Pnmt (phenylethanolamine-N-methyltransferase) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Pnmt (phenylethanolamine-N-methyltransferase) Rattus norvegicus
Symbol: Pnmt
Name: phenylethanolamine-N-methyltransferase
RGD ID: 3361
Description: Enables phenylethanolamine N-methyltransferase activity. Involved in several processes, including catecholamine metabolic process; cellular response to dexamethasone stimulus; and response to peptide hormone. Located in axon; dendrite; and perikaryon. Biomarker of hypertension and hypoglycemia. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human PNMT (phenylethanolamine N-methyltransferase); PARTICIPATES IN epinephrine biosynthetic pathway; alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
Previously known as: noradrenaline N-methyltransferase; Phenylethanolamine N-methyltransferase; PNMTase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21083,383,019 - 83,386,557 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,384,923 - 83,386,556 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,329,223 - 88,330,891 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,827,308 - 87,828,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,219,959 - 83,221,627 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,340,893 - 86,342,501 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,340,940 - 86,342,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,137,019 - 86,138,436 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1082,132,183 - 82,134,127 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Changes in P2Y2 receptor localization on adrenaline- and noradrenaline-containing chromaffin cells in the rat adrenal gland during development and aging. Afework M and Burnstock G, Int J Dev Neurosci. 2005 Nov;23(7):567-73. Epub 2005 Sep 2.
2. Adolescent alcohol exposure alters the central brain circuits known to regulate the stress response. Allen CD, etal., Neuroscience. 2011 Mar 5.
3. Purification and properties of phenylethanolamine-N-methyl transferase. AXELROD J, J Biol Chem. 1962 May;237:1657-60.
4. Phenylethanolamine N-methyltransferase gene expression in the heart and blood pressure response to oxytocin treatment in rats exposed to voluntary wheel running. Bakos J, etal., Ann N Y Acad Sci. 2008 Dec;1148:302-7.
5. Regulation of the adrenomedullary catecholaminergic system after mild, acute stress. Betito K, etal., Am J Physiol. 1994 Jul;267(1 Pt 2):R212-20.
6. Activation of Different Neuronal Phenotypes in the Rat Brain Induced by Liver Ischemia-Reperfusion Injury: Dual Fos/Neuropeptide Immunohistochemistry. Bundzikova J, etal., Cell Mol Neurobiol. 2010 Nov 9.
7. Simultaneous measurement of enzyme activity, protein, mRNA, and metabolites in small samples. Burke WJ, etal., Anal Biochem. 1995 Sep 20;230(2):345-8.
8. A highly sensitive assay for phenylethanolamine N-methyltransferase in human brain. Burke WJ, etal., Proc Soc Exp Biol Med. 1986 Jan;181(1):66-70.
9. Association of polymorphisms in the promoter region of the PNMT gene with essential hypertension in African Americans but not in whites. Cui J, etal., Am J Hypertens. 2003 Oct;16(10):859-63.
10. Some properties of phenylethanolamine-N-methyltransferase of rat brain. Díaz Borges JM, etal., Neurochem Res. 1978 Feb;3(1):15-26. doi: 10.1007/BF00964357.
11. Egr-1 activation of rat adrenal phenylethanolamine N-methyltransferase gene. Ebert SN, etal., J Biol Chem. 1994 Aug 19;269(33):20885-98.
12. Noradrenergic innervation of hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in rats. Fuzesi T, etal., Brain Res. 2009 Oct 19;1294:38-44. Epub 2009 Aug 6.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Chronic individual housing-induced stress decreased expression of catecholamine biosynthetic enzyme genes and proteins in spleen of adult rats. Gavrilovic L, etal., Neuroimmunomodulation. 2010;17(4):265-9. doi: 10.1159/000290042. Epub 2010 Mar 5.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Regulation of the rat phenylethanolamine N-methyltransferase gene by transcription factors Sp1 and MAZ. Her S, etal., Mol Pharmacol. 2003 Nov;64(5):1180-8.
17. Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis. Inouye KE, etal., Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E422-9. Epub 2004 Oct 19.
18. Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats. Inouye KE, etal., Endocrinology. 2006 Apr;147(4):1860-70. Epub 2006 Jan 5.
19. Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat. Jirout ML, etal., Hum Mol Genet. 2010 Jul 1;19(13):2567-80. Epub 2010 Apr 8.
20. Enhanced activity of central adrenergic neurons in two-kidney, one clip hypertension in Sprague-Dawley rats. Jung JY, etal., Neurosci Lett. 2004 Oct 7;369(1):14-8.
21. Resequencing PNMT in European hypertensive and normotensive individuals: no common susceptibilily variants for hypertension and purifying selection on intron 1. Kepp K, etal., BMC Med Genet. 2007 Jul 23;8:47.
22. Existence of cardiac PNMT mRNA in adult rats: elevation by stress in a glucocorticoid-dependent manner. Krizanova O, etal., Am J Physiol Heart Circ Physiol 2001 Sep;281(3):H1372-9.
23. Stressor specificity and effect of prior experience on catecholamine biosynthetic enzyme phenylethanolamine N-methyltransferase. Kvetnansky R Ann N Y Acad Sci. 2004 Dec;1032:117-29.
24. Catecholaminergic systems in stress: structural and molecular genetic approaches. Kvetnansky R, etal., Physiol Rev. 2009 Apr;89(2):535-606.
25. Prenatal morphine exposure affects sympathoadrenal axis activity and serotonin metabolism in adult male rats both under basal conditions and after an ether inhalation stress. Laborie C, etal., Neurosci Lett. 2005 Jun 24;381(3):211-6.
26. Upregulation of neuronal nitric oxide synthase mRNA and protein in adrenal medulla of water-deprived rats. Lai FJ, etal., J Histochem Cytochem. 2005 Jan;53(1):45-53.
27. Down-regulation of adrenal neuronal nitric oxide synthase mRNAs and proteins after deoxycorticosterone acetate-salt treatment in rats. Lai FJ, etal., J Steroid Biochem Mol Biol. 2006 Nov;101(4-5):197-203. Epub 2006 Sep 11.
28. Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer disease. Mann MB, etal., Am J Med Genet. 2001 May 8;105(4):312-6.
29. Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis. Mann MB, etal., J Neuroimmunol 2002 Mar;124(1-2):101-5.
30. Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling. Meijer OC, etal., Endocrinology. 2005 Mar;146(3):1438-48. Epub 2004 Nov 24.
31. Cloning of the rat adrenal medullary phenylethanolamine-N-methyltransferase. Mezey E Nucleic Acids Res 1989 Mar 11;17(5):2125.
32. Stress-induced alterations in catecholamine enzymes gene expression in the hypothalamic dorsomedial nucleus are modulated by caudal brain and not hypothalamic paraventricular nucleus neurons. Mravec B, etal., Brain Res Bull. 2007 Sep 14;74(1-3):147-54. Epub 2007 Jun 29.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
37. Social hierarchy affects gene expression for catecholamine biosynthetic enzymes in rat adrenal glands. Pohorecky LA, etal., Neuroendocrinology. 2004;80(1):42-51. Epub 2004 Sep 2.
38. Interactions between orexin-immunoreactive fibers and adrenaline or noradrenaline-expressing neurons of the lower brainstem in rats and mice. Puskas N, etal., Peptides. 2010 Aug;31(8):1589-97. Epub 2010 Apr 29.
39. GOA pipeline RGD automated data pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Central nucleus of amygdala projections to rostral ventrolateral medulla neurones activated by decreased blood pressure. Saha S, etal., Eur J Neurosci. 2005 Apr;21(7):1921-30.
42. Nerve growth factor regulates adrenergic expression. Tai TC, etal., Mol Pharmacol. 2006 Nov;70(5):1792-801. Epub 2006 Aug 22.
43. Expression levels of mRNAs for catecholamine biosynthetic enzymes as markers of acute response to contusion stress during the early postmortem period. Takahashi S Tohoku J Exp Med. 2008 Nov;216(3):239-48.
44. Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles. Tillinger A, etal., Gen Physiol Biophys. 2006 Dec;25(4):355-64.
45. Modulation by 6-hydroxydopamine of expression of the phenylethanolamine N-methyltransferase (PNMT) gene in the rat heart during immobilization stress. Tillinger A, etal., Stress. 2006 Dec;9(4):207-13.
46. Cholinergic and peptidergic regulation of phenylethanolamine N-methyltransferase gene expression. Wong DL, etal., Ann N Y Acad Sci 2002 Oct;971:19-26.
47. Stress and adrenergic function: HIF1alpha, a potential regulatory switch. Wong DL, etal., Cell Mol Neurobiol. 2010 Nov;30(8):1451-7. Epub 2010 Nov 3.
48. Response of the adrenomedullary system to early postnatal stress in the Brattleboro rat. Zelena D, etal., Ann N Y Acad Sci. 2008 Dec;1148:456-61.
49. Characterization of the expression pattern of adrenergic receptors in rat taste buds. Zhang Y, etal., Neuroscience. 2010 Sep 1;169(3):1421-37. Epub 2010 May 15.
Additional References at PubMed
PMID:2575695   PMID:7558218   PMID:7931317   PMID:11965360   PMID:12438093   PMID:12438094   PMID:12782392   PMID:12933902   PMID:16696852   PMID:19112418   PMID:19539715   PMID:21777029  
PMID:22007271   PMID:26475702  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21083,383,019 - 83,386,557 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,384,923 - 83,386,556 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,329,223 - 88,330,891 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,827,308 - 87,828,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,219,959 - 83,221,627 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,340,893 - 86,342,501 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,340,940 - 86,342,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,137,019 - 86,138,436 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1082,132,183 - 82,134,127 (+)NCBICelera
Cytogenetic Map10q31NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381739,668,019 - 39,670,475 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,667,981 - 39,670,475 (+)EnsemblGRCh38hg38GRCh38
GRCh371737,824,272 - 37,826,728 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,078,033 - 35,080,254 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,078,032 - 35,080,254NCBI
Celera1734,484,236 - 34,486,457 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,618,165 - 33,620,658 (+)NCBIHuRef
CHM1_11738,060,055 - 38,062,549 (+)NCBICHM1_1
T2T-CHM13v2.01740,531,584 - 40,534,040 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391198,277,449 - 98,279,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,277,276 - 98,279,007 (+)EnsemblGRCm39 Ensembl
GRCm381198,386,623 - 98,388,180 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,386,450 - 98,388,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,247,946 - 98,249,411 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,202,722 - 98,204,187 (+)NCBIMGSCv36mm8
Celera11108,040,856 - 108,042,321 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545114,416,121 - 14,417,901 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,414,836 - 14,417,972 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11727,179,738 - 27,182,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,618,399 - 17,620,691 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,835,277 - 17,837,180 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,835,277 - 17,837,180 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1922,808,505 - 22,810,587 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,808,601 - 22,810,551 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,280,958 - 22,282,522 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,602,151 - 23,603,715 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1922,374,797 - 22,376,361 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,635,796 - 22,637,358 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,760,897 - 22,762,461 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440560222,213,520 - 22,217,186 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,858,603 - 14,865,321 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493649014,858,682 - 14,861,614 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1222,648,398 - 22,649,999 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,648,396 - 22,651,520 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,110,418 - 23,111,803 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11666,496,290 - 66,498,840 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,496,027 - 66,499,111 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,407,873 - 37,410,511 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247953,408,627 - 3,410,304 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,408,559 - 3,410,669 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Pnmt
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:52
Interacting mature miRNAs:53
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,386,355 - 83,386,524 (+)MAPPERmRatBN7.2
Rnor_6.01086,342,301 - 86,342,469NCBIRnor6.0
Rnor_5.01086,138,236 - 86,138,404UniSTSRnor5.0
Celera1082,133,927 - 82,134,095UniSTS
RH 3.4 Map10852.0UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 6 10 2 2 4
Low 2 15 5 4 11 4 3 6 5 1 13 6 3
Below cutoff 1 20 16 9 8 9 5 5 28 20 16 5 5


RefSeq Acc Id: ENSRNOT00000073486   ⟹   ENSRNOP00000067392
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,384,923 - 83,386,556 (+)Ensembl
Rnor_6.0 Ensembl1086,340,940 - 86,342,858 (+)Ensembl
RefSeq Acc Id: NM_031526   ⟹   NP_113714
Rat AssemblyChrPosition (strand)Source
mRatBN7.21083,384,923 - 83,386,556 (+)NCBI
Rnor_6.01086,340,893 - 86,342,501 (+)NCBI
Rnor_5.01086,137,019 - 86,138,436 (+)NCBI
Celera1082,132,183 - 82,134,127 (+)RGD
RefSeq Acc Id: XM_039085209   ⟹   XP_038941137
Rat AssemblyChrPosition (strand)Source
mRatBN7.21083,383,019 - 83,386,557 (+)NCBI
Protein Sequences
Protein RefSeqs NP_113714 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941137 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA91779 (Get FASTA)   NCBI Sequence Viewer  
  CAA32428 (Get FASTA)   NCBI Sequence Viewer  
  CAA53082 (Get FASTA)   NCBI Sequence Viewer  
  P10937 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113714   ⟸   NM_031526
- UniProtKB: P10937 (UniProtKB/Swiss-Prot),   A6HIS1 (UniProtKB/TrEMBL),   M0RCR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067392   ⟸   ENSRNOT00000073486
RefSeq Acc Id: XP_038941137   ⟸   XM_039085209
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10937-F1-model_v2 AlphaFold P10937 1-285 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3361 AgrOrtholog
BioCyc Gene G2FUF-23370 BioCyc
BioCyc Pathway PWY-6342 [noradrenaline and adrenaline degradation] BioCyc
  PWY66-301 [catecholamine biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000046057 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067392 ENTREZGENE
  ENSRNOP00000067392.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073486 ENTREZGENE
  ENSRNOT00000073486.3 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NNMT/PNMT/TEMT_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NNMT_TEMT_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24661 UniProtKB/Swiss-Prot
  PTHR10867 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NNMT_PNMT_TEMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pnmt PhenoGen
PIRSF PNMTase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P10937 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pnmt  Phenylethanolamine N-methyltransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in the cardiac atria and ventricles, highest levels of mRNA present in the left atrium, expression is much lower in adult rats as compared to newborns 628457
gene_function synthesizes epinephrine from norepinephrine 628457
gene_regulation immobilization stress increases the levels of mRNA in the atria and ventricles 628457