PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B) - Rat Genome Database

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Gene: PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B) Homo sapiens
Analyze
Symbol: PPP1R1B
Name: protein phosphatase 1 regulatory inhibitor subunit 1B
RGD ID: 1347073
HGNC Page HGNC
Description: Enables protein phosphatase inhibitor activity. Involved in negative regulation of phosphoprotein phosphatase activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Implicated in bipolar disorder and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DARPP-32; DARPP32; dopamine and cAMP regulated phosphoprotein; dopamine and cAMP-regulated neuronal phosphoprotein 32; dopamine- and cAMP-regulated neuronal phosphoprotein; FLJ20940; protein phosphatase 1 regulatory subunit 1B; protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1739,626,740 - 39,636,626 (+)EnsemblGRCh38hg38GRCh38
GRCh381739,626,735 - 39,636,625 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371737,783,205 - 37,792,877 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,036,705 - 35,046,404 (+)NCBINCBI36hg18NCBI36
Build 341735,038,278 - 35,046,405NCBI
Celera1734,442,912 - 34,452,611 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1733,576,900 - 33,586,601 (+)NCBIHuRef
CHM1_11738,019,003 - 38,028,704 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
5-methoxytryptamine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (EXP)
all-trans-retinoic acid  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (EXP)
carbon nanotube  (ISO)
cisplatin  (EXP)
clorgyline  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
corticosterone  (ISO)
corticotropin  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyhalothrin  (ISO)
Deguelin  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
entinostat  (EXP)
ethanol  (ISO)
fluoxetine  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
graphite  (ISO)
haloperidol  (ISO)
indole-3-methanol  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ketamine  (ISO)
ketanserin  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
microcystin  (ISO)
morphine  (EXP,ISO)
nickel atom  (EXP)
oxidopamine  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
Pargyline  (ISO)
PCB138  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quinpirole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (EXP)
serotonin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (EXP)
tetrachloroethene  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
U-73122  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (EXP)
wortmannin  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1663529   PMID:1721636   PMID:1791981   PMID:2153935   PMID:2191086   PMID:2557337   PMID:6087160   PMID:6319627   PMID:6330098   PMID:8120638   PMID:8125298   PMID:9108011  
PMID:9920093   PMID:10604473   PMID:10807923   PMID:11134138   PMID:12124342   PMID:12477932   PMID:14508844   PMID:14702039   PMID:14991576   PMID:15010812   PMID:15188007   PMID:15345721  
PMID:15489334   PMID:16061638   PMID:16169070   PMID:16344560   PMID:16750903   PMID:17027969   PMID:17117180   PMID:17171661   PMID:17290303   PMID:17492506   PMID:17521792   PMID:17618027  
PMID:17683050   PMID:17695523   PMID:17948899   PMID:18055181   PMID:18058465   PMID:18199533   PMID:18270970   PMID:18470533   PMID:18573638   PMID:18579663   PMID:18808062   PMID:18954090  
PMID:19058789   PMID:19059449   PMID:19077115   PMID:19086053   PMID:19124506   PMID:19156168   PMID:19301121   PMID:19463699   PMID:19651774   PMID:19874574   PMID:19897079   PMID:19913121  
PMID:20074680   PMID:20468064   PMID:20483474   PMID:20580047   PMID:20628086   PMID:20631684   PMID:20836878   PMID:20874815   PMID:21041608   PMID:21369787   PMID:21447180   PMID:21453742  
PMID:21741919   PMID:21821092   PMID:21873635   PMID:22179181   PMID:22559203   PMID:22576830   PMID:22589394   PMID:23080070   PMID:23160836   PMID:23250204   PMID:23250732   PMID:23639477  
PMID:23715974   PMID:24035787   PMID:24276243   PMID:24395794   PMID:24704945   PMID:25416956   PMID:25779598   PMID:26178297   PMID:26561806   PMID:26818509   PMID:26918585   PMID:27475250  
PMID:27590997   PMID:27995567   PMID:28065797   PMID:28514442   PMID:28867659   PMID:29048604   PMID:29180608   PMID:30347192   PMID:30552871   PMID:31235784   PMID:31619735   PMID:31740718  
PMID:32499571   PMID:32735911  


Genomics

Comparative Map Data
PPP1R1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1739,626,740 - 39,636,626 (+)EnsemblGRCh38hg38GRCh38
GRCh381739,626,735 - 39,636,625 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371737,783,205 - 37,792,877 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,036,705 - 35,046,404 (+)NCBINCBI36hg18NCBI36
Build 341735,038,278 - 35,046,405NCBI
Celera1734,442,912 - 34,452,611 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1733,576,900 - 33,586,601 (+)NCBIHuRef
CHM1_11738,019,003 - 38,028,704 (+)NCBICHM1_1
Ppp1r1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,239,232 - 98,248,622 (+)NCBIGRCm39mm39
GRCm39 Ensembl1198,239,230 - 98,248,622 (+)Ensembl
GRCm381198,348,406 - 98,357,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,348,404 - 98,357,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,210,052 - 98,219,109 (+)NCBIGRCm37mm9NCBIm37
MGSCv361198,164,828 - 98,173,885 (+)NCBImm8
Celera11108,003,018 - 108,012,075 (+)NCBICelera
Cytogenetic Map11DNCBI
Ppp1r1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21083,347,731 - 83,356,775 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1083,347,731 - 83,356,775 (+)Ensembl
Rnor_6.01086,303,727 - 86,312,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,303,727 - 86,312,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,100,811 - 86,109,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,121,889 - 87,131,587 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11087,143,530 - 87,145,100 (+)NCBI
Celera1082,095,371 - 82,102,275 (+)NCBICelera
Cytogenetic Map10q31NCBI
Ppp1r1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,389,533 - 14,394,169 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,378,186 - 14,394,910 (+)NCBIChiLan1.0ChiLan1.0
PPP1R1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11717,868,965 - 17,878,116 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,868,965 - 17,878,120 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01717,652,216 - 17,662,085 (-)NCBIMhudiblu_PPA_v0panPan3
PPP1R1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,838,198 - 22,847,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,838,576 - 22,848,142 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,310,605 - 22,319,844 (-)NCBI
ROS_Cfam_1.0923,631,857 - 23,641,339 (-)NCBI
UMICH_Zoey_3.1922,404,434 - 22,413,913 (-)NCBI
UNSW_CanFamBas_1.0922,665,479 - 22,674,943 (-)NCBI
UU_Cfam_GSD_1.0922,790,595 - 22,800,065 (-)NCBI
Ppp1r1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,243,802 - 22,252,420 (-)NCBI
SpeTri2.0NW_00493649014,822,246 - 14,831,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,654,924 - 22,690,953 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,681,244 - 22,690,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,071,451 - 23,079,039 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,530,640 - 66,541,025 (-)NCBI
ChlSab1.1 Ensembl1666,530,488 - 66,541,242 (-)Ensembl
Vero_WHO_p1.0NW_02366607737,442,205 - 37,453,029 (-)NCBI
Ppp1r1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247953,432,179 - 3,439,490 (-)NCBI

Position Markers
WI-19537  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,792,592 - 37,792,864UniSTSGRCh37
Build 361735,046,118 - 35,046,390RGDNCBI36
Celera1734,452,325 - 34,452,597RGD
Cytogenetic Map17q11-q12UniSTS
Cytogenetic Map17q12UniSTS
HuRef1733,586,315 - 33,586,587UniSTS
GeneMap99-GB4 RH Map17304.32UniSTS
Whitehead-RH Map17338.1UniSTS
NCBI RH Map17445.6UniSTS
RH66410  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,792,603 - 37,792,723UniSTSGRCh37
Build 361735,046,129 - 35,046,249RGDNCBI36
Celera1734,452,336 - 34,452,456RGD
Cytogenetic Map17q11-q12UniSTS
Cytogenetic Map17q12UniSTS
HuRef1733,586,326 - 33,586,446UniSTS
PPP1R1B_4142  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,792,240 - 37,792,890UniSTSGRCh37
Build 361735,045,766 - 35,046,416RGDNCBI36
Celera1734,451,973 - 34,452,623RGD
HuRef1733,585,963 - 33,586,613UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3738
Count of miRNA genes:825
Interacting mature miRNAs:999
Transcripts:ENST00000254079, ENST00000394265, ENST00000394267, ENST00000492037, ENST00000579000, ENST00000580029, ENST00000580772, ENST00000580825, ENST00000582680, ENST00000583446
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3 363
Medium 1487 40 225 164 182 10 2325 441 2941 61 914 328 152 1042 1129 2
Low 907 1727 885 58 263 49 1284 934 354 180 419 967 14 1 162 1006
Below cutoff 27 1197 457 261 1127 263 711 803 42 83 80 234 6 653 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_030330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001242464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_181505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017025216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017025217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC087491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF233349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF435972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF435973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF435974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF435975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF464196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK124417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX616403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX616405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY070271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS566124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA136306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000254079   ⟹   ENSP00000254079
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,626,952 - 39,636,624 (+)Ensembl
RefSeq Acc Id: ENST00000394265   ⟹   ENSP00000377808
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,628,498 - 39,636,625 (+)Ensembl
RefSeq Acc Id: ENST00000394267   ⟹   ENSP00000377810
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,628,498 - 39,636,626 (+)Ensembl
RefSeq Acc Id: ENST00000492037
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,629,405 - 39,636,624 (+)Ensembl
RefSeq Acc Id: ENST00000579000   ⟹   ENSP00000462841
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,627,200 - 39,636,622 (+)Ensembl
RefSeq Acc Id: ENST00000580029
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,632,138 - 39,636,625 (+)Ensembl
RefSeq Acc Id: ENST00000580772
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,628,526 - 39,630,452 (+)Ensembl
RefSeq Acc Id: ENST00000580825   ⟹   ENSP00000462137
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,626,740 - 39,636,000 (+)Ensembl
RefSeq Acc Id: ENST00000582680   ⟹   ENSP00000462522
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,626,952 - 39,634,084 (+)Ensembl
RefSeq Acc Id: ENST00000583446
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,629,374 - 39,635,721 (+)Ensembl
RefSeq Acc Id: NM_001242464   ⟹   NP_001229393
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,628,503 - 39,636,624 (+)NCBI
GRCh371737,783,177 - 37,792,878 (+)ENTREZGENE
HuRef1733,576,900 - 33,586,601 (+)ENTREZGENE
CHM1_11738,020,577 - 38,028,704 (+)NCBI
Sequence:
RefSeq Acc Id: NM_032192   ⟹   NP_115568
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,626,952 - 39,636,624 (+)NCBI
GRCh371737,783,177 - 37,792,878 (+)ENTREZGENE
Build 361735,036,705 - 35,046,403 (+)NCBI Archive
HuRef1733,576,900 - 33,586,601 (+)ENTREZGENE
CHM1_11738,019,003 - 38,028,704 (+)NCBI
Sequence:
RefSeq Acc Id: NM_181505   ⟹   NP_852606
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,628,503 - 39,636,624 (+)NCBI
GRCh371737,783,177 - 37,792,878 (+)ENTREZGENE
Build 361735,038,279 - 35,046,404 (+)NCBI Archive
HuRef1733,576,900 - 33,586,601 (+)ENTREZGENE
CHM1_11738,020,577 - 38,028,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017025216   ⟹   XP_016880705
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,626,735 - 39,636,625 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017025217   ⟹   XP_016880706
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,628,505 - 39,636,625 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_115568   ⟸   NM_032192
- Peptide Label: isoform 1
- UniProtKB: Q9UD71 (UniProtKB/Swiss-Prot),   B3KVQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_852606   ⟸   NM_181505
- Peptide Label: isoform 2
- UniProtKB: Q9UD71 (UniProtKB/Swiss-Prot),   A0A024R1R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001229393   ⟸   NM_001242464
- Peptide Label: isoform 2
- UniProtKB: Q9UD71 (UniProtKB/Swiss-Prot),   A0A024R1R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016880705   ⟸   XM_017025216
- Peptide Label: isoform X1
- UniProtKB: Q9UD71 (UniProtKB/Swiss-Prot),   B3KVQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016880706   ⟸   XM_017025217
- Peptide Label: isoform X2
- UniProtKB: Q9UD71 (UniProtKB/Swiss-Prot),   A0A024R1R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000462137   ⟸   ENST00000580825
RefSeq Acc Id: ENSP00000462522   ⟸   ENST00000582680
RefSeq Acc Id: ENSP00000254079   ⟸   ENST00000254079
RefSeq Acc Id: ENSP00000462841   ⟸   ENST00000579000
RefSeq Acc Id: ENSP00000377810   ⟸   ENST00000394267
RefSeq Acc Id: ENSP00000377808   ⟸   ENST00000394265

Promoters
RGD ID:7234839
Promoter ID:EPDNEW_H23165
Type:initiation region
Name:PPP1R1B_4
Description:protein phosphatase 1 regulatory inhibitor subunit 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23166  EPDNEW_H23167  EPDNEW_H23168  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,626,707 - 39,626,767EPDNEW
RGD ID:7234841
Promoter ID:EPDNEW_H23166
Type:initiation region
Name:PPP1R1B_1
Description:protein phosphatase 1 regulatory inhibitor subunit 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23165  EPDNEW_H23167  EPDNEW_H23168  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,626,952 - 39,627,012EPDNEW
RGD ID:7234843
Promoter ID:EPDNEW_H23167
Type:initiation region
Name:PPP1R1B_3
Description:protein phosphatase 1 regulatory inhibitor subunit 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23165  EPDNEW_H23166  EPDNEW_H23168  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,627,289 - 39,627,349EPDNEW
RGD ID:7234845
Promoter ID:EPDNEW_H23168
Type:initiation region
Name:PPP1R1B_2
Description:protein phosphatase 1 regulatory inhibitor subunit 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23165  EPDNEW_H23166  EPDNEW_H23167  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,628,503 - 39,628,563EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31
pathogenic
NM_032192.4(PPP1R1B):c.72G>A (p.Gln24=) single nucleotide variant not provided [RCV000084767] Chr17:39627464 [GRCh38]
Chr17:37783717 [GRCh37]
Chr17:17q12
not provided
NM_032192.4(PPP1R1B):c.86G>A (p.Arg29Gln) single nucleotide variant not provided [RCV000084768] Chr17:39629174 [GRCh38]
Chr17:37785427 [GRCh37]
Chr17:17q12
not provided
NM_032192.4(PPP1R1B):c.393G>A (p.Glu131=) single nucleotide variant not provided [RCV000084769] Chr17:39634034 [GRCh38]
Chr17:37790287 [GRCh37]
Chr17:17q12
not provided
NM_032192.4(PPP1R1B):c.493C>A (p.Arg165Ser) single nucleotide variant not provided [RCV000084770] Chr17:39635654 [GRCh38]
Chr17:37791907 [GRCh37]
Chr17:17q12
not provided
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh38/hg38 17q12(chr17:39036037-39694679)x3 copy number gain See cases [RCV000140753] Chr17:39036037..39694679 [GRCh38]
Chr17:37192290..37850932 [GRCh37]
Chr17:34445816..35104458 [NCBI36]
Chr17:17q12
likely benign|uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q12(chr17:37313691-37868516)x3 copy number gain See cases [RCV000512247] Chr17:37313691..37868516 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q12(chr17:36972794-38033708)x4 copy number gain not provided [RCV000683933] Chr17:36972794..38033708 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q12(chr17:37387413-37879941)x3 copy number gain not provided [RCV000739510] Chr17:37387413..37879941 [GRCh37]
Chr17:17q12
benign
NM_032192.4(PPP1R1B):c.480A>G (p.Glu160=) single nucleotide variant not provided [RCV000962494] Chr17:39635641 [GRCh38]
Chr17:37791894 [GRCh37]
Chr17:17q12
benign
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2
pathogenic
GRCh37/hg19 17q12(chr17:37190609-37868002)x3 copy number gain not provided [RCV000849616] Chr17:37190609..37868002 [GRCh37]
Chr17:17q12
uncertain significance
NM_032192.4(PPP1R1B):c.593C>A (p.Ser198Tyr) single nucleotide variant not provided [RCV000955271] Chr17:39635843 [GRCh38]
Chr17:37792096 [GRCh37]
Chr17:17q12
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9287 AgrOrtholog
COSMIC PPP1R1B COSMIC
Ensembl Genes ENSG00000131771 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000254079 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000377808 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000377810 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000462137 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000462522 UniProtKB/TrEMBL
  ENSP00000462841 UniProtKB/TrEMBL
Ensembl Transcript ENST00000254079 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000394265 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000394267 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000579000 UniProtKB/TrEMBL
  ENST00000580825 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000582680 UniProtKB/TrEMBL
GTEx ENSG00000131771 GTEx
HGNC ID HGNC:9287 ENTREZGENE
Human Proteome Map PPP1R1B Human Proteome Map
InterPro DARPP-32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPP1R1A/B/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:84152 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 84152 ENTREZGENE
OMIM 604399 OMIM
PANTHER PTHR15417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15417:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DARPP-32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33639 PharmGKB
UniProt A0A024R1R3 ENTREZGENE, UniProtKB/TrEMBL
  B3KVQ9 ENTREZGENE, UniProtKB/TrEMBL
  J3KSJ8_HUMAN UniProtKB/TrEMBL
  J3KT77_HUMAN UniProtKB/TrEMBL
  PPR1B_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q547V9 UniProtKB/Swiss-Prot
  Q547W0 UniProtKB/Swiss-Prot
  Q9H7G1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PPP1R1B  protein phosphatase 1 regulatory inhibitor subunit 1B    protein phosphatase 1, regulatory (inhibitor) subunit 1B  Symbol and/or name change 5135510 APPROVED