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Gene: Rffl (ring finger and FYVE-like domain containing E3 ubiquitin protein ligase) Rattus norvegicus
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Symbol: Rffl
Name: ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Description: Predicted to have enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; and negative regulation of signal transduction. Predicted to colocalize with the tumor necrosis factor receptor superfamily complex. Biomarker of hypertension. Orthologous to human RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase rififylin; fring; FYVE-RING finger protein Sakura; LOC282844; MGC94279; ring finger and FYVE like domain containing protein; ring finger and FYVE-like domain containing 1; RING finger and FYVE-like domain-containing protein 1; RING finger protein SAKURA; RING-type E3 ubiquitin transferase rififylin
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01070,157,621 - 70,220,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01069,788,330 - 69,851,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,025,035 - 71,047,280 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11071,038,657 - 71,060,903 (-)NCBI
Celera1066,686,813 - 66,709,204 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Rffl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 727916
Created: 2003-11-05
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.