r1b (Rattus norvegicus)9068941 RGDPMID:16687181 and REF_RGD_ID:1582430
Ppp1r1bMousenegative regulation of female receptivity acts_upstream_of_or_withinIDA 2290270 PMID:10669419MGIPMID:10669419
Ppp1r1bMousenegative regulation of female receptivity acts_upstream_of_or_withinIMP 2290270 PMID:10669419MGIPMID:10669419
Ppp1r1bMouseresponse to amphetamine acts_upstream_of_or_withinIGIMGI:975232290270 PMID:17010100MGIPMID:17010100
Ppp1r1bMouseresponse to amphetamine acts_upstream_of_or_withinIMPMGI:37992912290270 PMID:18496528MGIPMID:18496528
Ppp1r1bMouseresponse to cocaine involved_inISOPpp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppp1r1bMouseresponse to cocaine  ISOPpp1r1b (Rattus norvegicus)9068941 RGDPMID:26142455 and REF_RGD_ID:13514094
Ppp1r1bMouseresponse to morphine acts_upstream_of_or_withinIMPMGI:37992912290270 PMID:18496528MGIPMID:18496528
Ppp1r1bMouseresponse to nicotine  ISOPpp1r1b (Rattus norvegicus)9068941 RGDPMID:22952905 and REF_RGD_ID:10059420
Ppp1r1bMouseresponse to nicotine involved_inISOPpp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
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Cellular Component
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Molecular Function
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Original Reference(s)
Ppp1r1bMouseD1 dopamine receptor binding  ISODrd1 (Rattus norvegicus)9068941 RGDPMID:19465068 and REF_RGD_ID:2311555
Ppp1r1bMouseD1 dopamine receptor binding enablesISOPpp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppp1r1bMouseD2 dopamine receptor binding  ISODrd2 (Rattus norvegicus)9068941 RGDPMID:19465068 and REF_RGD_ID:2311555
Ppp1r1bMouseD2 dopamine receptor binding enablesISOPpp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppp1r1bMouseD3 dopamine receptor binding enablesISOPpp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppp1r1bMouseD3 dopamine receptor binding  ISODrd3 (Rattus norvegicus)9068941 RGDPMID:19465068 and REF_RGD_ID:2311555
Ppp1r1bMouseD4 dopamine receptor binding  ISODrd4 (Rattus norvegicus)9068941 RGDPMID:19465068 and REF_RGD_ID:2311555
Ppp1r1bMouseD4 dopamine receptor binding enablesISOPpp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppp1r1bMouseD5 dopamine receptor binding  ISODrd5 (Rattus norvegicus)9068941 RGDPMID:19465068 and REF_RGD_ID:2311555
Ppp1r1bMouseD5 dopamine receptor binding enablesISOPpp1r1b (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppp1r1bMouseprotein binding enablesISOUniProtKB:Q12800 and UniProtKB:Q8WZ609068941 PMID:25416956IntActPMID:25416956
Ppp1r1bMouseprotein phosphatase inhibitor activity enablesISOUniProtKB:Q9UD712290270 GO_CentralGO_REF:0000119
Ppp1r1bMouseprotein phosphatase inhibitor activity enablesTAS 2290270 PMID:10854268MGIPMID:10854268
Ppp1r1bMouseprotein serine/threonine phosphatase inhibitor activity enablesTAS 2290270 PMID:1533862 and PMID:7485543MGIPMID:1533862 and PMID:7485543
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RGD Manual Annotations


  
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Original Reference(s)
Ppp1r1bMousedopamine signaling pathway   ISOPPP1R1B (Homo sapiens)11041163 RGD 
Ppp1r1bMousedopamine signaling pathway   ISOPPP1R1B (Homo sapiens)11041134 RGD 
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Original Reference(s)
Ppp1r1bMouseabnormal alcohol consumption  IAGP 5509061 MGIPMID:11150351
Ppp1r1bMouseabnormal behavior  IAGP 5509061 MGIPMID:18496528
Ppp1r1bMouseabnormal physiological response to xenobiotic  IAGP 5509061 MGIPMID:16525043
Ppp1r1bMousedecreased locomotor activity  IAGP 5509061 MGIPMID:20682746
Ppp1r1bMousedecreased physiological sensitivity to xenobiotic  IAGP 5509061 MGIPMID:9694658
Ppp1r1bMousedecreased physiological sensitivity to xenobiotic  IAGP 5509061 MGIPMID:10103106
Ppp1r1bMouseenhanced behavioral response to cocaine  IAGP 5509061 MGIPMID:10103106
Ppp1r1bMouseenhanced behavioral response to cocaine  IAGP 5509061 MGIPMID:20682746
Ppp1r1bMousehyperactivity  IAGP 5509061 MGIPMID:20682746
Ppp1r1bMousehyperactivity elicited by ethanol administration  IAGP 5509061 MGIPMID:11150351
Ppp1r1bMouseimpaired behavioral response to addictive substance  IAGP 5509061 MGIPMID:9694658
Ppp1r1bMouseimpaired behavioral response to addictive substance  IAGP 5509061 MGIPMID:14631045
Ppp1r1bMouseimpaired behavioral response to cocaine  IAGP 5509061 MGIPMID:9694658
Ppp1r1bMouseimpaired behavioral response to cocaine  IAGP 5509061 MGIPMID:20682746
Ppp1r1bMouseimpaired behavioral response to cocaine  IAGP 5509061 MGIPMID:18496528
Ppp1r1bMouseimpaired behavioral response to cocaine  IAGP 5509061 MGIPMID:16525043
Ppp1r1bMouseimpaired behavioral response to morphine  IAGP 5509061 MGIPMID:18496528
Ppp1r1bMouseimpaired behavioral response to xenobiotic  IAGP 5509061 MGIPMID:20682746
Ppp1r1bMouseimpaired conditioned place preference behavior  IAGP 5509061 MGIPMID:11150351
Ppp1r1bMouseimpaired conditioned place preference behavior  IAGP 5509061 MGIPMID:18496528
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Reference Title
Reference Citation
1. Neuronal replacement from endogenous precursors in the adult brain after stroke. Arvidsson A, etal., Nat Med. 2002 Sep;8(9):963-70. doi: 10.1038/nm747. Epub 2002 Aug 5.
2. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
3. Sex differences in a transgenic rat model of Huntington's disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males. Bode FJ, etal., Hum Mol Genet. 2008 Sep 1;17(17):2595-609. doi: 10.1093/hmg/ddn159. Epub 2008 May 23.
4. Chronic hyperdopaminergic activity of schizophrenia is associated with increased ¿FosB levels and cdk-5 signaling in the nucleus accumbens. Cantrup R, etal., Neuroscience. 2012 Oct 11;222:124-35. doi: 10.1016/j.neuroscience.2012.07.027. Epub 2012 Jul 20.
5. Intrastriatal injection of ionomycin profoundly changes motor response to l-DOPA and its underlying molecular mechanisms. Han C, etal., Neuroscience. 2017 Jan 6;340:23-33. doi: 10.1016/j.neuroscience.2016.10.033. Epub 2016 Oct 19.
6. Nanotherapeutic approach for opiate addiction using DARPP-32 gene silencing in an animal model of opiate addiction. Ignatowski TA, etal., J Neuroimmune Pharmacol. 2015 Mar;10(1):136-52. doi: 10.1007/s11481-015-9585-1. Epub 2015 Jan 22.
7. DARPP-32 to quantify intracerebral hemorrhage-induced neuronal death in basal ganglia. Jin H, etal., Transl Stroke Res. 2013 Feb;4(1):130-4. doi: 10.1007/s12975-012-0232-3. Epub 2012 Dec 12.
8. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
9. Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression. Kunii Y, etal., Mol Psychiatry. 2014 Feb;19(2):192-9. doi: 10.1038/mp.2012.174. Epub 2013 Jan 8.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Proteomic analysis of alterations induced by perinatal hypoxic-ischemic brain injury. Rosenkranz K, etal., J Proteome Res. 2012 Dec 7;11(12):5794-803. doi: 10.1021/pr3005869. Epub 2012 Nov 27.
16. PPARa modulation of mesolimbic dopamine transmission rescues depression-related behaviors. Scheggi S, etal., Neuropharmacology. 2016 Nov;110(Pt A):251-259. doi: 10.1016/j.neuropharm.2016.07.024. Epub 2016 Jul 22.
17. A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice. Toresson H and Campbell K, Development 2001 Dec;128(23):4769-80.
18. [Research on expression and function of phosphorylated DARPP-32 on pentylenetetrazol-induced epilepsy model of rat]. Wang W, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Jun;31(3):637-41.
19. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
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PMID:1533862   PMID:3339428   PMID:7485543   PMID:8889548   PMID:9247261   PMID:9694658   PMID:10021349   PMID:10103106   PMID:10349636   PMID:10516482   PMID:10556054   PMID:10669419  
PMID:10837805   PMID:10854268   PMID:10922068   PMID:10934256   PMID:11042159   PMID:11060228   PMID:11069952   PMID:11076861   PMID:11150351   PMID:11217851   PMID:11478427   PMID:11722604  
PMID:11880652   PMID:11955461   PMID:12068305   PMID:12181566   PMID:12466851   PMID:12477932   PMID:12538871   PMID:12571103   PMID:12805477   PMID:14627641   PMID:14631045   PMID:14741752  
PMID:14769920   PMID:14980377   PMID:15269172   PMID:15292232   PMID:15372366   PMID:15489334   PMID:15608059   PMID:15657149   PMID:15737638   PMID:15778968   PMID:15882093   PMID:16084497  
PMID:16104378   PMID:16120638   PMID:16123776   PMID:16141072   PMID:16141073   PMID:16157277   PMID:16162925   PMID:16189209   PMID:16525043   PMID:16602821   PMID:16691566   PMID:16971527  
PMID:17010100   PMID:17207476   PMID:17209049   PMID:17460091   PMID:17552992   PMID:17596448   PMID:17614941   PMID:17693396   PMID:17721516   PMID:18155847   PMID:18199763   PMID:18313668  
PMID:18367596   PMID:18443282   PMID:18496528   PMID:18509043   PMID:18614680   PMID:18755772   PMID:18790059   PMID:18923023   PMID:19007770   PMID:19050854   PMID:19158668   PMID:19208224  
PMID:19549840   PMID:19709628   PMID:19737990   PMID:19799774   PMID:19852993   PMID:19855026   PMID:19955426   PMID:20016109   PMID:20059953   PMID:20181579   PMID:20236221   PMID:20519520  
PMID:20682746   PMID:21048141   PMID:21205893   PMID:21267068   PMID:21452241   PMID:21508241   PMID:21677750   PMID:21741919   PMID:21814187   PMID:21873635   PMID:22142223   PMID:22507666  
PMID:22753408   PMID:22808246   PMID:23250204   PMID:23426664   PMID:23431145   PMID:23551948   PMID:23558143   PMID:23643747   PMID:23675505   PMID:23749646   PMID:23906769   PMID:24058659  
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Ppp1r1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,239,232 - 98,248,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,239,230 - 98,248,622 (+)EnsemblGRCm39 Ensembl
GRCm381198,348,406 - 98,357,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,348,404 - 98,357,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,210,052 - 98,219,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,164,828 - 98,173,885 (+)NCBIMGSCv36mm8
Celera11108,003,018 - 108,012,075 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
PPP1R1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,626,707 - 39,636,624 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,626,740 - 39,636,626 (+)EnsemblGRCh38hg38GRCh38
GRCh371737,783,205 - 37,792,877 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,036,705 - 35,046,404 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,038,278 - 35,046,405NCBI
Celera1734,442,912 - 34,452,611 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,576,900 - 33,586,601 (+)NCBIHuRef
CHM1_11738,019,003 - 38,028,704 (+)NCBICHM1_1
T2T-CHM13v2.01740,489,777 - 40,500,194 (+)NCBIT2T-CHM13v2.0
Ppp1r1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,843,948 - 83,853,063 (+)NCBIGRCr8
mRatBN7.21083,347,731 - 83,356,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,347,731 - 83,356,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,292,064 - 88,301,109 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,790,149 - 87,799,194 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,182,801 - 83,191,846 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,303,727 - 86,312,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,303,727 - 86,312,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,100,811 - 86,109,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,121,889 - 87,131,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,143,530 - 87,145,100 (+)NCBI
Celera1082,095,371 - 82,102,275 (+)NCBICelera
Cytogenetic Map10q31NCBI
Ppp1r1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,389,533 - 14,394,169 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,378,186 - 14,394,910 (+)NCBIChiLan1.0ChiLan1.0
PPP1R1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,318,752 - 25,328,622 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,213,568 - 27,223,301 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,652,216 - 17,662,085 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,868,965 - 17,878,116 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,868,965 - 17,878,120 (-)Ensemblpanpan1.1panPan2
PPP1R1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,838,198 - 22,847,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,838,576 - 22,848,142 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,310,605 - 22,319,844 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,631,857 - 23,641,339 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,631,868 - 23,641,337 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,404,434 - 22,413,913 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,665,479 - 22,674,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,790,595 - 22,800,065 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,243,802 - 22,252,420 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,822,213 - 14,831,349 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,822,246 - 14,831,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,680,980 - 22,690,952 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,681,244 - 22,690,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,071,451 - 23,079,039 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,530,640 - 66,541,025 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,530,488 - 66,541,242 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,442,205 - 37,453,029 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,431,689 - 3,439,545 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,432,179 - 3,439,490 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ppp1r1b
233 total Variants

Predicted Target Of
Summary Value
Count of predictions:2782
Count of miRNA genes:599
Interacting mature miRNAs:737
Transcripts:ENSMUST00000078694, ENSMUST00000132443, ENSMUST00000133700, ENSMUST00000137634, ENSMUST00000147415, ENSMUST00000150762, ENSMUST00000152525
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 58 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse

1 to 10 of 58 rows
AU040756  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,357,412 - 98,357,641UniSTSGRCm38
MGSCv371198,218,726 - 98,218,955UniSTSGRCm37
Celera11108,011,692 - 108,011,921UniSTS
Cytogenetic Map11DUniSTS
Whitehead/MRC_RH111306.2UniSTS






1 to 17 of 17 rows
RefSeq Transcripts NM_001313970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_144828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF281662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY640620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY640621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU700812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX239932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX240293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S80640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U23160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSMUST00000078694   ⟹   ENSMUSP00000077760
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,239,230 - 98,248,622 (+)Ensembl
GRCm38.p6 Ensembl1198,348,404 - 98,357,796 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132443
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,241,681 - 98,248,614 (+)Ensembl
GRCm38.p6 Ensembl1198,350,855 - 98,357,788 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133700
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,242,315 - 98,248,112 (+)Ensembl
GRCm38.p6 Ensembl1198,351,489 - 98,357,286 (+)Ensembl
Ensembl Acc Id: ENSMUST00000137634   ⟹   ENSMUSP00000123528
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,240,822 - 98,248,620 (+)Ensembl
GRCm38.p6 Ensembl1198,349,996 - 98,357,794 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147415
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,242,041 - 98,248,217 (+)Ensembl
GRCm38.p6 Ensembl1198,351,215 - 98,357,391 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150762   ⟹   ENSMUSP00000121147
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,240,822 - 98,248,620 (+)Ensembl
GRCm38.p6 Ensembl1198,349,996 - 98,357,794 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152525
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,245,422 - 98,247,929 (+)Ensembl
GRCm38.p6 Ensembl1198,354,596 - 98,357,103 (+)Ensembl
RefSeq Acc Id: NM_001313970   ⟹   NP_001300899
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,240,822 - 98,248,622 (+)NCBI
GRCm381198,349,996 - 98,357,796 (+)NCBI
Sequence:
RefSeq Acc Id: NM_144828   ⟹   NP_659077
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,239,232 - 98,248,622 (+)NCBI
GRCm381198,348,406 - 98,357,796 (+)NCBI
MGSCv371198,210,052 - 98,219,109 (+)RGD
Celera11108,003,018 - 108,012,075 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_659077   ⟸   NM_144828
- Peptide Label: isoform 1
- UniProtKB: Q6DV86 (UniProtKB/Swiss-Prot),   Q3URF2 (UniProtKB/Swiss-Prot),   A2A564 (UniProtKB/Swiss-Prot),   Q91XB5 (UniProtKB/Swiss-Prot),   Q60829 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001300899   ⟸   NM_001313970
- Peptide Label: isoform 2
- UniProtKB: Q60829 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000121147   ⟸   ENSMUST00000150762
Ensembl Acc Id: ENSMUSP00000123528   ⟸   ENSMUST00000137634
Ensembl Acc Id: ENSMUSP00000077760   ⟸   ENSMUST00000078694

Name Modeler Protein Id AA Range Protein Structure
AF-Q60829-F1-model_v2 AlphaFold Q60829 1-194 view protein structure

RGD ID:6821595
Promoter ID:MM_KWN:9560
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:OTTMUST00000005141
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,208,861 - 98,210,117 (+)MPROMDB
RGD ID:6821597
Promoter ID:MM_KWN:9562
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:OTTMUST00000005346
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,215,311 - 98,216,067 (+)MPROMDB
RGD ID:8676476
Promoter ID:EPDNEW_M16268
Type:initiation region
Name:Ppp1r1b_1
Description:Mus musculus protein phosphatase 1, regulatory subunit 1B , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381198,348,726 - 98,348,786EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000061718 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000078694 ENTREZGENE
  ENSMUST00000078694.13 UniProtKB/Swiss-Prot
  ENSMUST00000137634 ENTREZGENE
  ENSMUST00000137634.2 UniProtKB/Swiss-Prot
  ENSMUST00000150762.8 UniProtKB/Swiss-Prot
InterPro PPP1R1A/B/C UniProtKB/Swiss-Prot
KEGG Report mmu:19049 UniProtKB/Swiss-Prot
MGD MGI:94860 ENTREZGENE
NCBI Gene 19049 ENTREZGENE
PANTHER PTHR15417 UniProtKB/Swiss-Prot
  PTHR15417:SF2 UniProtKB/Swiss-Prot
Pfam DARPP-32 UniProtKB/Swiss-Prot
PhenoGen Ppp1r1b PhenoGen
UniProt A2A564 ENTREZGENE
  PPR1B_MOUSE UniProtKB/Swiss-Prot
  Q3URF2 ENTREZGENE
  Q60829 ENTREZGENE
  Q6DV86 ENTREZGENE
  Q91XB5 ENTREZGENE
  Q9ERU0_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2A564 UniProtKB/Swiss-Prot
  Q3URF2 UniProtKB/Swiss-Prot
  Q6DV86 UniProtKB/Swiss-Prot
  Q91XB5 UniProtKB/Swiss-Prot
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Ppp1r1b  protein phosphatase 1, regulatory inhibitor subunit 1B    protein phosphatase 1, regulatory (inhibitor) subunit 1B  Symbol and/or name change 5135510 APPROVED