Ppp1r1b (protein phosphatase 1, regulatory inhibitor subunit 1B) - Rat Genome Database

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Gene: Ppp1r1b (protein phosphatase 1, regulatory inhibitor subunit 1B) Mus musculus
Analyze
Symbol: Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
RGD ID: 736949
MGI Page MGI
Description: Predicted to enable dopamine receptor binding activity and protein phosphatase inhibitor activity. Acts upstream of or within several processes, including negative regulation of female receptivity; response to cocaine; and visual learning. Located in cytoplasm; neuronal cell body; and nucleus. Is expressed in central nervous system; limb mesenchyme; nucleus pulposus; retina; and ureteric tip. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AU040756; Dar; DARP; DARPP-32; Darpp32; dopamine- and cAMP-regulated neuronal phosphoprotein; protein phosphatase 1 regulatory subunit 1B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,239,232 - 98,248,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,239,230 - 98,248,622 (+)EnsemblGRCm39 Ensembl
GRCm381198,348,406 - 98,357,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,348,404 - 98,357,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,210,052 - 98,219,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,164,828 - 98,173,885 (+)NCBIMGSCv36mm8
Celera11108,003,018 - 108,012,075 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5-methoxytryptamine  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
camptothecin  (ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
clorgyline  (EXP)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
corticosterone  (EXP)
corticotropin  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyhalothrin  (ISO)
DDE  (ISO)
deguelin  (EXP)
dextran sulfate  (EXP)
dichloroacetic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
ethanol  (EXP)
eticlopride(1+)  (EXP)
fluoxetine  (EXP)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
graphite  (ISO)
haloperidol  (EXP)
indole-3-methanol  (ISO)
inulin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
ketamine  (ISO)
ketanserin  (EXP)
linuron  (ISO)
LY294002  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (EXP)
microcystin-LR  (ISO)
morphine  (ISO)
nickel atom  (ISO)
oxidopamine  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
Pargyline  (EXP)
PCB138  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
progesterone  (EXP)
quinpirole  (EXP)
resveratrol  (EXP)
roflumilast  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
serotonin  (EXP)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
tetrachloroethene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (EXP)
triclosan  (ISO)
U-73122  (EXP)
valproic acid  (EXP)
vancomycin  (EXP)
vincristine  (ISO)
wortmannin  (EXP)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neuronal replacement from endogenous precursors in the adult brain after stroke. Arvidsson A, etal., Nat Med. 2002 Sep;8(9):963-70. doi: 10.1038/nm747. Epub 2002 Aug 5.
2. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
3. Sex differences in a transgenic rat model of Huntington's disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males. Bode FJ, etal., Hum Mol Genet. 2008 Sep 1;17(17):2595-609. doi: 10.1093/hmg/ddn159. Epub 2008 May 23.
4. Chronic hyperdopaminergic activity of schizophrenia is associated with increased ¿FosB levels and cdk-5 signaling in the nucleus accumbens. Cantrup R, etal., Neuroscience. 2012 Oct 11;222:124-35. doi: 10.1016/j.neuroscience.2012.07.027. Epub 2012 Jul 20.
5. Intrastriatal injection of ionomycin profoundly changes motor response to l-DOPA and its underlying molecular mechanisms. Han C, etal., Neuroscience. 2017 Jan 6;340:23-33. doi: 10.1016/j.neuroscience.2016.10.033. Epub 2016 Oct 19.
6. Nanotherapeutic approach for opiate addiction using DARPP-32 gene silencing in an animal model of opiate addiction. Ignatowski TA, etal., J Neuroimmune Pharmacol. 2015 Mar;10(1):136-52. doi: 10.1007/s11481-015-9585-1. Epub 2015 Jan 22.
7. DARPP-32 to quantify intracerebral hemorrhage-induced neuronal death in basal ganglia. Jin H, etal., Transl Stroke Res. 2013 Feb;4(1):130-4. doi: 10.1007/s12975-012-0232-3. Epub 2012 Dec 12.
8. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
9. Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression. Kunii Y, etal., Mol Psychiatry. 2014 Feb;19(2):192-9. doi: 10.1038/mp.2012.174. Epub 2013 Jan 8.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Proteomic analysis of alterations induced by perinatal hypoxic-ischemic brain injury. Rosenkranz K, etal., J Proteome Res. 2012 Dec 7;11(12):5794-803. doi: 10.1021/pr3005869. Epub 2012 Nov 27.
16. PPARa modulation of mesolimbic dopamine transmission rescues depression-related behaviors. Scheggi S, etal., Neuropharmacology. 2016 Nov;110(Pt A):251-259. doi: 10.1016/j.neuropharm.2016.07.024. Epub 2016 Jul 22.
17. A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice. Toresson H and Campbell K, Development 2001 Dec;128(23):4769-80.
18. [Research on expression and function of phosphorylated DARPP-32 on pentylenetetrazol-induced epilepsy model of rat]. Wang W, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Jun;31(3):637-41.
19. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:1533862   PMID:3339428   PMID:7485543   PMID:8889548   PMID:9247261   PMID:9694658   PMID:10021349   PMID:10103106   PMID:10349636   PMID:10516482   PMID:10556054   PMID:10669419  
PMID:10837805   PMID:10854268   PMID:10922068   PMID:10934256   PMID:11042159   PMID:11060228   PMID:11069952   PMID:11076861   PMID:11150351   PMID:11217851   PMID:11478427   PMID:11722604  
PMID:11880652   PMID:11955461   PMID:12068305   PMID:12181566   PMID:12466851   PMID:12477932   PMID:12538871   PMID:12571103   PMID:12805477   PMID:14627641   PMID:14631045   PMID:14741752  
PMID:14769920   PMID:14980377   PMID:15269172   PMID:15292232   PMID:15372366   PMID:15489334   PMID:15608059   PMID:15657149   PMID:15737638   PMID:15778968   PMID:15882093   PMID:16084497  
PMID:16104378   PMID:16120638   PMID:16123776   PMID:16141072   PMID:16141073   PMID:16157277   PMID:16162925   PMID:16189209   PMID:16525043   PMID:16602821   PMID:16691566   PMID:16971527  
PMID:17010100   PMID:17207476   PMID:17209049   PMID:17460091   PMID:17552992   PMID:17596448   PMID:17614941   PMID:17693396   PMID:17721516   PMID:18155847   PMID:18199763   PMID:18313668  
PMID:18367596   PMID:18443282   PMID:18496528   PMID:18509043   PMID:18614680   PMID:18755772   PMID:18790059   PMID:18923023   PMID:19007770   PMID:19050854   PMID:19158668   PMID:19208224  
PMID:19549840   PMID:19709628   PMID:19737990   PMID:19799774   PMID:19852993   PMID:19855026   PMID:19955426   PMID:20016109   PMID:20059953   PMID:20181579   PMID:20236221   PMID:20519520  
PMID:20682746   PMID:21048141   PMID:21205893   PMID:21267068   PMID:21452241   PMID:21508241   PMID:21677750   PMID:21741919   PMID:21814187   PMID:21873635   PMID:22142223   PMID:22507666  
PMID:22753408   PMID:22808246   PMID:23250204   PMID:23426664   PMID:23431145   PMID:23551948   PMID:23558143   PMID:23643747   PMID:23675505   PMID:23749646   PMID:23906769   PMID:24058659  
PMID:24082127   PMID:24165879   PMID:24204683   PMID:24312250   PMID:24395794   PMID:24440754   PMID:24441682   PMID:24747358   PMID:24790185   PMID:24804781   PMID:24867253   PMID:24952961  
PMID:25128420   PMID:25254549   PMID:25548102   PMID:25692798   PMID:25762659   PMID:26099530   PMID:26324926   PMID:26376866   PMID:26389685   PMID:26465004   PMID:26490861   PMID:26639316  
PMID:26947946   PMID:27117402   PMID:27154297   PMID:27480591   PMID:27590997   PMID:27998980   PMID:28213137   PMID:28224988   PMID:28289129   PMID:28433741   PMID:28705898   PMID:29107639  
PMID:29752725   PMID:30413696   PMID:30529950   PMID:31060804   PMID:31225596   PMID:31235784   PMID:31300520   PMID:31491374   PMID:32170006   PMID:32242231   PMID:32325033   PMID:32561725  
PMID:32765228   PMID:33096475   PMID:33230547   PMID:34131032   PMID:34321999   PMID:34494344   PMID:34963132   PMID:35273083   PMID:35939707   PMID:36055413   PMID:36496200   PMID:36943865  
PMID:37532091   PMID:37561632   PMID:38132125  


Genomics

Comparative Map Data
Ppp1r1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,239,232 - 98,248,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,239,230 - 98,248,622 (+)EnsemblGRCm39 Ensembl
GRCm381198,348,406 - 98,357,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,348,404 - 98,357,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,210,052 - 98,219,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,164,828 - 98,173,885 (+)NCBIMGSCv36mm8
Celera11108,003,018 - 108,012,075 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
PPP1R1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,626,707 - 39,636,624 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,626,740 - 39,636,626 (+)EnsemblGRCh38hg38GRCh38
GRCh371737,783,205 - 37,792,877 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,036,705 - 35,046,404 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,038,278 - 35,046,405NCBI
Celera1734,442,912 - 34,452,611 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,576,900 - 33,586,601 (+)NCBIHuRef
CHM1_11738,019,003 - 38,028,704 (+)NCBICHM1_1
T2T-CHM13v2.01740,489,777 - 40,500,194 (+)NCBIT2T-CHM13v2.0
Ppp1r1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,843,948 - 83,853,063 (+)NCBIGRCr8
mRatBN7.21083,347,731 - 83,356,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,347,731 - 83,356,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,292,064 - 88,301,109 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,790,149 - 87,799,194 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,182,801 - 83,191,846 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,303,727 - 86,312,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,303,727 - 86,312,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,100,811 - 86,109,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,121,889 - 87,131,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,143,530 - 87,145,100 (+)NCBI
Celera1082,095,371 - 82,102,275 (+)NCBICelera
Cytogenetic Map10q31NCBI
Ppp1r1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,389,533 - 14,394,169 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,378,186 - 14,394,910 (+)NCBIChiLan1.0ChiLan1.0
PPP1R1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,318,752 - 25,328,622 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,213,568 - 27,223,301 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,652,216 - 17,662,085 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,868,965 - 17,878,116 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,868,965 - 17,878,120 (-)Ensemblpanpan1.1panPan2
PPP1R1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,838,198 - 22,847,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,838,576 - 22,848,142 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,310,605 - 22,319,844 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,631,857 - 23,641,339 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,631,868 - 23,641,337 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,404,434 - 22,413,913 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,665,479 - 22,674,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,790,595 - 22,800,065 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,243,802 - 22,252,420 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,822,213 - 14,831,349 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,822,246 - 14,831,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,680,980 - 22,690,952 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,681,244 - 22,690,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,071,451 - 23,079,039 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,530,640 - 66,541,025 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,530,488 - 66,541,242 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,442,205 - 37,453,029 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,431,689 - 3,439,545 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,432,179 - 3,439,490 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r1b
233 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2782
Count of miRNA genes:599
Interacting mature miRNAs:737
Transcripts:ENSMUST00000078694, ENSMUST00000132443, ENSMUST00000133700, ENSMUST00000137634, ENSMUST00000147415, ENSMUST00000150762, ENSMUST00000152525
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1301153Estq3_mestradiol regulated response QTL 3 (mouse)Not determined119689769399327028Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
AU040756  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,357,412 - 98,357,641UniSTSGRCm38
MGSCv371198,218,726 - 98,218,955UniSTSGRCm37
Celera11108,011,692 - 108,011,921UniSTS
Cytogenetic Map11DUniSTS
Whitehead/MRC_RH111306.2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001313970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_144828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF281662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY640620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY640621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU700812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX239932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX240293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S80640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U23160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000078694   ⟹   ENSMUSP00000077760
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,239,230 - 98,248,622 (+)Ensembl
GRCm38.p6 Ensembl1198,348,404 - 98,357,796 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132443
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,241,681 - 98,248,614 (+)Ensembl
GRCm38.p6 Ensembl1198,350,855 - 98,357,788 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133700
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,242,315 - 98,248,112 (+)Ensembl
GRCm38.p6 Ensembl1198,351,489 - 98,357,286 (+)Ensembl
Ensembl Acc Id: ENSMUST00000137634   ⟹   ENSMUSP00000123528
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,240,822 - 98,248,620 (+)Ensembl
GRCm38.p6 Ensembl1198,349,996 - 98,357,794 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147415
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,242,041 - 98,248,217 (+)Ensembl
GRCm38.p6 Ensembl1198,351,215 - 98,357,391 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150762   ⟹   ENSMUSP00000121147
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,240,822 - 98,248,620 (+)Ensembl
GRCm38.p6 Ensembl1198,349,996 - 98,357,794 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152525
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,245,422 - 98,247,929 (+)Ensembl
GRCm38.p6 Ensembl1198,354,596 - 98,357,103 (+)Ensembl
RefSeq Acc Id: NM_001313970   ⟹   NP_001300899
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,240,822 - 98,248,622 (+)NCBI
GRCm381198,349,996 - 98,357,796 (+)NCBI
Sequence:
RefSeq Acc Id: NM_144828   ⟹   NP_659077
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,239,232 - 98,248,622 (+)NCBI
GRCm381198,348,406 - 98,357,796 (+)NCBI
MGSCv371198,210,052 - 98,219,109 (+)RGD
Celera11108,003,018 - 108,012,075 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_659077   ⟸   NM_144828
- Peptide Label: isoform 1
- UniProtKB: Q6DV86 (UniProtKB/Swiss-Prot),   Q3URF2 (UniProtKB/Swiss-Prot),   A2A564 (UniProtKB/Swiss-Prot),   Q91XB5 (UniProtKB/Swiss-Prot),   Q60829 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001300899   ⟸   NM_001313970
- Peptide Label: isoform 2
- UniProtKB: Q60829 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000121147   ⟸   ENSMUST00000150762
Ensembl Acc Id: ENSMUSP00000123528   ⟸   ENSMUST00000137634
Ensembl Acc Id: ENSMUSP00000077760   ⟸   ENSMUST00000078694

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q60829-F1-model_v2 AlphaFold Q60829 1-194 view protein structure

Promoters
RGD ID:6821595
Promoter ID:MM_KWN:9560
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:OTTMUST00000005141
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,208,861 - 98,210,117 (+)MPROMDB
RGD ID:6821597
Promoter ID:MM_KWN:9562
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:OTTMUST00000005346
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,215,311 - 98,216,067 (+)MPROMDB
RGD ID:8676476
Promoter ID:EPDNEW_M16268
Type:initiation region
Name:Ppp1r1b_1
Description:Mus musculus protein phosphatase 1, regulatory subunit 1B , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381198,348,726 - 98,348,786EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94860 AgrOrtholog
Ensembl Genes ENSMUSG00000061718 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000078694 ENTREZGENE
  ENSMUST00000078694.13 UniProtKB/Swiss-Prot
  ENSMUST00000137634 ENTREZGENE
  ENSMUST00000137634.2 UniProtKB/Swiss-Prot
  ENSMUST00000150762.8 UniProtKB/Swiss-Prot
InterPro PPP1R1A/B/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19049 UniProtKB/Swiss-Prot
MGD MGI:94860 ENTREZGENE
NCBI Gene 19049 ENTREZGENE
PANTHER PTHR15417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15417:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DARPP-32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r1b PhenoGen
UniProt A2A564 ENTREZGENE
  PPR1B_MOUSE UniProtKB/Swiss-Prot
  Q3URF2 ENTREZGENE
  Q60829 ENTREZGENE
  Q6DV86 ENTREZGENE
  Q91XB5 ENTREZGENE
  Q9ERU0_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2A564 UniProtKB/Swiss-Prot
  Q3URF2 UniProtKB/Swiss-Prot
  Q6DV86 UniProtKB/Swiss-Prot
  Q91XB5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Ppp1r1b  protein phosphatase 1, regulatory inhibitor subunit 1B    protein phosphatase 1, regulatory (inhibitor) subunit 1B  Symbol and/or name change 5135510 APPROVED