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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621859
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp1r1b
Name: protein phosphatase 1, regulatory (inhibitor) subunit 1B
Acc ID: CHEBI:3892
Term: corticotropin
Definition: A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency.
Chemical ID: MESH:D000324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp1r1bmultiple interactionsISORGD:7369496480464CTDCocaine promotes the reaction [PPP1R1B protein results in increased abundance of Adrenocorticotropic Hormone]

PMID:10516482
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